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Dr

Mark Chong

Honorary
Medicine - St Vincent'S Hospital
Immune cell development
Epigenetics
Autoimmune
MicroRNAs
animals
mice
science & technology
micrornas
life sciences & biomedicine
Mark Chong's Profile Picture
Dr

Mark Chong

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
RNA Biology
Mark Chong's Profile Picture
Dr

Mark Chong

 

A/Prof. Mark M W Chong
Head, Genomics and Immunology Laboratory, St Vincent's Institute of Medical Research
Honorary Principal Research Fellow, Department of Medicine.

https://www.svi.edu.au/research_themes/genomics_and_immunology
https://orcid.org/0000-0002-3701-7397
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A/Prof Chong obtained his PhD from the University of Melbourne for research performed at the Walter and Eliza Hall Institute, followed by postdoctoral training at New York University in the United States.

A/Prof Chong's research team consists of a mixture of students (PhD, Masters, Honours and undergraduates), postdocs and research assistants working in two general research areas.

Firstly, the Chong laboratory interested in gene regulatory mechanisms that control the development of immune cell subsets and how abnormalities in these mechanisms contribute to autoimmune disease. In particular, their research focuses on T lymphocyte development in the thymus and myeloid lineage development in the bone marrow. Secondly, the Chong laboratory is interested in non-coding RNAs, particularly microRNAs. Their research primarily focuses on how these RNAs are transcribed and processed in order to generate functional molecules.

A/Prof Chong is always on the look out for talented students, postdocs and research assistants to join his team.

Selected recent publications:

1. Koay, et al. (2016), Thymic precursors to the Mucosal-Associated Invariant T cell lineage, Nat Immunol, 17:1300.

2. Johanson, et al. (2015), Drosha controls dendritic cell development by cleavage of messenger RNAs encoding inhibitors of myelopoiesis, Nat Immunol, 16:1134.

3. Srivastava, et al. (2015), Roquin binds microRNA-146a and Argonaute 2 and regulates microRNA homeostasis, Nat Commun, 6:6253.

4. Knuckles, et al. (2012), Drosha regulates neurogenesis by controlling Neurogenin2 expression independent of microRNAs, Nat Neurosci, 15:962.

5. Kaneko, et al. (2011), DICER dysregulation induces cytotoxic Alu RNA accumulation in age-related macular degeneration, Nature, 471:325.

6. Collins, et al. (2011), RUNX-mediated association of Cd4 and Cd8 enables coordinate gene regulation, Immunity, 34:303.

7. Karginov, et al. (2010), Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha and additional nucleases, Mol Cell, 38:781.

8. Cheloufi, et al. (2010), A Dicer-independent miRNA biogenesis pathway that requires Argonaute catalysis, Nature, 465:584.

9. Chong, et al. (2010) Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells, Genes Dev, 24:659.

10. Chong et al. (2010), Canonical and alternate functions of the microRNA biogenesis machinery, Genes Dev, 24:1951.

Scholarly Works

Displaying the 41 most recent scholarly works by Mark Chong.

Honours, Awards and Fellowships

2017

Senior Research Fellowship

National Health and Medical Research Council

2011

QEII Fellowship

Australian Research Council

2008

Senior Fellowship

Helen and Martin Kimmel Senior Stem Cell Center

2005

Campion-Ma-Playoust Memorial Award

Australian Society for Medical Research

2004

International Travel Award

International Congress of Immunology

2004

Postdoctoral Fellowship

Cancer Research Institute

2004

International Travel Award

Immunology of Diabetes Society

2003

International Travel Award

Federation of Clinical Immunology Societies

2003

International Travel Award

Juvenile Diabetes Research Foundation International

2002

New Investigator Award

Australasian Society for Immunology

2002

CASS Foundation Prize

Australian Health and Medical Research Congress

2001

Cleveland Young Investigator Award

Royal Melbourne Hospital

2000

Australian Postgraduate Award

Australian Government

13

Awards

Credentials

Positions


Honorary

Medicine - St Vincent'S Hospital

Member

Australian Society for Biochemistry and Molecular Biology

Member

The RNA Society

Member

Australian Society for Medical Research

Member

Australasian Society for Immunology

Education


Doctor of Philosophy

University of Melbourne

Bachelor of Science Honours

University of Melbourne

Bachelor of Arts

University of Melbourne