Mark Chong

MYL9 deficiency is neonatal lethal in mice due to abnormalities in the lung and the muscularis propria of the bladder and intestine

Chu-Han Huang, Joyce Schuring, Jarrod P Skinner, Lawrence Mok, Mark MW Chong

Journal article  |  2022  |  PLOS ONE

Class II myosin complexes are responsible for muscle contraction as well as other non-sarcomeric contractile functions in cells. M..

Inhibition of the antigen-presenting ability of dendritic cells by non-structural protein 2 of influenza A virus

Jian Lin, Yanan Cao, Jinjiao Zuo, Shuai Zhang, Qinghua Yu, Qian Yang, Abid Ullah Shaha, Mark MW Chong

Journal article  |  2022  |  VETERINARY MICROBIOLOGY

Influenza A viruses (IAV), including human IAV and avian IAV (H9N2 subtype), are recurring of influenza outbreaks worldwide in a w..

DROSHA but not DICER is required for human haematopoietic stem cell function

Karen Gu, Carina Walpole, Shayarana Gooneratne, Xin Liu, Oscar L Haigh, Kristen J Radford, Mark Mw Chong

Journal article  |  2022  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

OBJECTIVES: DROSHA and DICER have central roles in the biogenesis of microRNAs (miRNAs). However, we previously showed that in the..

Expression of the miR-17 similar to 92a cluster of microRNAs by regulatory T cells controls blood glucose homeostasis

Yangnan Zhang, Jarrod P Skinner, Mark MW Chong

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

Regulatory T cells (Tregs) are a specialized immune cell type that play important roles in regulating immune responses. However, t..

Single-Cell RNA Sequencing Approaches for Tracing T Cell Development

Seungyoul Oh, Daniel HD Gray, Mark MW Chong

Journal article  |  2021  |  JOURNAL OF IMMUNOLOGY

T cell development occurs in the thymus, where uncommitted progenitors are directed into a range of sublineages with distinct func..

A comparison of alternative mRNA splicing in the CD4 and CD8 T cell lineages

Xin Liu, Matthew Andrews, Jarrod P Skinner, Timothy M Johanson, Mark MW Chong

Journal article  |  2021  |  MOLECULAR IMMUNOLOGY

T cells can be subdivided into a number of different subsets that are defined by their distinct functions. While the specializatio..

Regulating gene expression in animals through RNA endonucleolytic cleavage

Karen Gu, Lawrence Mok, Mark MW Chong

Journal article  |  2018  |  HELIYON

The expression of any gene must be precisely controlled for appropriate function. This expression can be controlled at various lev..

Biologically active constituents of the secretome of human W8B2( ) cardiac stem cells

Shuai Nie, Xin Wang, Priyadharshini Sivakumaran, Mark MW Chong, Xin Liu, Tara Karnezis, Nadeeka Bandara, Kaloyan Takov, Cameron J Nowell, Stephen Wilcox, Mitch Shambrook, Andrew F Hill, Nicole C Harris, Andrew E Newcomb, Padraig Strappe, Ramin Shayan, Damian Hernandez, Jordan Clarke, Eric Hanssen, Sean M Davidson, et al.

Journal article  |  2018  |  SCIENTIFIC REPORTS

The benefits of adult stem cells for repair of the heart have been attributed to the repertoire of salutary paracrine activities t..

miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation

Maryaline Coffre, David Benhamou, David Riess, Lili Blumenberg, Valentina Snetkova, Marcus J Hines, Tirtha Chakraborty, Sofia Bajwa, Kari Jensen, Mark MW Chong, Lelise Getu, Gregg J Silverman, Robert Blelloch, Dan R Littman, Dinis Calado, Doron Melamed, Jane A Skok, Klaus Rajewsky, Sergei B Koralov

Journal article  |  2016  |  CELL REPORTS

B cell development is a tightly regulated process dependent on sequential rearrangements of immunoglobulin loci that encode the an..

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

Hui-Fern Koay, Nicholas A Gherardin, Anselm Enders, Liyen Loh, Laura K Mackay, Catarina F Almeida, Brendan E Russ, Claudia A Nold-Petry, Marcel F Nold, Sammy Bedoui, Zhenjun Chen, Alexandra J Corbett, Sidonia BG Eckle, Bronwyn Meehan, Yves d'Udekem, Igor E Konstantinov, Martha Lappas, Ligong Liu, Chris C Goodnow, David P Fairlie, et al.

Journal article  |  2016  |  NATURE IMMUNOLOGY

Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives presented by the antigen-presenting mole..