Peter Czabotar

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Rong Li, Antonia N Policheni, Emily Gruber, Cheng Huang, Alex J Fulcher, Jillian C Danne, Peter E Czabotar, Linda M Wakim, Justine D Mintern, Georg Ramm, Kristen J Radford, Irina Caminschi, Meredith O'Keeffe, Jose A Villadangos, Mark D Wright, et al.

Journal article  |  2020  |  eLife

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction o..

Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway

Catia L Pierotti, Maria C Tanzer, Annette Jacobsen, Joanne M Hildebrand, Jean-Marc Garnier, Pooja Sharma, Isabelle S Lucet, Angus D Cowan, Wilhelmus JA Kersten, Meng-Xiao Luo, Lung-Yu Liang, Cheree Fitzgibbon, Sarah E Garnish, Anne Hempel, Ueli Nachbur, David CS Huang, Peter E Czabotar, John Silke, Mark F van Delft, James M Murphy, et al.

Journal article  |  2020  |  ACS Chemical Biology

Necroptosis is an inflammatory form of programmed cell death that has been implicated in various human diseases. Compound 2 is a m..

Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association.

Tufa E Assafa, Sukhendu Nandi, Dariusz Śmiłowicz, Laura Galazzo, Markus Teucher, Christina Elsner, Stefanie Pütz, Stephanie Bleicken, Adeline Y Robin, Dana Westphal, Isabel Uson, Raphael Stoll, Peter E Czabotar, Nils Metzler-Nolte, Enrica Bordignon

Journal article  |  2020  |  Structure

Bcl-2 proteins orchestrate the mitochondrial pathway of apoptosis, pivotal for cell death. Yet, the structural details of the conf..

BAK core dimers bind lipids and can be bridged by them

Angus D Cowan, Nicholas A Smith, Jarrod J Sandow, Eugene A Kapp, Yepy H Rustam, James M Murphy, Jason M Brouwer, Jonathan P Bernardini, Michael J Roy, Ahmad Z Wardak, Iris K Tan, Andrew I Webb, Jacqueline M Gulbis, Brian J Smith, Gavin E Reid, Grant Dewson, Peter M Colman, Peter E Czabotar

Journal article  |  2020  |  Nature Structural & Molecular Biology

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Jonathan P Bernardini, Bernadine GC Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Zhong Yan Gan, James P Cooney, Marcel Doerflinger, Amanda E Au, Timothy R Blackmore, Gerbrand J van der Heden van Noort, Paul P Geurink, Huib Ovaa, Janet Newman, Alan Riboldi-Tunnicliffe, et al.

Journal article  |  2020  |  The EMBO Journal

Relating SMCHD1 structure to its function in epigenetic silencing

Alexandra D Gurzau, Marnie E Blewitt, Peter E Czabotar, James M Murphy, Richard W Birkinshaw

Journal article  |  2020  |  Biochemical Society Transactions

The structural maintenance of chromosomes hinge domain containing protein 1 (SMCHD1) is a large multidomain protein involved in ep..

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Joanne M Hildebrand, Maria Kauppi, Ian J Majewski, Zikou Liu, Allison J Cox, Sanae Miyake, Emma J Petrie, Michael A Silk, Zhixiu Li, Maria C Tanzer, Gabriela Brumatti, Samuel N Young, Cathrine Hall, Sarah E Garnish, Jason Corbin, Michael D Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C Josefsson, Kristin Rigbye, et al.

Journal article  |  2020  |  Nature Communications

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a singl..

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

Katherine A Davies, Cheree Fitzgibbon, Samuel N Young, Sarah E Garnish, Wayland Yeung, Diane Coursier, Richard W Birkinshaw, Jarrod J Sandow, Wil IL Lehmann, Lung-Yu Liang, Isabelle S Lucet, James D Chalmers, Wayne M Patrick, Natarajan Kannan, Emma J Petrie, Peter E Czabotar, James M Murphy

Journal article  |  2020  |  Nature Communications

Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues

Kelan Chen, Richard W Birkinshaw, Alexandra D Gurzau, Iromi Wanigasuriya, Ruoyun Wang, Megan Iminitoff, Jarrod J Sandow, Samuel N Young, Patrick J Hennessy, Tracy A Willson, Denise A Heckmann, Andrew Webb, Marnie E Blewitt, Peter E Czabotar, James M Murphy

Journal article  |  2020  |  Science Signaling

Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies

Emma J Petrie, Richard W Birkinshaw, Akiko Koide, Eric Denbaum, Joanne M Hildebrand, Sarah E Garnish, Katherine A Davies, Jarrod J Sandow, Andre L Samson, Xavier Gavin, Cheree Fitzgibbon, Samuel N Young, Patrick J Hennessy, Phoebe PC Smith, Andrew I Webb, Peter E Czabotar, Shohei Koide, James M Murphy

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of the United States of America

The necroptosis cell death pathway has been implicated in host defense and in the pathology of inflammatory diseases. While phosph..