Peter Czabotar

Dynamic reconfiguration of pro-apoptotic BAK on membranes

Jarrod J Sandow, Iris Kl Tan, Alan S Huang, Shashank Masaldan, Jonathan P Bernardini, Ahmad Z Wardak, Richard W Birkinshaw, Robert L Ninnis, Ziyan Liu, Destiny Dalseno, Daisy Lio, Giuseppi Infusini, Peter E Czabotar, Andrew Webb, Grant Dewson

Journal article  |  2021  |  EMBO JOURNAL

BAK and BAX, the effectors of intrinsic apoptosis, each undergo major reconfiguration to an activated conformer that self-associat..

BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia

Emma M Carrington, Cynthia Louis, Tobias Kratina, Manuela Hancock, Christine R Keenan, Nadia Iannarella, Rhys S Allan, Ahmad Z Wardak, Peter E Czabotar, Marco J Herold, Robyn L Schenk, Christine A White, Damian D'Silva, Yuyan Yang, Wesley Wong, Huon Wong, Vanessa L Bryant, Nicholas D Huntington, Jai Rautela, Robyn M Sutherland, et al.

Journal article  |  2021  |  BLOOD ADVANCES

Neutrophils help to clear pathogens and cellular debris, but can also cause collateral damage within inflamed tissues. Prolonged n..

Structure of detergent-activated BAK dimers derived from the inert monomer

Richard W Birkinshaw, Sweta Iyer, Daisy Lio, Cindy S Luo, Jason M Brouwer, Michelle S Miller, Adeline Y Robin, Rachel T Uren, Grant Dewson, Ruth M Kluck, Peter M Colman, Peter E Czabotar

Journal article  |  2021  |  MOLECULAR CELL

A body of data supports the existence of core (α2-α5) dimers of BAK and BAX in the oligomeric, membrane-perturbing conformation of..

Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-X-L and BCL-2

Michael J Roy, Amelia Vom, Toru Okamoto, Brian J Smith, Richard W Birkinshaw, Hong Yang, Houda Abdo, Christine A White, David Segal, David CS Huang, Jonathan B Baell, Peter M Colman, Peter E Czabotar, Guillaume Lessene

Journal article  |  2021  |  JOURNAL OF MEDICINAL CHEMISTRY

The BCL-2 family of proteins (including the prosurvival proteins BCL-2, BCL-XL, and MCL-1) is an important target for the developm..

A new crystal form of GABARAPL2

Kristen Scicluna, Grant Dewson, Peter E Czabotar, Richard W Birkinshaw

Journal article  |  2021  |  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS

The Atg8 protein family comprises the GABA type A receptor-associated proteins (GABARAPs) and microtubule-associated protein 1 lig..

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

Sarah E Garnish, Yanxiang Meng, Akiko Koide, Jarrod J Sandow, Eric Denbaum, Annette V Jacobsen, Wayland Yeung, Andre L Samson, Christopher R Horne, Cheree Fitzgibbon, Samuel N Young, Phoebe PC Smith, Andrew I Webb, Emma J Petrie, Joanne M Hildebrand, Natarajan Kannan, Peter E Czabotar, Shohei Koide, James M Murphy

Journal article  |  2021  |  NATURE COMMUNICATIONS

Phosphorylation of the MLKL pseudokinase by the RIPK3 kinase leads to MLKL oligomerization, translocation to, and permeabilization..

Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association

Tufa E Assafa, Sukhendu Nandi, Dariusz Smilowicz, Laura Galazzo, Markus Teucher, Christina Elsner, Stefanie Putz, Stephanie Bleicken, Adeline Y Robin, Dana Westphal, Isabel Uson, Raphael Stoll, Peter E Czabotar, Nils Metzler-Nolte, Enrica Bordignon

Journal article  |  2021  |  STRUCTURE

Bcl-2 proteins orchestrate the mitochondrial pathway of apoptosis, pivotal for cell death. Yet, the structural details of the conf..

Yeast- and antibody-based tools for studying tryptophan C-mannosylation

Alan John, Michael A Jarva, Sayali Shah, Runyu Mao, Stephane Chappaz, Richard W Birkinshaw, Peter E Czabotar, Alvin W Lo, Nichollas E Scott, Ethan D Goddard-Borger

Journal article  |  2021  |  NATURE CHEMICAL BIOLOGY

Tryptophan C-mannosylation is an unusual co-translational protein modification performed by metazoans and apicomplexan protists. T..

The regulation of necroptosis by post-translational modifications

Yanxiang Meng, Jarrod J Sandow, Peter E Czabotar, James M Murphy

Journal article  |  2021  |  CELL DEATH AND DIFFERENTIATION

Necroptosis is a caspase-independent, lytic form of programmed cell death whose errant activation has been widely implicated in ma..

RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Rong Li, Antonia N Policheni, Emily Gruber, Cheng Huang, Alex J Fulcher, Jillian C Danne, Peter E Czabotar, Linda M Wakim, Justine D Mintern, Georg Ramm, Kristen J Radford, Irina Caminschi, Meredith O'Keeffe, Jose A Villadangos, Mark D Wright, et al.

Journal article  |  2020  |  ELIFE

The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction o..