Peter Czabotar

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Joanne M Hildebrand, Maria Kauppi, Ian J Majewski, Zikou Liu, Allison J Cox, Sanae Miyake, Emma J Petrie, Michael A Silk, Zhixiu Li, Maria C Tanzer, Gabriela Brumatti, Samuel N Young, Cathrine Hall, Sarah E Garnish, Jason Corbin, Michael D Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C Josefsson, Kristin Rigbye, et al.

Journal article  |  2020  |  Nature Communications

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a singl..

Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies

Emma J Petrie, Richard W Birkinshaw, Akiko Koide, Eric Denbaum, Joanne M Hildebrand, Sarah E Garnish, Katherine A Davies, Jarrod J Sandow, Andre L Samson, Xavier Gavin, Cheree Fitzgibbon, Samuel N Young, Patrick J Hennessy, Phoebe PC Smith, Andrew I Webb, Peter E Czabotar, Shohei Koide, James M Murphy

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

The necroptosis cell death pathway has been implicated in host defense and in the pathology of inflammatory diseases. While phosph..

BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins

Tudor Moldoveanu, Peter E Czabotar

Journal article  |  2020  |  Cold Spring Harbor Perspectives in Biology

Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on

Piers Blombery, Ella R Thompson, Nguyen Tamia, Richard W Birkinshaw, Jia-Nan Gong, Xiangting Chen, Michelle McBean, Rachel Thijssen, Thomas Conway, Mary Ann Anderson, John F Seymour, David A Westerman, Peter E Czabotar, David CS Huang, Andrew W Roberts

Journal article  |  2020  |  Blood

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Mark F van Delft, Stephane Chappaz, Yelena Khakham, T Bui Chinh, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, et al.

Journal article  |  2019  |  Nature Chemical Biology

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contr..

Characterization of a novel venetoclax resistance mutation (BCL2 Phe104Ile) observed in follicular lymphoma

Piers Blombery, Richard W Birkinshaw, Tamia Nguyen, Jia-nan Gong, Ella R Thompson, Zhen Xu, David A Westerman, Peter E Czabotar, Michael Dickinson, David CS Huang, John F Seymour, Andrew W Roberts

Journal article  |  2019  |  British Journal of Haematology

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes

Julie Healer, Wilson Wong, Jennifer K Thompson, Wengqiang He, Richard W Birkinshaw, Kazutoyo Miura, Carol A Long, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Willem A de Jongh, Christopher Weir, Ella Svahn, Peter E Czabotar, Wai-Hong Tham, Ivo Mueller, Paul N Barlow, Alan F Cowman

Journal article  |  2019  |  Cellular Microbiology

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

Richard W Birkinshaw, Jia-nan Gong, Cindy S Luo, Daisy Lio, Christine A White, Mary Ann Anderson, Piers Blombery, Guillaume Lessene, Ian J Majewski, Rachel Thijssen, Andrew W Roberts, David CS Huang, Peter M Colman, Peter E Czabotar

Journal article  |  2019  |  Nature Communications

Correction for Bandala-Sanchez et al., CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function.

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Piers Blombery, Mary Ann Anderson, Jia-nan Gong, Rachel Thijssen, Richard W Birkinshaw, Ella R Thompson, Charis E Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas E Lew, Ian J Majewski, Daniel HD Gray, David A Westerman, Constantine S Tam, John F Seymour, Peter E Czabotar, David CS Huang, Andrew W Roberts

Journal article  |  2019  |  Cancer Discovery

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

Jonathan P Bernardini, Jason M Brouwer, Iris KL Tan, Jarrod J Sandow, Shuai Huang, Che A Stafford, Aleksandra Bankovacki, Christopher D Riffkin, Ahmad Z Wardak, Peter E Czabotar, Michael Lazarou, Grant Dewson

Journal article  |  2019  |  The EMBO Journal

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex

Wilson Wong, Rick Huang, Sebastien Menant, Chuan Hong, Jarrod J Sandow, Richard W Birkinshaw, Julie Healer, Anthony N Hodder, Usheer Kanjee, Christopher J Tonkin, Denise Heckmann, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Manoj T Duraisingh, Peter E Czabotar, Willem A de Jongh, Wai-Hong Tham, Andrew I Webb, Zhiheng Yu, et al.

Journal article  |  2019  |  Nature

The Structural Basis of Necroptotic Cell Death Signaling

Emma J Petrie, Peter E Czabotar, James M Murphy

Journal article  |  2019  |  Trends in Biochemical Sciences

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface

Fiona Moghaddas, Ping Zeng, Yuxia Zhang, Heike Schuetzle, Sebastian Brenner, Sigrun R Hofmann, Reinhard Berner, Yuanbo Zhao, Bingtai Lu, Xiaoyun Chen, Li Zhang, Suyun Cheng, Stefan Winkler, Kai Lehmberg, Scott W Canna, Peter E Czabotar, Ian P Wicks, Dominic De Nardo, Christian M Hedrich, Huasong Zeng, et al.

Journal article  |  2018  |  Journal of Allergy and Clinical Immunology

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Piers Blombery, Mary Ann Anderson, Jianan Gong, Rachel Thijssen, Richard W Birkinshaw, Ella Thompson, Charis E Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas Lew, Ian Majewski, Daniel Gray, David Alan Westerman, Constantine S Tam, John F Seymour, Peter E Czabotar, David Huang, Andrew W Roberts

Conference Proceedings  |  2018  |  Blood

Ensemble Properties of Bax Determine Its Function

Adeline Y Robin, Sweta Iyer, Richard W Birkinshaw, Jarrod Sandow, Ahmad Wardak, Cindy S Luo, Melissa Shi, Andrew Webb, Peter E Czabotar, Ruth M Kluck, Peter M Colman

Journal article  |  2018  |  Structure

The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis

Katherine A Davies, Maria C Tanzer, Michael DW Griffin, Yee Foong Mok, Samuel N Young, Rui Qin, Emma J Petrie, Peter E Czabotar, John Silke, James M Murphy

Journal article  |  2018  |  Cell Death & Differentiation

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

Esther Bandala-Sanchez, Naiara G Bediaga, Ethan D Goddard-Borger, Katrina Ngui, Gaetano Naselli, Natalie L Stone, Alana M Neale, Lesley A Pearce, Ahmad Wardak, Peter Czabotar, Thomas Haselhorst, Andrea Maggioni, Lauren A Hartley-Tassell, Timothy E Adams, Leonard C Harrison

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P-2 position of PEXEL peptidomimetics

William Nguyen, Anthony N Hodder, Richard Bestel de Lezongard, Peter E Czabotar, Kate E Jarman, Matthew T O'Neill, Jennifer K Thompson, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Journal article  |  2018  |  European Journal of Medicinal Chemistry

Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Emma J Petrie, Jarrod J Sandowl, Annette Jacobsen, Brian J Smith, Michael DW Griffin, Isabelle S Lucet, Weiwen Dai, Samuel N Young, Maria C Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D Cowan, Joanne M Hildebrand, Wilhelmus JA Kersten, Guillaume Lessene, John Silke, Peter E Czabotar, Andrew Webb, James M Murphy

Journal article  |  2018  |  Nature Communications

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

Francine FS Ke, Hannah K Vanyai, Angus D Cowan, Alex RD Delbridge, Lachlan Whitehead, Stephanie Grabow, Peter E Czabotar, Anne K Voss, Andreas Strasser

Journal article  |  2018  |  Cell

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi, Ilio Vitale, Stuart A Aaronson, John M Abrams, Dieter Adam, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews, Margherita Annicchiarico-Petruzzelli, Alexey V Antonov, Eli Arama, Eric H Baehrecke, Nickolai A Barlev, Nicolas G Bazan, Francesca Bernassola, Mathieu JM Bertrand, Katiuscia Bianchi, Mikhail V Blagosklonny, et al.

Journal article  |  2018  |  Cell Death & Differentiation

The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation

Richard W Birkinshaw, Peter E Czabotar

Journal article  |  2017  |  Seminars in Cell & Developmental Biology

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors

Phillip P Sharp, Jean-Marc Garnier, Tamas Hatfaludi, Zhen Xu, David Segal, Kate E Jarman, Helene Jousset, Alexandra Garnham, John T Feutrill, Anthony Cuzzupe, Peter Hall, Scott Taylor, Carl R Walkley, Dean Tyler, Mark A Dawson, Peter Czabotar, Andrew F Wilks, Stefan Glaser, David CS Huang, Christopher J Burns

Journal article  |  2017  |  ACS Medicinal Chemistry Letters

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

Jason M Brouwer, Ping Lan, Angus D Cowan, Jonathan P Bernardini, Richard W Birkinshaw, Mark F van Delft, Brad E Sleebs, Adeline Y Robin, Ahmad Wardak, Iris K Tan, Boris Reljic, Erinna F Lee, W Douglas Fairlie, Melissa J Call, Brian J Smith, Grant Dewson, Guillaume Lessene, Peter M Colman, Peter E Czabotar

Journal article  |  2017  |  Molecular Cell

Evolutionary divergence of the necroptosis effector MLKL

MC Tanzer, I Matti, JM Hildebrand, SN Young, A Wardak, A Tripaydonis, EJ Petrie, AL Mildenhall, DL Vaux, JE Vince, PE Czabotar, J Silke, JM Murphy

Journal article  |  2016  |  Cell Death & Differentiation

Physiological restraint of Bak by Bcl-x(L) is essential for cell survival

Erinna F Lee, Stephanie Grabow, Stephane Chappaz, Grant Dewson, Colin Hockings, Ruth M Kluck, Marlyse A Debrincat, Daniel H Gray, Matthew T Witkowski, Marco Evangelista, Anne Pettikiriarachchi, Philippe Bouillet, Rachael M Lane, Peter E Czabotar, Peter M Colman, Brian J Smith, Benjamin T Kile, W Douglas Fairlie

Journal article  |  2016  |  Genes & Development

Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes Mediate Merozoite Binding to Human Erythrocytes

Clara S Lin, Alessandro D Uboldi, Christian Epp, Hermann Bujard, Takafumi Tsuboi, Peter E Czabotar, Alan F Cowman

Journal article  |  2016  |  Journal of Biological Chemistry

The hinge domain of the epigenetic repressor Smchd1 adopts an unconventional homodimeric configuration

Kelan Chen, Peter E Czabotar, Marnie E Blewitt, James M Murphy

Journal article  |  2016  |  Biochemical Journal

Preparing Samples for Crystallization of Bcl-2 Family Complexes.

Marc Kvansakul, Peter E Czabotar

Journal article  |  2016  |  Methods in molecular biology (Clifton, N.J.)

High-resolution protein structures determined by X-ray crystallography or NMR have proven invaluable for deciphering the molecular..

A tale of two domains - a structural perspective of the pseudokinase, MLKL

Peter E Czabotar, James M Murphy

Journal article  |  2015  |  FEBS Journal

Structural basis for plasmep sin V inhibition that blocks export of malaria proteins to human erythrocytes

Anthony N Hodder, Brad E Sleebs, Peter E Czabotar, Michelle Gazdik, Yibin Xu, Matthew T O'Neill, Sash Lopaticki, Thomas Nebl, Tony Triglia, Brian J Smith, Kym Lowes, Justin A Boddey, Alan F Cowman

Journal article  |  2015  |  Nature Structural & Molecular Biology

Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation

Kelan Chen, Jiang Hu, Darcy L Moore, Ruijie Liu, Sarah A Kessans, Kelsey Breslin, Isabelle S Lucet, Andrew Keniry, Huei San Leong, Clare L Parish, Douglas J Hilton, Richard JLF Lemmers, Silvere M van der Maarel, Peter E Czabotar, Renwick CJ Dobson, Matthew E Ritchie, Graham F Kay, James M Murphy, Marnie E Blewitt

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction

AY Robin, K Krishna Kumar, D Westphal, AZ Wardak, GV Thompson, G Dewson, PM Colman, PE Czabotar

Journal article  |  2015  |  Cell Death & Disease

Transmembrane Complexes of DAP12 Crystallized in Lipid Membranes Provide Insights into Control of Oligomerization in Immunoreceptor Assembly

Konstantin Knoblich, Soohyung Park, Mariam Lutfi, Leonie van 't Hag, Charlotte E Conn, Shane A Seabrook, Janet Newman, Peter E Czabotar, Wonpil Im, Matthew E Call, Melissa J Call

Journal article  |  2015  |  Cell Reports

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax

C Hockings, K Anwari, RL Ninnis, J Brouwer, M O'Hely, M Evangelista, MG Hinds, PE Czabotar, EF Lee, WD Fairlie, G Dewson, RM Kluck

Journal article  |  2015  |  Cell Death & Disease

Characterisation of a novel A1-specific monoclonal antibody

MJ Lang, MS Brennan, LA O'Reilly, E Ottina, PE Czabotar, E Whitlock, WD Fairlie, L Tai, A Strasser, MJ Herold

Journal article  |  2014  |  Cell Death & Disease

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Joanne M Hildebrand, Maria C Tanzer, Isabelle S Lucet, Samuel N Young, Sukhdeep K Spall, Pooja Sharma, Catia Pierotti, Jean-Marc Garnier, Renwick CJ Dobson, Andrew I Webb, Anne Tripaydonis, Jeffrey J Babon, Mark D Mulcair, Martin J Scanlon, Warren S Alexander, Andrew F Wilks, Peter E Czabotar, Guillaume Lessene, James M Murphy, John Silke

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Discovery of a Potent and Selective BCL-X-L Inhibitor with in Vivo Activity

Zhi-Fu Tao, Lisa Hasvold, Le Wang, Xilu Wang, Andrew M Petros, Chang H Park, Erwin R Boghaert, Nathaniel D Catron, Jun Chen, Peter M Colman, Peter E Czabotar, Kurt Deshayes, Wayne J Fairbrother, John A Flygare, Sarah G Hymowitz, Sha Jin, Russell A Judge, Michael FT Koehler, Peter J Kovar, Guillaume Lessene, et al.

Journal article  |  2014  |  ACS Medicinal Chemistry Letters

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane

Dana Westphal, Grant Dewson, Marie Menard, Paul Frederick, Sweta Iyer, Ray Bartolo, Leonie Gibson, Peter E Czabotar, Brian J Smith, Jerry M Adams, Ruth M Kluck

Journal article  |  2014  |  Proceedings of the National Academy of Sciences

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

Jason M Brouwer, Dana Westphal, Grant Dewson, Adeline Y Robin, Rachel T Uren, Ray Bartolo, Geoff V Thompson, Peter M Colman, Ruth M Kluck, Peter E Czabotar

Journal article  |  2014  |  Molecular Cell

The Merozoite Surface Protein 1 Complex Is a Platform for Binding to Human Erythrocytes by Plasmodium falciparum

Clara S Lin, Alessandro D Uboldi, Danushka Marapana, Peter E Czabotar, Christian Epp, Hermann Bujard, Nicole L Taylor, Matthew A Perugini, Anthony N Hodder, Alan F Cowman

Journal article  |  2014  |  Journal of Biological Chemistry

Structure-Guided Rescaffolding of Selective Antagonists of BCL-X-L

Michael FT Koehler, Philippe Bergeron, Edna F Choo, Kevin Lau, Chudi Ndubaku, Danette Dudley, Paul Gibbons, Brad E Sleebs, Carl S Rye, George Nikolakopoulos, Chinh Bui, Sanji Kulasegaram, Wilhelmus JA Kersten, Brian J Smith, Peter E Czabotar, Peter M Colman, David CS Huang, Jonathan B Baell, Keith G Watson, Lisa Hasvold, et al.

Journal article  |  2014  |  ACS Medicinal Chemistry Letters

Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway

MJ Roy, A Vom, PE Czabotar, G Lessene

Journal article  |  2014  |  British Journal of Pharmacology

Further Insights into the Effects of Pre-organizing the BimBH3 Helix

Toru Okamoto, David Segal, Kerry Zobel, Anna Fedorova, Hong Yang, Wayne J Fairbrother, David CS Huang, Brian J Smith, Kurt Deshayes, Peter E Czabotar

Journal article  |  2014  |  ACS Chemical Biology

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS

Shenggen Yao, Dana Westphal, Jeffrey J Babon, Geoff V Thompson, Adeline Y Robin, Jerry M Adams, Peter M Colman, Peter E Czabotar

Journal article  |  2014  |  Archives of Biochemistry and Biophysics

De-Novo Designed Library of Benzoylureas as Inhibitors of BCL-X-L: Synthesis, Structural and Biochemical Characterization

Ryan M Brady, Amelia Vom, Michael J Roy, Nathan Toovey, Brian J Smith, Rebecca M Moss, Effie Hatzis, David CS Huang, John P Parisot, Hong Yang, Ian P Street, Peter M Colman, Peter E Czabotar, Jonathan B Baell, Guillaume Lessene

Journal article  |  2014  |  Journal of Medicinal Chemistry

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

James M Murphy, Isabelle S Lucet, Joanne M Hildebrand, Maria C Tanzer, Samuel N Young, Pooja Sharma, Guillaume Lessene, Warren S Alexander, Jeffrey J Babon, John Silke, Peter E Czabotar

Journal article  |  2014  |  Biochemical Journal

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Peter E Czabotar, Guillaume Lessene, Andreas Strasser, Jerry M Adams

Journal article  |  2014  |  Nature Reviews Molecular Cell Biology

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb, Samuel N Young, Leila N Varghese, Gillian M Tannahill, Esme C Hatchell, Ian J Majewski, Toru Okamoto, Renwick CJ Dobson, Douglas J Hilton, Jeffrey J Babon, Nicos A Nicola, et al.

Journal article  |  2013  |  Immunity

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X-L

Brad E Sleebs, Wilhemus JA Kersten, Sanji Kulasegaram, George Nikolakopoulos, Effie Hatzis, Rebecca M Moss, John P Parisot, Hong Yang, Peter E Czabotar, W Douglas Fairlie, Erinna F Lee, Jerry M Adams, Lin Chen, Mark F van Delft, Kym N Lowes, Andrew Wei, David CS Huang, Peter M Colman, Ian P Street, Jonathan B Baell, et al.

Journal article  |  2013  |  Journal of Medicinal Chemistry

Structure-guided design of a selective BCL-X-L inhibitor

Guillaume Lessene, Peter E Czabotar, Brad E Sleebs, Kerry Zobel, Kym N Lowes, Jerry M Adams, Jonathan B Baell, Peter M Colman, Kurt Deshayes, Wayne J Fairbrother, John A Flygare, Paul Gibbons, Wilhelmus JA Kersten, Sanji Kulasegaram, Rebecca M Moss, John P Parisot, Brian J Smith, Ian P Street, Hong Yang, David CS Huang, et al.

Journal article  |  2013  |  Nature Chemical Biology

Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor alpha 1

Nicholas T Redpath, Yibin Xu, Nicholas J Wilson, Louis J Fabri, Manuel Baca, Arna E Andrews, Hal Braley, Ping Lu, Cheryl Ireland, Robin E Ernst, Andrea Woods, Gail Forrest, Zhiqiang An, Dennis M Zaller, William R Strohl, Cindy S Luo, Peter E Czabotar, Thomas PJ Garrett, Douglas J Hilton, Andrew D Nash, et al.

Journal article  |  2013  |  Biochemical Journal

Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity

Toru Okamoto, Kerry Zobel, Anna Fedorova, Clifford Quan, Hong Yang, Wayne J Fairbrother, David CS Huang, Brian J Smith, Kurt Deshayes, Peter E Czabotar

Journal article  |  2013  |  ACS Chemical Biology

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

Peter E Czabotar, Dana Westphal, Grant Dewson, Stephen Ma, Colin Hockings, W Douglas Fairlie, Erinna F Lee, Shenggen Yao, Adeline Y Robin, Brian J Smith, David CS Huang, Ruth M Kluck, Jerry M Adams, Peter M Colman

Journal article  |  2013  |  Cell

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

Anthony N Hodder, Peter E Czabotar, Alessandro D Uboldi, Oliver B Clarke, Clara S Lin, Julie Healer, Brian J Smith, Alan F Cowman

Journal article  |  2012  |  Journal of Biological Chemistry

The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments

Jian-Guo Zhang, Peter E Czabotar, Antonia N Policheni, Irina Caminschi, Soo San Wan, Susie Kitsoulis, Kirsteen M Tullett, Adeline Y Robin, Rajini Brammananth, Mark F van Delft, Jinhua Lu, Lorraine A O'Reilly, Emma C Josefsson, Benjamin T Kile, Wei Jin Chin, Justine D Mintern, Maya A Olshina, Wilson Wong, Jake Baum, Mark D Wright, et al.

Journal article  |  2012  |  IMMUNITY

Cytosolic Bax DOES IT REQUIRE BINDING PROTEINS TO KEEP ITS PRO-APOPTOTIC ACTIVITY IN CHECK?

Sandra Vogel, Nina Raulf, Stephanie Bregenhorn, Martin L Biniossek, Ulrich Maurer, Peter Czabotar, Christoph Borner

Journal article  |  2012  |  Journal of Biological Chemistry

Catalytic mechanism and cofactor preference of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus

Sudhir R Dommaraju, Con Dogovski, Peter E Czabotar, Lilian Hor, Brian J Smith, Matthew A Perugini

Journal article  |  2011  |  Archives of Biochemistry and Biophysics

Molecular biology of Bax and Bak activation and action

Dana Westphal, Grant Dewson, Peter E Czabotar, Ruth M Kluck

Journal article  |  2011  |  Biochimica et Biophysica Acta - Molecular Cell Research

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Brad E Sleebs, Peter E Czabotar, Wayne J Fairbrother, W Douglas Fairlie, John A Flygare, David CS Huang, Wilhelmus JA Kersten, Michael FT Koehler, Guillaume Lessene, Kym Lowes, John P Parisot, Brian J Smith, Morey L Smith, Andrew J Souers, Ian P Street, Hong Yang, Jonathan B Baell

Journal article  |  2011  |  Journal of Medicinal Chemistry

Mutation to Bax beyond the BH3 Domain Disrupts Interactions with Pro-survival Proteins and Promotes Apoptosis

Peter E Czabotar, Erinna F Lee, Geoff V Thompson, Ahmad Z Wardak, W Douglas Fairlie, Peter M Colman

Journal article  |  2011  |  Journal of Biological Chemistry

Crystal Structure of the Entire Ectodomain of gp130 INSIGHTS INTO THE MOLECULAR ASSEMBLY OF THE TALL CYTOKINE RECEPTOR COMPLEXES

Yibin Xu, Nadia J Kershaw, Cindy S Luo, Priscilla Soo, Michael J Pocock, Peter E Czabotar, Douglas J Hilton, Nicos A Nicola, Thomas PJ Garrett, Jian-Guo Zhang

Journal article  |  2010  |  Journal of Biological Chemistry

Bcl-2 Family Proteins as Therapeutic Targets

Peter E Czabotar, Guillaume Lessene

Journal article  |  2010  |  Current Pharmaceutical Design

Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their alpha 6 Helices

Grant Dewson, Tobias Kratina, Peter Czabotar, Catherine L Day, Jerry M Adams, Ruth M Kluck

Journal article  |  2009  |  Molecular Cell

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

Erinna F Lee, Peter E Czabotar, Hong Yang, Brad E Sleebs, Guillaume Lessene, Peter M Colman, Brian J Smith, W Douglas Fairlie

Journal article  |  2009  |  Journal of Biological Chemistry

Bax activation by Bim?

PE Czabotar, PM Colman, DCS Huang

Journal article  |  2009  |  Cell Death Differ.

High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)

Erinna F Lee, Jack D Sadowsky, Brian J Smith, Peter E Czabotar, Kimberly J Peterson-Kaufman, Peter M Colman, Samuel H Gellman, W Douglas Fairlie

Journal article  |  2009  |  Angewandte Chemie International Edition

BCL-2 family antagonists for cancer therapy

Guillaume Lessene, Peter E Czabotar, Peter M Colman

Journal article  |  2008  |  Nature Reviews Drug Discovery

Structural plasticity underpins promiscuous binding of the prosurvival protein a1

Callum Smits, Peter E Czabotar, Mark G Hinds, Catherine L Day

Journal article  |  2008  |  Structure

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

Erinna F Lee, Peter E Czabotar, Mark F Van Delft, Ewa M Michalak, Michelle J Boyle, Simon N Willis, Hamsa Puthalakath, Philippe Bouillet, Peter M Colman, David CS Huang, W Douglas Fairlie

Journal article  |  2008  |  Journal of Cell Biology

Crystal structure of ABT-737 complexed with Bcl-x(L): implications for selectivity of antagonists of the Bcl-2 family

EF Lee, PE Czabotar, BJ Smith, K Deshayes, K Zobel, PM Colman, WD Fairlie

Journal article  |  2007  |  Cell Death & Differentiation

Structural insights into the degradation of Mcl-1 induced by BH3 domains

Peter E Czabotar, Erinna F Lee, Mark F van Delft, Catherine L Day, Brian J Smith, David CS Huang, W Douglas Fairlie, Mark G Hinds, Peter M Colman

Journal article  |  2007  |  Proceedings of the National Academy of Sciences

Studies of structural changes in the M2 proton channel of influenza A virus by tryptophan fluorescence.

Peter E Czabotar, Stephen R Martin, Alan J Hay

Conference Proceedings  |  2004  |  Virus Research

Studies of tryptophan fluorescence of purified influenza A virus M2 protein have identified two pH-dependent structural changes. (..

A model for the cytoplasmic domain of the influenza A virus M2 channel by analogy to the HIV-1 Vpu protein.

José W Saldanha, Peter E Czabotar, Alan J Hay, William R Taylor

Journal article  |  2002  |  Protein & Peptide Letters

A model for the cytoplasmic domain of the M2 proton channel of influenza A virus was formulated based primarily on the cytoplasmic..

Identification of regions within the third FnIII-like domain of the IL-5Ralpha involved in IL-5 interaction.

PE Czabotar, J Holland, CJ Sanderson

Journal article  |  2000  |  Cytokine

Previously, two binding sites for interleukin 5 (IL-5) were identified on the IL-5 receptor alpha chain (IL-5Ralpha). They are loc..

Identification of residues involved in binding of IL5 to betacom using betaIL3 and betacom chimeras.

PE Czabotar, J Holland, CJ Sanderson

Journal article  |  1999  |  FEBS Letters

In mice there are two forms of the beta chain used in the IL3 receptor system, betacom and betaIL3. betacom is used by the IL3, IL..