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A/Prof

Grant Dewson

Honorary
science & technology
apoptosis
animals
life sciences & biomedicine
humans
mice
bcl-2 homologous antagonist-killer protein
cell biology
bcl-2-associated x protein
Grant Dewson's Profile Picture
A/Prof

Grant Dewson

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Mitochondria Research
Grant Dewson's Profile Picture
A/Prof

Grant Dewson

 

Research interest

A focus of my research program is the molecular interactions that regulate the mitochondrial pathway to apoptotic cell death. This is defining how apoptosis is tightly controlled in healthy cells, and how it becomes dysregulated in disease.

We aim to facilitate therapeutic target identification and rational design of compounds to directly manipulate the apoptotic pathway. Promoting apoptosis has applications for cancer therapy, while blocking cell death has potential as a treatment for ischaemia or degenerative diseases. This follows the paradigm that has resulted in the development of BH3 mimetic drugs, which are in clinical trials for the treatment of certain cancers.

My lab is also interested in the molecular control of mitophagy (mitochondrial quality control). Mitophagy is controlled by the E3 ubiquitin ligase Parkin, which is mutated in degenerative conditions including certain forms of Parkinson’s disease. It is also emerging as an important tumour suppressor.

We are investigating how Parkin interacts with the apoptosis machinery to co-ordinate mitochondrial quality control, how its activity influences the growth and survival of tumours, and whether this machinery represents a novel target for the treatment of cancer.

www.wehi.edu.au/people/grant-dewson

Scholarly Works

Displaying the 74 most recent scholarly works by Grant Dewson.

Credentials

Positions


Honorary

Medical Biology (W.E.H.I.)