Daniel Gray

MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3( )regulatory T cells

Charis E Teh, Alissa K Robbins, Darren C Henstridge, Grant Dewson, Sarah T Diepstraten, Gemma Kelly, Mark A Febbraio, Sarah S Gabriel, Lorraine A O'Reilly, Andreas Strasser, Daniel HD Gray

Journal article  |  2020  |  Cell Death & Differentiation

FOXP3+ regulatory T (Treg) cells are essential for maintaining immunological tolerance. Given their importance in immune-related d..

ImmGen at 15

Stephanie Vargas Aguilar, Oscar Aguilar, Rhys Allan, El Ad David Amir, Veronique Angeli, Maxim N Artyomov, Natasha Asinovski, Jilian Astarita, K Frank Austen, Geetika Bajpai, Nora Barrett, Alev Baysoy, Christophe Benoist, Angelique Bellemare-Pelletier, Brad Berg, Adam Best, Natalie Bezman, David Blair, Julie M Blander, Milena Bogunovic, et al.

Journal article  |  2020  |  Nature Immunology

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

Michael A Dengler, Charis E Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Marco J Herold, Daniel H Gray, Gemma L Kelly, Andrew W Roberts, Jerry M Adams

Journal article  |  2020  |  Oncogene

Apoptosis-regulating BCL-2 family members, which can promote malignant transformation and resistance to therapy, have become prime..

Characterization of a novel human BFL-1-specific monoclonal antibody

Lahiru Gangoda, Charis E Teh, Michael A Dengler, Sarah A Best, Clare E Weeden, Lin Tai, Erinna F Lee, Walter D Fairlie, Kate D Sutherland, Leonard C Harrison, Daniel H Gray, Andreas Strasser, Marco J Herold

Journal article  |  2020  |  Cell Death & Differentiation

Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells

Charis E Teh, Jia-Nan Gong, David Segal, Tania Tan, Cassandra J Vandenberg, Pasquale L Fedele, Michael SY Low, George Grigoriadis, Simon J Harrison, Andreas Strasser, Andrew W Roberts, David CS Huang, Garry P Nolan, Daniel HD Gray, Melissa E Ko

Journal article  |  2020  |  Cell Death & Differentiation

Multiple myeloma is an incurable and fatal cancer of immunoglobulin-secreting plasma cells. Most conventional therapies aim to ind..

The 2019 Lasker Award: T cells and B cells, whose life and death are essential for function of the immune system

Daniel HD Gray, David L Vaux, Andreas Strasser

Journal article  |  2019  |  Cell Death & Differentiation

Deletion of self-reactive CCR7-thymocytes in the absence of MHC expression on thymic epithelial cells

Rushika C Wirasinha, Anna Chan, Jin Yan Yap, Daniel Y Hu, Charis E Teh, Daniel HD Gray, Christopher C Goodnow, Stephen R Daley

Journal article  |  2019  |  Cell Death & Differentiation

The selection of αβ T cells in the thymus is punctuated by checkpoints at which thymocytes differentiate or undergo apoptosis. Wav..

CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3( ) regulatory T cells

Antonia Polichen, Keisuke Horikawa, Liz Milla, Jennifer Kofler, Philippe Bouillet, Gabrielle T Belz, Lorraine A O'Reilly, Christopher C Goodnow, Andreas Strasser, Daniel HD Gray

Journal article  |  2019  |  Immunology & Cell Biology

FOXP3+ regulatory T (Treg) cells are essential for immunological tolerance and immune homeostasis. Despite a great deal of interes..

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes

Yuhao Jiao, Joanne E Davis, Jai Rautela, Emma M Carrington, Mandy J Ludford-Menting, Wilford Goh, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Rachel Koldej, Daniel Gray, David Huang, Ben T Kile, Andrew M Lew, David S Ritchie, Nicholas D Huntington

Journal article  |  2019  |  Cell Death & Differentiation

Allogeneic hematopoietic stem cell transplantation (alloSCT) is used to treat over 15,000 patients with acute myeloid leukemia (AM..

Chronically stimulated human MAIT cells are unexpectedly potent IL-13 producers

Jason Kelly, Yosuke Minoda, Tobias Meredith, Garth Cameron, Marie-Sophie Philipp, Daniel G Pellicci, Alexandra J Corbett, Christian Kurts, Daniel HD Gray, Dale Godfrey, George Kannourakis, Stuart P Berzins

Journal article  |  2019  |  Immunology & Cell Biology

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

Helen M McRae, Alexandra L Garnham, Yifang Hu, Matthew T Witkowski, Mark A Corbett, Mathew P Dixon, Rose E May, Bilal N Sheikh, William Chiang, Andrew J Kueh, Tan A Nguyen, Kevin Man, Renee Gloury, Brandon J Aubrey, Antonia Policheni, Ladina Di Rago, Warren S Alexander, Daniel HD Gray, Andreas Strasser, Edwin D Hawkins, et al.

Journal article  |  2019  |  Blood

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Piers Blombery, Mary Ann Anderson, Jia-nan Gong, Rachel Thijssen, Richard W Birkinshaw, Ella R Thompson, Charis E Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas E Lew, Ian J Majewski, Daniel HD Gray, David A Westerman, Constantine S Tam, John F Seymour, Peter E Czabotar, David CS Huang, Andrew W Roberts

Journal article  |  2019  |  Cancer Discovery

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer

Sheau W Lok, James R Whittle, Francois Vaillant, Charis E Teh, Louisa L Lo, Antonia N Policheni, Alice RT Bergin, Jayesh Desai, Sarah Ftouni, Luke C Gandolfo, Danny Liew, He K Liu, G Bruce Mann, Kate Moodie, Anand Murugasu, Bhupinder Pal, Andrew W Roberts, Mark A Rosenthal, Kylie Shackleton, Maria Joao Silva, et al.

Journal article  |  2019  |  Cancer Discovery

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

Rishu Agarwal, Yih-Chih Chan, Constantine S Tam, Tane Hunter, Dane Vassiliadis, Charis E Teh, Rachel Thijssen, Paul Yeh, Stephen Q Wong, Sarah Ftouni, Enid YN Lam, Mary Ann Anderson, Christiane Pott, Omer Gilan, Charles C Bell, Kathy Knezevic, Piers Blombery, Kathleen Rayeroux, Adrian Zordan, Jason Li, et al.

Journal article  |  2019  |  Nature Medicine

Combined BCL-2 and HDAC Targeting Has Potent and TP53 Independent Activity in AML

Jessica M Salmon, Giovanna Pomilio, Donia M Moujalled, Sarah Macraild, Charis E Teh, Sewa Riajl, Adam Ivey, Tse-Chieh Teh, Paul G Ekert, Laurence Kraus-Berthier, Ioana Kloos, Marie Schoumacher, Daniel Gray, Andrew H Wei

Conference Proceedings  |  2018  |  Blood

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

Piers Blombery, Mary Ann Anderson, Jianan Gong, Rachel Thijssen, Richard W Birkinshaw, Ella Thompson, Charis E Teh, Tamia Nguyen, Zhen Xu, Christoffer Flensburg, Thomas Lew, Ian Majewski, Daniel Gray, David Alan Westerman, Constantine S Tam, John F Seymour, Peter E Czabotar, David Huang, Andrew W Roberts

Conference Proceedings  |  2018  |  Blood

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and-7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1 beta Activation

James E Vince, Dominic De Nardo, Wenqing Gao, Angelina J Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M Lindqvist, Philippe Bouillet, Mark A Rizzacasa, Si Ming Man, John Silke, Seth L Masters, Guillaume Lessene, David CS Huang, Daniel HD Gray, Benjamin T Kile, Feng Shao, Kate E Lawlor

Journal article  |  2018  |  Cell Reports

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Hui San Chin, Mark X Li, Iris KL Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, et al.

Journal article  |  2018  |  Nature Communications

Characterization of Blimp-1 function in effector regulatory T cells

Erika Cretney, Patrick SK Leung, Stephanie Trezise, Dane M Newman, Lucille C Rankin, Charis E Teh, Tracy L Putoczki, Daniel HD Gray, Gabrielle T Belz, Lisa A Mielke, Sheila Dias, Stephen L Nutt

Journal article  |  2018  |  Journal of Autoimmunity

How do thymic epithelial cells die?

Reema Jain, Justine D Mintern, Iris Tan, Grant Dewson, Andreas Strasser, Daniel HD Gray

Journal article  |  2018  |  Cell Death & Differentiation

Immune homeostasis in health and disease

Nicholas D Huntington, Daniel HD Gray

Journal article  |  2018  |  Immunology and Cell Biology

Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment

Sarah A Best, David P De Souza, Ariena Kersbergen, Antonia N Policheni, Saravanan Dayalan, Dedreia Tull, Vivek Rathi, Daniel H Gray, Matthew E Ritchie, Malcolm J McConville, Kate D Sutherland

Journal article  |  2018  |  Cell Metabolism

A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice

Reema Jain, Julie M Sheridan, Antonia Policheni, Melanie Heinlein, Luke C Gandolfo, Grant Dewson, Gordon K Smyth, Stephen N Sansom, Nai Yang Fu, Jane E Visvader, Georg A Hollander, Andreas Strasser, Daniel HD Gray

Journal article  |  2017  |  Blood

The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules

Emma M Carrington, David M Tarlinton, Daniel H Gray, Nicholas D Huntington, Yifan Zhan, Andrew M Lew

Journal article  |  2017  |  Immunology & Cell Biology

Thymospheres Are Formed by Mesenchymal Cells with the Potential to Generate Adipocytes, but Not Epithelial Cells

Julie M Sheridan, Ashleigh Keown, Antonia Policheni, Siti NA Roesley, Noa Rivlin, Noam Kadouri, Matthew E Ritchie, Reema Jain, Jakub Abramson, Tracy SP Heng, Daniel HD Gray

Journal article  |  2017  |  Cell Reports

An Unbiased Linkage Approach Reveals That the p53 Pathway Is Coupled to NK Cell Maturation

Roxanne Collin, Charles St-Pierre, Lorie Guilbault, Victor Mullins-Dansereau, Antonia Policheni, Fanny Guimont-Desrochers, Adam-Nicolas Pelletier, Daniel H Gray, Elliot Drobetsky, Claude Perreault, Erin E Hillhouse, Sylvie Lesage

Journal article  |  2017  |  The Journal of Immunology

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

Emma Nolan, Peter Savas, Antonia N Policheni, Phillip K Darcy, Francois Vaillant, Christopher P Mintoff, Sathana Dushyanthen, Mariam Mansour, Jia-Min B Pang, Stephen B Fox, Charles M Perou, Jane E Visvader, Daniel HD Gray, Sherene Loi, Geoffrey J Lindeman

Journal article  |  2017  |  Science translational medicine

Cell death and thymic tolerance

Stephen R Daley, Charis Teh, Daniel Y Hu, Andreas Strasser, Daniel HD Gray

Journal article  |  2017  |  Immunological Reviews

Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment

Robyn L Schenk, Selma Tuzlak, Emma M Carrington, Yifan Zhan, Susanne Heinzel, Charis E Teh, Daniel H Gray, Lin Tai, Andrew M Lew, Andreas Villunger, Andreas Strasser, Marco J Herold

Journal article  |  2017  |  Cell Death & Differentiation

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

Charlotte Viant, Sophie Guia, Robert J Hennessy, Jai Rautela, Kim Pham, Claire Bernat, Wilford Goh, Yuhao Jiao, Rebecca Delconte, Michael Roger, Vanina Simon, Fernando Souza-Fonseca-Guimaraes, Stephanie Grabow, Gabrielle T Belz, Benjamin T Kile, Andreas Strasser, Daniel Gray, Phillip D Hodgkin, Bruce Beutler, Eric Vivier, et al.

Journal article  |  2017  |  Journal of Experimental Medicine

Mutant p53 Enhances the Development and Sustained Growth of MYC-Driven Lymphoma and Exerts a Dominant Negative Effect Preferentially Deregulating Pathways for Metabolism and DNA Repair

Brandon J Aubrey, Ana Janic, Yunshun Chen, Gordon K Smyth, Andrew J Kueh, Stephen Wilcox, Margs S Brennan, Lin Tai, Daniel HD Gray, Charis Teh, Ann Lin, Catherine Chang, Lorraine A O'Reilly, Marco J Herold, Andreas Strasser, Gemma L Kelly

Conference Proceedings  |  2016  |  Blood

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Charis E Teh, Najoua Lalaoui, Reema Jain, Antonia N Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A O'Reilly, Dale I Godfrey, Gordon K Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, et al.

Journal article  |  2016  |  NATURE COMMUNICATIONS

Genetic interrogation of circulating multiple myeloma cells at single-cell resolution

Jens G Lohr, Sora Kim, Joshua Gould, Birgit Knoechel, Yotam Drier, Matthew J Cotton, Daniel Gray, Nicole Birrer, Bang Wong, Gavin Ha, Cheng-Zhong Zhang, Guangwu Guo, Matthew Meyerson, Andrew J Yee, Jesse S Boehm, Noopur Raje, Todd R Golub

Journal article  |  2016  |  Science Translational Medicine

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease

Laetitia Le Texier, Katie E Lineburg, Benjamin Cao, Cameron McDonald-Hyman, Lucie Leveque-El Mouttie, Jemma Nicholls, Michelle Melino, Blessy C Nalkurthi, Kylie A Alexander, Bianca Teal, Stephen J Blake, Fernando Souza-Fonseca-Guimaraes, Christian R Engwerda, Rachel D Kuns, Steven W Lane, Michele Teng, Charis Teh, Daniel Gray, Andrew D Clouston, Susan K Nilsson, et al.

Journal article  |  2016  |  JCI Insight

Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection

Haiyin Liu, Reema Jain, Jing Guan, Vivian Vuong, Satoshi Ishido, Nicole L La Gruta, Daniel H Gray, Jose A Villadangos, Justine D Mintern

Journal article  |  2016  |  JOURNAL OF EXPERIMENTAL MEDICINE

CIS is a potent checkpoint in NK cell-mediated tumor immunity

Rebecca B Delconte, Tatiana B Kolesnik, Laura F Dagley, Jai Rautela, Wei Shi, Eva M Putz, Kimberley Stannard, Jian-Guo Zhang, Charis Teh, Matt Firth, Takashi Ushiki, Christopher E Andoniou, Mariapia A Degli-Esposti, Phillip P Sharp, Caroline E Sanvitale, Giuseppe Infusini, Nicholas PD Liau, Edmond M Linossi, Christopher J Burns, Sebastian Carotta, et al.

Journal article  |  2016  |  Nature Immunology

Physiological restraint of Bak by Bcl-x(L) is essential for cell survival

Erinna F Lee, Stephanie Grabow, Stephane Chappaz, Grant Dewson, Colin Hockings, Ruth M Kluck, Marlyse A Debrincat, Daniel H Gray, Matthew T Witkowski, Marco Evangelista, Anne Pettikiriarachchi, Philippe Bouillet, Rachael M Lane, Peter E Czabotar, Peter M Colman, Brian J Smith, Benjamin T Kile, W Douglas Fairlie

Journal article  |  2016  |  Genes & Development

Differential Responsiveness of Innate-like IL-17-and IFN-beta-Producing gamma delta T Cells to Homeostatic Cytokines

Theresa M Corpuz, Jessica Stolp, Hee-Ok Kim, Gabriela V Pinget, Daniel HD Gray, Jae-Ho Cho, Jonathan Sprent, Kylie E Webster

Journal article  |  2016  |  The Journal of Immunology

Control of Cell Survival and Apoptosis

Daniel Gray, Andreas Strasser

Book Chapter  |  2016

Impact of loss of NF-kappa B1, NF-kappa B2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr)/(lpr) mutant mice

JT Low, P Hughes, A Lin, U Siebenlist, R Jain, K Yaprianto, DHD Gray, S Gerondakis, A Strasser, LA O'Reilly

Journal article  |  2016  |  Immunology & Cell Biology

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Claudia Selck, Esteban N Gurzov, Thomas C Brodnicki, Kate L Graham, Jibran A Wali, Yifan Zhan, Daniel Gray, Andreas Strasser, Janette Allison, Helen E Thomas, Thomas WH Kay

Journal article  |  2015  |  Diabetes

Reinforcing the 'gauntlet' of thymic negative selection via exosomal transfer of self-antigens

Julie Sheridan, Daniel Gray

Journal article  |  2015  |  Immunology & Cell Biology

Loss of c-REL but not NF-kappa B2 prevents autoimmune disease driven by FasL mutation

LA O'Reilly, P Hughes, A Lin, P Waring, U Siebenlist, R Jain, DHD Gray, S Gerondakis, A Strasser

Journal article  |  2015  |  Cell Death & Differentiation

Can you rely on Treg cells on the rebound?

Charis E Teh, Daniel HD Gray

Journal article  |  2014  |  European Journal of Immunology

Isolation of thymic epithelial cells and analysis by flow cytometry.

Reema Jain, Daniel HD Gray

Journal article  |  2014  |  Current Protocols in Immunology

The epithelial cells of the thymus govern the differentiation of hematopoietic precursors into T cells, which are critical for acq..

Multilineage Potential and Self-Renewal Define an Epithelial Progenitor Cell Population in the Adult Thymus

Kahlia Wong, Natalie L Lister, Marco Barsanti, Joanna MC Lim, Maree V Hammett, Danika M Khong, Christopher Siatskas, Daniel HD Gray, Richard L Boyd, Ann P Chidgey

Journal article  |  2014  |  Cell Reports

Erratum: Consortium biology in immunology: The perspective from the Immunological Genome Project

C Benoist, L Lanier, M Merad, D Mathis, J Ericson, M Painter, S Davis, C Laplace, G Hyatt, H Paik, K Rothamel, R Cruse, G Doran, T Heng, N Asinovski, A Ortiz-Lopes, A Ergun, D Gray, E Wakamatsu, J Hill, et al.

Journal article  |  2014  |  Nature Reviews Immunology

Uhrf to T-reg cells: reinforcing the mucosal peacekeepers

Daniel HD Gray, Adrian Liston

Journal article  |  2014  |  Nature Immunology

Homeostatic control of regulatory T cell diversity

Adrian Liston, Daniel HD Gray

Journal article  |  2014  |  Nature Reviews Immunology

Transgenic Expression of GM-CSF in T Cells Causes Disseminated Histiocytosis

Annemarie E van Nieuwenhuijze, Elise Coghill, Daniel Gray, Sandro Prato, Donald Metcalf, Warren S Alexander, Ian P Wicks

Journal article  |  2014  |  American Journal of Pathology

Function of the thymic medulla The thymic medulla: who needs it?

Daniel Gray

Journal article  |  2013  |  Immunology & Cell Biology

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3( ) regulatory T cells

Wim Pierson, Benedicte Cauwe, Antonia Policheni, Susan M Schlenner, Dean Franckaert, Julien Berges, Stephanie Humblet-Baron, Susann Schonefeldt, Marco J Herold, David Hildeman, Andreas Strasser, Philippe Bouillet, Li-Fan Lu, Patrick Matthys, Antonio A Freitas, Rita J Luther, Casey T Weaver, James Dooley, Daniel HD Gray, Adrian Liston

Journal article  |  2013  |  Nature Immunology

The transcriptional landscape of alpha beta T cell differentiation

Michael Mingueneau, Taras Kreslavsky, Daniel Gray, Tracy Heng, Richard Cruse, Jeffrey Ericson, Sean Bendall, Matt Spitzer, Garry Nolan, Koichi Kobayashi, Harald von Boehmer, Diane Mathis, Christophe Benoist, Adam J Best, Jamie Knell, Ananda Goldrath, Vladimir Jojic, Daphne Koller, Tal Shay, Aviv Regev, et al.

Journal article  |  2013  |  Nature Immunology

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

Liz J Valente, Daniel HD Gray, Ewa M Michalak, Josefina Pinon-Hofbauer, Alex Egle, Clare L Scott, Ana Janic, Andreas Strasser

Journal article  |  2013  |  Cell Reports

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

Kylie D Mason, Ann Lin, Lorraine Robb, Emma C Josefsson, Katya J Henley, Daniel HD Gray, Benjamin T Kile, Andrew W Roberts, Andreas Strasser, David CS Huang, Paul Waring, Lorraine A O'Reilly

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism

Dina Danso-Abeam, Kim A Staats, Dean Franckaert, Ludo Van Den Bosch, Adrian Liston, Daniel HD Gray, James Dooley

Journal article  |  2013  |  European Journal of Immunology

Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection

KJ Campbell, DHD Gray, N Anstee, A Strasser, S Cory

Journal article  |  2012  |  Cell Death & Differentiation

Consortium biology in immunology: the perspective from the Immunological Genome Project

Christophe Benoist, Lewis Lanier, Miriam Merad, Diane Mathis

Journal article  |  2012  |  Nature Reviews Immunology

The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens

Daniel HD Gray, Fiona Kupresanin, Stuart P Berzins, Marco J Herold, Lorraine A O'Reilly, Philippe Bouillet, Andreas Strasser

Journal article  |  2012  |  Immunity

The NF-kappa B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties

Raffi Gugasyan, Elisha Horat, Sarah A Kinkel, Fiona Ross, George Grigoriadis, Daniel Gray, Meredith O'Keeffe, Stuart P Berzins, Gabrielle T Belz, Raelene J Grumont, Ashish Banerjee, Andreas Strasser, Dale I Godfrey, Philip N Tsichlis, Steve Gerondakis

Journal article  |  2012  |  EMBO Journal

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-alpha receptor

Aikaterini S Papadopoulou, James Dooley, Michelle A Linterman, Wim Pierson, Olga Ucar, Bruno Kyewski, Saulius Zuklys, Georg A Hollander, Patrick Matthys, Daniel HD Gray, Bart De Strooper, Adrian Liston

Journal article  |  2012  |  Nature Immunology

Defects in the Bcl-2-Regulated Apoptotic Pathway Lead to Preferential Increase of CD25(low)Foxp3( ) Anergic CD4( ) T Cells

Yifan Zhan, Yuxia Zhang, Daniel Gray, Emma M Carrington, Philippe Bouillet, Hyun-Ja Ko, Lorraine O'Reilly, Ian P Wicks, Andreas Strasser, Andrew M Lew

Journal article  |  2011  |  Journal of Immunology

Correction: A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus.

Guo-Jen Huang, Adrian L Smith, Daniel HD Gray, Cormac Cosgrove, Benjamin H Singer, Andrew Edwards, Stuart Sim, Jack M Parent, Alyssa Johnsen, Richard Mott, Diane Mathis, Paul Klenerman, Christophe Benoist, Jonathan Flint

Journal article  |  2011  |  PLoS Biology

Transcriptomes of the B and T lineages compared by multiplatform microarray profiling.

Michio W Painter, Scott Davis, Richard R Hardy, Diane Mathis, Christophe Benoist, undefined Immunological Genome Project Consortium

Journal article  |  2011  |  The Journal of Immunology

T and B lymphocytes are developmentally and functionally related cells of the immune system, representing the two major branches o..

A Genetic and Functional Relationship between T Cells and Cellular Proliferation in the Adult Hippocampus

Guo-Jen Huang, Adrian L Smith, Daniel HD Gray, Cormac Cosgrove, Benjamin H Singer, Andrew Edwards, Stuart Sim, Jack M Parent, Alyssa Johnsen, Richard Mott, Diane Mathis, Paul Klenerman, Christophe Benoist, Jonathan Flint

Journal article  |  2010  |  PloS Biol.

Visualization and Identification of IL-7 Producing Cells in Reporter Mice

Renata I Mazzucchelli, Soren Warming, Scott M Lawrence, Masaru Ishii, Mehrnoosh Abshari, A Valance Washington, Lionel Feigenbaum, Andrew C Warner, Davis J Sims, Wen Qing Li, Julie A Hixon, Daniel HD Gray, Benjamin E Rich, Matthew Morrow, Miriam R Anver, James Cherry, Dieter Naf, Lawrence R Sternberg, Daniel W McVicar, Andrew G Farr, et al.

Journal article  |  2009  |  PLoS ONE

XIAP discriminates between type I and type II FAS-induced apoptosis

Philipp J Jost, Stephanie Grabow, Daniel Gray, Mark D McKenzie, Ueli Nachbur, David CS Huang, Philippe Bouillet, Helen E Thomas, Christoph Borner, John Silke, Andreas Strasser, Thomas Kaufmann

Journal article  |  2009  |  Nature

Genetic Inversion in Mast Cell-Deficient W-sh Mice Interrupts Corin and Manifests as Hematopoietic and Cardiac Aberrancy

Peter A Nigrovic, Daniel HD Gray, Tatiana Jones, Jenny Hallgren, Frank C Kuo, Blair Chaletzky, Michael Gurish, Diane Mathis, Christophe Benoist, David M Lee

Journal article  |  2008  |  Am. J. Pathol.

The Immunological Genome Project: networks of gene expression in immune cells

Tracy SP Heng, Michio W Painter

Journal article  |  2008  |  Nature Immunology

The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cells

Natalie Seach, Tomoo Ueno, Anne L Fletcher, Tamara Lowen, Monika Mattesich, Christian R Engwerda, Hamish S Scott, Carl F Ware, Ann P Chidgey, Daniel HD Gray, Richard L Boyd

Journal article  |  2008  |  J. Immunol.

Unbiased analysis, enrichment and purification of thymic stromal cells

Daniel HD Gray, Anne L Fletcher, Maree Hammett, Natalie Seach, Tomoo Ueno, Lauren F Young, Jade Barbuto, Richard L Boyd, Ann P Chidgey

Journal article  |  2008  |  J. Immunol. Methods

Danger-free autoimmune disease in Aire-deficient mice

Daniel HD Gray, Irina Gavanescu, Christophe Benoist, Diane Mathis

Journal article  |  2007  |  Proc. Natl. Acad. Sci. U. S. A.

Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected

Emily S Venanzi, Daniel HD Gray, Christophe Benoist, Diane Mathis

Journal article  |  2007  |  J. Immunol.

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

Daniel Gray, Jakub Abramson, Christophe Benoist, Diane Mathis

Journal article  |  2007  |  J. Exp. Med.

A unique thymic fibroblast population revealed by the monoclonal antibody MTS-15

Daniel HD Gray, Dedreia Tull, Tomoo Ueno, Natalie Seach, Brendan J Classon, Ann Chidgey, Malcolm J McConville, Richard L Boyd

Journal article  |  2007  |  Journal of Immunology

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells

Daniel HD Gray, Natalie Seach, Tomoo Ueno, Morag K Milton, Adrian Liston, Andrew M Lew, Christopher C Goodnow, Richard L Boyd

Journal article  |  2006  |  Blood

Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration

O Alpdogan, VM Hubbard, OM Smith, N Patel, S Lu, GL Goldberg, DH Gray, J Feinman, AA Kochman, JM Eng, D Suh, SJ Muriglan, RL Boyd, MRM van den Brink

Journal article  |  2006  |  Blood

Effects of castration on thymocyte development in two different models of thymic involution

TSP Heng, GL Goldberg, DHD Gray, JS Sutherland, AP Chidgey, RL Boyd

Journal article  |  2005  |  J. Immunol.

Genetic lesions in T-cell tolerance and thresholds for autoimmunity

A Liston, S Lesage, DHD Gray, RL Boyd, CC Goodnow

Journal article  |  2005  |  Immunol. Rev.

Controlling the thymic microenvironment

DHD Gray, T Ueno, AP Chidgey, M Malin, GL Goldberg, Y Takahama, RL Boyd

Journal article  |  2005  |  Curr. Opin. Immunol.

Generalized resistance to thymic deletion in the NOD mouse: A polygenic trait characterized by defective induction of Bim

A Liston, S Lesage, DHD Gray, LA O'Reilly, A Strasser, AM Fahrer, RL Boyd, J Wilson, AG Baxter, EM Gallo, GR Crabtree, KM Peng, SR Wilson, CC Goodnow

Journal article  |  2004  |  Immunity

Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity

A Liston, DHD Gray, S Lesage, AL Fletcher, J Wilson, KE Webster, HS Scott, RL Boyd, L Peltonen, CC Goodnow

Journal article  |  2004  |  J. Exp. Med.

Correction.

Tomoo Ueno, Fumi Saito, Daniel HD Gray, Sachiyo Kuse, Kunio Hieshima, Hideki Nakano, Terutaka Kakiuchi, Martin Lipp, Richard L Boyd, Yousuke Takahama

Journal article  |  2004  |  Journal of Experimental Medicine

Thymus and Tolerance in Transplantation

DHD Gray, JW Gill, AO Trounson, RL Boyd

Book Chapter  |  2004

CCR7 signals are essential for cortex-medulla migration of developing thymocytes

T Ueno, F Saito, DHD Gray, S Kuse, K Hieshima, H Nakano, T Kakiuchi, M Lipp, RL Boyd, Y Takahama

Journal article  |  2004  |  J. Exp. Med.

Thymic generation and regeneration

J Gill, M Malin, J Sutherland, D Gray, G Hollander, R Boyd

Journal article  |  2003  |  Immunol. Rev.

Stromal cells provide the matrix for migration of early lymphoid progenitors through the thymic cortex

SE Prockop, S Palencia, CM Ryan, K Gordon, D Gray, HT Petrie

Journal article  |  2002  |  J. Immunol.

Role for CCR7 Ligands in the emigration of newly generated T lymphocytes from the neonatal thymus

T Ueno, K Hara, MS Willis, MA Malin, UE Hopken, DHD Gray, K Matsushima, M Lipp, TA Springer, RL Boyd, O Yoshie, Y Takahama

Journal article  |  2002  |  Immunity

Analysis of thymic stromal cell populations using flow cytometry

DHD Gray, AP Chidgey, RL Boyd

Journal article  |  2002  |  J. Immunol. Methods