Daniel Gray

Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition

Hesham DD Abdulla, Raed Alserihi, Christoffer Flensburg, Waruni Abeysekera, Meng-Xiao Luo, Daniel HD Gray, Xiaodong Liu, Gordon KK Smyth, Warren SS Alexander, Ian JJ Majewski, Matthew PP McCormack

Journal article  |  2023  |  JOURNAL OF EXPERIMENTAL MEDICINE

Cell competition has recently emerged as an important tumor suppressor mechanism in the thymus that inhibits autonomous thymic mai..

Dietary tryptophan deficiency promotes gut RORγt Treg cells at the expense of Gata3 Treg cells and alters commensal microbiota metabolism.

Lucille C Rankin, Katherine A Kaiser, Kenia de Los Santos-Alexis, Heekuk Park, Anne-Catrin Uhlemann, Daniel HD Gray, Nicholas Arpaia

Journal article  |  2023  |  Cell Rep

Micronutrient deficiency is a major cause of disease throughout the world. Yet, how perturbations influence the immune-microbiome ..

Venetoclax treatment in cancer patients has limited impact on circulating T and NK cells.

Charis E Teh, Hongke Peng, Mengxiao Luo, Tania Tan, Marie Trussart, Lauren J Howson, Chong Chyn Chua, Christine Muttiah, Fiona C Brown, Matthew E Ritchie, Andrew H Wei, Andrew W Roberts, Vanessa L Bryant, Mary Ann Anderson, Geoffrey J Lindeman, David Ching Siang Huang, Rachel Thijssen, Daniel HD Gray

Journal article  |  2022  |  Blood Adv

Venetoclax is an effective treatment for certain blood cancers, such as chronic lymphocytic leukemia (CLL) and acute myeloid leuke..

Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy

Rachel Thijssen, Luyi Tian, Mary Ann Anderson, Christoffer Flensburg, Andrew Jarratt, Alexandra L Garnham, Jafar S Jabbari, Hongke Peng, Thomas E Lew, Charis E Teh, Quentin Gouil, Angela Georgiou, Tania Tan, Tirta M Djajawi, Constantine S Tam, John F Seymour, Piers Blombery, Daniel HD Gray, Ian J Majewski, Matthew E Ritchie, et al.

Journal article  |  2022  |  BLOOD

Venetoclax (VEN) inhibits the prosurvival protein BCL2 to induce apoptosis and is a standard therapy for chronic lymphocytic leuke..

Location, location, location! Rewiring IL-2 circuits defines context-specific outcomes

Lucille Rankin, Daniel Gray

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

Here, we highlight a recent publication by Whyte et al. that reveals diverse immune outcomes of interleukin (IL)-2 expression in d..

PD-1 cooperates with AIRE-mediated tolerance to prevent lethal autoimmune disease.

Antonia N Policheni, Charis E Teh, Alissa Robbins, Selma Tuzlak, Andreas Strasser, Daniel HD Gray

Journal article  |  2022  |  Proc Natl Acad Sci U S A

Immunological tolerance is established and maintained by a diverse array of safeguards that work together to protect against autoi..

Caspase-8 has dual roles in regulatory T cell homeostasis balancing immunity to infection and collateral inflammatory damage

Charis E Teh, Simon P Preston, Alissa K Robbins, Michael D Stutz, James Cooney, Michelle P Clark, Antonia N Policheni, Cody C Allison, Liana Mackiewicz, Philip Arandjelovic, Gregor Ebert, Marcel Doerflinger, Tania Tan, Lucille C Rankin, Peggy P Teh, Gabrielle T Belz, Axel Kallies, Andreas Strasser, Marc Pellegrini, Daniel HD Gray

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

Targeting the potent immunosuppressive properties of FOXP3+ regulatory T cells (Tregs) has substantial therapeutic potential for t..

Single-Cell Profiling of the Intrinsic Apoptotic Pathway by Mass Cytometry (CyTOF).

Tania Tan, Daniel HD Gray, Charis E Teh

Journal article  |  2022  |  Methods Mol Biol

Mass cytometry time-of-flight (CyTOF) is a technology for the study of complex biological processes at the single-cell level. The ..

The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance

Melanie Heinlein, Luke C Gandolfo, Kelin Zhao, Charis E Teh, Nghi Nguyen, Jonathan B Baell, Yael Goldfarb, Jakub Abramson, Johannes Wichmann, Anne K Voss, Andreas Strasser, Gordon K Smyth, Tim Thomas, Daniel HD Gray

Journal article  |  2022  |  SCIENCE IMMUNOLOGY

The autoimmune regulator (AIRE) induces the transcription of thousands of peripheral tissue genes (PTGs) in thymic epithelial cell..

Mesenchymal stromal cell apoptosis is required for their therapeutic function

Swee Heng Milon Pang, Joshua D'Rozario, Senora Mendonca, Tejasvini Bhuvan, Natalie L Payne, Di Zheng, Assifa Hisana, Georgia Wallis, Adele Barugahare, David Powell, Jai Rautela, Nicholas D Huntington, Grant Dewson, David CS Huang, Daniel HD Gray, Tracy SP Heng

Journal article  |  2021  |  NATURE COMMUNICATIONS

Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in preclinical models, but the lack of clarity ar..