Gaoqian Feng

Multi-functional antibodies are induced by the RTS,S malaria vaccine and associated with protection in a phase I/IIa trial.

Liriye Kurtovic, Tanmaya Atre, Gaoqian Feng, Bruce D Wines, Jo-Anne Chan, Michelle J Boyle, Damien R Drew, P Mark Hogarth, Freya JI Fowkes, Elke S Bergmann-Leitner, James G Beeson

Journal article  |  2020  |  The Journal of Infectious Diseases

BACKGROUND: RTS,S is the leading malaria vaccine candidate, but only confers partial efficacy against malaria in children. RTS,S i..

Contribution of Functional Antimalarial Immunity to Measures of Parasite Clearance in Therapeutic Efficacy Studies of Artemisinin Derivatives

Katherine O'Flaherty, Ricardo Ataide, Sophie G Zaloumis, Elizabeth A Ashley, Rosanna Powell, Gaoqian Feng, Linda Reiling, Arjen M Dondorp, Nicholas P Day, Mehul Dhorda, Rick M Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tinh Hien Tran, Ye Htut, Mayfong Mayxay, M Abul Faiz, James G Beeson, Francois Nosten, et al.

Journal article  |  2019  |  Journal of Infectious Diseases

BACKGROUND: Antibodies to the blood-stages of malaria enhance parasite-clearance and antimalarial efficacy. The antibody subclass ..

IgM in human immunity to Plasmodium falciparum malaria

MJ Boyle, JA Chan, I Handayuni, L Reiling, G Feng, A Hilton, L Kurtovic, D Oyong, KA Piera, BE Barber, T William, DP Eisen, G Minigo, C Langer, DR Drew, F de Labastida Rivera, FH Amante, TN Williams, S Kinyanjui, K Marsh, et al.

Journal article  |  2019  |  Science Advances

Induction and decay of functional complement-fixing antibodies by the RTS,S malariavaccine in children, and a negative impact of malaria exposure

Liriye Kurtovic, Paul A Agius, Gaoqian Feng, Damien R Drew, Itziar Ubillos, Jahit Sacarlal, John J Aponte, Freya JI Fowkes, Carlota Dobano, James G Beeson

Journal article  |  2019  |  BMC Medicine

Targets of complement-fixing antibodies in protective immunity against malaria in children

Linda Reiling, Michelle J Boyle, Michael T White, Danny W Wilson, Gaoqian Feng, Rupert Weaver, D Herbert Opi, Kristina EM Persson, Jack S Richards, Peter M Siba, Freya JI Fowkes, Eizo Takashima, Takafumi Tsuboi, Ivo Mueller, James G Beeson

Journal article  |  2019  |  Nature Communications

Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells

Xi Zen Yap, Rachel J Lundie, Gaoqian Feng, Joanne Pooley, James G Beeson, Meredith O'Keeffe

Journal article  |  2019  |  Frontiers in Immunology

Challenges and strategies for developing efficacious and long-lasting malaria vaccines

James G Beeson, Liriye Kurtovic, Carlota Dobano, D Herbert Opi, Jo-Anne Chan, Gaoqian Feng, Michael F Good, Linda Reiling, Michelle J Boyle

Journal article  |  2019  |  Science Translational Medicine

Human Immunization With a Polymorphic Malaria Vaccine Candidate Induced Antibodies to Conserved Epitopes That Promote Functional Antibodies to Multiple Parasite Strains

Gaoqian Feng, Michelle J Boyle, Nadia Cross, Jo-Anne Chan, Linda Roiling, Faith Osier, Danielle Stanisic, Ivo Mueller, Robin F Anders, James S McCarthy, Jack S Richards, James G Beeson

Journal article  |  2018  |  The Journal of Infectious Diseases

Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

Liriye Kurtovic, Marije C Behet, Gaoqian Feng, Linda Reiling, Kiprotich Chelimo, Arlene E Dent, Ivo Mueller, James W Kazura, Robert W Sauerwein, Freya JI Fowkes, James G Beeson

Journal article  |  2018  |  BMC Medicine

Identifying Immune Correlates of Protection Against Plasmodium falciparum Through a Novel Approach to Account for Heterogeneity in Malaria Exposure

Aida Valmaseda, Eusebio Macete, Augusto Nhabomba, Caterina Guinovart, Pedro Aide, Azucena Bardaji, Quique Bassat, Tacilta Nhampossa, Sonia Maculuve, Aina Casellas, Llorenc Quinto, Sergi Sanz, Alfons Jimenez, Gaoqian Feng, Christine Langer, Linda Reiling, K Sony Reddy, Alok Pandey, Chetan E Chitnis, Virander S Chauhan, et al.

Journal article  |  2018  |  Clinical Infectious Diseases