Gaoqian Feng

Multifunctional Antibodies Are Induced by the RTS,S Malaria Vaccine and Associated With Protection in a Phase 1/2a Trial

Liriye Kurtovic, Tanmaya Atre, Gaoqian Feng, Bruce D Wines, Jo-Anne Chan, Michelle J Boyle, Damien R Drew, P Mark Hogarth, Freya J Fowkes, Elke S Bergmann-Leitner, James G Beeson

Journal article  |  2021  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: RTS,S is the leading malaria vaccine candidate but only confers partial efficacy against malaria in children. RTS,S is..

Mechanisms and targets of Fc gamma-receptor mediated immunity to malaria sporozoites

Gaoqian Feng, Bruce D Wines, Liriye Kurtovic, Jo-Anne Chan, Philippe Boeuf, Vanessa Mollard, Anton Cozijnsen, Damien R Drew, Rob J Center, Daniel L Marshall, Sandra Chishimba, Geoffrey McFadden, Arlene E Dent, Kiprotich Chelimo, Michelle J Boyle, James W Kazura, P Mark Hogarth, James G Beeson

Journal article  |  2021  |  NATURE COMMUNICATIONS

A highly protective vaccine will greatly facilitate achieving and sustaining malaria elimination. Understanding mechanisms of anti..

Contribution of Functional Antimalarial Immunity to Measures of Parasite Clearance in Therapeutic Efficacy Studies of Artemisinin Derivatives

Katherine O'Flaherty, Ricardo Ataide, Sophie G Zaloumis, Elizabeth A Ashley, Rosanna Powell, Gaoqian Feng, Linda Reiling, Arjen M Dondorp, Nicholas P Day, Mehul Dhorda, Rick M Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tinh Hien Tran, Ye Htut, Mayfong Mayxay, M Abul Faiz, James G Beeson, Francois Nosten, et al.

Journal article  |  2019  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: Antibodies to the blood stages of malaria parasites enhance parasite clearance and antimalarial efficacy. The antibody..

IgM in human immunity to Plasmodium falciparum malaria

MJ Boyle, JA Chan, I Handayuni, L Reiling, G Feng, A Hilton, L Kurtovic, D Oyong, KA Piera, BE Barber, T William, DP Eisen, G Minigo, C Langer, DR Drew, F de Labastida Rivera, FH Amante, TN Williams, S Kinyanjui, K Marsh, et al.

Journal article  |  2019  |  SCIENCE ADVANCES

Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain und..

Induction and decay of functional complement-fixing antibodies by the RTS,S malariavaccine in children, and a negative impact of malaria exposure

Liriye Kurtovic, Paul A Agius, Gaoqian Feng, Damien R Drew, Itziar Ubillos, Jahit Sacarlal, John J Aponte, Freya JI Fowkes, Carlota Dobano, James G Beeson

Journal article  |  2019  |  BMC MEDICINE

BACKGROUND: Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S confers partial p..

Targets of complement-fixing antibodies in protective immunity against malaria in children

Linda Reiling, Michelle J Boyle, Michael T White, Danny W Wilson, Gaoqian Feng, Rupert Weaver, D Herbert Opi, Kristina EM Persson, Jack S Richards, Peter M Siba, Freya JI Fowkes, Eizo Takashima, Takafumi Tsuboi, Ivo Mueller, James G Beeson

Journal article  |  2019  |  NATURE COMMUNICATIONS

Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication in naturally-acquired and vaccine-in..

Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells

Xi Zen Yap, Rachel J Lundie, Gaoqian Feng, Joanne Pooley, James G Beeson, Meredith O'Keeffe

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Dendritic cells are key linkers of innate and adaptive immunity. Efficient dendritic cell activation is central to the acquisition..

Challenges and strategies for developing efficacious and long-lasting malaria vaccines

James G Beeson, Liriye Kurtovic, Carlota Dobano, D Herbert Opi, Jo-Anne Chan, Gaoqian Feng, Michael F Good, Linda Reiling, Michelle J Boyle

Journal article  |  2019  |  SCIENCE TRANSLATIONAL MEDICINE

Although there has been major recent progress in malaria vaccine development, substantial challenges remain for achieving highly e..

Human Immunization With a Polymorphic Malaria Vaccine Candidate Induced Antibodies to Conserved Epitopes That Promote Functional Antibodies to Multiple Parasite Strains

Gaoqian Feng, Michelle J Boyle, Nadia Cross, Jo-Anne Chan, Linda Roiling, Faith Osier, Danielle Stanisic, Ivo Mueller, Robin F Anders, James S McCarthy, Jack S Richards, James G Beeson

Journal article  |  2018  |  JOURNAL OF INFECTIOUS DISEASES

Background: Overcoming antigenic diversity is a key challenge in the development of effective Plasmodium falciparum malaria vaccin..

Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

Liriye Kurtovic, Marije C Behet, Gaoqian Feng, Linda Reiling, Kiprotich Chelimo, Arlene E Dent, Ivo Mueller, James W Kazura, Robert W Sauerwein, Freya JI Fowkes, James G Beeson

Journal article  |  2018  |  BMC MEDICINE

BACKGROUND: Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody..