Gillian Mitchell

Evaluation of implementation of risk management guidelines for carriers of pathogenic variants in mismatch repair genes: a nationwide audit of familial cancer clinics

B Meiser, R Kaur, J Kirk, A Morrow, M Peate, WKT Wong, E McPike, E Cops, C Dowson, R Austin, M Fine, L Thrupp, R Ward, F Macrae, JE Hiller, AH Trainer, G Mitchell

Journal article  |  2020  |  Familial Cancer

INTRODUCTION: This nationwide study assessed the impact of Lynch syndrome-related risk management guidelines on clinicians' recomm..

The predicted impact and cost-effectiveness of systematic testing of people with incident colorectal cancer for Lynch syndrome

Yoon-Jung Kang, James Killen, Michael Caruana, Kate Simms, Natalie Taylor, Ian M Frayling, Tristan Snowsill, Nicola Huxley, Veerle MH Coupe, Suzanne Hughes, Victoria Freeman, Alex Boussioutas, Alison H Trainer, Robyn L Ward, Gillian Mitchell, Finlay A Macrae, Karen Canfell

Journal article  |  2020  |  Medical Journal of Australia

Cost-effectiveness of long-term clinical management of BRCA pathogenic variant carriers

Lara Petelin, Lucinda Hossack, Mary Shanahan, Gillian Mitchell, Danny Liew, Paul A James, Alison H Trainer

Journal article  |  2020  |  Genetics in Medicine

PURPOSE: Women who inherit a BRCA1 or BRCA2 pathogenic variant are at high risk of developing breast and ovarian cancer. Evidence ..

A Microsimulation Model for Evaluating the Effectiveness of Cancer Risk Management for BRCA Pathogenic Variant Carriers: miBRovaCAre

Lara Petelin, Lucinda Hossack, Gillian Mitchell, Danny Liew, Alison H Trainer, Paul A James

Journal article  |  2019  |  Value in Health

Cancer screening in Australia: future directions in melanoma, Lynch syndrome, and liver, lung and prostate cancers

Marianne F Weber, Henry M Marshall, Nicole Rankin, Stephen Duffy, Kwun M Fong, Kate Dunlop, Lauren Humphreys, Amelia K Smit, Anne E Cust, Natalie Taylor, Gillian Mitchell, Yoon-Jung Kang, Kathy Tucker, Mark Jenkins, Finlay Macrae, Ian Lockart, Mark Danta, Bruce K Armstrong, Megan Howe

Journal article  |  2019  |  Public Health Research & Practice

Comparing theory and non-theory based implementation approaches to improving referral practices in cancer genetics: a cluster randomised trial protocol

April Morrow, Emily Hogden, Yoon-Jung Kang, Julia Steinberg, Karen Canfell, Michael J Solomon, James G Kench, Anthony J Gill, Tim Shaw, Nicholas Pachter, Bonny Parkinson, Luke Wolfenden, Gillian Mitchell, Finlay Macrae, Kathy Tucker, Natalie Taylor

Journal article  |  2019  |  Trials

Assessing the medical workforces perceived barriers to the prescription of risk-reducing medication for women at high-risk of breast cancer

Sarah Sutherland, Bettina Meiser, Rajneesh Kaur, Gillian Mitchell, Judy Kirk, Michelle Peate, WK Tim Wong, Annabel Goodwin

Journal article  |  2019  |  The Breast Journal

Current mismatch repair deficiency tumor testing practices and capabilities: A survey of Australian pathology providers

Lyon Mascarenhas, Susan Shanley, Gillian Mitchell, Amanda B Spurdle, Finlay Macrae, Nicholas Pachter, Daniel D Buchanan, Robyn L Ward, Stephen Fox, Elaine Duxbury, Rebecca Driessen, Alex Boussioutas

Journal article  |  2018  |  Asia-Pacific Journal of Clinical Oncology

Cost-effectiveness and comparative effectiveness of cancer risk management strategies in BRCA1/2 mutation carriers: a systematic review

Lara Petelin, Alison H Trainer, Gillian Mitchell, Danny Liew, Paul A James

Journal article  |  2018  |  Genetics in Medicine

Heterogeneity and Uncertainties Specific to Genome-Based Health Technological Assessments

Lara Petelin, Danny Liew, Gillian Mitchell, Paul A James, Alison H Trainer

Journal article  |  2018  |  Value in Health

Psychological outcomes and surgical decisions after genetic testing in women newly diagnosed with breast cancer with and without a family history

Bettina Meiser, Veronica F Quinn, Gillian Mitchell, Kathy Tucker, Kaaren J Watts, Belinda Rahman, Michelle Peate, Christobel Saunders, Elizabeth Geelhoed, Margaret Gleeson, Kristine Barlow-Stewart, Michael Field, Marion Harris, Yoland C Antill, Rachel Susman, Michael T Bowen, Llew Mills, Judy Kirk

Journal article  |  2018  |  European Journal of Human Genetics

Making Sense of SNPs: Women's Understanding and Experiences of Receiving a Personalized Profile of Their Breast Cancer Risks

Mary-Anne Young, Laura Elenor Forrest, Victoria-Mae Rasmussen, Paul James, Gillian Mitchell, Sarah Dilys Sawyer, Katrina Reeve, Nina Hallowell

Journal article  |  2018  |  Journal of Genetic Counseling

A population-based analysis of germline BRCA1 and BRCA2 testing among ovarian cancer patients in an era of histotype-specific approaches to ovarian cancer prevention.

Gillian E Hanley, Jessica N McAlpine, Dianne Miller, David Huntsman, Kasmintan A Schrader, C Blake Gilks, Gillian Mitchell

Journal article  |  2018  |  BMC Cancer

BACKGROUND: Identifying female carriers of BRCA1 and BRCA2 mutations is imperative for prevention of ovarian cancer and breast can..

Consumer attitudes towards the establishment of a national Australian familial cancer research database by the Inherited Cancer Connect (ICCon) Partnership

Laura Forrest, Gillian Mitchell, Letitia Thrupp, Lara Petelin, Kate Richardson, Lyon Mascarenhas, Mary-Anne Young

Journal article  |  2018  |  Journal of Community Genetics

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Roger L Milne, Karoline B Kuchenbaecker, Kyriaki Michailidou, Jonathan Beesley, Siddhartha Kar, Sara Lindstrom, Shirley Hui, Audrey Lemacon, Penny Soucy, Joe Dennis, Xia Jiang, Asha Rostamianfar, Hilary Finucane, Manjeet K Bolla, Lesley McGuffog, Qin Wang, Cora M Aalfs, Marcia Adams, Julian Adlard, Simona Agata, et al.

Journal article  |  2017  |  Nature Genetics

Surveillance in Germline TP53 Mutation Carriers Utilizing Whole-Body Magnetic Resonance Imaging

Mandy L Ballinger, Nicholas J Ferris, Kate Moodie, Gillian Mitchell, Sue Shanley, Paul A James, David M Thomas

Journal article  |  2017  |  JAMA Oncology

Motivators and barriers of tamoxifen use as risk-reducing medication amongst women at increased breast cancer risk: a systematic literature review

B Meiser, WKT Wong, M Peate, C Julian-Reynier, J Kirk, G Mitchell

Journal article  |  2017  |  Hereditary Cancer in Clinical Practice

Psychosocial and behavioral impact of breast cancer risk assessed by testing for common risk variants: protocol of a prospective study

Tatiane Yanes, Bettina Meiser, Mary-Anne Young, Rajneesh Kaur, Gillian Mitchell, Kristine Barlow-Stewart, Tony Roscioli, Jane Halliday, Paul James

Journal article  |  2017  |  BMC Cancer

Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores

Julie Lecarpentier, Valentina Silvestri, Karoline B Kuchenbaecker, Daniel Barrowdale, Joe Dennis, Lesley McGuffog, Penny Soucy, Goska Leslie, Piera Rizzolo, Anna Sara Navazio, Virginia Valentini, Veronica Zelli, Andrew Lee, Ali Amin Al Olama, Jonathan P Tyrer, Melissa Southey, Esther M John, Thomas A Conner, David E Goldgar, Saundra S Buys, et al.

Journal article  |  2017  |  Journal of Clinical Oncology

Psychosocial morbidity in TP53 mutation carriers: is whole-body cancer screening beneficial?

Kate A McBride, Mandy L Ballinger, Timothy E Schlub, Mary-Anne Young, Martin HN Tattersall, Judy Kirk, Ros Eeles, Emma Killick, Leslie G Walker, Sue Shanley, David M Thomas, Gillian Mitchell

Journal article  |  2017  |  Familial Cancer

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Catherine M Phelan, Karoline B Kuchenbaecker, Jonathan P Tyrer, Siddhartha P Kar, Kate Lawrenson, Stacey J Winham, Joe Dennis, Ailith Pirie, Marjorie J Riggan, Ganna Chornokur, Madalene A Earp, Paulo C Lyra, Janet M Lee, Simon Coetzee, Jonathan Beesley, Lesley McGuffog, Penny Soucy, Ed Dicks, Andrew Lee, Daniel Barrowdale, et al.

Journal article  |  2017  |  Nature Genetics

Streamlined genetic education is effective in preparing women newly diagnosed with breast cancer for decision making about treatment-focused genetic testing: a randomized controlled noninferiority trial

Veronica F Quinn, Bettina Meiser, Judy Kirk, Kathy M Tucker, Kaaren J Watts, Belinda Rahman, Michelle Peate, Christobel Saunders, Elizabeth Geelhoed, Margaret Gleeson, Kristine Barlow-Stewart, Michael Field, Marion Harris, Yoland C Antill, Linda Cicciarelli, Karen Crowe, Michael T Bowen, Gillian Mitchell

Journal article  |  2017  |  Genetics in Medicine

Exploring clinicians' attitudes about using aspirin for risk reduction in people with Lynch Syndrome with no personal diagnosis of colorectal cancer

Yanni Chen, Michelle Peate, Rajneesh Kaur, Bettina Meiser, Tim Wong, Judy Kirk, Robyn L Ward, Annabel Goodwin, Finlay Macrae, Janet Hiller, Alison H Trainer, Gillian Mitchell

Journal article  |  2017  |  Familial Cancer

Breast cancer risk prediction using a polygenic risk score in the familial setting: a prospective study from the Breast Cancer Family Registry and kConFab

Hongyan Li, Bingjian Feng, Alexander Miron, Xiaoqing Chen, Jonathan Beesley, Emmanuella Bimeh, Daniel Barrowdale, Esther M John, Mary B Daly, Irene L Andrulis, Saundra S Buys, Peter Kraft, Heather Thorne, Georgia Chenevix-Trench, Melissa C Southey, Antonis C Antoniou, Paul A James, Mary Beth Terry, Kelly-Anne Phillips, John L Hopper, et al.

Journal article  |  2017  |  Genetics in Medicine

Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women

Timothy R Rebbeck, Tara M Friebel, Nandita Mitra, Fei Wan, Stephanie Chen, Irene L Andrulis, Paraskevi Apostolou, Norbert Arnold, Banu K Arun, Daniel Barrowdale, Javier Benitez, Raanan Berger, Pascaline Berthet, Ake Borg, Saundra S Buys, Trinidad Caldes, Jonathan Carter, Jocelyne Chiquette, Kathleen BM Claes, Fergus J Couch, et al.

Journal article  |  2016  |  Breast Cancer Research

When knowledge of a heritable gene mutation comes out of the blue: treatment-focused genetic testing in women newly diagnosed with breast cancer

B Meiser, VF Quinn, M Gleeson, J Kirk, KM Tucker, B Rahman, C Saunders, KJ Watts, M Peate, E Geelhoed, K Barlow-Stewart, M Field, M Harris, YC Antill, G Mitchell

Journal article  |  2016  |  European Journal of Human Genetics

A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop, Heather Thorne, Shahneen Sandhu, Anne Hamilton, Christopher Mintoff, Elizabeth Christie, Odette Spruyt, Scott Williams, Orla McNally, Linda Mileshkin, Sumitra Ananda, Julene Hallo, Sherene Loi, Clare Scott, Peter Savas, Lisa Devereux, Patricia O'Brien, Sameera Gunawardena, Clare Hampson, Kate Strachan, et al.

Journal article  |  2016  |  Nature Biotechnology

Monogenic and polygenic determinants of sarcoma risk: an international genetic study

Mandy L Ballinger, David L Goode, Isabelle Ray-Coquard, Paul A James, Gillian Mitchell, Eveline Niedermayr, Ajay Puri, Joshua D Schiffman, Gillian S Dite, Arcadi Cipponi, Robert G Maki, Andrew S Brohl, Ola Myklebost, Eva W Stratford, Susanne Lorenz, Sung-Min Ahn, Jin-Hee Ahn, Jeong Eun Kim, Sue Shanley, Victoria Beshay, et al.

Journal article  |  2016  |  The Lancet Oncology

An international survey of surveillance schemes for unaffected BRCA1 and BRCA2 mutation carriers.

Dana Madorsky-Feldman, Miri Sklair-Levy, Tamar Perri, Yael Laitman, Shani Paluch-Shimon, Rita Schmutzler, Kerstin Rhiem, Jenny Lester, Beth Y Karlan, Christian F Singer, Tom Van Maerken, Kathleen Claes, Joan Brunet, Angel Izquierdo, Alex Teulé, Jong Won Lee, Sung-Won Kim, Banu Arun, Anna Jakubowska, Jan Lubinski, et al.

Journal article  |  2016  |  Breast Cancer Research and Treatment

Female BRCA1/BRCA2 mutation carriers are at substantially increased risk for developing breast and/or ovarian cancer, and are offe..

Testing for Hereditary Predisposition in Patients with Gynecologic Cancers, Quo Vadis?

Gillian Mitchell, Kasmintan A Schrader

Journal article  |  2016  |  Surgical Pathology Clinics

Genetic testing for a hereditary predisposition to gynecologic cancers has been available clinically since the 1990s. Since then, ..

No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing

Douglas F Easton, Fabienne Lesueur, Brennan Decker, Kyriaki Michailidou, Jun Li, Jamie Allen, Craig Luccarini, Karen A Pooley, Mitul Shah, Manjeet K Bolla, Qin Wang, Joe Dennis, Jamil Ahmad, Ella R Thompson, Francesca Damiola, Maroulio Pertesi, Catherine Voegele, Noura Mebirouk, Nivonirina Robinot, Geoffroy Durand, et al.

Journal article  |  2016  |  Journal of Medical Genetics

Panel Testing for Familial Breast Cancer: Calibrating the Tension Between Research and Clinical Care

Ella R Thompson, Simone M Rowley, Na Li, Simone McInerny, Lisa Devereux, Michelle W Wong-Brown, Alison H Trainer, Gillian Mitchell, Rodney J Scott, Paul A James, Ian G Campbell

Journal article  |  2016  |  Journal of Clinical Oncology

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170

Alison M Dunning, Kyriaki Michailidou, Karoline B Kuchenbaecker, Deborah Thompson, Juliet D French, Jonathan Beesley, Catherine S Healey, Siddhartha Kar, Karen A Pooley, Elena Lopez-Knowles, Ed Dicks, Daniel Barrowdale, Nicholas A Sinnott-Armstrong, Richard C Sallari, Kristine M Hillman, Susanne Kaufmann, Haran Sivakumaran, Mahdi Moradi Marjaneh, Jason S Lee, Margaret Hills, et al.

Journal article  |  2016  |  Nature Genetics

Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation.

Jacek Gronwald, Karen Glass, Barry Rosen, Beth Karlan, Nadine Tung, Susan L Neuhausen, Pal Moller, Peter Ainsworth, Ping Sun, Steven A Narod, Jan Lubinski, Joanne Kotsopoulos, undefined Hereditary Breast Cancer Clinical Study Group

Journal article  |  2016  |  Fertility and Sterility

OBJECTIVE: To evaluate the relationship between use of fertility medication (i.e., selective estrogen receptor [ER] modulator, gon..

Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2

Valentina Silvestri, Daniel Barrowdale, Anna Marie Mulligan, Susan L Neuhausen, Stephen Fox, Beth Y Karlan, Gillian Mitchell, Paul James, Darcy L Thull, Kristin K Zorn, Natalie J Carter, Katherine L Nathanson, Susan M Dornchek, Timothy R Rebbeck, Susan J Ramus, Robert L Nussbaum, Olufunrnilayo I Olopade, Johanna Rantala, Sook-Yee Yoon, Maria A Caligo, et al.

Journal article  |  2016  |  Breast Cancer Research

Efficacy and safety of olaparib monotherapy in germline BRCA1/2 mutation carriers with advanced ovarian cancer and three or more lines of prior therapy

Susan M Domchek, Carol Aghajanian, Ronnie Shapira-Frommer, Rita K Schmutzler, M William Audeh, Michael Friedlander, Judith Balmana, Gillian Mitchell, Georgeta Fried, Salomon M Stemmer, Ayala Hubert, Ora Rosengarten, Niklas Loman, Jane D Robertson, Helen Mann, Bella Kaufman

Journal article  |  2016  |  Gynecologic Oncology

Timing and context: important considerations in the return of genetic results to research participants

Kate A McBride, Nina Hallowell, Martin HN Tattersall, Judy Kirk, Mandy L Ballinger, David M Thomas, Gillian Mitchell, Mary-Anne Young

Journal article  |  2016  |  Journal of Community Genetics

Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families

Jun Li, Huong Meeks, Bing-Jian Feng, Sue Healey, Heather Thorne, Igor Makunin, Jonathan Ellis, Ian Campbell, Melissa Southey, Gillian Mitchell, David Clouston, Judy Kirk, David Goldgar, Georgia Chenevix-Trench

Journal article  |  2016  |  Journal of Medical Genetics

Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer

Susan J Ramus, Honglin Song, Ed Dicks, Jonathan P Tyrer, Adam N Rosenthal, Maria P Intermaggio, Lindsay Fraser, Aleksandra Gentry-Maharaj, Jane Hayward, Susan Philpott, Christopher Anderson, Christopher K Edlund, David Conti, Patricia Harrington, Daniel Barrowdale, David D Bowtell, Kathryn Alsop, Gillian Mitchell, Mine S Cicek, Julie M Cunningham, et al.

Journal article  |  2015  |  JNCI: Journal of the National Cancer Institute

Reevaluation of the BRCA2 truncating allele c.9976A > T (p.Lys3326Ter) in a familial breast cancer context

Ella R Thompson, Kylie L Gorringe, Simone M Rowley, Na Li, Simone McInerny, Michelle W Wong-Brown, Lisa Devereux, Jason Li, Alison H Trainer, Gillian Mitchell, Rodney J Scott, Paul A James, Ian G Campbell

Journal article  |  2015  |  Sci Rep

BRCA1 and BRCA2 genetic testing-pitfalls and recommendations for managing variants of uncertain clinical significance

DM Eccles, G Mitchell, ANA Monteiro, R Schmutzler, FJ Couch, AB Spurdle, EB Gomez-Garcia

Journal article  |  2015  |  Annals of Oncology

FANCM c.5791C > T nonsense mutation (rs144567652) induces exon skipping, affects DNA repair activity and is a familial breast cancer risk factor

Paolo Peterlongo, Irene Catucci, Mara Colombo, Laura Caleca, Eliseos Mucaki, Massimo Bogliolo, Maria Marin, Francesca Damiola, Loris Bernard, Valeria Pensotti, Sara Volorio, Valentina Dall'Olio, Alfons Meindl, Claus Bartram, Christian Sutter, Harald Surowy, Valerie Sornin, Marie-Gabrielle Dondon, Severine Eon-Marchais, Dominique Stoppa-Lyonnet, et al.

Journal article  |  2015  |  Human Molecular Genetics

MRI screening for breast cancer in women at high risk; isthe Australian breast MRI screening access program addressing the needs of women at high risk of breast cancer?

Tess Schenberg, Gillian Mitchell, Donna Taylor, Christobel Saunders

Journal article  |  2015  |  Journal of Medical Radiation Sciences

Prevalence of PALB2 mutations in Australian familial breast cancer cases and controls

Ella R Thompson, Kylie L Gorringe, Simone M Rowley, Michelle W Wong-Brown, Simone McInerny, Na Li, Alison H Trainer, Lisa Devereux, Maria A Doyle, Jason Li, Richard Lupat, Martin B Delatycki, Gillian Mitchell, Paul A James, Rodney J Scott, Ian G Campbell

Journal article  |  2015  |  Breast Cancer Res

Altered significance of D'Amico risk classification in patients with prostate cancer linked to a familial breast cancer (kConFab) cohort

Damien Bolton, Yuan Cheng, Amber J Willems-Jones, Jason Li, Eveline Niedermeyr, Gillian Mitchell, David Clouston, Nathan Lawrentschuk, Ania Sliwinski, Stephen Fox, Heather Thorne

Journal article  |  2015  |  BJU Int

Surveillance recommendations for patients with germline TP53 mutations

Mandy L Ballinger, Gillian Mitchell, David M Thomas

Journal article  |  2015  |  Current Opinion in Oncology

Breast Tissue Composition and Immunophenotype and Its Relationship with Mammographic Density in Women at High Risk of Breast Cancer

Jia-Min B Pang, David J Byrne, Elena A Takano, Nicholas Jene, Lara Petelin, Joanne McKinley, Catherine Poliness, Christobel Saunders, Donna Taylor, Gillian Mitchell, Stephen B Fox

Journal article  |  2015  |  PLOS ONE

Health professionals' evaluation of delivering treatment-focused genetic testing to women newly diagnosed with breast cancer

Kirsten FL Douma, Bettina Meiser, Judy Kirk, Gillian Mitchell, Christobel Saunders, Belinda Rahman, Mariana S Sousa, Kristine Barlow-Stewart, Margaret Gleeson, Kathy Tucker

Journal article  |  2015  |  Familial Cancer

Large genomic rearrangements in the familial breast and ovarian cancer gene BRCA1 are associated with an increased frequency of high risk features

Paul A James, Sarah Sawyer, Samantha Boyle, Mary-Anne Young, Serguei Kovalenko, Rebecca Doherty, Joanne McKinley, Kathryn Alsop, Victoria Beshay, Marion Harris, Stephen Fox, Geoffrey J Lindeman, Gillian Mitchell

Journal article  |  2015  |  Familial Cancer

The role of the prostate cancer gene 3 urine test in addition to serum prostate-specific antigen level in prostate cancer screening among breast cancer, early-onset gene mutation carriers.

Ruben G Cremers, Rosalind A Eeles, Elizabeth K Bancroft, Janneke Ringelberg-Borsboom, Hans F Vasen, Christi J Van Asperen, undefined IMPACT Steering Committee, Jack A Schalken, Gerald W Verhaegh, Lambertus A Kiemeney

Journal article  |  2015  |  Urologic Oncology: Seminars and Original Investigations

OBJECTIVE: To evaluate the additive value of the prostate cancer gene 3 (PCA3) urine test to serum prostate-specific antigen (PSA)..

An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

Sophie Blein, Claire Bardel, Vincent Danjean, Lesley McGuffog, Sue Healey, Daniel Barrowdale, Andrew Lee, Joe Dennis, Karoline B Kuchenbaecker, Penny Soucy, Mary Beth Terry, Wendy K Chung, David E Goldgar, Saundra S Buys, Ramunas Janavicius, Laima Tihomirova, Nadine Tung, Cecilia M Dorfling, Elizabeth J van Rensburg, Susan L Neuhausen, et al.

Journal article  |  2015  |  Breast Cancer Research

Association of Type and Location of BRCA1 and BRCA2 Mutations With Risk of Breast and Ovarian Cancer

Timothy R Rebbeck, Nandita Mitra, Fei Wan, Olga M Sinilnikova, Sue Healey, Lesley McGuffog, Sylvie Mazoyer, Georgia Chenevix-Trench, Douglas F Easton, Antonis C Antoniou, Katherine L Nathanson

Journal article  |  2015  |  JAMA

Patient-derived Xenografts Reveal that Intraductal Carcinoma of the Prostate Is a Prominent Pathology in BRCA2 Mutation Carriers with Prostate Cancer and Correlates with Poor Prognosis

Gail P Risbridger, Renea A Taylor, David Clouston, Ania Sliwinski, Heather Thorne, Sally Hunter, Jason Li, Gillian Mitchell, Declan Murphy, Mark Frydenberg, David Pook, John Pedersen, Roxanne Toivanen, Hong Wang, Melissa Papargiris, Mitchell G Lawrence, Damien M Bolton

Journal article  |  2015  |  Eur Urol

Connecting patients, researchers and clinical genetics services: the experiences of participants in the Australian Ovarian Cancer Study (AOCS)

Ashley Crook, Loren Plunkett, Laura E Forrest, Nina Hallowell, Samantha Wake, Kathryn Alsop, Margaret Gleeson, David Bowtell, Gillian Mitchell, Mary-Anne Young

Journal article  |  2015  |  European Journal of Human Genetics

Germline Mutation in BRCA1 or BRCA2 and Ten-Year Survival for Women Diagnosed with Epithelial Ovarian Cancer

Francisco J Candido-dos-Reis, Honglin Song, Ellen L Goode, Julie M Cunningham, Brooke L Fridley, Melissa C Larson, Kathryn Alsop, Ed Dicks, Patricia Harrington, Susan J Ramus, Anna de Fazio, Gillian Mitchell, Sian Fereday, Kelly L Bolton, Charlie Gourley, Caroline Michie, Beth Karlan, Jenny Lester, Christine Walsh, Ilana Cass, et al.

Journal article  |  2015  |  Clinical Cancer Research

Olaparib Monotherapy in Patients With Advanced Cancer and a Germline BRCA1/2 Mutation

Bella Kaufman, Ronnie Shapira-Frommer, Rita K Schmutzler, M William Audeh, Michael Friedlander, Judith Balmana, Gillian Mitchell, Georgeta Fried, Salomon M Stemmer, Ayala Hubert, Ora Rosengarten, Mariana Steiner, Niklas Loman, Karin Bowen, Anitra Fielding, Susan M Domchek

Journal article  |  2015  |  Journal of Clinical Oncology

Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study

Elizabeth K Bancroft, Elizabeth C Page, Elena Castro, Hans Lilja, Andrew Vickers, Daniel Sjoberg, Melissa Assel, Christopher S Foster, Gillian Mitchell, Kate Drew, Lovise Maehle, Karol Axcrona, D Gareth Evans, Barbara Bulman, Diana Eccles, Donna McBride, Christi van Asperen, Hans Vasen, Lambertus A Kiemeney, Janneke Ringelberg, et al.

Journal article  |  2014  |  European Urology

Baseline and post prophylactic tubal-ovarian surgery CA125 levels in BRCA1 and BRCA2 mutation carriers

Ying Chen, Elizabeth Bancroft, Sue Ashley, Audrey Arden-Jones, Sarah Thomas, Susan Shanley, Sibel Saya, Emma Wakeling, Rosalind Eeles

Journal article  |  2014  |  Familial Cancer

Li-Fraumeni syndrome: cancer risk assessment and clinical management

Kate A McBride, Mandy L Ballinger, Emma Killick, Judy Kirk, Martin HN Tattersall, Rosalind A Eeles, David M Thomas, Gillian Mitchell

Journal article  |  2014  |  Nature Reviews Clinical Oncology

Molecular correlates of platinum response in human high-grade serous ovarian cancer patient-derived xenografts

Monique D Topp, Lynne Hartley, Michele Cook, Valerie Heong, Emma Boehm, Lauren McShane, Jan Pyman, Orla McNally, Sumitra Ananda, Marisol Harrell, Dariush Etemadmoghadam, Laura Galletta, Kathryn Alsop, Gillian Mitchell, Stephen B Fox, Jeffrey B Kerr, Karla J Hutt, Scott H Kaufmann, Elizabeth M Swisher, David D Bowtell, et al.

Journal article  |  2014  |  Molecular Oncology

Prophylactic bilateral salpingectomy as a prevention strategy in women at high-risk of ovarian cancer: a mini-review.

Tess Schenberg, Gillian Mitchell

Journal article  |  2014  |  Frontiers in Oncology

Risk-reducing bilateral salpingo-oophorectomy is a proven strategy to reduce the risk of serous ovarian cancer associated with ger..

The incidence of PALB2 c.3113G > A in women with a strong family history of breast and ovarian cancer attending familial cancer centres in Australia

Zhi L Teo, Sarah D Sawyer, Paul A James, Gillian Mitchell, Alison H Trainer, Geoffrey J Lindeman, Kylie Shackleton, Linda Cicciarelli, Melissa C Southey

Journal article  |  2013  |  Familial Cancer

Synthetic lethality between CCNE1 amplification and loss of BRCA1

Dariush Etemadmoghadam, Barbara A Weir, George Au-Yeung, Kathryn Alsop, Gillian Mitchell, Joshy George, Sally Davis, Alan D D'Andrea, Kaylene Simpson, William C Hahn, David DL Bowtell

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

The Angelina Jolie effect

Paul A James, Gillian Mitchell, Michael Bogwitz, Geoffrey J Lindeman

Journal article  |  2013  |  Medical Journal of Australia

The attitudes of people with sarcoma and their family towards genomics and incidental information arising from genetic research.

Mary-Anne Young, Amy Herlihy, Gillian Mitchell, David M Thomas, Mandy Ballinger, Kathy Tucker, Craig R Lewis, Susan Neuhaus, undefined International Sarcoma Kindred Study, Jane Halliday

Journal article  |  2013  |  Clinical Sarcoma Research

PURPOSE: The study aimed to examine attitudes of individuals diagnosed with sarcoma and their family members towards genetics, gen..

High Frequency of Germline TP53 Mutations in a Prospective Adult-Onset Sarcoma Cohort

Gillian Mitchell, Mandy L Ballinger, Stephen Wong, Chelsee Hewitt, Paul James, Mary-Anne Young, Arcadi Cipponi, Tiffany Pang, David L Goode, Alex Dobrovic, David M Thomas

Journal article  |  2013  |  PLoS One

Tumour morphology predicts PALB2 germline mutation status

ZL Teo, E Provenzano, GS Dite, DJ Park, C Apicella, SD Sawyer, PA James, G Mitchell, AH Trainer, GJ Lindeman, K Shackleton, L Cicciarelli, SS Buys, IL Andrulis, AM Mulligan, G Glendon, EM John, MB Terry, M Daly, FA Odefrey, et al.

Journal article  |  2013  |  British Journal of Cancer

Oncology health professionals' attitudes toward treatment-focused genetic testing for women newly diagnosed with breast cancer

Stephanie Burcher, Bettina Meiser, Gillian Mitchell, Christobel Saunders, Belinda Rahman, Kathy Tucker, Kristine Barlow-Stewart, Kaaren Watts, Margaret Gleeson, Judy Kirk

Journal article  |  2013  |  Personalized Medicine

Nonequivalent Gene Expression and Copy Number Alterations in High-Grade Serous Ovarian Cancers with BRCA1 and BRCA2 Mutations

Joshy George, Kathryn Alsop, Dariush Etemadmoghadam, Heather Hondow, Thomas Mikeska, Alexander Dobrovic, Anna DeFazio, Gordon K Smyth, Douglas A Levine, Gillian Mitchell, David D Bowtell

Journal article  |  2013  |  Clinical Cancer Research

Estimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer

DR Barnes, D Barrowdale, J Beesley, X Chen, PA James, JL Hopper, D Goldgar, G Chenevix-Trench, AC Antoniou, G Mitchell

Journal article  |  2013  |  British Journal of Cancer

Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men

Emma Killick, Richard Morgan, Francesca Launchbury, Elizabeth Bancroft, Elizabeth Page, Elena Castro, Zsofia Kote-Jarai, Armen Aprikian, Ignacio Blanco, Virginia Clowes, Susan Domchek, Fiona Douglas, Diana Eccles, D Gareth Evans, Marion Harris, Judy Kirk, Jimmy Lam, Geoffrey Lindeman, Gillian Mitchell, Nicholas Pachter, et al.

Journal article  |  2013  |  Scientific Reports

The responses of research participants and their next of kin to receiving feedback of genetic test results following participation in the Australian Ovarian Cancer Study

Nina Hallowell, Kathryn Alsop, Margaret Gleeson, Ashley Crook, Loren Plunkett, David Bowtell, Gillian Mitchell, Mary-Anne Young

Journal article  |  2013  |  Genetics in Medicine

No evidence for PALB2 methylation in high-grade serous ovarian cancer

Thomas Mikeska, Kathryn Alsop, Gillian Mitchell, David DL Bowtell, Alexander Dobrovic

Journal article  |  2013  |  Journal of Ovarian Research

Analysis of RAD51D in Ovarian Cancer Patients and Families with a History of Ovarian or Breast Cancer

Ella R Thompson, Simone M Rowley, Sarah Sawyer, Diana M Eccles, Alison H Trainer, Gillian Mitchell, Paul A James, Ian G Campbell

Journal article  |  2013  |  PLoS One

High Levels of Genomic Aberrations in Serous Ovarian Cancers Are Associated with Better Survival

Lars O Baumbusch, Aslaug Helland, Yun Wang, Knut Liestol, Marci E Schaner, Ruth Holm, Dariush Etemadmoghadam, Kathryn Alsop, Pat Brown, Gillian Mitchell, Sian Fereday, Anna DeFazio, David DL Bowtell, Gunnar B Kristensen, Ole Christian Lingjaerde, Anne-Lise Borresen-Dale

Journal article  |  2013  |  PLoS One

A Role for Common Genomic Variants in the Assessment of Familial Breast Cancer

Sarah Sawyer, Gillian Mitchell, Joanne McKinley, Georgia Chenevix-Trench, Jonathan Beesley, Xiao Qing Chen, David Bowtell, Alison H Trainer, Marion Harris, Geoffrey J Lindeman, Paul A James

Journal article  |  2012  |  Journal of Clinical Oncology

Are we being overly cautious? A qualitative inquiry into the experiences and perceptions of treatment-focused germline BRCA genetic testing amongst women recently diagnosed with breast cancer

E Zilliacus, B Meiser, M Gleeson, K Watts, K Tucker, EA Lobb, G Mitchell

Journal article  |  2012  |  Supportive Care in Cancer

Profiles of Genomic Instability in High-Grade Serous Ovarian Cancer Predict Treatment Outcome

Zhigang C Wang, Nicolai Juul Birkbak, Aedin C Culhane, Ronny Drapkin, Aquila Fatima, Ruiyang Tian, Matthew Schwede, Kathryn Alsop, Kathryn E Daniels, Huiying Piao, Joyce Liu, Dariush Etemadmoghadam, Alexander Miron, Helga B Salvesen, Gillian Mitchell, Anna DeFazio, John Quackenbush, Ross S Berkowitz, J Dirk Iglehart, David DL Bowtell, et al.

Journal article  |  2012  |  Clinical Cancer Research

The consequences of risk reducing salpingo-oophorectomy: the case for a coordinated approach to long-term follow up post surgical menopause

Carmel Pezaro, Paul James, Joanne McKinley, Mary Shanahan, Mary-Anne Young, Gillian Mitchell

Journal article  |  2012  |  Familial Cancer

Exome Sequencing Identifies Rare Deleterious Mutations in DNA Repair Genes FANCC and BLM as Potential Breast Cancer Susceptibility Alleles

Ella R Thompson, Maria A Doyle, Georgina L Ryland, Simone M Rowley, David YH Choong, Richard W Tothill, Heather Thorne, Daniel R Barnes, Jason Li, Jason Ellul, Gayle K Philip, Yoland C Antill, Paul A James, Alison H Trainer, Gillian Mitchell, Ian G Campbell

Journal article  |  2012  |  PLoS Genetics

How should we discuss genetic testing with women newly diagnosed with breast cancer? Design and implementation of a randomized controlled trial of two models of delivering education about treatment-focused genetic testing to younger women newly diagnosed with breast cancer

Kaaren J Watts, Bettina Meiser, Gillian Mitchell, Judy Kirk, Christobel Saunders, Michelle Peate, Jessica Duffy, Patrick J Kelly, Margaret Gleeson, Kristine Barlow-Stewart, Belinda Rahman, Michael Friedlander, Kathy Tucker

Journal article  |  2012  |  BMC Cancer

BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation-Positive Women With Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group

Kathryn Alsop, Sian Fereday, Cliff Meldrum, Anna deFazio, Catherine Emmanuel, Joshy George, Alexander Dobrovic, Michael J Birrer, Penelope M Webb, Colin Stewart, Michael Friedlander, Stephen Fox, David Bowtell, Gillian Mitchell

Journal article  |  2012  |  Journal of Clinical Oncology

Analysis of KLLN as a high-penetrance breast cancer predisposition gene

Ella R Thompson, Kylie L Gorringe, David YH Choong, Diana M Eccles, Gillian Mitchell, Ian G Campbell

Journal article  |  2012  |  Breast Cancer Research and Treatment

Triple-negative breast cancer: making the most of a misnomer

Nicole Mccarthy, Gillian Mitchell, Michael Bilous, Nicholas Wilcken, Geoffrey J Lindeman

Journal article  |  2012  |  Asia-Pacific Journal of Clinical Oncology

Getting to the point: what women newly diagnosed with breast cancer want to know about treatment-focused genetic testing.

Bettina Meiser, Margaret Gleeson, Kaaren Watts, Michelle Peate, Elvira Zilliacus, Kristine Barlow-Stewart, Christobel Saunders, Gillian Mitchell, Judy Kirk

Journal article  |  2012  |  Oncology Nursing Forum

PURPOSE/OBJECTIVES: To identify young women's information preferences regarding treatment-focused genetic testing (TFGT) and to de..

There is no decision to make: Experiences and attitudes toward treatment-focused genetic testing among women diagnosed with ovarian cancer

B Meiser, M Gleeson, N Kasparian, K Barlow-Stewart, M Ryan, K Watts, D Menon, G Mitchell, K Tucker

Journal article  |  2012  |  Gynecologic Oncology

Analysis of RAD51C Germline Mutations in High-Risk Breast and Ovarian Cancer Families and Ovarian Cancer Patients

Ella R Thompson, Samantha E Boyle, Julie Johnson, Georgina L Ryland, Sarah Sawyer, David YH Choong, Georgia Chenevix-Trench, Alison H Trainer, Geoffrey J Lindeman, Gillian Mitchell, Paul A James, Ian G Campbell

Journal article  |  2012  |  Human Mutation

Challenges to the Development of New Agents for Molecularly Defined Patient Subsets: Lessons From BRCA1/2-Associated Breast Cancer

Susan M Domchek, Gillian Mitchell, Geoffrey J Lindeman, Nadine M Tung, Judith Balmana, Steven J Isakoff, Rita Schmutzler, M William Audeh, Niklas Loman, Clare Scott, Michael Friedlander, Bella Kaufman, Judy E Garber, Andrew Tutt, Mark E Robson

Journal article  |  2011  |  Journal of Clinical Oncology

The tubal hypothesis of ovarian cancer: caution needed

Ian M Collins, Susan M Domchek, David G Huntsman, Gillian Mitchell

Journal article  |  2011  |  Lancet Oncology

Practicalities of developing a breast magnetic resonance imaging screening service for women at high risk for breast cancer

Belinda E Kiely, Lucinda K Hossack, Clair L Shadbolt, Anna Davis, Robin Cassumbhoy, Kate Moodie, Yoland Antill, Gillian Mitchell

Journal article  |  2011  |  ANZ Journal of Surgery

The role of poly adenosine diphosphate ribose polymerase inhibitors in breast and ovarian cancer: Current status and future directions

Fiona Chionh, Gillian Mitchell, Geoffrey J Lindeman, Michael Friedlander, Clare L Scott

Journal article  |  2011  |  Asia-Pacific Journal of Clinical Oncology

Decreased Prostate Cancer-Specific Survival of Men with BRCA2 Mutations from Multiple Breast Cancer Families

Heather Thorne, Amber J Willems, Eveline Niedermayr, Ivan MY Hoh, Jason Li, David Clouston, Gillian Mitchell, Stephen Fox, John L Hopper, Damien Bolton

Journal article  |  2011  |  Cancer prevention research

A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes

Heather L Hondow, Stephen B Fox, Gillian Mitchell, Rodney J Scott, Victoria Beshay, Stephen Q Wong, Alexander Dobrovic

Journal article  |  2011  |  BMC Cancer

A response to the forgotten fallopian tube

David DL Bowtell, Michael Friedlander, Michael Quinn, Gillian Mitchell

Journal article  |  2011  |  Nature Reviews Cancer

kConFab: a familial breast cancer consortium facilitating research and translational oncology.

Heather Thorne, Gillian Mitchell, Stephen Fox, undefined kConFab consortium

Journal article  |  2011  |  JNCI Monographs

In 2005, 100,514 Australians were diagnosed with cancer, and over 10,000 of these cancers will be due to heritable causes. The imp..

Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study

Anita V Mitra, Elizabeth K Bancroft, Yolanda Barbachano, Elizabeth C Page, CS Foster, C Jameson, G Mitchell, GJ Lindeman, A Stapleton, G Suthers, DG Evans, D Cruger, I Blanco, C Mercer, J Kirk, L Maehle, S Hodgson, L Walker, L Izatt, F Douglas, et al.

Journal article  |  2011  |  British Journal of Urology

Gene Methylation in Breast Ductal Fluid from BRCA1 and BRCA2 Mutation Carriers

Yoland C Antill, Gillian Mitchell, Sandra A Johnson, Lisa Devereux, Alvin Milner, Juliana Di Iuiio, Geoffrey J Lindeman, Judy Kirk, Kelly Anne Phillips, Ian G Campbell

Journal article  |  2010  |  Cancer Epidemiology, Biomarkers & Prevention

Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis

Elena A Takano, Gillian Mitchell, Stephen B Fox, Alexander Dobrovic

Journal article  |  2008  |  BMC Cancer

Genome-wide association study identifies novel breast cancer susceptibility loci

Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, et al.

Journal article  |  2007  |  Nature

Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation

G Mitchell, YC Antill, W Murray, J Kirk, E Salisbury, GJ Lindeman, J Di Iulio, AD Milner, L Devereaux, KA Phillips

Journal article  |  2005  |  Breast Cancer Research