Marc Pellegrini

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

Adam K Wheatley, Phillip Pymm, Robyn Esterbauer, Melanie H Dietrich, Wen Shi Lee, Damien Drew, Hannah G Kelly, Li-Jin Chan, Francesca L Mordant, Katrina A Black, Amy Adair, Hyon-Xhi Tan, Jennifer A Juno, Kathleen M Wragg, Thakshila Amarasena, Ester Lopez, Kevin J Selva, Ebene R Haycroft, James P Cooney, Hariprasad Venugopal, et al.

Journal article  |  2021  |  CELL REPORTS

Potent neutralizing monoclonal antibodies are one of the few agents currently available to treat COVID-19. SARS-CoV-2 variants of ..

Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis.

Yifan Zhan, Yuxia Zhang, Shengbo Zhang, Hannah Coughlan, Pedro L Baldoni, Nicolas Jacquelot, Wang HJ Cao, Simon Preston, Cynthia Louis, Jai Rautela, Marc Pellegrini, Ian P Wicks, Warren S Alexander, Leonard C Harrison, Andrew M Lew, Gordon K Smyth, Stephen L Nutt, Michaël Chopin

Journal article  |  2021  |  Sci Immunol

[Figure: see text].

Macrophage and neutrophil death programs differentially confer resistance to tuberculosis

Michael Dominic Stutz, Cody Charles Allison, Samar Ojaimi, Simon Peter Preston, Marcel Doerflinger, Philip Arandjelovic, Lachlan Whitehead, Stefanie M Bader, Daniel Batey, Marie-Liesse Asselin-Labat, Marco J Herold, Andreas Strasser, Nicholas P West, Marc Pellegrini

Journal article  |  2021  |  IMMUNITY

Apoptosis can potently defend against intracellular pathogens by directly killing microbes and eliminating their replicative niche..

Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models

Michelle P Clark, Thao Huynh, Shringar Rao, Liana Mackiewicz, Hugh Mason, Shahla Romal, Michael D Stutz, Sang H Ahn, Linda Earnest, Vitina Sozzi, Margaret Littlejohn, Bang M Tran, Norbert Wiedemann, Elizabeth Vincan, Joseph Torresi, Hans J Netter, Tokameh Mahmoudi, Peter Revill, Marc Pellegrini, Gregor Ebert

Journal article  |  2021  |  CELL DEATH & DISEASE

A major unmet clinical need is a therapeutic capable of removing hepatitis B virus (HBV) genome from the liver of infected individ..

Procalcitonin and Interleukin-10 May Assist in Early Prediction of Bacteraemia in Children With Cancer and Febrile Neutropenia

Marcel Doerflinger, Gabrielle M Haeusler, Connie SN Li-Wai-Suen, Julia E Clark, Monica Slavin, Franz E Babl, Zoe Allaway, Francoise Mechinaud, Gordon K Smyth, Richard De Abreu Lourenco, Bob Phillips, Marc Pellegrini, Karin A Thursky

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

Objectives: Febrile neutropenia (FN) causes treatment disruption and unplanned hospitalization in children with cancer. Serum biom..

Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice

Phillip Pymm, Amy Adair, Li-Jin Chan, James P Cooney, Francesca L Mordant, Cody C Allison, Ester Lopez, Ebene R Haycroft, Matthew T O'Neill, Li Lynn Tan, Melanie H Dietrich, Damien Drew, Marcel Doerflinger, Michael A Dengler, Nichollas E Scott, Adam K Wheatley, Nicholas A Gherardin, Hariprasad Venugopal, Deborah Cromer, Miles P Davenport, et al.

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralizing antibodies are important for immunity against SARS-CoV-2 and as therapeutics for the prevention and treatment of COVI..

Correspondence on 'Clinical course of coronavirus disease 2019 (COVID-19) in a series of 17 patients with systemic lupus under long-term treatment with hydroxychloroquine'

Mandana Nikpour, Benjamin Teh, Ian P Wicks, Marc Pellegrini

Journal article  |  2021  |  ANNALS OF THE RHEUMATIC DISEASES

Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands

Brigette C Duckworth, Fanny Lafouresse, Verena C Wimmer, Benjamin J Broomfield, Lennard Dalit, Yannick O Alexandre, Amania A Sheikh, Raymond Z Qin, Carolina Alvarado, Lisa A Mielke, Marc Pellegrini, Scott N Mueller, Thomas Boudier, Kelly L Rogers, Joanna R Groom

Journal article  |  2021  |  NATURE IMMUNOLOGY

T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we d..

Correction: FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.

Han You, Marc Pellegrini, Katsuya Tsuchihara, Kazuo Yamamoto, Georg Hacker, Miriam Erlacher, Andreas Villunger, Tak W Mak

Journal article  |  2021  |  J Exp Med

The authors regret that a reference related to Fig. 2 A was missing in the original version of this paper. Data in Fig. 2 A were p..

Successful identification of predictive profiles for infection utilising systems-level immune analysis: a pilot study in patients with relapsed and refractory multiple myeloma

Marcel Doerflinger, Alexandra L Garnham, Saskia Freytag, Simon J Harrison, H Miles Prince, Hang Quach, Monica A Slavin, Marc Pellegrini, Benjamin W Teh

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: Patients with multiple myeloma (MM) are at increased risk for infection. Clinical assessment of infection risk is incr..