Marc Pellegrini

A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection

Simon P Preston, Cody C Allison, Jan Schaefer, William Clow, Stefanie M Bader, Sophie Collard, Wasan O Forsyth, Michelle P Clark, Alexandra L Garnham, Connie SN Li-Wai-Suen, Thanushi Peiris, Jack Teale, Liana Mackiewicz, Sophia Davidson, Marcel Doerflinger, Marc Pellegrini

Journal article  |  2023  |  CELL DEATH & DISEASE

Necroptosis is a lytic and inflammatory form of cell death that is highly constrained to mitigate detrimental collateral tissue da..

Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL -mediated Necroptosis From Contributing to Liver Pathologies

Simon P Preston, Michael D Stutz, Cody C Allison, Ueli Nachbur, Quentin Gouil, Manh Tran Bang, Valerie Duvivier, Philip Arandjelovic, James P Cooney, Liana Mackiewicz, Yanxiang Meng, Jan Schaefer, Stefanie M Bader, Hongke Peng, Zina Valaydon, Pravin Rajasekaran, Charlie Jennison, Sash Lopaticki, Ann Farrell, Marno Ryan, et al.

Journal article  |  2022  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury incl..

Killing in self-defense: proapoptotic drugs to eliminate intracellular pathogens.

Jan Schaefer, William Clow, Reet Bhandari, Mari Kimura, Lewis Williams, Marc Pellegrini

Journal article  |  2022  |  Curr Opin Immunol

Intracellular infections rely on host cell survival for replication and have evolved several mechanisms to prevent infected cells ..

Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

Phillip Pymm, Samuel J Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P Cooney, Kathryn C Davidson, Ebene R Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L Grimley, Damian FJ Purcell, Stephen J Kent, Adam K Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W Chung, Kanta Subbarao, et al.

Journal article  |  2022  |  ISCIENCE

The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monocl..

How toxic is an old friend? A review of the safety of hydroxychloroquine in clinical practice

Jessica L Fairley, Mandana Nikpour, Heather G Mack, Maria Brosnan, Amanda M Saracino, Marc Pellegrini, Ian P Wicks

Journal article  |  2022  |  INTERNAL MEDICINE JOURNAL

Hydroxychloroquine (HCQ) and its close relative chloroquine (CQ) were initially used as antimalarial agents but are now widely pre..

Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation.

Salimeh Ebrahimnezhaddarzi, Catherina H Bird, Cody C Allison, Daniel E Tuipulotu, Xenia Kostoulias, Christophe Macri, Michael D Stutz, Gilu Abraham, Dion Kaiserman, Siew Siew Pang, Si Ming Man, Justine D Mintern, Thomas Naderer, Anton Y Peleg, Marc Pellegrini, James C Whisstock, Phillip I Bird

Journal article  |  2022  |  Immunol Cell Biol

To control infections phagocytes can directly kill invading microbes. Macrophage-expressed gene 1 (Mpeg1), a pore-forming protein ..

Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria

Stefanie M Bader, Simon P Preston, Katie Saliba, Adam Lipszyc, Zoe L Grant, Liana Mackiewicz, Andrew Baldi, Anne Hempel, Michelle P Clark, Thanushi Peiris, William Clow, Jan Bjelic, Michael D Stutz, Philip Arandjelovic, Jack Teale, Fashuo Du, Leigh Coultas, James M Murphy, Cody C Allison, Marc Pellegrini, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Caspase-8 transduces signals from death receptor ligands, such as tumor necrosis factor, to drive potent responses including infla..

Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death

Lin Liu, Jarrod J Sandow, Deena M Leslie Pedrioli, Andre L Samson, Natasha Silke, Tobias Kratina, Rebecca L Ambrose, Marcel Doerflinger, Zhaoqing Hu, Emma Morrish, Diep Chau, Andrew J Kueh, Cheree Fitzibbon, Marc Pellegrini, Jaclyn S Pearson, Michael O Hottiger, Andrew Webb, Najoua Lalaoui, John Silke

Journal article  |  2022  |  SCIENCE ADVANCES

Tumor necrosis factor (TNF) is a key component of the innate immune response. Upon binding to its receptor, TNFR1, it promotes pro..

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors

Dale J Calleja, Nathan Kuchel, Bernadine GC Lu, Richard W Birkinshaw, Theresa Klemm, Marcel Doerflinger, James P Cooney, Liana Mackiewicz, Amanda E Au, Yu Q Yap, Timothy R Blackmore, Kasiram Katneni, Elly Crighton, Janet Newman, Kate E Jarman, Melissa J Call, Bernhard C Lechtenberg, Peter E Czabotar, Marc Pellegrini, Susan A Charman, et al.

Journal article  |  2022  |  FRONTIERS IN CHEMISTRY

The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalizati..

Programmed cell death: the pathways to severe COVID-19?

Stefanie M Bader, James P Cooney, Marc Pellegrini, Marcel Doerflinger

Journal article  |  2022  |  Biochem J

Two years after the emergence of SARS-CoV-2, our understanding of COVID-19 disease pathogenesis is still incomplete. Despite unpre..