Marc Pellegrini

Current and emerging therapies to combat persistent intracellular pathogens

Philip Arandjelovic, Marcel Doerflinger, Marc Pellegrini

Journal article  |  2019  |  Current Opinion in Pharmacology

Intracellular pathogens such as HIV, hepatitis B virus, and Mycobacterium tuberculosis are responsible for millions of deaths worl..

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection

Amania A Sheikh, Lucy Cooper, Meiqi Feng, Fernando Souza-Fonseca-Guimaraes, Fanny Lafouresse, Brigette C Duckworth, Nicholas D Huntington, James J Moon, Marc Pellegrini, Stephen L Nutt, Gabrielle T Belz, Kim L Good-Jacobson, Joanna R Groom

Journal article  |  2019  |  Cell Reports

Constitutive overexpression of TNF in BPSM1 mice causes iBALT and bone marrow nodular lymphocytic hyperplasia

Cyril Seillet, Elysa Carr, Derek Lacey, Michael D Stutz, Marc Pellegrini, Lachlan Whitehead, Joel Rimes, Edwin D Hawkins, Ben Roediger, Gabrielle T Belz, Philippe Bouillet

Journal article  |  2019  |  Immunology and Cell Biology

Mycobacterium tuberculosis: prePPARing and Maintaining the Replicative Niche

Michael D Stutz, Marc Pellegrini

Journal article  |  2018  |  Trends in Microbiology

The e Antigen Is an Interferon Resistance Protein That Allows the Hepatitis B Virus to Evade the Early Immune Response.

Zina Valaydon, Gregor Ebert, Liana Mackiewicz, Simon Preston, Paul V Desmond, Vitina Sozzi, Peter Revill, Alexander JV Thompson, Marc Pellegrini

Conference Proceedings  |  2018  |  HEPATOLOGY

Is Receptor-Interacting Protein Kinase 3 a Viable Therapeutic Target for Mycobacterium tuberculosis Infection?

Michael D Stutz, Samar Ojaimi, Gregor Ebert, Marc Pellegrini

Journal article  |  2018  |  Frontiers in Immunology

Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted

Michael D Stutz, Samar Ojaimi, Cody Allison, Simon Preston, Philip Arandjelovic, Joanne M Hildebrand, Jarrod J Sandow, Andrew I Webb, John Silke, Warren S Alexander, Marc Pellegrini

Journal article  |  2018  |  Cell Death & Differentiation

Mycobacterium tuberculosis: Rewiring host cell signaling to promote infection

Michael D Stutz, Michelle P Clark, Marcel Doerflinger, Marc Pellegrini

Journal article  |  2018  |  Journal of Leukocyte Biology

Therapeutic manipulation of host cell death pathways to facilitate clearance of persistent viral infections

James Cooney, Cody Allison, Simon Preston, Marc Pellegrini

Journal article  |  2018  |  Journal of Leukocyte Biology

Transcription Factor IRF4 Promotes CD8( ) T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

Kevin Man, Sarah S Gabriel, Yang Liao, Renee Gloury, Simon Preston, Darren C Henstridge, Marc Pellegrini, Dietmar Zehn, Friederike Berberich-Siebelt, Mark A Febbraio, Wei Shi, Axel Kallies

Journal article  |  2017  |  Immunity

DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice

Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J Herold, Andreas Strasser, Andreas Villunger

Journal article  |  2017  |  Nature Communications

Predicting Risk of Infection in Patients with Newly Diagnosed Multiple Myeloma: Utility of Immune Profiling

Benjamin W Teh, Simon J Harrison, Cody Charles Allison, Monica A Slavin, Tim Spelman, Leon J Worth, Karin A Thursky, David Ritchie, Marc Pellegrini

Journal article  |  2017  |  Frontiers in Immunology

Editorial overview: Offence is the best defense: host-pathogen interactions driving evolution of human immunity and the germs we live with Marc Pellegrini and Elizabeth Hartland

Marc Pellegrini, Elizabeth Hartland

Journal article  |  2017  |  Current Opinion in Immunology

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

Tan A Nguyen, Blake RC Smith, Michelle D Tate, Gabrielle T Belz, Marilou H Barrios, Kirstin D Elgass, Alexandra S Weisman, Paul J Baker, Simon P Preston, Lachlan Whitehead, Alexandra Garnham, Rachel J Lundie, Gordon K Smyth, Marc Pellegrini, Meredith O'Keeffe, Ian P Wicks, Seth L Masters, Craig P Hunter, Ken C Pang

Journal article  |  2017  |  Immunity

Granzyme K-deficient mice show no evidence of impaired antiviral immunity

Lars T Joeckel, Cody C Allison, Marc Pellegrini, Catherina H Bird, Phillip I Bird

Journal article  |  2017  |  Immunology and Cell Biology

CRISPR/Cas9-The ultimate weapon to battle infectious diseases?

M Doerflinger, W Forsyth, G Ebert, M Pellegrini, MJ Herold

Journal article  |  2017  |  Cellular Microbiology

Vaccines licensed and in clinical trials for the prevention of dengue

J Torresi, G Ebert, M Pellegrini

Journal article  |  2017  |  Human Vaccines & Immunotherapeutics

Interleukin-7

M Pellegrini, P Ohashi

Book Chapter  |  2017

The role of tumour necrosis factor in hepatitis B infection: Jekyll and Hyde

Zina Valaydon, Marc Pellegrini, Alexander Thompson, Paul Desmond, Peter Revill, Gregor Ebert

Journal article  |  2016  |  Clinical & Translational Immunology

Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice

Marcel Doerflinger, Jason Glab, Christina Nedeva, Irvin Jose, Ann Lin, Lorraine O'Reilly, Cody Allison, Marc Pellegrini, Richard S Hotchkiss, Hamsa Puthalakath

Journal article  |  2016  |  Scientific Reports

CXCR5( ) follicular cytotoxic T cells control viral infection in B cell follicles

Yew Ann Leong, Yaping Chen, Hong Sheng Ong, Di Wu, Kevin Man, Claire Deleage, Martina Minnich, Benjamin J Meckiff, Yunbo Wei, Zhaohua Hou, Dimitra Zotos, Kevin A Fenix, Anurag Atnerkar, Simon Preston, Jeffrey G Chipman, Greg J Beilman, Cody C Allison, Lei Sun, Peng Wang, Jiawei Xu, et al.

Journal article  |  2016  |  Nature Immunology

Acetylation of the Cd8 Locus by KAT6A Determines Memory T Cell Diversity

Dane M Newman, Shinya Sakaguchi, Aaron Lun, Simon Preston, Marc Pellegrini, Kseniya Khamina, Andreas Bergthaler, Stephen L Nutt, Gordon K Smyth, Anne K Voss, Tim Thomas, Wilfried Ellmeier, Gabrielle T Belz, Rhys S Allan

Journal article  |  2016  |  Cell Reports

Role of proapoptotic BH3-only proteins in Listeria monocytogenes infection

Camilla Margaroli, Susanne Oberle, Christine Lavanchy, Stefanie Scherer, Muriel Rosa, Andreas Strasser, Marc Pellegrini, Dietmar Zehn, Hans Acha-Orbea, Driss Ehirchiou

Journal article  |  2016  |  European Journal of Immunology

RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity

Michael Chopin, Simon P Preston, Aaron TL Lun, Julie Tellier, Gordon K Smyth, Marc Pellegrini, Gabrielle T Belz, Lynn M Corcoran, Jane E Visvader, Li Wu, Stephen L Nutt

Journal article  |  2016  |  Cell Reports

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

Laura K Mackay, Martina Minnich, Natasja AM Kragten, Yang Liao, Benjamin Nota, Cyril Seillet, Ali Zaid, Kevin Man, Simon Preston, David Freestone, Asolina Braun, Erica Wynne-Jones, Felix M Behr, Regina Stark, Daniel G Pellicci, Dale I Godfrey, Gabrielle T Belz, Marc Pellegrini, Thomas Gebhardt, Meinrad Busslinger, et al.

Journal article  |  2016  |  Science

NF kappa B1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells

Elisha de Valle, George Grigoriadis, Lorraine A O'Reilly, Simon N Willis, Mhairi J Maxwell, Lynn M Corcoran, Evelyn Tsantikos, Jasper KS Cornish, Kirsten A Fairfax, Ajithkumar Vasanthakumar, Mark A Febbraio, Margaret L Hibbs, Marc Pellegrini, Ashish Banerjee, Philip D Hodgkin, Axel Kallies, Fabienne Mackay, Andreas Strasser, Steve Gerondakis, Raffi Gugasyan

Journal article  |  2016  |  The Journal of Experimental Medicine

A molecular threshold for effector CD8( ) T cell differentiation controlled by transcription factors Blimp-1 and T-bet

Annie Xin, Frederick Masson, Yang Liao, Simon Preston, Tianxia Guan, Renee Gloury, Moshe Olshansky, Jian-Xin Lin, Peng Li, Terence P Speed, Gordon K Smyth, Matthias Ernst, Warren J Leonard, Marc Pellegrini, Susan M Kaech, Stephen L Nutt, Wei Shi, Gabrielle T Belz, Axel Kallies

Journal article  |  2016  |  Nature Immunology

Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation

Victoria Ryg-Cornejo, Lisa Julia Ioannidis, Ann Ly, Chris Yu Chiu, Julie Tellier, Danika Lea Hill, Simon Peter Preston, Marc Pellegrini, Di Yu, Stephen Laurence Nutt, Axel Kallies, Diana Silvia Hansen

Journal article  |  2016  |  Cell Reports

Hydrodynamic Injection as a Method of Gene Delivery in Mice: A Model of Chronic Hepatitis B Virus Infection.

Simon P Preston, Marc Pellegrini, Gregor Ebert

Book Chapter  |  2016  |  Methods in Molecular Biology

Gene delivery methods are important for both therapeutic intervention and as tools in research to address specific questions. Hydr..

Hepatitis B virus and inhibitor of apoptosis proteins - a vulnerable liaison

G Ebert, M Pellegrini

Journal article  |  2016  |  Cell Death Discovery

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

Gregor Ebert, Cody Allison, Simon Preston, James Cooney, Jesse G Toe, Michael D Stutz, Samar Ojaimi, Nikola Baschuk, Ueli Nachbur, Joseph Torresi, John Silke, C Glenn Begley, Marc Pellegrini

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus

Gregor Ebert, Simon Preston, Cody Allison, James Cooney, Jesse G Toe, Michael D Stutz, Samar Ojaimi, Hamish W Scott, Nikola Baschuk, Ueli Nachbur, Joseph Torresi, Ruth Chin, Danielle Colledge, Xin Lie, Nadia Warner, Peter Revill, Scott Bowden, John Silke, C Glenn Begley, Marc Pellegrini

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

Emma M Carrington, Jian-Guo Zhang, Robyn M Sutherland, Ingela B Vikstrom, Jamie L Brady, Priscilla Soo, David Vremec, Cody Allison, Erinna F Lee, W Douglas Fairlie, Philippe Bouillet, Stephanie Grabow, Eleonora Ottina, Marco J Herold, Marc Pellegrini, David CS Huang, David M Tarlinton, Andreas Strasser, Andrew M Lew, Yifan Zhan

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Fas regulates neutrophil lifespan during viral and bacterial infection

Joanne A O'Donnell, Catherine L Kennedy, Marc Pellegrini, Cameron J Nowell, Jian-Guo Zhang, Lorraine A O'Reilly, Louise Cengia, Stuart Dias, Seth L Masters, Elizabeth L Hartland, Andrew W Roberts, Motti Gerlic, Ben A Croker

Journal article  |  2015  |  Journal of Leukocyte Biology

Cancer drugs for hepatitis B treatment: what do we know?

Gregor Ebert, Marc Pellegrini

Journal article  |  2015  |  Future Virology

Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins

S Kurtulus, A Sholl, J Toe, P Tripathi, J Raynor, K-P Li, M Pellegrini, DA Hildeman

Journal article  |  2015  |  Cell Death & Differentiation

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways

Emma C Josefsson, Deborah L Burnett, Marion Lebois, Marlyse A Debrincat, Michael J White, Katya J Henley, Rachael M Lane, Diane Moujalled, Simon P Preston, Lorraine A O'Reilly, Marc Pellegrini, Donald Metcalf, Andreas Strasser, Benjamin T Kile

Journal article  |  2014  |  Nature Communications

Changing treatment paradigms for patients with plasma cell myeloma: Impact upon immune determinants of infection

Benjamin W Teh, Simon J Harrison, Marc Pellegrini, Karin A Thursky, Leon J Worth, Monica A Slavin

Journal article  |  2014  |  Blood Reviews

TB incidence and characteristics in the remote gulf province of Papua New Guinea: a prospective study

Gail B Cross, Katie Coles, Mandana Nikpour, Owen A Moore, Justin Denholm, Emma S McBryde, Damon P Eisen, Beverlyn Warigi, Robyn Carter, Sushil Pandey, Paul Harino, Peter Siba, Christopher Coulter, Ivo Mueller, Suparat Phuanukoonnon, Marc Pellegrini

Journal article  |  2014  |  BMC Infectious Diseases

Promoting immunity during chronic infection-The therapeutic potential of common gamma-chain cytokines

Jesse G Toe, Marc Pellegrini, Tak Wah Mak

Journal article  |  2013  |  Molecular Immunology

The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells

Kevin Man, Maria Miasari, Wei Shi, Annie Xin, Darren C Henstridge, Simon Preston, Marc Pellegrini, Gabrielle T Belz, Gordon K Smyth, Mark A Febbraio, Stephen L Nutt, Axel Kallies

Journal article  |  2013  |  Nature Immunology

Host pathogen interactions at the coalface of immunity

Marc Pellegrini, Bruce D Walker

Journal article  |  2013  |  Current Opinion in Immunology

Guarding effector T-cell survival: all for one, Mcl-1 for all?

E Ottina, M Pellegrini, A Villunger

Journal article  |  2013  |  Cell Death & Differentiation

ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system

Amy E Lin, Gregor Ebert, Yongkai Ow, Simon P Preston, Jesse G Toe, James P Cooney, Hamish W Scott, Masato Sasaki, Samuel D Saibil, Dilan Dissanayake, Raymond H Kim, Andrew Wakeham, Annick You-Ten, Arda Shahinian, Gordon Duncan, Jennifer Silvester, Pamela S Ohashi, Tak W Mak, Marc Pellegrini

Journal article  |  2013  |  Nature Immunology

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

Seth L Masters, Motti Gerlic, Donald Metcalf, Simon Preston, Marc Pellegrini, Joanne A O'Donnell, Kate McArthur, Tracey M Baldwin, Stephane Chevrier, Cameron J Nowell, Louise H Cengia, Katya J Henley, Janelle E Collinge, Daniel L Kastner, Lionel Feigenbaum, Douglas J Hilton, Warren S Alexander, Benjamin T Kile, Ben A Croker

Journal article  |  2012  |  Immunity

Loss of the signaling adaptor TRAF1 causes CD8( ) T cell dysregulation during human and murine chronic infection

Chao Wang, Ann J McPherson, R Brad Jones, Kim S Kawamura, Gloria HY Lin, Philipp A Lang, Thanuja Ambagala, Marc Pellegrini, Thomas Calzascia, Nasra Aidarus, Alisha R Elford, Feng Yun Yue, Elisabeth Kremmer, Colin M Kovacs, Erika Benko, Cecile Tremblay, Jean-Pierre Routy, Nicole F Bernard, Mario A Ostrowski, Pamela S Ohashi, et al.

Journal article  |  2012  |  The Journal of Experimental Medicine

IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3

Ben A Croker, Hiu Kiu, Marc Pellegrini, Jesse Toe, Simon Preston, Donald Metcalf, Joanne A O'Donnell, Louise H Cengia, Kate McArthur, Nicos A Nicola, Warren S Alexander, Andrew W Roberts

Journal article  |  2012  |  Immunology and Cell Biology

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

Marc Pellegrini, Thomas Calzascia, Jesse G Toe, Simon P Preston, Amy E Lin, Alisha R Elford, Arda Shahinian, Philipp A Lang, Karl S Lang, Michel Morre, Brigitte Assouline, Katharina Lahl, Tim Sparwasser, Thomas F Tedder, Ji-hye Paik, Ronald A DePinho, Sameh Basta, Pamela S Ohashi, Tak W Mak

Journal article  |  2011  |  Cell

Fighting cancers from within: augmenting tumor immunity with cytokine therapy

Marc Pellegrini, Tak W Mak, Pamela S Ohashi

Journal article  |  2010  |  Trends in Pharmacological Sciences

Tumor immune therapy: Lessons from infection and implications for cancer - Can IL-7 help overcome immune inhibitory networks?

Marc Pellegrini, Tak W Mak

Journal article  |  2010  |  European Journal of Immunology

c-Rel but not NF-kappa B1 is important for T regulatory cell development

Elissa K Deenick, Alisha R Elford, Marc Pellegrini, Haken Hall, Tak W Mak, Pamela S Ohashi

Journal article  |  2010  |  European Journal of Immunology

Erratum: Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies (Nature Medicine (2009) 15 (528-536))

M Pellegrini, T Calzascia, AR Elford, A Shahinian, AE Lin, D Dissanayake, S Dhanji, LT Nguyen, MA Gronski, M Morre, B Assouline, K Lahl, T Sparwasser, PS Ohashi, TW Mak

Journal article  |  2009  |  Nature Medicine

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

Marc Pellegrini, Thomas Calzascia, Alisha R Elford, Arda Shahinian, Amy E Lin, Dilan Dissanayake, Salim Dhanji, Linh T Nguyen, Matthew A Gronski, Michel Morre, Brigitte Assouline, Katharina Lahl, Tim Sparwasser, Pamela S Ohashi, Tak W Mak

Journal article  |  2009  |  Nature Medicine

Hematopoietic cell-derived interferon controls viral replication and virus-induced disease

Philipp A Lang, Luisa Cervantes-Barragan, Admar Verschoor, Alexander A Navarini, Mike Recher, Marc Pellegrini, Lukas Flatz, Andreas Bergthaler, Kenya Honda, Burkhard Ludewig, Pamela S Ohashi, Karl S Lang

Journal article  |  2009  |  Blood

CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity.

Thomas Calzascia, Marc Pellegrini, Albert Lin, Kristine M Garza, Alisha R Elford, Arda Shahinian, Pamela S Ohashi, Tak W Mak

Journal article  |  2008  |  Proceedings of the National Academy of Sciences

There are many inhibitory mechanisms that function at the cellular and molecular levels to maintain tolerance. Despite this, self-..

TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice

Thomas Calzascia, Marc Pellegrini, Hakan Hall, Laurent Sabbagh, Nobuyuki Ono, Alisha R Elford, Tak W Mak, Pamela S Ohashi

Journal article  |  2007  |  Journal of Clinical Investigation

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

Han You, Marc Pellegrini, Katsuya Tsuchihara, Kazuo Yamamoto, Georg Hacker, Miriam Erlacher, Andreas Villunger, Tak W Mak

Journal article  |  2006  |  The Journal of Experimental Medicine

NF-κB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo

RG Jones, SD Saibil, JM Pun, AR Elford, M Bonnard, M Pellegrini, S Arya, ME Parsons, CM Krawczyk, S Gerondakis, WC Yeh, JM Woodgett, MR Boothby, PS Ohashi

Journal article  |  2005  |  Journal of Immunology

FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells

M Pellegrini, S Bath, VS Marsden, DCS Huang, D Metcalf, AW Harris, A Strasser

Journal article  |  2005  |  Blood

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

H Chau, V Wong, NJ Chen, HL Huang, WJ Lin, C Mirtsos, AR Elford, M Bonnard, A Wakeham, AI You-Ten, B Lemmers, L Salmena, M Pellegrini, R Hakem, TW Mak, P Ohashi, WC Yeh

Journal article  |  2005  |  The Journal of Experimental Medicine

Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice

M Pellegrini, P Bouillet, M Robati, GT Belz, GM Davey, A Strasser

Journal article  |  2004  |  Journal of Experimental Medicine

Interleukin (IL)-7 receptor (R) signaling is essential for T and B lymphopoiesis by promoting proliferation, differentiation, and ..

T-lymphocyte death during shutdown of an immune response

A Strasser, M Pellegrini

Journal article  |  2004  |  Trends Immunol.

Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation

CL Scott, M Schuler, VS Marsden, A Egle, M Pellegrini, D Nesic, S Gerondakis, SL Nutt, DR Green, A Strasser

Journal article  |  2004  |  J. Cell Biol.

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

M Pellegrini, G Belz, P Bouillet, A Strasser

Journal article  |  2003  |  Proceedings of the National Academy of Sciences of the United States of America

Erratum: BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes (Nature (2002) 415 (922-926))

P Bouillet, JF Purton, DI Godfrey, LC Zhang, L Coultas, H Puthalakath, M Pellegrini, S Cory, JM Adams, A Strasser

Journal article  |  2002  |  Nature

How, when, and why do lymphocytes die?

A Strasser, K Newton, LA O'Reilly, M Pellegrini, L O'Connor, H Puthalakath, L Cullen, L Tai, L Coultas, DCS Huang, A Villunger, P Bouillet, ML Bath, DL Vaux, S Cory, JM Adams, AW Harris

Journal article  |  2000  |  Immunologist

A portrait of the Bcl-2 protein family: Life, death, and the whole picture

M Pellegrini, A Strasser

Journal article  |  1999  |  Journal of Clinical Immunology