Freya Fowkes

Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial

Paul A Agius, Julia C Cutts, Win Han Oo, Aung Thi, Katherine O'Flaherty, Kyaw Zayar Aung, Htin Kyaw Thu, Poe Poe Aung, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, Zahra Razook, Alyssa E Barry, Win Htike, Angela Devine, Julie A Simpson, Brendan S Crabb, James G Beeson, Naanki Pasricha, et al.

Journal article  |  2020  |  PLOS MEDICINE

BACKGROUND: The World Health Organization has yet to endorse deployment of topical repellents for malaria prevention as part of pu..

Multi-functional antibodies are induced by the RTS,S malaria vaccine and associated with protection in a phase I/IIa trial.

Liriye Kurtovic, Tanmaya Atre, Gaoqian Feng, Bruce D Wines, Jo-Anne Chan, Michelle J Boyle, Damien R Drew, P Mark Hogarth, Freya JI Fowkes, Elke S Bergmann-Leitner, James G Beeson

Journal article  |  2020  |  J Infect Dis

BACKGROUND: RTS,S is the leading malaria vaccine candidate, but only confers partial efficacy against malaria in children. RTS,S i..

Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review

Julia C Cutts, Paul A Agius, Lin Zaw, Rosanna Powell, Kerryn Moore, Bridget Draper, Julie A Simpson, Freya JI Fowkes

Journal article  |  2020  |  BMC MEDICINE

BACKGROUND: In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumula..

Induction and Kinetics of Complement-Fixing Antibodies Against Plasmodium vivax Merozoite Surface Protein 3 alpha and Relationship With Immunoglobulin G Subclasses and Immunoglobulin M

Damian A Oyong, Danny W Wilson, Bridget E Barber, Timothy William, Jianlin Jiang, Mary R Galinski, Freya JI Fowkes, Matthew J Grigg, James G Beeson, Nicholas M Anstey, Michelle J Boyle

Journal article  |  2019  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: Complement-fixing antibodies are important mediators of protection against Plasmodium falciparum malaria. However, com..

Contribution of Functional Antimalarial Immunity to Measures of Parasite Clearance in Therapeutic Efficacy Studies of Artemisinin Derivatives

Katherine O'Flaherty, Ricardo Ataide, Sophie G Zaloumis, Elizabeth A Ashley, Rosanna Powell, Gaoqian Feng, Linda Reiling, Arjen M Dondorp, Nicholas P Day, Mehul Dhorda, Rick M Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tinh Hien Tran, Ye Htut, Mayfong Mayxay, M Abul Faiz, James G Beeson, Francois Nosten, et al.

Journal article  |  2019  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: Antibodies to the blood stages of malaria parasites enhance parasite clearance and antimalarial efficacy. The antibody..

IgM in human immunity to Plasmodium falciparum malaria

MJ Boyle, JA Chan, I Handayuni, L Reiling, G Feng, A Hilton, L Kurtovic, D Oyong, KA Piera, BE Barber, T William, DP Eisen, G Minigo, C Langer, DR Drew, F de Labastida Rivera, FH Amante, TN Williams, S Kinyanjui, K Marsh, et al.

Journal article  |  2019  |  SCIENCE ADVANCES

Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain und..

Understanding the interactions between iron supplementation, infectious disease and adverse birth outcomes is essential to guide public health recommendations

Freya JI Fowkes, Eliza Davidson, Paul A Agius, James G Beeson

Journal article  |  2019  |  BMC MEDICINE

Pregnant women are highly susceptible to anaemia and iron deficiency due to the increased demands of pregnancy as well as other fa..

UNINTENDED PREGNANCY AND FAMILY PLANNING USE AMONG ANTENATAL ATTENDEES IN EAST NEW BRITAIN, PAPUA NEW GUINEA

Elizabeth Peach, Chris Morgan, Michelle Scoullar, Freya Fowkes, Elissa Kennedy, Stanley Luchters, Andrew Vallely, Lisa Vallely, Angela Kelly, Leanne Robinson, Brendan Crabb, Peter Siba, William Pomat, JG Beeson

Conference Proceedings  |  2019  |  INTERNAL MEDICINE JOURNAL

Antibody Targets on the Surface of Plasmodium falciparum-Infected Erythrocytes That Are Associated With Immunity to Severe Malaria in Young Children

Jo-Anne Chan, Michelle J Boyle, Kerryn A Moore, Linda Reiling, Zaw Lin, Wina Hasang, Marion Avril, Laurens Manning, Ivo Mueller, Moses Laman, Timothy Davis, Joseph D Smith, Stephen J Rogerson, Julie A Simpson, Freya JI Fowkes, James G Beeson

Journal article  |  2019  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: Sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the microvasculature contributes to pathogenesis..

Induction and decay of functional complement-fixing antibodies by the RTS,S malariavaccine in children, and a negative impact of malaria exposure

Liriye Kurtovic, Paul A Agius, Gaoqian Feng, Damien R Drew, Itziar Ubillos, Jahit Sacarlal, John J Aponte, Freya JI Fowkes, Carlota Dobano, James G Beeson

Journal article  |  2019  |  BMC MEDICINE

BACKGROUND: Leading malaria vaccine, RTS,S, is based on the circumsporozoite protein (CSP) of sporozoites. RTS,S confers partial p..