Tu Nguyen

Rare Germline Variants in ATM Predispose to Prostate Cancer: A PRACTICAL Consortium Study

Questa Karlsson, Mark N Brook, Tokhir Dadaev, Sarah Wakerell, Edward J Saunders, Kenneth Muir, David E Neal, Graham G Giles, Robert J MacInnis, Stephen N Thibodeau, Shannon K McDonnell, Lisa Cannon-Albright, Manuel R Teixeira, Paula Paulo, Marta Cardoso, Chad Huff, Donghui Li, Yu Yao, Paul Scheet, Jennifer B Permuth, et al.

Journal article  |  2021  |  EUROPEAN UROLOGY ONCOLOGY

BACKGROUND: Germline ATM mutations are suggested to contribute to predisposition to prostate cancer (PrCa). Previous studies have ..

Breast and Prostate Cancer Risks for Male BRCA1 and BRCA2 Pathogenic Variant Carriers Using Polygenic Risk Scores.

Daniel R Barnes, Valentina Silvestri, Goska Leslie, Lesley McGuffog, Joe Dennis, Xin Yang, Julian Adlard, Bjarni A Agnarsson, Munaza Ahmed, Kristiina Aittomäki, Irene L Andrulis, Adalgeir Arason, Norbert Arnold, Bernd Auber, Jacopo Azzollini, Judith Balmaña, Rosa B Barkardottir, Daniel Barrowdale, Julian Barwell, Muriel Belotti, et al.

Journal article  |  2021  |  J Natl Cancer Inst

BACKGROUND: Recent population-based female breast cancer and prostate cancer polygenic risk scores (PRS) have been developed. We a..

Genomic Risk Prediction for Breast Cancer in Older Women

Paul Lacaze, Andrew Bakshi, Moeen Riaz, Suzanne G Orchard, Jane Tiller, Johannes T Neumann, Prudence R Carr, Amit D Joshi, Yin Cao, Erica T Warner, Alisa Manning, Tu Nguyen-Dumont, Melissa C Southey, Roger L Milne, Leslie Ford, Robert Sebra, Eric Schadt, Lucy Gately, Peter Gibbs, Bryony A Thompson, et al.

Journal article  |  2021  |  CANCERS

Genomic risk prediction models for breast cancer (BC) have been predominantly developed with data from women aged 40-69 years. Pro..

Prospective Evaluation of the Addition of Polygenic Risk Scores to Breast Cancer Risk Models

Sherly X Li, Roger L Milne, Tu Nguyen-Dumont, Xiaochuan Wang, Dallas R English, Graham G Giles, Melissa C Southey, Antonis C Antoniou, Andrew Lee, Shuai Li, Ingrid Winship, John L Hopper, Mary Beth Terry, Robert J MacInnis

Journal article  |  2021  |  JNCI CANCER SPECTRUM

Background: The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm and the International Breast Can..

Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer

Burcu F Darst, Tokhir Dadaev, Ed Saunders, Xin Sheng, Peggy Wan, Loreall Pooler, Lucy Y Xia, Stephen Chanock, Sonja Berndt, Susan M Gapstur, Victoria Stevens, Demetrius Albanes, Stephanie J Weinstein, Vincent Gnanapragasam, Graham G Giles, Tu Nguyen-Dumont, Roger L Milne, Mark Pomerantz, Julie A Schmidt, Lorelei Mucci, et al.

Journal article  |  2021  |  JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

BACKGROUND: There is an urgent need to identify factors specifically associated with aggressive prostate cancer (PCa) risk. We inv..

Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer

Tu Nguyen-Dumont, James G Dowty, Robert J MacInnis, Jason A Steen, Moeen Riaz, Pierre-Antoine Dugue, Anne-Laure Renault, Fleur Hammet, Maryam Mahmoodi, Derrick Theys, Helen Tsimiklis, Gianluca Severi, Damien Bolton, Paul Lacaze, Robert Sebra, Eric Schadt, John McNeil, Graham G Giles, Roger L Milne, Melissa C Southey

Journal article  |  2021  |  CANCERS

While gene panel sequencing is becoming widely used for cancer risk prediction, its clinical utility with respect to predicting ag..

Population-Based Estimates of the Age-Specific Cumulative Risk of Breast Cancer for Pathogenic Variants in CHEK2: Findings from the Australian Breast Cancer Family Registry

Tu Nguyen-Dumont, James G Dowty, Jason A Steen, Anne-Laure Renault, Fleur Hammet, Maryam Mahmoodi, Derrick Theys, Amanda Rewse, Helen Tsimiklis, Ingrid M Winship, Graham G Giles, Roger L Milne, John L Hopper, Melissa C Southey

Journal article  |  2021  |  CANCERS

Case-control studies of breast cancer have consistently shown that pathogenic variants in CHEK2 are associated with about a 3-fold..

Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer

Daniel J Schaid, Shannon K McDonnell, Liesel M FitzGerald, Lissa DeRycke, Zachary Fogarty, Graham G Giles, Robert J MacInnis, Melissa C Southey, Tu Nguyen-Dumont, Geraldine Cancel-Tassin, Oliver Cussenot, Alice S Whittemore, Weiva Sieh, Nilah Monnier Ioannidis, Chih-Lin Hsieh, Janet L Stanford, Johanna Schleutker, Cheryl D Cropp, John Carpten, Josef Hoegel, et al.

Journal article  |  2021  |  EUROPEAN UROLOGY

BACKGROUND: Family history of prostate cancer (PCa) is a well-known risk factor, and both common and rare genetic variants are ass..

Association of variably methylated tumour DNA regions with overall survival for invasive lobular breast cancer

Medha Suman, Pierre-Antoine Dugue, Ee Ming Wong, JiHoon Eric Joo, John L Hopper, Tu Nguyen-Dumont, Graham G Giles, Roger L Milne, Catriona McLean, Melissa C Southey

Journal article  |  2021  |  CLINICAL EPIGENETICS

BACKGROUND: Tumour DNA methylation profiling has shown potential to refine disease subtyping and improve the diagnosis and prognos..

Analytical validation of an error-corrected ultra-sensitive ctDNA next-generation sequencing assay

Heidi Fettke, Jason A Steen, Edmond M Kwan, Patricia Bukczynska, Shivakumar Keerthikumar, David Goode, Maria Docanto, Nicole Ng, Luciano Martelotto, Christine Hauser, Melissa C Southey, Arun A Azad, Tu Nguyen-Dumont

Journal article  |  2020  |  BIOTECHNIQUES

Plasma circulating tumor DNA (ctDNA) analysis has emerged as a minimally invasive means to perform molecular tumor typing. Here we..