Stephanie Chappaz

Correction: An essential role for α4A-tubulin in platelet biogenesis.

Catherine Strassel, Maria M Magiera, Arnaud Dupuis, Morgane Batzenschlager, Agnès Hovasse, Irina Pleines, Paul Guéguen, Anita Eckly, Sylvie Moog, Léa Mallo, Quentin Kimmerlin, Stéphane Chappaz, Jean-Marc Strub, Natarajan Kathiresan, Henri de la Salle, Alain Van Dorsselaer, Claude Ferec, Jean-Yves Py, Christian Gachet, Christine Schaeffer-Reiss, et al.

Journal article  |  2021  |  Life Sci Alliance

Homeostatic apoptosis prevents competition-induced atrophy in follicular B cells

Stephane Chappaz, Kate McArthur, Liam Kealy, Charity W Law, Maximilien Tailler, Rachael M Lane, Anna Lieschke, Matthew E Ritchie, Kim L Good-Jacobson, Andreas Strasser, Benjamin T Kile

Journal article  |  2021  |  CELL REPORTS

While the intrinsic apoptosis pathway is thought to play a central role in shaping the B cell lineage, its precise role in mature ..

Generation of Murine Bone Marrow and Fetal Liver Chimeras.

Stéphane Chappaz, Tahnee L Saunders, Benjamin T Kile

Journal article  |  2021  |  Curr Protoc

The generation of radiation chimeras allows researchers to substitute the hematopoietic system of a mouse with that of one or more..

Yeast- and antibody-based tools for studying tryptophan C-mannosylation

Alan John, Michael A Jarva, Sayali Shah, Runyu Mao, Stephane Chappaz, Richard W Birkinshaw, Peter E Czabotar, Alvin W Lo, Nichollas E Scott, Ethan D Goddard-Borger

Journal article  |  2021  |  NATURE CHEMICAL BIOLOGY

Tryptophan C-mannosylation is an unusual co-translational protein modification performed by metazoans and apicomplexan protists. T..

Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice

Stephane Chappaz, Charity W Law, Mark R Dowling, Kirstyn T Carey, Rachael M Lane, Linh H Ngo, Vihandha O Wickramasinghe, Gordon K Smyth, Matthew E Ritchie, Benjamin T Kile

Journal article  |  2020  |  BLOOD ADVANCES

In eukaryotic cells, messenger RNA (mRNA) molecules are exported from the nucleus to the cytoplasm, where they are translated. The..

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Genevieve Pepin, Dominic De Nardo, Christina L Rootes, Tomalika Ullah, Sumaiah S Al-Asmari, Katherine R Balka, Hong-Mei Li, Kylie M Quinn, Fiona Moghaddas, Stephane Chappaz, Benjamin T Kile, Eric F Morand, Seth L Masters, Cameron R Stewart, Bryan RG Williams, Michael Gantier

Journal article  |  2020  |  MBIO

Activation of cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in antiviral responses to many DNA viruses. Sensing of ..

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Mark F van Delft, Stephane Chappaz, Yelena Khakham, T Bui Chinh, Marlyse A Debrincat, Kym N Lowes, Jason M Brouwer, Christoph Grohmann, Phillip P Sharp, Laura F Dagley, Lucy Li, Kate McArthur, Meng-Xiao Luo, Hui San Chin, W Douglas Fairlie, Erinna F Lee, David Segal, Stephane Duflocq, Romina Lessene, Sabrina Bernard, et al.

Journal article  |  2019  |  NATURE CHEMICAL BIOLOGY

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contr..

An essential role for α4A-tubulin in platelet biogenesis.

Catherine Strassel, Maria M Magiera, Arnaud Dupuis, Morgane Batzenschlager, Agnès Hovasse, Irina Pleines, Paul Guéguen, Anita Eckly, Sylvie Moog, Léa Mallo, Quentin Kimmerlin, Stéphane Chappaz, Jean-Marc Strub, Natarajan Kathiresan, Henri de la Salle, Alain Van Dorsselaer, Claude Ferec, Jean-Yves Py, Christian Gachet, Christine Schaeffer-Reiss, et al.

Journal article  |  2019  |  Life Sci Alliance

During platelet biogenesis, microtubules (MTs) are arranged into submembranous structures (the marginal band) that encircle the ce..

VDAC2 enables BAX to mediate apoptosis and limit tumor development

Hui San Chin, Mark X Li, Iris KL Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX..

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Kate McArthur, Lachlan W Whitehead, John M Heddleston, Lucy Li, Benjamin S Padman, Viola Oorschot, Niall D Geoghegan, Stephane Chappaz, Sophia Davidson, Hui San Chin, Rachael M Lane, Marija Dramicanin, Tahnee L Saunders, Canny Sugiana, Romina Lessene, Laura D Osellame, Teng-Leong Chew, Grant Dewson, Michael Lazarou, Georg Ramm, et al.

Journal article  |  2018  |  SCIENCE

Mitochondrial apoptosis is mediated by BAK and BAX, two proteins that induce mitochondrial outer membrane permeabilization, leadin..