Leigh Coultas

Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria

Stefanie M Bader, Simon P Preston, Katie Saliba, Adam Lipszyc, Zoe L Grant, Liana Mackiewicz, Andrew Baldi, Anne Hempel, Michelle P Clark, Thanushi Peiris, William Clow, Jan Bjelic, Michael D Stutz, Philip Arandjelovic, Jack Teale, Fashuo Du, Leigh Coultas, James M Murphy, Cody C Allison, Marc Pellegrini, et al.

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Caspase-8 transduces signals from death receptor ligands, such as tumor necrosis factor, to drive potent responses including infla..

The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal

Yuqing Yang, Andrew J Kueh, Zoe L Grant, Waruni Abeysekera, Alexandra L Garnham, Stephen Wilcox, Craig D Hyland, Ladina Di Rago, Don Metcalf, Warren S Alexander, Leigh Coultas, Gordon K Smyth, Anne K Voss, Tim Thomas

Journal article  |  2022  |  BLOOD

The histone acetyltransferase HBO1 (MYST2, KAT7) is indispensable for postgastrulation development, histone H3 lysine 14 acetylati..

The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis (vol 148, dev199581, 2021)

Zoe L Grant, Peter F Hickey, Waruni Abeysekera, Lachlan Whitehead, Sabrina M Lewis, Robert CA Symons, Tracey M Baldwin, Daniela Amann-Zalcenstein, Alexandra L Garnham, Shalin H Naik, Gordon K Smyth, Tim Thomas, Anne K Voss, Leigh Coultas

Journal article  |  2021  |  DEVELOPMENT

Shalin H. Naik was inadvertently omitted from the author list. The complete list of authors, their affiliations, contributions and..

The people behind the papers - Zoe Grant, Tim Thomas, Anne Voss and Leigh Coultas

Zoe Grant, Tim Thomas, Anne Voss, Leigh Coultas

Journal article  |  2021  |  DEVELOPMENT

Abstract The histone acetyltransferase HBO1 (KAT1) is required for histone H3 lysine 14 acetylation, which is cruci..

The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis

Zoe L Grant, Peter F Hickey, Waruni Abeysekera, Lachlan Whitehead, Sabrina M Lewis, Robert CA Symons, Tracey M Baldwin, Daniela Amann-Zalcenstein, Alexandra L Garnham, Gordon K Smyth, Tim Thomas, Anne K Voss, Leigh Coultas

Journal article  |  2021  |  DEVELOPMENT

Blood vessel growth and remodelling are essential during embryonic development and disease pathogenesis. The diversity of endothel..

Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy

Michael Y He, Michael M Halford, Ruofei Liu, James P Roy, Zoe L Grant, Leigh Coultas, Niko Thio, Omer Gilan, Yih-Chih Chan, Mark A Dawson, Marc G Achen, Steven A Stacker

Journal article  |  2021  |  COMMUNICATIONS BIOLOGY

Angiogenesis underlies development, physiology and pathogenesis of cancer, eye and cardiovascular diseases. Inhibiting aberrant an..

Blocking endothelial apoptosis revascularizes the retina in a model of ischemic retinopathy

Zoe L Grant, Lachlan Whitehead, Vickie HY Wong, Zheng He, Richard Y Yan, Abigail R Miles, Andrew Benest, David O Bates, Claudia Prahst, Katie Bentley, Bang Bui, Robert CA Symons, Leigh Coultas

Journal article  |  2020  |  JOURNAL OF CLINICAL INVESTIGATION

Aberrant, neovascular retinal blood vessel growth is a vision-threatening complication in ischemic retinal diseases. It is driven ..

Caspase-8 modulates physiological and pathological angiogenesis during retina development

Nathalie Tisch, Aida Freire-Valls, Rosario Yerbes, Isidora Paredes, Silvia La Porta, Xiaohong Wang, Rosa Martin-Perez, Laura Castro, Wendy Wei-Lynn Wong, Leigh Coultas, Boris Strilic, Hermann-Josef Grone, Thomas Hielscher, Carolin Mogler, Ralf H Adams, Peter Heiduschka, Lena Claesson-Welsh, Massimiliano Mazzone, Abelardo Lopez-Rivas, Thomas Schmidt, et al.

Journal article  |  2019  |  JOURNAL OF CLINICAL INVESTIGATION

During developmental angiogenesis, blood vessels grow and remodel to ultimately build a hierarchical vascular network. Whether, ho..

Growth factor signaling pathways in vascular development and disease

Zoe L Grant, Leigh Coultas

Journal article  |  2019  |  GROWTH FACTORS

Angiogenic blood vessel growth is essential to ensure organs receive adequate blood supply to support normal organ function and ho..

Endothelial cell apoptosis in angiogenesis and vessel regression

Emma C Watson, Zoe L Grant, Leigh Coultas

Journal article  |  2017  |  CELLULAR AND MOLECULAR LIFE SCIENCES

Blood vessel regression is an essential process for ensuring blood vessel networks function at optimal efficiency and for matching..