Mark Dowling

Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice

Stephane Chappaz, Charity W Law, Mark R Dowling, Kirstyn T Carey, Rachael M Lane, Linh H Ngo, Vihandha O Wickramasinghe, Gordon K Smyth, Matthew E Ritchie, Benjamin T Kile

Journal article  |  2020  |  BLOOD ADVANCES

In eukaryotic cells, messenger RNA (mRNA) molecules are exported from the nucleus to the cytoplasm, where they are translated. The..

CLINICAL OUTCOMES FROM VENETOCLAX BASED THERAPY IN PATIENTS WITH RELAPSED/REFRACTORY B-CELL LYMPHOMAS

KL Lewis, M Dowling, K Bavishi, AK Øvlisen, N Hamad, P Choi, A Grigg, S P'Ng, R Filshie, DS Ritchie, I Bilmon, HM Prince, M Wolf, M Hertzberg, H Chuah, TC El-Galaly, CS Tam, JF Seymour, CY Cheah

Conference Proceedings  |  2019  |  Hematological Oncology

Neurological Complications after Allogeneic Transplantation - Can We Do Better?

Mark R Dowling, Karen K Ballen

Journal article  |  2019  |  Acta Haematol

Regulatory T Cells Suppress Effector T Cell Proliferation by Limiting Division Destiny

Mark R Dowling, Andrey Kan, Susanne Heinzel, Julia M Marchingo, Philip D Hodgkin, Edwin D Hawkins

Journal article  |  2018  |  FRONTIERS IN IMMUNOLOGY

Understanding how the strength of an effector T cell response is regulated is a fundamental problem in immunology with implication..

Neurologic complications after allogeneic hematopoietic stem cell transplantation: risk factors and impact

MR Dowling, S Li, BR Dey, SL McAfee, HR Hock, TR Spitzer, Y-B Chen, KK Ballen

Journal article  |  2018  |  BONE MARROW TRANSPLANTATION

Neurologic complications (NCs) may be a significant source of morbidity and mortality after hematopoietic cell transplantation (HC..

Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling

M Lebois, MR Dowling, P Gangatirkar, PD Hodgkin, BT Kile, WS Alexander, EC Josefsson

Journal article  |  2016  |  JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Stochastic Measurement Models for Quantifying Lymphocyte Responses Using Flow Cytometry

Andrey Kan, Damian Pavlyshyn, John F Markham, Mark R Dowling, Susanne Heinzel, Jie HS Zhou, Julia M Marchingo, Philip D Hodgkin

Journal article  |  2016  |  PLOS ONE

Adaptive immune responses are complex dynamic processes whereby B and T cells undergo division and differentiation triggered by pa..

Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion

Julia M Marchingo, Andrey Kan, Robyn M Sutherland, Ken R Duffy, Cameron J Wellard, Gabrielle T Belz, Andrew M Lew, Mark R Dowling, Susanne Heinzel, Philip D Hodgkin

Journal article  |  2014  |  SCIENCE

T cell responses are initiated by antigen and promoted by a range of costimulatory signals. Understanding how T cells integrate al..

Why the immune system takes its chances with randomness

Philip D Hodgkin, Mark R Dowling, Ken R Duffy

Journal article  |  2014  |  NATURE REVIEWS IMMUNOLOGY

As a research community, we have not yet acquired all of the data required to answer how both deterministic and stochastic process..

Stretched cell cycle model for proliferating lymphocytes

Mark R Dowling, Andrey Kan, Susanne Heinzel, Jie HS Zhou, Julia M Marchingo, Cameron J Wellard, John F Markham, Philip D Hodgkin

Journal article  |  2014  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stochastic variation in cell cycle time is a consistent feature of otherwise similar cells within a growing population. Classic st..