Gregor Ebert

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Jonathan P Bernardini, Bernadine GC Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Zhong Yan Gan, James P Cooney, Marcel Doerflinger, Amanda E Au, Timothy R Blackmore, Gerbrand J van der Heden van Noort, Paul P Geurink, Huib Ovaa, Janet Newman, Alan Riboldi-Tunnicliffe, et al.

Journal article  |  2020  |  The EMBO Journal

Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo.

Emma Morrish, Liana Mackiewicz, Natasha Silke, Marc Pellegrini, John Silke, Gabriela Brumatti, Gregor Ebert

Journal article  |  2020  |  Viruses

Chronic hepatitis B virus (HBV) infection remains a global health threat and affects hundreds of millions worldwide. Small molecul..

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection.

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  Immunity

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling

Manh Tran Bang, Dustin James Flanagan, Gregor Ebert, Nadia Warner, Tran Hoanh, Theodora Fifis, Georgios Kastrappis, Christopher Christophi, Marc Pellegrini, Joseph Torresi, Toby James Phesse, Elizabeth Vincan

Journal article  |  2020  |  Cancers

An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms. Infection wi..

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection

Gregor Ebert, Sash Lopaticki, Matthew T O'Neill, Ryan WJ Steel, Marcel Doerflinger, Pravin Rajasekaran, Annie SP Yang, Sara Erickson, Lisa Ioannidis, Philip Arandjelovic, Liana Mackiewicz, Cody Allison, John Silke, Marc Pellegrini, Justin A Boddey

Journal article  |  2020  |  Cell Reports

Plasmodium sporozoites infect the liver and develop into exoerythrocytic merozoites that initiate blood-stage disease. The hepatoc..

Virology Downunder, a meeting commentary from the 2019 Lorne Infection and Immunity Conference, Australia

Gregor Ebert, Prasad N Paradkar, Sarah L Londrigan

Journal article  |  2019  |  Virology Journal

Virology at the Lorne Infection and Immunity Conference 2019

Sarah L Londrigan, Gregor Ebert, Prasad N Paradkar

Journal article  |  2019  |  Virologica Sinica

The utility of monomeric HBV genomes for interrogating the HBV cccDNA minichromosome, using in vitro and in vivo models of HBV replication

Thao Huynh, Michelle Clark, Liana Mackiewicz, Vitini Sozzi, Hugh Mason, Marc Pellegrini, Greg Ebert, Hans J Netter, Peter Revill

Conference Proceedings  |  2019  |  JOURNAL OF HEPATOLOGY

The e Antigen Is an Interferon Resistance Protein That Allows the Hepatitis B Virus to Evade the Early Immune Response.

Zina Valaydon, Gregor Ebert, Liana Mackiewicz, Simon Preston, Paul V Desmond, Vitina Sozzi, Peter Revill, Alexander JV Thompson, Marc Pellegrini

Conference Proceedings  |  2018  |  HEPATOLOGY

Is Receptor-Interacting Protein Kinase 3 a Viable Therapeutic Target for Mycobacterium tuberculosis Infection?

Michael D Stutz, Samar Ojaimi, Gregor Ebert, Marc Pellegrini

Journal article  |  2018  |  Frontiers in Immunology

A fully humanized IgG-like bispecific antibody for effective dual targeting of CXCR3 and CCR6

Remy Robert, Laurent Juglair, Ee X Lim, Caroline Ang, Carl JH Wang, Gregor Ebert, Olan Dolezal, Charles R Mackay

Journal article  |  2017  |  PLOS ONE

CRISPR/Cas9-The ultimate weapon to battle infectious diseases?

M Doerflinger, W Forsyth, G Ebert, M Pellegrini, MJ Herold

Journal article  |  2017  |  Cellular Microbiology

Vaccines licensed and in clinical trials for the prevention of dengue

J Torresi, G Ebert, M Pellegrini

Journal article  |  2017  |  Human Vaccines & Immunotherapeutics

The role of tumour necrosis factor in hepatitis B infection: Jekyll and Hyde

Zina Valaydon, Marc Pellegrini, Alexander Thompson, Paul Desmond, Peter Revill, Gregor Ebert

Journal article  |  2016  |  Clinical & Translational Immunology

Hydrodynamic Injection as a Method of Gene Delivery in Mice: A Model of Chronic Hepatitis B Virus Infection.

Simon P Preston, Marc Pellegrini, Gregor Ebert

Book Chapter  |  2016  |  Methods in Molecular Biology

Gene delivery methods are important for both therapeutic intervention and as tools in research to address specific questions. Hydr..

Hepatitis B virus and inhibitor of apoptosis proteins - a vulnerable liaison

G Ebert, M Pellegrini

Journal article  |  2016  |  CELL DEATH DISCOVERY

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

Gregor Ebert, Cody Allison, Simon Preston, James Cooney, Jesse G Toe, Michael D Stutz, Samar Ojaimi, Nikola Baschuk, Ueli Nachbur, Joseph Torresi, John Silke, C Glenn Begley, Marc Pellegrini

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus

Gregor Ebert, Simon Preston, Cody Allison, James Cooney, Jesse G Toe, Michael D Stutz, Samar Ojaimi, Hamish W Scott, Nikola Baschuk, Ueli Nachbur, Joseph Torresi, Ruth Chin, Danielle Colledge, Xin Lie, Nadia Warner, Peter Revill, Scott Bowden, John Silke, C Glenn Begley, Marc Pellegrini

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

Cancer drugs for hepatitis B treatment: what do we know?

Gregor Ebert, Marc Pellegrini

Journal article  |  2015  |  Future Virology

ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system

Amy E Lin, Gregor Ebert, Yongkai Ow, Simon P Preston, Jesse G Toe, James P Cooney, Hamish W Scott, Masato Sasaki, Samuel D Saibil, Dilan Dissanayake, Raymond H Kim, Andrew Wakeham, Annick You-Ten, Arda Shahinian, Gordon Duncan, Jennifer Silvester, Pamela S Ohashi, Tak W Mak, Marc Pellegrini

Journal article  |  2013  |  Nature Immunology

5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice.

Gregor Ebert, Hendrik Poeck, Julie Lucifora, Nikola Baschuk, Knud Esser, Irene Esposito, Gunther Hartmann, Ulrike Protzer

Journal article  |  2011  |  Gastroenterology

BACKGROUND & AIMS: Approved therapies for chronic hepatitis B include systemic administration of interferon (IFN)-alfa and inhibit..

T cells redirected against hepatitis B virus surface proteins eliminate infected hepatocytes.

Felix Bohne, Markus Chmielewski, Gregor Ebert, Katja Wiegmann, Timo Kürschner, Andreas Schulze, Stephan Urban, Martin Krönke, Hinrich Abken, Ulrike Protzer

Journal article  |  2008  |  Gastroenterology

BACKGROUND & AIMS: The final goal in hepatitis B therapy is eradication of the hepatitis B virus (HBV) replication template, the s..