Gregor Ebert

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.

Christoph Grohmann, Francesca Walker, Mark Devlin, Meng-Xiao Luo, Anderly C Chüeh, Judy Doherty, François Vaillant, Gwo-Yaw Ho, Matthew J Wakefield, Clare E Weeden, Alvin Kamili, Jayne Murray, Sela T Po'uha, Janet Weinstock, Serena R Kane, Maree C Faux, Esmee Broekhuizen, Ye Zheng, Kristy Shield-Artin, Nadia J Kershaw, et al.

Journal article  |  2021  |  Cell Death & Disease

Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limita..

Clinical MDR1 inhibitors enhance Smac-mimetic bioavailability to kill murine LSCs and improve survival in AML models

Emma Morrish, Anthony Copeland, Donia M Moujalled, Jason A Powell, Natasha Silke, Ann Lin, Kate E Jarman, Jarrod J Sandow, Gregor Ebert, Liana Mackiewicz, Jessica A Beach, Elizabeth L Christie, Alexander C Lewis, Giovanna Pomilio, Karla C Fischer, Laura MacPherson, David DL Bowtell, Andrew Webb, Marc Pellegrini, Mark A Dawson, et al.

Journal article  |  2020  |  Blood Advances

The specific targeting of inhibitor of apoptosis (IAP) proteins by Smac-mimetic (SM) drugs, such as birinapant, has been tested in..

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Andrew J Kueh, Lin Tai, Annabell Bachem, Elise Gressier, Niall D Geoghegan, Stephen Wilcox, Kelly L Rogers, Alexandra L Garnham, Michael A Dengler, Stefanie M Bader, Gregor Ebert, Jaclyn S Pearson, Dominic De Nardo, Nancy Wang, Chenying Yang, et al.

Journal article  |  2020  |  Immunity

Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necropt..

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Jonathan P Bernardini, Bernadine GC Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Zhong Yan Gan, James P Cooney, Marcel Doerflinger, Amanda E Au, Timothy R Blackmore, Gerbrand J van der Heden van Noort, Paul P Geurink, Huib Ovaa, Janet Newman, Alan Riboldi-Tunnicliffe, et al.

Journal article  |  2020  |  The EMBO Journal

Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo

Emma Morrish, Liana Mackiewicz, Natasha Silke, Marc Pellegrini, John Silke, Gabriela Brumatti, Gregor Ebert

Journal article  |  2020  |  Viruses

Chronic hepatitis B virus (HBV) infection remains a global health threat and affects hundreds of millions worldwide. Small molecul..

The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling

Manh Tran Bang, Dustin James Flanagan, Gregor Ebert, Nadia Warner, Tran Hoanh, Theodora Fifis, Georgios Kastrappis, Christopher Christophi, Marc Pellegrini, Joseph Torresi, Toby James Phesse, Elizabeth Vincan

Journal article  |  2020  |  Cancers

An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms. Infection wi..

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection

Gregor Ebert, Sash Lopaticki, Matthew T O'Neill, Ryan WJ Steel, Marcel Doerflinger, Pravin Rajasekaran, Annie SP Yang, Sara Erickson, Lisa Ioannidis, Philip Arandjelovic, Liana Mackiewicz, Cody Allison, John Silke, Marc Pellegrini, Justin A Boddey

Journal article  |  2020  |  Cell Reports

Plasmodium sporozoites infect the liver and develop into exoerythrocytic merozoites that initiate blood-stage disease. The hepatoc..

Virology Downunder, a meeting commentary from the 2019 Lorne Infection and Immunity Conference, Australia

Gregor Ebert, Prasad N Paradkar, Sarah L Londrigan

Journal article  |  2019  |  Virology Journal

Virology at the Lorne Infection and Immunity Conference 2019

Sarah L Londrigan, Gregor Ebert, Prasad N Paradkar

Journal article  |  2019  |  Virologica Sinica

The utility of monomeric HBV genomes for interrogating the HBV cccDNA minichromosome, using in vitro and in vivo models of HBV replication

Thao Huynh, Michelle Clark, Liana Mackiewicz, Vitini Sozzi, Hugh Mason, Marc Pellegrini, Greg Ebert, Hans J Netter, Peter Revill

Conference Proceedings  |  2019  |  JOURNAL OF HEPATOLOGY