Delphine Merino

Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2( ve) breast cancer metastasis

Aadya Nagpal, Richard P Redvers, Xiawei Ling, Scott Ayton, Miriam Fuentes, Elnaz Tavancheh, Irmina Diala, Alshad Lalani, Sherene Loi, Steven David, Robin L Anderson, Yvonne Smith, Delphine Merino, Delphine Denoyer, Normand Pouliot

Journal article  |  2019  |  Breast Cancer Research

Breast tumour organoids: promising models for the genomic and functional characterisation of breast cancer

Charlotte Roelofs, Frederic Hollande, Richard Redvers, Robin L Anderson, Delphine Merino

Journal article  |  2019  |  Biochemical Society Transactions

Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer

D Merino, TS Weber, A Serrano, F Vaillant, K Liu, B Pal, L Di Stefano, J Schreuder, D Lin, Y Chen, ML Asselin-Labat, TN Schumacher, D Cameron, GK Smyth, AT Papenfuss, GJ Lindeman, JE Visvader, SH Naik

Journal article  |  2019  |  Nature Communications

Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition

Clare E Weeden, Casey Ah-Cann, Aliaksei Z Holik, Julie Pasquet, Jean-Marc Garnier, Delphine Merino, Guillaume Lessene, Marie-Liesse Asselin-Labat

Journal article  |  2018  |  Oncogene

Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

Delphine Merino, James R Whittle, Francois Vaillant, Antonin Serrano, Jia-Nan Gong, Goknur Giner, Ana Leticia Maragno, Maia Chanrion, Emilie Schneider, Bhupinder Pal, Xiang Li, Grant Dewson, Julius Grasel, Kevin Liu, Najoua Lalaoui, David Segal, Marco J Herold, David CS Huang, Gordon K Smyth, Olivier Geneste, et al.

Journal article  |  2017  |  Science Translational Medicine

Elementary: breast cancer culprits leave their signatures on the double helix

Delphine Merino, Bhupinder Pal, Anthony T Papenfuss

Journal article  |  2016  |  Cell Death & Differentiation

Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer

D Merino, SW Lok, JE Visvader, GJ Lindeman

Journal article  |  2016  |  Oncogene

Impact of conditional deletion of the pro-apoptotic BCL-2 family member BIM in mice

MJ Herold, R Stuchbery, D Merino, T Willson, A Strasser, D Hildeman, P Bouillet

Journal article  |  2014  |  Cell Death & Disease

Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199

SL Khaw, D Merino, MA Anderson, SP Glaser, P Bouillet, AW Roberts, DCS Huang

Journal article  |  2014  |  Leukemia

Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer

Francois Vaillant, Delphine Merino, Lily Lee, Kelsey Breslin, Bhupinder Pal, Matthew E Ritchie, Gordon K Smyth, Michael Christie, Louisa J Phillipson, Christopher J Burns, G Bruce Mann, Jane E Visvader, Geoffrey J Lindeman

Journal article  |  2013  |  Cancer Cell

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression

D Merino, A Strasser, P Bouillet

Journal article  |  2012  |  Oncogene

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

Delphine Merino, Seong L Khaw, Stefan P Glaser, Daniel J Anderson, Lisa D Belmont, Chihunt Wong, Peng Yue, Mikara Robati, Belinda Phipson, Walter D Fairlie, Erinna F Lee, Kirsteen J Campbell, Cassandra J Vandenberg, Suzanne Cory, Andrew W Roberts, Mary JC Ludlam, David CS Huang, Philippe Bouillet

Journal article  |  2012  |  Blood

Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo

C Clybouw, D Merino, T Nebl, F Masson, M Robati, L O'Reilly, A Huebner, RJ Davis, A Strasser, P Bouillet

Journal article  |  2012  |  Cell Death & Differentiation

Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells

Edwina Naik, Lorraine A O'Reilly, Marie-Liesse Asselin-Labat, Delphine Merino, Ann Lin, Michele Cook, Leigh Coultas, Philippe Bouillet, Jerry M Adams, Andreas Strasser

Journal article  |  2011  |  Journal of Experimental Medicine

TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT

Najoua Lalaoui, Aymeric Morle, Delphine Merino, Guillaume Jacquemin, Elisabetta Iessi, Alexandre Morizot, Sarah Shirley, Bruno Robert, Eric Solary, Carmen Garrido, Olivier Micheau

Journal article  |  2011  |  PLOS ONE

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

Delphine Merino, Maybelline Giam, Peter D Hughes, Owen M Siggs, Klaus Heger, Lorraine A O'Reilly, Jerry M Adams, Andreas Strasser, Erinna F Lee, Walter D Fairlie, Philippe Bouillet

Journal article  |  2009  |  Journal of Cell Biology

The Bcl-2 family in autoimmune and degenerative disorders

Delphine Merino, Philippe Bouillet

Journal article  |  2009  |  Apoptosis

MicroRNAs and lymphocyte homeostasis - Dangerous eggs in a single basket

Delphine Merino, Philippe Bouillet

Journal article  |  2008  |  IMMUNOLOGY AND CELL BIOLOGY