Adeline Robin

Structure of detergent-activated BAK dimers derived from the inert monomer

Richard W Birkinshaw, Sweta Iyer, Daisy Lio, Cindy S Luo, Jason M Brouwer, Michelle S Miller, Adeline Y Robin, Rachel T Uren, Grant Dewson, Ruth M Kluck, Peter M Colman, Peter E Czabotar

Journal article  |  2021  |  MOLECULAR CELL

A body of data supports the existence of core (α2-α5) dimers of BAK and BAX in the oligomeric, membrane-perturbing conformation of..

Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association

Tufa E Assafa, Sukhendu Nandi, Dariusz Smilowicz, Laura Galazzo, Markus Teucher, Christina Elsner, Stefanie Putz, Stephanie Bleicken, Adeline Y Robin, Dana Westphal, Isabel Uson, Raphael Stoll, Peter E Czabotar, Nils Metzler-Nolte, Enrica Bordignon

Journal article  |  2021  |  STRUCTURE

Bcl-2 proteins orchestrate the mitochondrial pathway of apoptosis, pivotal for cell death. Yet, the structural details of the conf..

Tyrosine metabolism: identification of a key residue in the acquisition of prephenate aminotransferase activity by 1β aspartate aminotransferase.

Cecile Giustini, Matthieu Graindorge, David Cobessi, Serge Crouzy, Adeline Robin, Gilles Curien, Michel Matringe

Journal article  |  2019  |  FEBS J

Alternative routes for the post-chorismate branch of the biosynthetic pathway leading to tyrosine exist, the 4-hydroxyphenylpyruva..

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association

Michael A Dengler, Adeline Y Robin, Leonie Gibson, Mark X Li, Jarrod J Sandow, Sweta Iyer, Andrew Webb, Dana Westphal, Grant Dewson, Jerry M Adams

Journal article  |  2019  |  CELL REPORTS

To elicit apoptosis, BAX metamorphoses from an inert cytosolic monomer into homo-oligomers that permeabilize the mitochondrial out..

Ensemble Properties of Bax Determine Its Function

Adeline Y Robin, Sweta Iyer, Richard W Birkinshaw, Jarrod Sandow, Ahmad Wardak, Cindy S Luo, Melissa Shi, Andrew Webb, Peter E Czabotar, Ruth M Kluck, Peter M Colman

Journal article  |  2018  |  STRUCTURE

BAX and BAK are essential mediators of intrinsic apoptosis that permeabilize the mitochondrial outer membrane. BAX activation requ..

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

Jason M Brouwer, Ping Lan, Angus D Cowan, Jonathan P Bernardini, Richard W Birkinshaw, Mark F van Delft, Brad E Sleebs, Adeline Y Robin, Ahmad Wardak, Iris K Tan, Boris Reljic, Erinna F Lee, W Douglas Fairlie, Melissa J Call, Brian J Smith, Grant Dewson, Guillaume Lessene, Peter M Colman, Peter E Czabotar

Journal article  |  2017  |  MOLECULAR CELL

Certain BH3-only proteins transiently bind and activate Bak and Bax, initiating their oligomerization and the permeabilization of ..

Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction

AY Robin, K Krishna Kumar, D Westphal, AZ Wardak, GV Thompson, G Dewson, PM Colman, PE Czabotar

Journal article  |  2015  |  CELL DEATH & DISEASE

The BH3-only protein Bim is a potent direct activator of the proapoptotic effector protein Bax, but the structural basis for its a..

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

Jason M Brouwer, Dana Westphal, Grant Dewson, Adeline Y Robin, Rachel T Uren, Ray Bartolo, Geoff V Thompson, Peter M Colman, Ruth M Kluck, Peter E Czabotar

Journal article  |  2014  |  MOLECULAR CELL

Apoptotic stimuli activate and oligomerize the proapoptotic proteins Bak and Bax, resulting in mitochondrial outer-membrane permea..

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

Peter E Czabotar, Dana Westphal, Grant Dewson, Stephen Ma, Colin Hockings, W Douglas Fairlie, Erinna F Lee, Shenggen Yao, Adeline Y Robin, Brian J Smith, David CS Huang, Ruth M Kluck, Jerry M Adams, Peter M Colman

Journal article  |  2013  |  CELL

In stressed cells, apoptosis ensues when Bcl-2 family members Bax or Bak oligomerize and permeabilize the mitochondrial outer memb..

Silver coordination polymers with isonicotinic acid derived short polyethylene glycol-Synthesis, structures, anion effect and solution behavior

KM Fromm, JL Sagué, AY Robin

Journal article  |  2013  |  Inorganica Chimica Acta

Silver coordination compounds and one-dimensional polymers have been studied, using a linear, flexible N-donor ligand. The solid s..