Yibin Xu

The signalling conformation of the insulin receptor ectodomain

Felix Weis, John G Menting, Mai B Margetts, Shu Jin Chan, Yibin Xu, Norbert Tennagels, Paulus Wohlfart, Thomas Langer, Christoph W Mueller, Matthias K Dreyer, Michael C Lawrence

Journal article  |  2018  |  Nature Communications

SIMBAD: a sequence-independent molecular-replacement pipeline.

Adam J Simpkin, Felix Simkovic, Jens MH Thomas, Martin Savko, Andrey Lebedev, Ville Uski, Charles Ballard, Marcin Wojdyr, Rui Wu, Ruslan Sanishvili, Yibin Xu, María Natalia Lisa, Alejandro Buschiazzo, William Shepard, Daniel J Rigden, Ronan M Keegan

Journal article  |  2018  |  Acta Crystallographica Section D Structural Biology

The conventional approach to finding structurally similar search models for use in molecular replacement (MR) is to use the sequen..

How ligand binds to the type 1 insulin-like growth factor receptor

Yibin Xu, Geoffrey K-W Kong, John G Menting, Mai B Margetts, Carlie A Delaine, Lauren M Jenkin, Vladislav V Kiselyov, Pierre De Meyts, Briony E Forbes, Michael C Lawrence

Journal article  |  2018  |  Nature Communications

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

Lin Chen, Yibin Xu, Wilson Wong, Jennifer K Thompson, Julie Healer, Ethan D Goddard-Borger, Michael C Lawrence, Alan F Cowman

Journal article  |  2017  |  eLife

Structural basis for plasmep sin V inhibition that blocks export of malaria proteins to human erythrocytes

Anthony N Hodder, Brad E Sleebs, Peter E Czabotar, Michelle Gazdik, Yibin Xu, Matthew T O'Neill, Sash Lopaticki, Thomas Nebl, Tony Triglia, Brian J Smith, Kym Lowes, Justin A Boddey, Alan F Cowman

Journal article  |  2015  |  Nature Structural & Molecular Biology

LRIG1 Extracellular Domain: Structure and Function Analysis

Yibin Xu, Priscilla Soo, Francesca Walker, Hui Hua Zhang, Nicholas Redpath, Chin Wee Tan, Nicos A Nicola, Timothy E Adams, Thomas P Garrett, Jian-Guo Zhang, Antony W Burgess

Journal article  |  2015  |  Journal of Molecular Biology

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

Lin Chen, Yibin Xu, Julie Healer, Jenny K Thompson, Brian J Smith, Michael C Lawrence, Alan F Cowman

Journal article  |  2014  |  eLife

Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor alpha 1

Nicholas T Redpath, Yibin Xu, Nicholas J Wilson, Louis J Fabri, Manuel Baca, Arna E Andrews, Hal Braley, Ping Lu, Cheryl Ireland, Robin E Ernst, Andrea Woods, Gail Forrest, Zhiqiang An, Dennis M Zaller, William R Strohl, Cindy S Luo, Peter E Czabotar, Thomas PJ Garrett, Douglas J Hilton, Andrew D Nash, et al.

Journal article  |  2013  |  Biochemical Journal

Crystal Structure of the Entire Ectodomain of gp130 INSIGHTS INTO THE MOLECULAR ASSEMBLY OF THE TALL CYTOKINE RECEPTOR COMPLEXES

Yibin Xu, Nadia J Kershaw, Cindy S Luo, Priscilla Soo, Michael J Pocock, Peter E Czabotar, Douglas J Hilton, Nicos A Nicola, Thomas PJ Garrett, Jian-Guo Zhang

Journal article  |  2010  |  Journal of Biological Chemistry

Structure of the adenylylation domain of E. coli glutamine synthetase adenylyl transferase: evidence for gene duplication and evolution of a new active site.

Yibin Xu, Paul D Carr, Subhash G Vasudevan, David L Ollis

Journal article  |  2010  |  Journal of Molecular Biology

The X-ray structure of the C-terminal fragment, containing residues 449-946, of Escherichia coli glutamine synthetase adenylyl tra..

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Thomas PJ Garrett, Antony W Burgess, Hui K Gan, Rod B Luwor, Glenn Cartwright, Francesca Walker, Suzanne G Orchard, Andrew HA Clayton, Edouard C Nice, Julie Rothacker, Bruno Catimel, Webster K Cavenee, Lloyd J Old, Elisabeth Stockert, Gerd Ritter, Timothy E Adams, Peter A Hoyne, K Dane Wittrup, Ginger Chao, Jennifer R Cochran, et al.

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

The domains carrying the opposing activities in adenylyltransferase are separated by a central regulatory domain.

Paula Clancy, Yibin Xu, Wally C van Heeswijk, Subhash G Vasudevan, David L Ollis

Journal article  |  2007  |  FEBS Journal

Adenylyltransferase is a bifunctional enzyme that controls the enzymatic activity of dodecameric glutamine synthetase in Escherich..

Expression, purification and crystallization of the C-terminal domain of Escherichia coli adenylyltransferase.

Yibin Xu, Daying Wen, Carmen Brown, Chun-Jung Chen, Paul D Carr, David L Ollis, Subhash G Vasudevan

Journal article  |  2005  |  Acta Crystallographica Section F Structural Biology and Crystallization Communications

The C-terminal domain of adenylyltransferase (ATase) from Escherichia coli has been overexpressed, purified and crystallized in a ..

Structure of the N-terminal domain of Escherichia coli glutamine synthetase adenylyltransferase.

Yibin Xu, Rongguand Zhang, Andrzej Joachimiak, Paul D Carr, Thomas Huber, Subhash G Vasudevan, David L Ollis

Journal article  |  2004  |  Structure

We report the crystal structure of the N-terminal domain of Escherichia coli adenylyltransferase that catalyzes the reversible nuc..

Expression, purification, crystallization, and preliminary X-ray analysis of the N-terminal domain of Escherichia coli adenylyl transferase.

Yibin Xu, Daying Wen, Paula Clancy, Paul D Carr, David L Ollis, Subhash G Vasudevan

Journal article  |  2004  |  Protein Expression and Purification

A soluble N-terminal domain of the Escherichia coli adenylyl transferase (ATase) is responsible for deadenylylation activity of th..

The structures of the PII proteins from the cyanobacteria Synechococcus sp. PCC 7942 and Synechocystis sp. PCC 6803.

Yibin Xu, Paul D Carr, Paula Clancy, Mario Garcia-Dominguez, Karl Forchhammer, Francisco Florencio, Subhash G Vasudevan, Nicole Tandeau de Marsac, David L Ollis

Journal article  |  2003  |  Acta Crystallographica Section D Biological Crystallography

The PII proteins from the cyanobacteria Synechococcus sp. PCC 7942 and Synechocystis sp. PCC 6803 have been crystallized and high-..

The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals.

Andrew J Brooks, Magnus Johansson, Anna V John, Yibin Xu, David A Jans, Subhash G Vasudevan

Journal article  |  2002  |  Journal of Biological Chemistry

Dengue virus NS5 protein is a multifunctional RNA-dependent RNA polymerase that is essential for virus replication. We have shown ..

The structure of the PII-ATP complex.

Y Xu, PD Carr, T Huber, SG Vasudevan, DL Ollis

Journal article  |  2001  |  European Journal of Biochemistry

PII is a signal transduction protein that is part of the cellular machinery used by many bacteria to regulate the activity of glut..

GlnK, a PII-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition.

Y Xu, E Cheah, PD Carr, WC van Heeswijk, HV Westerhoff, SG Vasudevan, DL Ollis

Journal article  |  1998  |  Journal of Molecular Biology

GlnK is a recently discovered homologue of the PII signal protein, an indicator of the nitrogen status of bacteria. PII occupies a..

The crystal structure of bikunin from the inter-alpha-inhibitor complex: a serine protease inhibitor with two Kunitz domains.

Y Xu, PD Carr, JM Guss, DL Ollis

Journal article  |  1998  |  Journal of Molecular Biology

Bikunin is a serine protease inhibitor found in the blood serum and urine of humans and other animals. Its sequence shows internal..