Yibin Xu

The signalling conformation of the insulin receptor ectodomain

Felix Weis, John G Menting, Mai B Margetts, Shu Jin Chan, Yibin Xu, Norbert Tennagels, Paulus Wohlfart, Thomas Langer, Christoph W Mueller, Matthias K Dreyer, Michael C Lawrence

Journal article  |  2018  |  NATURE COMMUNICATIONS

Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin..

SIMBAD: a sequence-independent molecular-replacement pipeline.

Adam J Simpkin, Felix Simkovic, Jens MH Thomas, Martin Savko, Andrey Lebedev, Ville Uski, Charles Ballard, Marcin Wojdyr, Rui Wu, Ruslan Sanishvili, Yibin Xu, María Natalia Lisa, Alejandro Buschiazzo, William Shepard, Daniel J Rigden, Ronan M Keegan

Journal article  |  2018  |  Acta Crystallogr D Struct Biol

The conventional approach to finding structurally similar search models for use in molecular replacement (MR) is to use the sequen..

How ligand binds to the type 1 insulin-like growth factor receptor

Yibin Xu, Geoffrey K-W Kong, John G Menting, Mai B Margetts, Carlie A Delaine, Lauren M Jenkin, Vladislav V Kiselyov, Pierre De Meyts, Briony E Forbes, Michael C Lawrence

Journal article  |  2018  |  NATURE COMMUNICATIONS

Human type 1 insulin-like growth factor receptor is a homodimeric receptor tyrosine kinase that signals into pathways directing no..

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

Lin Chen, Yibin Xu, Wilson Wong, Jennifer K Thompson, Julie Healer, Ethan D Goddard-Borger, Michael C Lawrence, Alan F Cowman

Journal article  |  2017  |  ELIFE

Plasmodium falciparum causes malaria in humans with over 450,000 deaths annually. The asexual blood stage involves invasion of ery..

Structural basis for plasmep sin V inhibition that blocks export of malaria proteins to human erythrocytes

Anthony N Hodder, Brad E Sleebs, Peter E Czabotar, Michelle Gazdik, Yibin Xu, Matthew T O'Neill, Sash Lopaticki, Thomas Nebl, Tony Triglia, Brian J Smith, Kym Lowes, Justin A Boddey, Alan F Cowman

Journal article  |  2015  |  NATURE STRUCTURAL & MOLECULAR BIOLOGY

Plasmepsin V, an essential aspartyl protease of malaria parasites, has a key role in the export of effector proteins to parasite-i..

LRIG1 Extracellular Domain: Structure and Function Analysis

Yibin Xu, Priscilla Soo, Francesca Walker, Hui Hua Zhang, Nicholas Redpath, Chin Wee Tan, Nicos A Nicola, Timothy E Adams, Thomas P Garrett, Jian-Guo Zhang, Antony W Burgess

Journal article  |  2015  |  JOURNAL OF MOLECULAR BIOLOGY

We have expressed and purified three soluble fragments of the human LRIG1-ECD (extracellular domain): the LRIG1-LRR (leucine-rich ..

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes

Lin Chen, Yibin Xu, Julie Healer, Jenny K Thompson, Brian J Smith, Michael C Lawrence, Alan F Cowman

Journal article  |  2014  |  ELIFE

Plasmodium falciparum causes the most severe form of malaria in humans and is responsible for over 700,000 deaths annually. It is ..

Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor alpha 1

Nicholas T Redpath, Yibin Xu, Nicholas J Wilson, Louis J Fabri, Manuel Baca, Arna E Andrews, Hal Braley, Ping Lu, Cheryl Ireland, Robin E Ernst, Andrea Woods, Gail Forrest, Zhiqiang An, Dennis M Zaller, William R Strohl, Cindy S Luo, Peter E Czabotar, Thomas PJ Garrett, Douglas J Hilton, Andrew D Nash, et al.

Journal article  |  2013  |  BIOCHEMICAL JOURNAL

Gene deletion studies in mice have revealed critical roles for IL (interleukin)-4 and -13 in asthma development, with the latter c..

Crystal Structure of the Entire Ectodomain of gp130 INSIGHTS INTO THE MOLECULAR ASSEMBLY OF THE TALL CYTOKINE RECEPTOR COMPLEXES

Yibin Xu, Nadia J Kershaw, Cindy S Luo, Priscilla Soo, Michael J Pocock, Peter E Czabotar, Douglas J Hilton, Nicos A Nicola, Thomas PJ Garrett, Jian-Guo Zhang

Journal article  |  2010  |  JOURNAL OF BIOLOGICAL CHEMISTRY

gp130 is the shared signal-transducing receptor subunit for the large and important family of interleukin 6-like cytokines. Previo..

Structure of the adenylylation domain of E. coli glutamine synthetase adenylyl transferase: evidence for gene duplication and evolution of a new active site.

Yibin Xu, Paul D Carr, Subhash G Vasudevan, David L Ollis

Journal article  |  2010  |  J Mol Biol

The X-ray structure of the C-terminal fragment, containing residues 449-946, of Escherichia coli glutamine synthetase adenylyl tra..