Gary Hime

Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

Bikshapathi Jagga, Megan Edwards, Miriam Pagin, Kylie M Wagstaff, David Aragao, Noelia Roman, Jeffrey D Nanson, Shane R Raidal, Nicole Dominado, Murray Stewart, David A Jans, Gary R Hime, Silvia K Nicolis, Christopher F Basler, Jade K Forwood

Journal article  |  2021  |  NATURE COMMUNICATIONS

SOX (SRY-related HMG-box) transcription factors perform critical functions in development and cell differentiation. These roles de..

Low levels of Grainy head isoforms regulate Drosophila midgut intestinal stem cell differentiation

Nicole Dominado, Franca Casagranda, Nicole Siddall, Helen Abud, Gary Hime

Journal article  |  2020

Regeneration of the Drosophila midgut epithelium depends upon differential expression of transcription factors in intestinal stem ..

Musashi regulates follicle stem cell maintenance and epithelial niche homeostasis in the Drosophila ovary

Nicole Siddall, Franca Casagranda, Nicole Dominado, James Heaney, Jessie Sutherland, Eileen McLaughlin, Gary Hime

Journal article  |  2020

The Musashi (Msi) family of RNA-binding proteins regulate maintenance and differentiation of stem cells in multiple tissues of dif..

'Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway'

Diana J Micati, Karthika Radhakrishnan, Julia C Young, Ewa Rajpert-De Meyts, Gary R Hime, Helen E Abud, Kate L Loveland

Journal article  |  2020  |  ANDROLOGY

BACKGROUND: Snail transcription factors mediate key cellular transitions in many developmental processes, including spermatogenesi..

RNA binding protein Musashi-2 regulates PIWIL1 and TBX1 in mouse spermatogenesis

Jessie M Sutherland, Alexander P Sobinoff, Barbara A Fraser, Kate A Redgrove, Nicole A Siddall, Peter Koopman, Gary R Hime, Eileen A McLaughlin

Journal article  |  2018  |  JOURNAL OF CELLULAR PHYSIOLOGY

RNA-binding proteins (RBP) are important facilitators of post-transcriptional gene regulation. We have previously established that..

Differential expression profiles of conserved Snail transcription factors in the mouse testis

DJ Micati, GR Hime, EA McLaughlin, HE Abud, KL Loveland

Journal article  |  2018  |  ANDROLOGY

Snail transcription factors are key regulators of cellular transitions during embryonic development and tumorigenesis. The closely..

Esrp1 is a marker of mouse fetal germ cells and differentially expressed during spermatogenesis

Shaghayegh Saeidi, Farnaz Shapouri, Robb U de Iongh, Franca Casagranda, Jessie M Sutherland, Patrick S Western, Eileen A McLaughlin, Mary Familari, Gary R Hime

Journal article  |  2018  |  PLOS ONE

ESRP1 regulates alternative splicing, producing multiple transcripts from its target genes in epithelial tissues. It is upregulate..

Tob1 and Tob2 mark distinct RNA processing granules in differentiating lens fibre cells

Robbert De Iongh, Rafaela Perez, Mary Familari, Gemma Martinez, Frank J Lovicu, Gary Hime

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

A Drosophila toolkit for defining gene function in spermatogenesis

NA Siddall, GR Hime

Journal article  |  2017  |  REPRODUCTION

Expression profiling and genomic sequencing methods enable the accumulation of vast quantities of data that relate to the expressi..

Rbf Regulates Drosophila Spermatogenesis via Control of Somatic Stem and Progenitor Cell Fate in the Larval Testis

Nicole Dominado, John E La Marca, Nicole A Siddall, James Heaney, Mai Tran, Yu Cai, Fengwei Yu, Hongyan Wang, W Gregory Somers, Leonie M Quinn, Gary R Hime

Journal article  |  2016  |  STEM CELL REPORTS

The Drosophila testis has been fundamental to understanding how stem cells interact with their endogenous microenvironment, or nic..