Balasubramanian Krishnamurthy

Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice

Satoru Akazawa, Leanne Mackin, Gaurang Jhala, Stacey Fynch, Tara Catterall, Claudia Selck, Kate L Graham, Balasubramanian Krishnamurthy, Evan G Pappas, Chun-Ting J Kwong, Andrew PR Sutherland, Thomas WH Kay, Thomas C Brodnicki, Helen E Thomas

Journal article  |  2021  |  Diabetologia

AIMS/HYPOTHESIS: Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in..

The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-gamma and Common gamma Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice

Tingting Ge, Gaurang Jhala, Stacey Fynch, Satoru Akazawa, Sara Litwak, Evan G Pappas, Tara Catterall, Ishan Vakil, Andrew J Long, Lisa M Olson, Balasubramanian Krishnamurthy, Thomas W Kay, Helen E Thomas

Journal article  |  2020  |  Frontiers in Immunology

Cytokines that signal through the JAK-STAT pathway, such as interferon-γ (IFN-γ) and common γ chain cytokines, contribute to the d..

OR32-06 Opportunistic Assessment of Pituitary Gland with Routine MRI and PET/CT Can Guide in Earlier and Increased Identification of Hypophysitis in Patients Treated with Combination Checkpoint Inhibitors

Anna Galligan, Amir Iravani, Arian Lasocki, Roslyn Wallace, Alison Weppler, George Au-Yeung, Nirupa Sachithanandan, Cherie Ying Chiang, John Wentworth, Peter Grahame Colman, Thomas William Kay, Balasubramanian Krishnamurthy, Shahneen Sandhu

Conference Proceedings  |  2020  |  Journal of the Endocrine Society

Abstract Background: Hypophysitis is one of the commonly reported adverse events related to immune checkpoint inhib..

SUN-127 Diagnostic Challenges Associated with the Rising Incidence of Endocrine Toxicity in the Era of Combination Immunotherapy

Anna Galligan, Amir Iravani, Arian Lasocki, Roslyn Wallace, Alison Weppler, George Au-Yeung, Nirupa Sachithanandan, Cherie Ying Chiang, John Wentworth, Peter Grahame Colman, Thomas William Kay, Balasubramanian Krishnamurthy, Shahneen Sandhu

Conference Proceedings  |  2020  |  Journal of the Endocrine Society

Abstract Background: Immune checkpoint blockade is now established as standard of care in several malignancies. Tri..

TITLE: CONTINUOUS GLUCOSE MONITORING VERSUS SELF-MONITORING OF BLOOD GLUCOSE TO ASSESS GLYCEMIA IN GESTATIONAL DIABETES.

Dessi Zaharieva, Jessie H Teng, May Lea Ong, Melissa H Lee, Barbora Paldus, Linda Jackson, Christine A Holihan, Alexis Shub, Sheetal Tipnis, Ohad Cohen, David Norman O'Neal, Balasubramanian Krishnamurthy

Journal article  |  2020  |  Diabetes Technology & Therapeutics

BACKGROUND: Gestational diabetes mellitus (GDM) management using self-monitoring blood glucose (SMBG) does not normalise pregnancy..

MISSED AND LATE MEAL BOLUSES WITH FASTER ACTING INSULIN ASPART (FIASP) VS INSULIN ASPART USING THE MEDTRONIC ADVANCED HYBRID CLOSED LOOP SYSTEM

M Lee, S Vogrin, B Paldus, J Lu, H Jones, S Wyatt, E Netzer, D Morrison, C Sims, A Jenkins, B Krishnamurthy, R Macisaac, B Grosman, A Roy, N Kurtz, D O'Neal

Conference Proceedings  |  2020  |  DIABETES TECHNOLOGY & THERAPEUTICS

ASSESSMENT OF GLYCAEMIA BY FINGERSTICK BLOOD GLUCOSE MONITORING MAY UNDERESTIMATE THE REQUIREMENT FOR INSULIN TO ADDRESS ELEVATED NOCTURNAL GLUCOSE LEVELS IN WOMEN WITH GDM

D Zaharieva, B Krishnamurthy, J Teng, M Ong, M Lee, B Paldus, C Houlihan, A Shub, O Cohen, D O'Neal

Conference Proceedings  |  2020  |  DIABETES TECHNOLOGY & THERAPEUTICS

Comment on Trinh et al. Successful Treatment of Immune Checkpoint Inhibitor-Induced Diabetes With Infliximab. Diabetes Care 2019;42:e153-e154

Anna Galligan, Balasubramanian Krishnamurthy, Thomas W Kay

Journal article  |  2020  |  Diabetes Care

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice

Prerak M Trivedi, Stacey Fynch, Lucy M Kennedy, Jonathan Chee, Balasubramanian Krishnamurthy, Lorraine A O'Reilly, Andreas Strasser, Thomas WH Kay, Helen E Thomas

Journal article  |  2019  |  Cell Death Discovery

CD8+ T cells play a central role in beta-cell destruction in type 1 diabetes. CD8+ T cells use two main effector pathways to kill ..

The Clinical Case for the Integration of a Ketone Sensor as Part of a Closed Loop Insulin Pump System.

Melissa H Lee, Barbora Paldus, Balasubramanium Krishnamurthy, Sybil A McAuley, Rajiv Shah, Alicia J Jenkins, David N O'Neal

Journal article  |  2019  |  Journal of Diabetes Science and Technology

Closed loop (CL) systems deliver insulin with a rapid onset and offset in action. Although favorable overall, the absence of a lon..