Balasubramanian Krishnamurthy

Diabetes IN hospital - Glucose and Outcomes in the COVID-19 pandemic (DINGO COVID-19): the 2020 Melbourne hospital experience prior to novel variants and vaccinations

Rahul D Barmanray, Joanna Y Gong, Mervyn Kyi, Dev Kevat, Mohammad A Islam, Anna Galligan, Georgina R Manos, Indu Nair, Nayomi Perera, Nicholas K Adams, Ashvin Nursing, Annabelle M Warren, Peter S Hamblin, Richard J MacIsaac, Elif Ekinci, Balasubramanian Krishnamurthy, Harin Karunajeewa, Kirsty Buising, Kumar Visvanathan, Thomas WH Kay, et al.

Journal article  |  2022  |  INTERNAL MEDICINE JOURNAL

BACKGROUND AND AIMS: A relationship between diabetes, glucose and COVID-19 outcomes has been reported in international cohorts. Th..

Investigating the efficacy of baricitinib in new onset type 1 diabetes mellitus (BANDIT)-study protocol for a phase 2, randomized, placebo controlled trial

M Waibel, HE Thomas, JM Wentworth, JJ Couper, RJ MacIsaac, FJ Cameron, M So, B Krishnamurthy, MC Doyle, TW Kay

Journal article  |  2022  |  TRIALS

BACKGROUND: Type 1 diabetes (T1D) places an extraordinary burden on individuals and their families, as well as on the healthcare s..

Interferons limit autoantigen-specific CD8 T-cell expansion in the non-obese diabetic mouse.

Gaurang Jhala, Balasubramanian Krishnamurthy, Thomas C Brodnicki, Tingting Ge, Satoru Akazawa, Claudia Selck, Prerak M Trivedi, Evan G Pappas, Leanne Mackin, Nicola Principe, Erwan Brémaud, David J De George, Louis Boon, Ian Smyth, Jonathan Chee, Thomas WH Kay, Helen E Thomas

Journal article  |  2022  |  Cell Rep

Interferon gamma (IFNγ) is a proinflammatory cytokine implicated in autoimmune diseases. However, deficiency or neutralization of ..

Case Report: Hypoglycemia Due to a Novel Activating Glucokinase Variant in an Adult - a Molecular Approach

Anojian Koneshamoorthy, Dilan Seniveratne-Epa, Genevieve Calder, Matthew Sawyer, Thomas WH Kay, Stephen Farrell, Thomas Loudovaris, Lina Mariana, Davis McCarthy, Ruqian Lyu, Xin Liu, Peter Thorn, Jason Tong, Lit Kim Chin, Margaret Zacharin, Alison Trainer, Shelby Taylor, Richard J MacIsaac, Nirupa Sachithanandan, Helen E Thomas, et al.

Journal article  |  2022  |  FRONTIERS IN ENDOCRINOLOGY

We present a case of an obese 22-year-old man with activating GCK variant who had neonatal hypoglycemia, re-emerging with hypoglyc..

Diabetes induced by checkpoint inhibition in nonobese diabetic mice can be prevented or reversed by a JAK1/JAK2 inhibitor.

Tingting Ge, Amber-Lee Phung, Gaurang Jhala, Prerak Trivedi, Nicola Principe, David J De George, Evan G Pappas, Sara Litwak, Laura Sanz-Villanueva, Tara Catterall, Stacey Fynch, Louis Boon, Thomas W Kay, Jonathan Chee, Balasubramanian Krishnamurthy, Helen E Thomas

Journal article  |  2022  |  Clin Transl Immunology

OBJECTIVES: Immune checkpoint inhibitors have achieved clinical success in cancer treatment, but this treatment causes immune-rela..

Severe acute respiratory syndrome coronavirus 2 as a potential cause of type 1 diabetes facilitated by spike protein receptor binding domain attachment to human islet cells: An illustrative case study and experimental data

Nisha Venkatesh, Natalie Astbury, Merlin C Thomas, Carlos J Rosado, Evan Pappas, Balasubramanian Krishnamurthy, Richard J MacIsaac, Thomas WH Kay, Helen E Thomas, David N O'Neal

Journal article  |  2021  |  DIABETIC MEDICINE

AIMS: Aim of this study is to report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, responsible for coron..

Reducing adverse events associated with the glucagon stimulation test for the assessment of growth hormone deficiency in adults with a high prevalence of pituitary hormone deficiencies

Reetu Gogna, Caroline Jung, Kylie McLachlan, Balasubramanian Krishnamurthy, Alice Hong, Maresa Derbyshire, Katerina Kiburg, Margaret Zacharin, Richard J MacIsaac, Nirupa Sachithanandan, Carmela Caputo

Journal article  |  2021  |  CLINICAL ENDOCRINOLOGY

DESIGN: A retrospective review of the adverse events (AEs) in 78 patients during the glucagon stimulation test (GST) for the asses..

Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice

Gaurang Jhala, Claudia Selck, Jonathan Chee, Chun-Ting J Kwong, Evan G Pappas, Helen E Thomas, Thomas WH Kay, Balasubramanian Krishnamurthy

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans and non-obese diabetic (NOD) ..

Harnessing CD8( ) T-cell exhaustion to treat type 1 diabetes

Chun-Ting J Kwong, Claudia Selck, Krisna Tahija, Lachlan J McAnaney, Dan Le, Thomas WH Kay, Helen E Thomas, Balasubramanian Krishnamurthy

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

Although immune interventions have shown great promise in type 1 diabetes mellitus (T1D) clinical trials, none are yet in routine ..

Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice

Satoru Akazawa, Leanne Mackin, Gaurang Jhala, Stacey Fynch, Tara Catterall, Claudia Selck, Kate L Graham, Balasubramanian Krishnamurthy, Evan G Pappas, Chun-Ting J Kwong, Andrew PR Sutherland, Thomas WH Kay, Thomas C Brodnicki, Helen E Thomas

Journal article  |  2021  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in..