Balasubramanian Krishnamurthy

Severe acute respiratory syndrome coronavirus 2 as a potential cause of type 1 diabetes facilitated by spike protein receptor binding domain attachment to human islet cells: An illustrative case study and experimental data

Nisha Venkatesh, Natalie Astbury, Merlin C Thomas, Carlos J Rosado, Evan Pappas, Balasubramanian Krishnamurthy, Richard J MacIsaac, Thomas WH Kay, Helen E Thomas, David N O'Neal

Journal article  |  2021  |  DIABETIC MEDICINE

AIMS: Aim of this study is to report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, responsible for coron..

Reducing adverse events associated with the glucagon stimulation test for the assessment of growth hormone deficiency in adults with a high prevalence of pituitary hormone deficiencies

Reetu Gogna, Caroline Jung, Kylie McLachlan, Balasubramanian Krishnamurthy, Alice Hong, Maresa Derbyshire, Katerina Kiburg, Margaret Zacharin, Richard J MacIsaac, Nirupa Sachithanandan, Carmela Caputo

Journal article  |  2021  |  CLINICAL ENDOCRINOLOGY

DESIGN: A retrospective review of the adverse events (AEs) in 78 patients during the glucagon stimulation test (GST) for the asses..

Tolerance to Proinsulin-1 Reduces Autoimmune Diabetes in NOD Mice

Gaurang Jhala, Claudia Selck, Jonathan Chee, Chun-Ting J Kwong, Evan G Pappas, Helen E Thomas, Thomas WH Kay, Balasubramanian Krishnamurthy

Journal article  |  2021  |  FRONTIERS IN IMMUNOLOGY

T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans and non-obese diabetic (NOD) ..

Harnessing CD8( ) T-cell exhaustion to treat type 1 diabetes

Chun-Ting J Kwong, Claudia Selck, Krisna Tahija, Lachlan J McAnaney, Dan Le, Thomas WH Kay, Helen E Thomas, Balasubramanian Krishnamurthy

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

Although immune interventions have shown great promise in type 1 diabetes mellitus (T1D) clinical trials, none are yet in routine ..

Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice

Satoru Akazawa, Leanne Mackin, Gaurang Jhala, Stacey Fynch, Tara Catterall, Claudia Selck, Kate L Graham, Balasubramanian Krishnamurthy, Evan G Pappas, Chun-Ting J Kwong, Andrew PR Sutherland, Thomas WH Kay, Thomas C Brodnicki, Helen E Thomas

Journal article  |  2021  |  DIABETOLOGIA

AIMS/HYPOTHESIS: Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in..

The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-gamma and Common gamma Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice

Tingting Ge, Gaurang Jhala, Stacey Fynch, Satoru Akazawa, Sara Litwak, Evan G Pappas, Tara Catterall, Ishan Vakil, Andrew J Long, Lisa M Olson, Balasubramanian Krishnamurthy, Thomas W Kay, Helen E Thomas

Journal article  |  2020  |  FRONTIERS IN IMMUNOLOGY

Cytokines that signal through the JAK-STAT pathway, such as interferon-γ (IFN-γ) and common γ chain cytokines, contribute to the d..

OR32-06 Opportunistic Assessment of Pituitary Gland with Routine MRI and PET/CT Can Guide in Earlier and Increased Identification of Hypophysitis in Patients Treated with Combination Checkpoint Inhibitors

Anna Galligan, Amir Iravani, Arian Lasocki, Roslyn Wallace, Alison Weppler, George Au-Yeung, Nirupa Sachithanandan, Cherie Ying Chiang, John Wentworth, Peter Grahame Colman, Thomas William Kay, Balasubramanian Krishnamurthy, Shahneen Sandhu

Conference Proceedings  |  2020  |  Journal of the Endocrine Society

Abstract Background: Hypophysitis is one of the commonly reported adverse events related to immune checkpoint inhib..

SUN-127 Diagnostic Challenges Associated with the Rising Incidence of Endocrine Toxicity in the Era of Combination Immunotherapy

Anna Galligan, Amir Iravani, Arian Lasocki, Roslyn Wallace, Alison Weppler, George Au-Yeung, Nirupa Sachithanandan, Cherie Ying Chiang, John Wentworth, Peter Grahame Colman, Thomas William Kay, Balasubramanian Krishnamurthy, Shahneen Sandhu

Conference Proceedings  |  2020  |  Journal of the Endocrine Society

Abstract Background: Immune checkpoint blockade is now established as standard of care in several malignancies. Tri..

TITLE: CONTINUOUS GLUCOSE MONITORING VERSUS SELF-MONITORING OF BLOOD GLUCOSE TO ASSESS GLYCEMIA IN GESTATIONAL DIABETES.

Dessi Zaharieva, Jessie H Teng, May Lea Ong, Melissa H Lee, Barbora Paldus, Linda Jackson, Christine A Holihan, Alexis Shub, Sheetal Tipnis, Ohad Cohen, David Norman O'Neal, Balasubramanian Krishnamurthy

Journal article  |  2020  |  Diabetes Technology and Therapeutics

BACKGROUND: Gestational diabetes mellitus (GDM) management using self-monitoring blood glucose (SMBG) does not normalise pregnancy..

MISSED AND LATE MEAL BOLUSES WITH FASTER ACTING INSULIN ASPART (FIASP) VS INSULIN ASPART USING THE MEDTRONIC ADVANCED HYBRID CLOSED LOOP SYSTEM

M Lee, S Vogrin, B Paldus, J Lu, H Jones, S Wyatt, E Netzer, D Morrison, C Sims, A Jenkins, B Krishnamurthy, R Macisaac, B Grosman, A Roy, N Kurtz, D O'Neal

Conference Proceedings  |  2020  |  DIABETES TECHNOLOGY & THERAPEUTICS