Morag Young

Regulation of mineralocorticoid receptor activation by circadian protein TIMELESS

Colin D Clyne, Kevin P Kusnadi, Alexander Cowcher, James Morgan, Jun Yang, Peter J Fuller, Morag J Young

Journal article  |  2023  |  JOURNAL OF MOLECULAR ENDOCRINOLOGY

The mineralocorticoid receptor (MR) is a ligand-activated transcription factor that regulates cardiorenal physiology and disease. ..

Mineralocorticoid receptor antagonists, heart failure and predictive biomarkers

Nikshay Karthigan, Siobhan Lockwood, Anthony White, Jun Yang, Morag J Young

Journal article  |  2022  |  JOURNAL OF ENDOCRINOLOGY

The mineralocorticoid receptor is a steroid hormone receptor that is well known for its involvement in fluid and electrolyte homeo..

Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants

Jason C Lao, Christine B Bui, Merrin A Pang, Steven X Cho, Ina Rudloff, Kirstin Elgass, Jan Schroder, Anton Maksimenko, Niamh E Mangan, Malcolm R Starkey, Elisabeth M Skuza, Yu BY Sun, Friederike Beker, Clare L Collins, Omar F Kamlin, Kai Konig, Atul Malhotra, Kenneth Tan, Christiane Theda, Morag J Young, et al.

Journal article  |  2022  |  SCIENCE TRANSLATIONAL MEDICINE

Postnatal maturation of the immune system is poorly understood, as is its impact on illnesses afflicting term or preterm infants, ..

Hypertension Management in Stroke Prevention Time to Consider Primary Aldosteronism

Josephine McCarthy, Jun Yang, Ben Clissold, Morag J Young, Peter J Fuller, Thanh Phan

Journal article  |  2021  |  STROKE

Primary aldosteronism confers a higher risk of stroke, atrial fibrillation, and cardiovascular disease than blood pressure matched..

Relationship Between the Aldosterone-to-Renin Ratio and Blood Pressure in Young Adults: A Longitudinal Study

Jun Yang, Stella May Gwini, Lawrence J Beilin, Markus Schlaich, Michael Stowasser, Morag J Young, Peter J Fuller, Trevor Mori

Journal article  |  2021  |  HYPERTENSION

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The Role of the Mineralocorticoid Receptor and Mineralocorticoid Receptor-Directed Therapies in Heart Failure

Morag J Young, Monica Kanki, Nikshay Karthigan, Penny Konstandopoulos

Journal article  |  2021  |  ENDOCRINOLOGY

Mineralocorticoid receptor (MR) antagonists (MRA), also referred to as aldosterone blockers, are now well-recognized for their cli..

Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism

Eric R Barros, Juan Pablo Rigalli, Alejandra Tapia-Castillo, Andrea Vecchiola, Morag J Young, Joost GJ Hoenderop, Rene JM Bindels, Carlos E Fardella, Cristian A Carvajal

Journal article  |  2021  |  ENDOCRINOLOGY

CONTEXT: Primary aldosteronism (PA) represents 6% to 10% of all essential hypertension patients and is diagnosed using the aldoste..

Mineralocorticoid receptor actions in cardiovascular development and disease

Morag J Young, Colin D Clyne

Journal article  |  2021  |  EXPLORING NUCLEAR RECEPTORS

Mineralocorticoid receptors (MRs) are transcriptional regulators that mediate the diverse physiological and pathophysiological act..

A Multicenter Study of Neutrophil-to-Lymphocyte Ratio in Primary Aldosteronism.

Renata Libianto, Jinbo Hu, Min R Chee, Jesse Hoo, Yin Y Lim, Jimmy Shen, Qifu Li, Morag J Young, Peter J Fuller, Jun Yang

Journal article  |  2020  |  J Endocr Soc

BACKGROUND: Hypertensive patients with primary aldosteronism (PA) have a higher risk of cardiovascular complications than those wi..

Galectin-7 Impairs Placentation and Causes Preeclampsia Features in Mice

Ellen Menkhorst, Wei Zhou, Leilani L Santos, Sarah Delforce, Teresa So, Kate Rainczuk, Hannah Loke, Argyro Syngelaki, Swati Varshney, Nicholas Williamson, Kirsty Pringle, Morag J Young, Kypros H Nicolaides, Yves St-Pierre, Eva Dimitriadis

Journal article  |  2020  |  Hypertension

Preeclampsia is a serious pregnancy-induced disorder unique to humans. The etiology of preeclampsia is poorly understood; however,..