Susan Haupt

TP53 Status, Patient Sex, and the Immune Response as Determinants of Lung Cancer Patient Survival.

Donald Freudenstein, Cassandra Litchfield, Franco Caramia, Gavin Wright, Benjamin J Solomon, David Ball, Simon P Keam, Paul Neeson, Ygal Haupt, Sue Haupt

Journal article  |  2020  |  Cancers

Lung cancer poses the greatest cancer-related death risk and males have poorer outcomes than females, for unknown reasons. Patient..

High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot.

Simon P Keam, Heloise Halse, Thu Nguyen, Minyu Wang, Nicolas Van Kooten Losio, Catherine Mitchell, Franco Caramia, David J Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott G Williams, Paul J Neeson

Journal article  |  2020  |  Journal for ImmunoTherapy of Cancer

BACKGROUND: Prostate cancer (PCa) has a profoundly immunosuppressive microenvironment and is commonly immune excluded with few inf..

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

Arjelle Decasa Agupitan, Paul Neeson, Scott Williams, Jason Howitt, Sue Haupt, Ygal Haupt

Journal article  |  2020  |  International Journal of Molecular Sciences

Awareness of the importance of immunity in controlling cancer development triggered research into the impact of its key oncogenic ..

Predicting radiation-induced immune trafficking and activation in localized prostate cancer

Scott Williams, Simon P Keam, Heloise Halse, Nguyen Thu, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Shahneen Kaur Sandhu, Piers Blombery, Ygal Haupt, Paul J Neeson

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

E6AP Promotes a Metastatic Phenotype in Prostate Cancer

Cristina Gamell, Ivona Bandilovska, Twishi Gulati, Arielle Kogan, Syer Choon Lim, Zaklina Kovacevic, Elena A Takano, Clelia Timpone, Arjelle D Agupitan, Cassandra Litchfield, Giovanni Blandino, Lisa G Horvath, Stephen B Fox, Scott G Williams, Andrea Russo, Enzo Gallo, Piotr J Paul, Catherine Mitchell, Shahneen Sandhu, Simon P Keam, et al.

Journal article  |  2019  |  iScience

Although primary prostate cancer is largely curable, progression to metastatic disease is associated with very poor prognosis. E6A..

Cannibalism in Breast Cancer: The Dangers of Overeating

Sue Haupt, Simon P Keam, Ygal Haupt

Journal article  |  2019  |  Trends in Cancer

Cancer cells devouring their neighbours to survive drug treatment is an abhorrent concept. Yet it holds hope for exploring new ant..

Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network

Sue Haupt, Franco Caramia, Alan Herschtal, Thierry Soussi, Guillermina Lozano, Hu Chen, Han Liang, Terence P Speed, Ygal Haupt

Journal article  |  2019  |  Nature Communications

The disproportionately high prevalence of male cancer is poorly understood. We tested for sex-disparity in the functional integrit..

Predicting radiation-induced immune trafficking and activation in localized prostate cancer

Simon Keam, Heloise Halse, Nguyen ThuNgoc, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott Williams, Paul Neeson

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Huiqin Chen, Alison Slater, Kerry Ardley, Laura Kirby, Keefe T Chan, Natalie Brajanovski, Lorey K Smith, Aparna D Rao, Emily J Lelliott, Margarete Kleinschmidt, Ismael A Vergara, Anthony T Papenfuss, Peter Lau, Prerana Ghosh, Sue Haupt, et al.

Journal article  |  2019  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E6AP goes viral: the role of E6AP in viral- and non-viral-related cancers

Ivona Bandilovska, Simon P Keam, Cristina Gamell, Claudia Machicado, Sue Haupt, Ygal Haupt

Journal article  |  2019  |  Carcinogenesis

Since its discovery, the E3 ubiquitin ligase E6-associated protein (E6AP) has been studied extensively in two pathological context..

A quantitative model to predict pathogenicity of missense variants in the TP53 gene

Cristina Fortuno, Arcadi Cipponi, Mandy L Ballinger, Sean Tavtigian, Magali Olivier, Vatsal Ruparel, Ygal Haupt, Sue Haupt, Kathy Tucker, Amanda B Spurdle, David M Thomas, Paul A James

Journal article  |  2019  |  Human Mutation

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

Alex RD Delbridge, Andrew J Kueh, Francine Ke, Natasha M Zamudio, Farrah El-Saafin, Natasha Jansz, Gao-Yuan Wang, Megan Iminitoff, Tamara Beck, Sue Haupt, Yifang Hu, Rose E May, Lachlan Whitehead, Lin Tai, William Chiang, Marco J Herold, Ygal Haupt, Gordon K Smyth, Tim Thomas, Marnie E Blewitt, et al.

Journal article  |  2019  |  Cell Reports

Direct evidence of a clonal and tumor-directed T cell response to prostate cancer brachytherapy.

Scott Williams, Simon Keam, Heloise Halse, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phil Darcy, Shahneen Kaur Sandhu, Piers Blombery, Ygal Haupt, Paul J Neeson

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

The long and the short of it: the MDM4 tail so far

Sue Haupt, Javier Octavio Mejia-Hernandez, Reshma Vijayakumaran, Simon P Keam, Ygal Haupt

Journal article  |  2019  |  Journal of Molecular Cell Biology

Copy number analysis identifies ESR1 and MDM4 as drivers of progression in invasive lobular breast carcinoma

JM Atkinson, L Cao, A Basudan, MJ Sikora, A Bahreini, N Tasdemir, RC Jankowitz, PF McAuliffe, D Dabbs, S Haupt, Y Haupt, PC Peter Lucas, AV Lee, S Oesterreich

Conference Proceedings  |  2019  |  Poster Session Abstracts

Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma

Lan Cao, Ahmed Basudan, Matthew J Sikora, Amir Bahreini, Nilgun Tasdemir, Kevin M Levine, Rachel C Jankowitz, Priscilla F McAuliffe, David Dabbs, Sue Haupt, Ygal Haupt, Peter C Lucas, Adrian Lee, Steffi Oesterreich, Jennifer M Atkinson

Journal article  |  2019  |  Cancer Letters

Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer following invasive ductal carcino..

Proteotranscriptomic Measurements of E6-Associated Protein (E6AP) Targets in DU145 Prostate Cancer Cells

Twishi Gulati, Cheng Huang, Franco Caramia, Dinesh Raghu, Piotr J Paul, Robert JA Goode, Simon P Keam, Scott G Williams, Sue Haupt, Oded Kleifeld, Ralf B Schittenhelm, Cristina Gamell, Ygal Haupt

Journal article  |  2018  |  Molecular & Cellular Proteomics

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

Shashank Masaldan, Sharnel AS Clatworthy, Cristina Gamell, Peter M Meggyesy, Antonia-Tonia Rigopoulos, Sue Haupt, Ygal Haupt, Delphine Denoyer, Paul A Adlard, Ashley I Bush, Michael A Cater

Journal article  |  2018  |  REDOX BIOLOGY

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

Jacob T Jackson, Ashley P Ng, Benjamin J Shields, Sue Haupt, Ygal Haupt, Matthew P McCormack

Journal article  |  2018  |  Blood Advances

New insights on the regulation of INK4/ARF locus expression

Cristina Gamell, Doron Ginsberg, Sue Haupt, Ygal Haupt

Journal article  |  2017  |  Oncotarget

E6AP promotes prostate cancer by reducing p27 expression

Dinesh Raghu, Piotr Jan Paul, Twishi Gulati, Siddhartha Deb, Christine Khoo, Andrea Russo, Enzo Gallo, Giovanni Blandino, Ai-Leen Chan, Elena Takano, Shahneen K Sandhu, Stephen B Fox, Scott Williams, Sue Haupt, Cristina Gamell, Ygal Haupt

Journal article  |  2017  |  Oncotarget

MDM4 is a rational target for treating breast cancers with mutant p53

Panimaya Jeffreena Miranda, Daniel Buckley, Dinesh Raghu, Jia-Min B Pang, Elena A Takano, Reshma Vijayakumaran, Amina FAS Teunisse, Atara Posner, Tahlia Procter, Marco J Herold, Cristina Gamell, Jean-Christophe Marine, Stephen B Fox, Aart Jochemsen, Sue Haupt, Ygal Haupt

Journal article  |  2017  |  The Journal of Pathology

Inhibiting the system x((C)over-bar)/glutathione axis selectively targets cancers with mutant-p53 accumulation

David S Liu, Cuong P Duong, Sue Haupt, Karen G Montgomery, Colin M House, Walid J Azar, Helen B Pearson, Oliver M Fisher, Matthew Read, Glen R Guerra, Ygal Haupt, Carleen Cullinane, Klas G Wiman, Lars Abrahmsen, Wayne A Phillips, Nicholas J Clemons

Journal article  |  2017  |  Nature Communications

The role of MDM2 and MDM4 in breast cancer development and prevention

Sue Haupt, Reshma Vijayakumaran, Panimaya Jeffreena Miranda, Andrew Burgess, Elgene Lim, Ygal Haupt

Journal article  |  2017  |  Journal of Molecular Cell Biology

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer

Cristina Gamell, Twishi Gulati, Yaara Levav-Cohen, Richard J Young, Hongdo Do, Pat Pilling, Elena Takano, Neil Watkins, Stephen B Fox, Prudence Russell, Doron Ginsberg, Brendon J Monahan, Gavin Wright, Alex Dobrovic, Sue Haupt, Ben Solomon, Ygal Haupt

Journal article  |  2017  |  Science Signaling

P53 at the start of the 21st century: lessons from elephants.

Sue Haupt, Ygal Haupt

Journal article  |  2017  |  F1000Research

Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised func..

Uncovering a novel pathway for p16 silencing: Therapeutic implications for lung cancer

C Gamell, T Gulati, B Solomon, S Haupt, Y Haupt

Journal article  |  2017  |  Molecular & Cellular Oncology

Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP

PJ Paul, D Raghu, A-L Chan, T Gulati, L Lambeth, E Takano, MJ Herold, J Hagekyriakou, RL Vessella, C Fedele, M Shackleton, ED Williams, S Fox, S Williams, S Haupt, C Gamell, Y Haupt

Journal article  |  2016  |  ONCOGENE

Clinical Overview of MDM2/X-Targeted Therapies

Andrew Burgess, Kee Ming Chia, Sue Haupt, David Thomas, Ygal Haupt, Elgene Lim

Journal article  |  2016  |  FRONTIERS IN ONCOLOGY

Mutant p53 Drives Cancer by Subverting Multiple Tumor Suppression Pathways

Sue Haupt, Dinesh Raghu, Ygal Haupt

Journal article  |  2016  |  FRONTIERS IN ONCOLOGY

Regulation of Mutant p53 Protein Expression

Reshma Vijayakumaran, Kah Hin Tan, Panimaya Jeffreena Miranda, Sue Haupt, Ygal Haupt

Journal article  |  2015  |  Frontiers in Oncology

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

David SH Liu, Matthew Read, Carleen Cullinane, Walid J Azar, Christina M Fennell, Karen G Montgomery, Sue Haupt, Ygal Haupt, Klas G Wiman, Cuong P Duong, Nicholas J Clemons, Wayne A Phillips

Journal article  |  2015  |  GUT

Targeting Mdmx to treat breast cancers with wild-type p53

S Haupt, D Buckley, J-MB Pang, J Panimaya, PJ Paul, C Gamell, EA Takano, Y Ying Lee, S Hiddingh, T-M Rogers, AFAS Teunisse, MJ Herold, J-C Marine, SB Fox, A Jochemsen, Y Haupt

Journal article  |  2015  |  Cell Death & Disease

Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities

Madhusudhan Kollareddy, Elizabeth Dimitrova, Krishna C Vallabhaneni, Adriano Chan, Thuc Le, Krishna M Chauhan, Zunamys I Carrero, Gopalakrishnan Ramakrishnan, Kounosuke Watabe, Ygal Haupt, Sue Haupt, Radhika Pochampally, Gerard R Boss, Damian G Romero, Caius G Radu, Luis A Martinez

Journal article  |  2015  |  Nature Communications

p53 calls upon CIA (Calcium Induced Apoptosis) to counter stress

Sue Haupt, Dinesh Raghu, Ygal Haupt

Journal article  |  2015  |  Frontiers in Oncology

Role of p53 in the progression of gastric cancer

Rita A Busuttil, Giada V Zapparoli, Sue Haupt, Christina Fennell, Stephen Q Wong, Jia-Min B Pang, Elena A Takeno, Catherine Mitchell, Natasha Di Costanzo, Stephen Fox, Ygal Haupt, Alexander Dobrovic, Alex Boussioutas

Journal article  |  2014  |  ONCOTARGET

Expression of E6AP and PML predicts for prostate cancer progression and cancer-specific death

SE Birch, JG Kench, E Takano, P Chan, A-L Chan, K Chiam, A-S Veillard, P Stricker, S Haupt, Y Haupt, L Horvath, SB Fox

Journal article  |  2014  |  Annals of Oncology

PML tumour suppression and beyond: Therapeutic implications

Cristina Gamell, Piotr Jan Paul, Ygal Haupt, Sue Haupt

Journal article  |  2014  |  FEBS Letters

The p53-Mdm2 loop: a critical juncture of stress response.

Yaara Levav-Cohen, Zehavit Goldberg, Kah Hin Tan, Osnat Alsheich-Bartok, Valentina Zuckerman, Sue Haupt, Ygal Haupt

Book Chapter  |  2014  |  Sub-cellular biochemistry

The presence of a functional p53 protein is a key factor for the proper suppression of cancer development. A loss of p53 activity,..

Stimulating p53 down-under: a report from the 1st Australian p53 Workshop

PM Neilsen, AW Braithwaite, C Gamell, S Haupt, A Janic, A Strasser, K Wolyniec, Y Haupt

Journal article  |  2013  |  Cell Death & Differentiation

The E6AP E3 ubiquitin ligase regulates the cellular response to oxidative stress

K Wolyniec, Y Levav-Cohen, Y-H Jiang, S Haupt, Y Haupt

Journal article  |  2013  |  Oncogene

Interplay between p53 and VEGF: how to prevent the guardian from becoming a villain

S Haupt, C Gamell, K Wolyniec, Y Haupt

Journal article  |  2013  |  Cell Death & Differentiation

Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner

Sue Haupt, Catherine Mitchell, Vincent Corneille, Jake Shortt, Stephen Fox, Pier Paolo Pandolfi, Mireia Castillo-Martin, Dennis M Bonal, Carlos Cordon-Cardo, Guillermina Lozano, Ygal Haupt

Journal article  |  2013  |  CELL CYCLE

c-Abl Phosphorylates E6AP and Regulates Its E3 Ubiquitin Ligase Activity

Ai-Leen Chan, Tamar Grossman, Valentina Zuckerman, Dafne Campigli Di Giammartino, Ofra Moshe, Martin Scheffner, Brendon Monahan, Pat Pilling, Yong-Hui Jiang, Sue Haupt, Ora Schueler-Furman, Ygal Haupt

Journal article  |  2013  |  Biochemistry

New Strategies to Direct Therapeutic Targeting of PML to Treat Cancers.

Kamil Wolyniec, Dennis A Carney, Sue Haupt, Ygal Haupt

Journal article  |  2013  |  Frontiers in Oncology

The tumor suppressor function of the promyelocytic leukemia (PML) protein was first identified as a result of its dysregulation in..

Restoring PML tumor suppression to combat cancer

Kamil Wolyniec, Ai-Leen Chan, Sue Haupt, Ygal Haupt

Journal article  |  2012  |  Cell Cycle

MDM4 is a key therapeutic target in cutaneous melanoma

Agnieszka Gembarska, Flavie Luciani, Clare Fedele, Elisabeth A Russell, Michael Dewaele, Stephanie Villar, Aleksandra Zwolinska, Sue Haupt, Job de Lange, Dana Yip, James Goydos, Jody J Haigh, Ygal Haupt, Lionel Larue, Aart Jochemsen, Hubing Shi, Gatien Moriceau, Roger S Lo, Ghanem Ghanem, Mark Shackleton, et al.

Journal article  |  2012  |  NATURE MEDICINE

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

Kamil Wolyniec, Jake Shortt, Elisa de Stanchina, Yaara Levav-Cohen, Osnat Alsheich-Bartok, Igal Louria-Hayon, Vincent Corneille, Beena Kumar, Simone J Woods, Stephen Opat, Ricky W Johnstone, Clare L Scott, David Segal, Pier Paolo Pandolfi, Stephen Fox, Andreas Strasser, Yong-Hui Jiang, Scott W Lowe, Sue Haupt, Ygal Haupt

Journal article  |  2012  |  BLOOD

E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts

Y Levav-Cohen, K Wolyniec, O Alsheich-Bartok, A-L Chan, SJ Woods, Y-H Jiang, S Haupt, Y Haupt

Journal article  |  2012  |  Oncogene

Mutant p53 subverts PLK2 function in a novel, reinforced loop of corruption

Sue Haupt, Ygal Haupt

Journal article  |  2012  |  Cell Cycle

Synchronized release of Doxil and Nutlin-3 by remote degradation of polysaccharide matrices and its possible use in the local treatment of colorectal cancer

Mirela Nadler-Milbauer, Lior Apter, Ygal Haupt, Sue Haupt, Yechezkel Barenholz, Tamara Minko, Abraham Rubinstein

Journal article  |  2011  |  Journal of Drug Targeting

The p53-Mdm2 Loop: A Critical Juncture of Stress Response

Yaara Levav-Cohen, Zehavit Goldberg, Osnat Alsheich-Bartok, Valentina Zuckerman, Sue Haupt, Ygal Haupt

Book Chapter  |  2010

Tumour suppression by p53: the importance of apoptosis and cellular senescence

Valentina Zuckerman, Kamil Wolyniec, Ronit V Sionov, Sue Haupt, Ygal Haupt

Journal article  |  2009  |  The Journal of Pathology

E6AP promotes the degradation of the PML tumor suppressor

I Louria-Hayon, O Alsheich-Bartok, Y Levav-Cohen, I Silberman, M Berger, T Grossman, K Matentzoglu, Y-H Jiang, S Muller, M Scheffner, S Haupt, Y Haupt

Journal article  |  2009  |  Cell Death & Differentiation

Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53

Sue Haupt, Silvia di Agostino, Inbal Mizrahi, Osnat Alsheich-Bartok, Mathijs Voorhoeve, Alex Damalas, Giovanni Blandino, Ygal Haupt

Journal article  |  2009  |  Cancer Research

T cell survival and function requires the c-Abl tyrosine kinase

Isabelle Silberman, Ronit Vogt Sionov, Valentina Zuckerman, Sue Haupt, Zehavit Goldberg, Andreas Strasser, Zami S Ben-Sasson, Michal Baniyash, Anthony J Koleske, Ygal Haupt

Journal article  |  2008  |  Cell Cycle

p53 controls hPar1 function and expression

Z Salah, S Haupt, M Maoz, L Baraz, V Rotter, T Peretz, Y Haupt, R Bar-Shavit

Journal article  |  2008  |  Oncogene

PML enhances the regulation of p53 by CK1 in response to DNA damage

O Alsheich-Bartok, S Haupt, I Alkalay-Snir, S Saito, E Appella, Y Haupt

Journal article  |  2008  |  Oncogene

Importance of p53 for cancer onset and therapy

Sue Haupt, Ygal Haupt

Journal article  |  2006  |  Anti-Cancer Drugs

Celecoxib can induce cell death independently of cyclooxygenase-2, p53, Mdm2, c-Abl and reactive oxygen species

Sue Haupt, Jackie Kleinstern, Ygal Haupt, Abraham Rubinstein

Journal article  |  2006  |  Anti-Cancer Drugs

Luminal delivery and dosing considerations of local celecoxib administration to colorectal cancer.

Sue Haupt, Tamar Zioni, Irith Gati, Jackie Kleinstern, Abraham Rubinstein

Journal article  |  2006  |  European Journal of Pharmaceutical Sciences

The purpose of this study was to develop a biodegradable drug platform composed of chitosan and guar gum and to explore the possib..

Clues from worms: a Slug at Puma promotes the survival of blood progenitors.

S Haupt, O Alsheich-Bartok, Y Haupt

Journal article  |  2006  |  Cell Death & Differentiation

Mdm2 in growth signaling and cancer.

Yaara Levav-Cohen, Sue Haupt, Ygal Haupt

Journal article  |  2005  |  Growth Factors

Genetic and biochemical evidence have demonstrated a direct link between Mdm2 and cancer development. Elevated expression of Mdm2 ..

C-Abl as a modulator of p53.

Yaara Levav-Cohen, Zehavit Goldberg, Valentina Zuckerman, Tamar Grossman, Sue Haupt, Ygal Haupt

Journal article  |  2005  |  Biochemical and Biophysical Research Communications

P53 is renowned as a cellular tumor suppressor poised to instigate remedial responses to various stress insults that threaten DNA ..

Local prevention of oxidative stress in the intestinal epithelium of the rat by adhesive liposomes of superoxide dismutase and tempamine.

Tareq Taha Jubeh, Sivan Antler, Susan Haupt, Yechezkel Barenholz, Abraham Rubinstein

Journal article  |  2005  |  Molecular Pharmaceutics

The purpose of the present study was to investigate whether the local prevention of luminal superoxide-mediated biological damage ..

Manipulation of the tumor suppressor p53 for potentiating cancer therapy

S Haupt, Y Haupt

Journal article  |  2004  |  Seminars in Cancer Biology

Improving cancer therapy through p53 management.

Susan Haupt, Ygal Haupt

Journal article  |  2004  |  Cell Cycle

The tumor suppressor p53 normally acts to appropriately coordinate cellular responses to stress stimuli. When p53 activity is disa..

Apoptosis - the p53 network.

Susan Haupt, Michael Berger, Zehavit Goldberg, Ygal Haupt

Journal article  |  2003  |  Journal of Cell Science

Exposure to cellular stress can trigger the p53 tumor suppressor, a sequence-specific transcription factor, to induce cell growth ..

P53 licensed to kill? Operating the assassin.

Susan Haupt, Igal Louria-Hayon, Ygal Haupt

Journal article  |  2003  |  Journal of Cellular Biochemistry

The p53 protein is a key player in the cellular response to stress. Proper regulation of p53 is imperative for the suppression of ..

Regional peptide uptake study in the rat intestinal mucosa: glatiramer acetate as a model drug.

Susan Haupt, Efrat Gil, Regin Tirosh, Ety Klinger, Alexander Gad, Abraham Rubinstein

Journal article  |  2002  |  Pharmaceutical Research

PURPOSE: To identify regions of the rat intestine that are able to internalize from the lumen oligopeptides, using the model drug ..

The colon as a possible target for orally administered peptide and protein drugs.

Susan Haupt, Abraham Rubinstein

Journal article  |  2002  |  Critical Reviews in Therapeutic Drug Carrier Systems

Oral administration offers a potential portal to the superficial layers of the gastrointestinal (GI) tract (local delivery) and to..

Drug targeting by surface cationization.

S Blau, TT Jubeh, SM Haupt, A Rubinstein

Journal article  |  2000  |  Critical Reviews in Therapeutic Drug Carrier Systems

Cationization of drug products and carriers involves a direct modification or attachment of conveying or accompanying components, ..