Susan Haupt

Sex disparities matter in cancer development and therapy

Sue Haupt, Franco Caramia, Sabra L Klein, Joshua B Rubin, Ygal Haupt

Journal article  |  2021  |  NATURE REVIEWS CANCER

Curing cancer through precision medicine is the paramount aim of the new wave of molecular and genomic therapies. Currently, wheth..

Cancer and Tumour Suppressor p53 Encounters at the Juncture of Sex Disparity

Sue Haupt, Ygal Haupt

Journal article  |  2021  |  FRONTIERS IN GENETICS

There are many differences in cancer manifestation between men and women. New understanding of the origin of these point to fundam..

Mdm2 inhibition synergises with endocrine therapy or cdk4/6 inhibition for the treatment of estrogen receptor-positive breast cancer

Neil Portman, Heloisa Milioli, Sarah Alexandrou, Rhiannon Coulson, Aliza Yong, Kristine Fernandez, KeeMing Chia, Ensar Halilovic, Davendra Segara, Andrew Parker, Sue Haupt, Ygal Haupt, Wayne Tilley, Alex Swarbrick, Liz Caldon, Elgene Lim

Conference Proceedings  |  2021  |  CANCER RESEARCH

580 High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot

Simon Keam, Heloise Halse, ThuNgoc Nguyen, Minyu Wang, Nicolas Van Kooten Losio, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott Williams, Paul Neeson

Conference Proceedings  |  2020  |  Journal for ImmunoTherapy of Cancer

BackgroundProstate cancer is frequently cured with high dose-rate brachytherapy (HDRBT) radiation as a front-line treatment. Altho..

Immune molecular profiling of a multiresistant primary prostate cancer with a neuroendocrine-like phenotype: a case report

Scott G Williams, Han Xian Aw Yeang, Catherine Mitchell, Franco Caramia, David J Byrne, Stephen B Fox, Sue Haupt, Ralf B Schittenhelm, Paul J Neeson, Ygal Haupt, Simon P Keam

Journal article  |  2020  |  BMC UROLOGY

BACKGROUND: Understanding the drivers of recurrence in aggressive prostate cancer requires detailed molecular and genomic understa..

MDM2 inhibition in combination with endocrine therapy and CDK4/6 inhibition for the treatment of ER-positive breast cancer

Neil Portman, Heloisa H Milioli, Sarah Alexandrou, Rhiannon Coulson, Aliza Yong, Kristine J Fernandez, Kee Ming Chia, Ensar Halilovic, Davendra Segara, Andrew Parker, Sue Haupt, Ygal Haupt, Wayne D Tilley, Alex Swarbrick, C Elizabeth Caldon, Elgene Lim

Journal article  |  2020  |  BREAST CANCER RESEARCH

BACKGROUND: Resistance to endocrine therapy is a major clinical challenge in the management of oestrogen receptor (ER)-positive br..

TP53 Status, Patient Sex, and the Immune Response as Determinants of Lung Cancer Patient Survival

Donald Freudenstein, Cassandra Litchfield, Franco Caramia, Gavin Wright, Benjamin J Solomon, David Ball, Simon P Keam, Paul Neeson, Ygal Haupt, Sue Haupt

Journal article  |  2020  |  CANCERS

Lung cancer poses the greatest cancer-related death risk and males have poorer outcomes than females, for unknown reasons. Patient..

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

Arjelle Decasa Agupitan, Paul Neeson, Scott Williams, Jason Howitt, Sue Haupt, Ygal Haupt

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Awareness of the importance of immunity in controlling cancer development triggered research into the impact of its key oncogenic ..

Predicting radiation-induced immune trafficking and activation in localized prostate cancer

Scott Williams, Simon P Keam, Heloise Halse, Nguyen Thu, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Shahneen Kaur Sandhu, Piers Blombery, Ygal Haupt, Paul J Neeson

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot

Simon P Keam, Heloise Halse, Thu Nguyen, Minyu Wang, Nicolas Van Kooten Losio, Catherine Mitchell, Franco Caramia, David J Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott G Williams, Paul J Neeson

Journal article  |  2020  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

BACKGROUND: Prostate cancer (PCa) has a profoundly immunosuppressive microenvironment and is commonly immune excluded with few inf..