Katherine Hannan

Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway

Katherine M Hannan, Priscilla Soo, Mei S Wong, Justine K Lee, Nadine Hein, Perlita Poh, Kira D Wysoke, Tobias D Williams, Christian Montellese, Lorey K Smith, Sheren J Al-Obaidi, Lorena Nunez-Villacis, Megan Pavy, Jin-Shu He, Kate M Parsons, Karagh E Loring, Tess Morrison, Jeannine Diesch, Gaetan Burgio, Rita Ferreira, et al.

Journal article  |  2022  |  CELL REPORTS

The nucleolar surveillance pathway monitors nucleolar integrity and responds to nucleolar stress by mediating binding of ribosomal..

A new method for determining ribosomal DNA copy number shows differences between Saccharomyces cerevisiae populations

Diksha Sharma, Sylvie Hermann-Le Denmat, Nicholas J Matzke, Katherine Hannan, Ross D Hannan, Justin M O'Sullivan, Austen RD Ganley

Journal article  |  2022  |  GENOMICS

Ribosomal DNA genes (rDNA) encode the major ribosomal RNAs and in eukaryotes typically form tandem repeat arrays. Species have cha..

Abstract 2155: PMR-116, a novel inhibitor of ribosome biogenesis with antitumor activity in preclinical models of prostate cancer

Alisee Huglo, Richard Rebello, Mitchell Lawrence, Gail Risbridger, Denis Drygin, Mustapha Haddach, Katherine Hannan, Ross Hannan, Luc Furic

Conference Proceedings  |  2022  |  Cancer Research

Abstract Advanced prostate cancer is characterised by mutations and amplifications of genes involved in regulating ..

The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma

Chang-Won Kang, Katherine M Hannan, Anneke C Blackburn, Amos HP Loh, Kuick Chik Hong, Goh Jian Yuan, Nadine Hein, Denis Drygin, Ross D Hannan, Lucy A Coupland

Journal article  |  2022  |  INVESTIGATIONAL NEW DRUGS

BACKGROUND: Uterine leiomyosarcoma is a rare aggressive smooth muscle cancer with poor survival rates. RNA Polymerase I (Pol I) ac..

Functional microRNA targetome undergoes degeneration-induced shift in the retina

Joshua A Chu-Tan, Adrian V Cioanca, Zhi-Ping Feng, Yvette Wooff, Ulrike Schumann, Riemke Aggio-Bruce, Hardip Patel, Matt Rutar, Katherine Hannan, Konstantin Panov, Jan Provis, Riccardo Natoli

Journal article  |  2021  |  MOLECULAR NEURODEGENERATION

BACKGROUND: MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-relat..

The Ribosomal Gene Loci-The Power behind the Throne

Konstantin I Panov, Katherine Hannan, Ross D Hannan, Nadine Hein

Journal article  |  2021  |  GENES

Nucleoli form around actively transcribed ribosomal RNA (rRNA) genes (rDNA), and the morphology and location of nucleolus-associat..

The Synthesis and Biological Evaluation of Some C-9 and C-10 Substituted Derivatives of the RNA Polymerase I Transcription Inhibitor CX-5461

Madushani Amarasiri, Yen Vo, Michael G Gardiner, Perlita Poh, Priscilla Soo, Megan Pavy, Nadine Hein, Rita Ferreira, Katherine M Hannan, Ross D Hannan, Martin G Banwell

Journal article  |  2021  |  AUSTRALIAN JOURNAL OF CHEMISTRY

The regio-isomeric alkynyl-substituted derivatives, 2 and 3, of the RNA Polymerase I (Pol I) transcription inhibitor CX-5461 (1) w..

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

Shunfei Yan, Jiachen Xuan, Natalie Brajanovski, Madeleine RC Tancock, Piyush B Madhamshettiwar, Kaylene J Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen E Sheppard, Katherine M Hannan, Ross D Hannan, Elaine Sanij, Richard B Pearson, Keefe T Chan

Journal article  |  2020  |  BRITISH JOURNAL OF CANCER

BACKGROUND: Intrinsic and acquired drug resistance represent fundamental barriers to the cure of high-grade serous ovarian carcino..

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Jennifer R Devlin, Keefe T Chan, David P De Souza, Malcolm J McConville, Grant A McArthur, George Thomas, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Katherine M Hannan, Jian Kang, Richard B Pearson

Journal article  |  2020  |  EMBO JOURNAL

Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our previous first-i..

Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC-Driven Cancer Progression

Jixuan Gao, MoonSun Jung, Chelsea Mayoh, Pooja Venkat, Katherine M Hannan, Jamie Fletcher, Alvin Kamili, Andrew J Gifford, Eric P Kusnadi, Richard B Pearson, Ross D Hannan, Michelle Haber, Murray D Norris, Klaartje Somers, Michelle J Henderson

Journal article  |  2020  |  CANCER RESEARCH

The ability of the N-MYC transcription factor to drive cancer progression is well demonstrated in neuroblastoma, the most common e..