Katherine Hannan

A functional genetic screen defines the AKT-induced senescence signaling network

Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Piyush B Madhamshettiwar, Jeannine Diesch, Lassi Paavolainen, Peter Horvath, Ross D Hannan, Amee J George, Elaine Sanij, Katherine M Hannan, Kaylene J Simpson, Richard B Pearson

Journal article  |  2020  |  Cell Death & Differentiation

Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival..

Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer

Shunfei Yan, Piyush Madhamshettiwar, Kaylene Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen Sheppard, Katherine Hannan, Ross Hannan, Elaine Sanij, Richard Pearson, Keefe Chan

Journal article  |  2019

Abstract Limited effective therapeutic options are available for patients with recurrent high-grade serous carcinoma (HGSC), the m..

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

Pei Y Liu, Andrew E Tee, Giorgio Milazzo, Katherine M Hannan, Jesper Maag, Sujanna Mondal, Bernard Atmadibrata, Nenad Bartonicek, Hui Peng, Nicholas Ho, Chelsea Mayoh, Roberto Ciaccio, Yuting Sun, Michelle J Henderson, Jixuan Gao, Celine Everaert, Amy J Hulme, Matthew Wong, Qing Lan, Belamy B Cheung, et al.

Journal article  |  2019  |  Nature Communications

The majority of patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein over-expression di..

PGRMC1 phosphorylation and cell plasticity 1: glycolysis, mitochondria, tumor growth

Bashar Thejer, Partho Adhikary, Amandeep Kaur, Sarah Teakel, Ashleigh Van Oosterum, Ishith Seth, Marina Pajic, Kate Hannan, Megan Pavy, Perlita Poh, Jalal Jazayeri, Thiri Zaw, Dana Pascovici, Marina Ludescher, Michael Pawlak, Juan Cassano, Lynne Turnbull, Mitra Jazayeri, Alexander James, Craig Coorey, et al.

Journal article  |  2019

SUMMARY Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrime..

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Klaartje Somers, Victoria W Wen, Shiloh MC Middlemiss, Brenna Osborne, Helen Forgham, MoonSun Jung, Mawar Karsa, Molly Clifton, Angelika Bongers, Jixuan Gao, Chelsea Mayoh, Newsha Raoufi-Rad, Eric P Kusnadi, Kate M Hannan, David A Scott, Alan Kwek, Bing Liu, Claudia Flemming, Daria A Chudakova, Ruby Pandher, et al.

Journal article  |  2019  |  Oncogene

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

Elaine Sanij, Katherine Hannan, Shunfei Yan, Jiachen Xuan, Jessica Ahern, Keefe Chan, Jinbae Son, Olga Kondrashova, Elizabeth Lieschke, Matthew Wakefield, Anna Trigos, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Kum Kum Khanna, Linda Mileshkin, Grant McArthur, et al.

Journal article  |  2019

Abstract High-grade serous ovarian cancer (HGSOC) accounts for the majority of ovarian cancer and has a dismal prognosis. PARP inh..

A High-Throughput Screening Approach to Identify Therapeutics for the Treatment of Diamond-Blackfan Anaemia

Lorena Nunez Villacis, Sheren J Al-Obaidi, Piyush Madhamshettiwar, Nadine Hein, Jun Chen, Priscilla Soo, Perlita Poh, Megan Pavy, Kaylene J Simpson, Thomas John Gonda, Richard B Pearson, Johan Flygare, Katherine M Hannan, Amee J George, Ross Hannan

Conference Proceedings  |  2018  |  Blood

Algorithmic advice for paediatric behavioural sleep problems to reduce outpatient waitlists: pilot randomised controlled trial

K Hannan, H Hiscock, G Roberts, E Sciberras, K McLean, J Quach, A Griffiths, C Simpson, J Bridie

Conference Proceedings  |  2018  |  JOURNAL OF SLEEP RESEARCH

High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology

Jin-Shu He, Priscilla Soo, Maurits Evers, Kate M Parsons, Nadine Hein, Katherine M Hannan, Ross D Hannan, Amee J George

Journal article  |  2018  |  ASSAY and Drug Development Technologies

Inhibition of Pol I Transcription a New Chance in the Fight Against Cancer

Nadine Hein, Kathrine M Hannan, James D'Rozario, Ross Hannan

Journal article  |  2017  |  Technology in Cancer Research & Treatment

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R Devlin, Amee J George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J Harrison, James D Rozario, et al.

Journal article  |  2017  |  Blood

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Sandy S Hung, Analia Lesmana, Abigail Peck, Rachel Lee, Elly Tchoubrieva, Katherine M Hannan, Jane Lin, Karen E Sheppard, Katarzyna Jastrzebski, Leonie M Quinn, Lawrence I Rothblum, Richard B Pearson, Ross D Hannan, Elaine Sanij

Journal article  |  2017  |  Gene

Advanced pancreatic ductal adenocarcinoma - Complexities of treatment and emerging therapeutic options.

Chandra Diwakarla, Katherine Hannan, Nadine Hein, Desmond Yip

Journal article  |  2017  |  World Journal of Gastroenterology

Pancreatic ductal adenocarcinoma is a devastating disease with a poor prognosis regardless of stage. To date the mainstay of thera..

A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer

Shunfei Yan, Keefe T Chan, Kaylene J Simpson, Elaine Sanij, Karen E Sheppard, Katherine M Hannan, Ross D Hannan, Richard B Pearson

Conference Proceedings  |  2017  |  Synthetic Lethality and Viability

Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis

Louise E Kerry, Elaine E Pegg, Donald P Cameron, James Budzak, Gretchen Poortinga, Katherine M Hannan, Ross D Hannan, Gloria Rudenko

Journal article  |  2017  |  PLOS Neglected Tropical Diseases

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

Shunfei Yan, Daniel Frank, Jinbae Son, Katherine M Hannan, Ross D Hannan, Keefe T Chan, Richard B Pearson, Elaine Sanij

Journal article  |  2017  |  International Journal of Molecular Sciences

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence

Keefe T Chan, Lassi Paavolainen, Katherine M Hannan, Amee J George, Ross D Hannan, Kaylene J Simpson, Peter Horvath, Richard B Pearson

Journal article  |  2016  |  ASSAY and Drug Development Technologies

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

Jian Kang, Eric P Kusnadi, Allison J Ogden, Rodney J Hicks, Lukas Bammert, Ulrike Kutay, Sandy Hung, Elaine Sanij, Ross D Hannan, Katherine M Hannan, Richard B Pearson

Journal article  |  2016  |  Oncotarget

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George, Katherine M Hannan, Gretchen Poortinga, Karen E Sheppard, Kum Kum Khanna, Ricky W Johnstone, Denis Drygin, Grant A McArthur, Richard B Pearson, Elaine Sanij, Ross D Hannan

Journal article  |  2016  |  Oncotarget

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Jennifer R Devlin, Katherine M Hannan, Nadine Hein, Carleen Cullinane, Eric Kusnadi, Pui Yee Ng, Amee J George, Jake Shortt, Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Jian Kang, Denis Drygin, Sean O'Brien, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson

Journal article  |  2016  |  Cancer Discovery

S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila

Naomi C Mitchell, Elissaveta B Tchoubrieva, Arjun Chahal, Simone Woods, Amanda Lee, Jane I Lin, Linda Parsons, Katarzyna Jastrzebski, Gretchen Poortinga, Katherine M Hannan, Richard B Pearson, Ross D Hannan, Leonie M Quinn

Journal article  |  2015  |  Cellular Signalling

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy

Simone J Woods, Katherine M Hannan, Richard B Pearson, Ross D Hannan

Journal article  |  2015  |  Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Regulation of rDNA transcription in response to growth factors, nutrients and energy

Eric P Kusnadi, Katherine M Hannan, Rodney J Hicks, Ross D Hannan, Richard B Pearson, Jian Kang

Journal article  |  2015  |  Gene

Targeting the nucleolus for cancer intervention

Jaclyn E Quin, Jennifer R Devlin, Donald Cameron, Kate M Hannan, Richard B Pearson, Ross D Hannan

Journal article  |  2014  |  Biochimica et Biophysica Acta-Molecular Basis of Disease

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

Karen E Sheppard, Carleen Cullinane, Katherine M Hannan, Meaghan Wall, Joanna Chan, Frances Barber, Jung Foo, Donald Cameron, Amelia Neilsen, Pui Ng, Jason Ellul, Margarete Kleinschmidt, Kathryn M Kinross, David D Bowtell, James G Christensen, Rodney J Hicks, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Wayne A Phillips, et al.

Journal article  |  2013  |  European Journal of Cancer

The nucleolus: an emerging target for cancer therapy

Nadine Hein, Katherine M Hannan, Amee J George, Elaine Sanij, Ross D Hannan

Journal article  |  2013  |  Trends in Molecular Medicine

AKT signalling is required for ribosomal RNA synthesis and progression of E mu-Myc B-cell lymphoma in vivo

Jennifer R Devlin, Katherine M Hannan, Pui Y Ng, Megan J Bywater, Jake Shortt, Carleen Cullinane, Grant A McArthur, Ricky W Johnstone, Ross D Hannan, Richard B Pearson

Journal article  |  2013  |  The FEBS Journal

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Jake Shortt, Benjamin P Martin, Andrea Newbold, Katherine M Hannan, Jennifer R Devlin, Adele J Baker, Rachael Ralli, Carleen Cullinane, Clemens A Schmitt, Maurice Reimann, Michael N Hall, Meaghan Wall, Ross D Hannan, Richard B Pearson, Grant A McArthur, Ricky W Johnstone

Journal article  |  2013  |  Blood

Dysregulation of RNA polymerase I transcription during disease

KM Hannan, E Sanij, LI Rothblum, RD Hannan, RB Pearson

Journal article  |  2013  |  Biochimica et Biophysica Acta. Gene Regulatory Mechanisms

Autophagy Induction Is a Tor- and Tp53-Independent Cell Survival Response in a Zebrafish Model of Disrupted Ribosome Biogenesis

Yeliz Boglev, Andrew P Badrock, Andrew J Trotter, Qian Du, Elsbeth J Richardson, Adam C Parslow, Sebastian J Markmiller, Nathan E Hall, Tanya A de Jong-Curtain, Annie Y Ng, Heather Verkade, Elke A Ober, Holly A Field, Donghun Shin, Chong H Shin, Katherine M Hannan, Ross D Hannan, Richard B Pearson, Seok-Hyung Kim, Kevin C Ess, et al.

Journal article  |  2013  |  PLoS Genetics

The mTORC1 Inhibitor Everolimus Prevents and Treats E mu-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Meaghan Wall, Gretchen Poortinga, Kym L Stanley, Ralph K Lindemann, Michael Bots, Christopher J Chan, Megan J Bywater, Kathryn M Kinross, Megan V Astle, Kelly Waldeck, Katherine M Hannan, Jake Shortt, Mark J Smyth, Scott W Lowe, Ross D Hannan, Richard B Pearson, Ricky W Johnstone, Grant A McArthur

Journal article  |  2013  |  Cancer Discovery

Too much or too little Harnessing senescence to control oncogene-driven cancer

Katherine M Hannan, Richard B Pearson

Journal article  |  2012  |  Cell Cycle

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, RD Hannan, RB Pearson

Journal article  |  2012  |  Oncogene

The Nucleolus and Ribosomal Genes in Aging and Senescence

Nadine Hein, Elaine Sanij, Jaclyn Quin, Katherine M Hannan, Austen Ganley, Ross D Hannan

Book Chapter  |  2012

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

Joanna C Chan, Katherine M Hannan, Kim Riddell, Yee Ng Pui, Abigail Peck, Rachel S Lee, Sandy Hung, Megan V Astle, Megan Bywater, Meaghan Wall, Gretchen Poortinga, Katarzyna Jastrzebski, Karen E Sheppard, Brian A Hemmings, Michael N Hall, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson

Journal article  |  2011  |  Science Signaling

A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth

Katarzyna Jastrzebski, Katherine M Hannan, Colin M House, Sandy S-C Hung, Richard B Pearson, Ross D Hannan

Journal article  |  2011  |  Cellular Signaling

Determination of the Exact Molecular Requirements for Type 1 Angiotensin Receptor Epidermal Growth Factor Receptor Transactivation and Cardiomyocyte Hypertrophy

Nicola J Smith, Hsiu-Wen Chan, Hongwei Qian, Allison M Bourne, Katherine M Hannan, Fiona J Warner, Rebecca H Ritchie, Richard B Pearson, Ross D Hannan, Walter G Thomas

Journal article  |  2011  |  Hypertension

Signaling to the Ribosome in Cancer-It Is More Than Just mTORC1

Katherine M Hannan, Elaine Sanij, Nadine Hein, Ross D Hannan, Richard B Pearson

Journal article  |  2011  |  IUBMB Life

Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity.

Rachel S Lee, Colin M House, Briony E Cristiano, Ross D Hannan, Richard B Pearson, Katherine M Hannan

Journal article  |  2011  |  Enzyme Research

The AKT protooncogene mediates many cellular processes involved in normal development and disease states such as cancer. The three..

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase

Nicholas A Veldhuis, Valentina A Valova, Ann P Gaeth, Nickless Palstra, Katherine M Hannan, Belinda J Michell, Leonard E Kelly, Ian Jennings, Bruce E Kemp, Richard B Pearson, Phillip J Robinson, James Camakaris

Journal article  |  2009  |  International Journal of Biochemistry and Cell Biology

UBF levels determine the number of active ribosomal RNA genes in mammals

Elaine Sanij, Gretchen Poortinga, Kerith Sharkey, Sandy Hung, Timothy P Holloway, Jaclyn Quin, Elysia Robb, Lee H Wong, Walter G Thomas, Victor Stefanovsky, Tom Moss, Lawrence Rothblum, Katherine M Hannan, Grant A McArthur, Richard B Pearson, Ross D Hannan

Journal article  |  2008  |  Journal of Cell Biology

Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function

Katarzyna Jastrzebski, Katherine M Hannan, Elissaveta B Tchoubrieva, Ross D Hannan, Richard B Pearson

Journal article  |  2007  |  Growth Factors

A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition

Briony E Cristiano, Joanna C Chan, Katherine M Hannan, Nicole A Lundie, Nelly J Marmy-Conus, Ian G Campbell, Wayne A Phillips, Melissa Robbie, Ross D Hannan, Richard B Pearson

Journal article  |  2006  |  Cancer Research

Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta

KM Hannan, RJ Dilley, ST de Dios, PJ Little

Journal article  |  2003  |  Arteriosclerosis, Thrombosis, and Vascular Biology

OBJECTIVE: Vascular endothelium is emerging as a therapeutic target for atherosclerotic macrovascular disease in diabetes using or..

Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase

I Voskoboinik, R Fernando, N Veldhuis, KM Hannan, N Marmy-Conus, RB Pearson, J Camakaris

Journal article  |  2003  |  Biochemical and Biophysical Research Communications

Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex

KM Hannan, G Thomas, RB Pearson

Journal article  |  2003  |  Biochemical Journal

Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase

NM Conus, KM Hannan, BE Cristiano, BA Hemmings, RB Pearson

Journal article  |  2002  |  Journal of Biological Chemistry

Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling

N Marmy-Conus, KM Hannan, RB Pearson

Journal article  |  2002  |  FEBS Letters

Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells

ST de Dios, KM Hannan, RJ Dilley, MA Hill, PJ Little

Journal article  |  2001  |  Journal of Diabetes and its Complications

Diabetes is associated with a high level of mortality due to cardiovascular disease resulting from accelerated coronary artery ath..

Diabetes-induced vascular hypertrophy is accompanied by activation of Na -H exchange and prevented by Na -H exchange inhibition

K Jandeleit-Dahm, KM Hannan, CA Farrelly, TJ Allen, JR Rumble, RE Gilbert, ME Cooper, PJ Little

Journal article  |  2000  |  Circulation Research

Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1

KM Hannan, RD Hannan, SD Smith, LS Jefferson, MY Lun, LI Rothblum

Journal article  |  2000  |  Oncogene

RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest

KM Hannan, BK Kennedy, AH Cavanaugh, RD Hannan, I Hirschler-Laszkiewicz, LS Jefferson, LI Rothblum

Journal article  |  2000  |  Oncogene

Regulation of ribosomal DNA transcription by insulin

KM Hannan, LI Rothblum, LS Jefferson

Journal article  |  1998  |  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of ribosomal DNA transcription by insulin.

KM Hannan, LI Rothblum, LS Jefferson

Journal article  |  1998  |  American Journal of Physiology-Cell Physiology

The experiments reported here used 3T6-Swiss albino mouse fibroblasts and H4-II-E-C3 rat hepatoma cells as model systems to examin..

Mechanisms regulating the vascular smooth muscle Na H exchanger (NHE-1) in diabetes

KM Hannan, PJ Little

Conference Proceedings  |  1998  |  Biochemistry and Cell Biology

Vascular disease is a major component of the complications associated with diabetes. The pathology involves hypertrophy and prolif..