Rebecca Bilardi

Ganciclovir-induced mutations are present in a diverse spectrum of post-transplant malignancies.

Hu Fang, Helen HN Yan, Rebecca A Bilardi, Christoffer Flensburg, Haocheng Yang, Jayne A Barbour, Hoi Cheong Siu, Michelle Turski, Edward Chew, Zhen Xu, Siu T Lam, Rakesh Sharma, Mengya Xu, Junshi Li, Ho W Ip, Carol YM Cheung, Michael SY Huen, E Alejandro Sweet-Cordero, Ian J Majewski, Suet Y Leung, et al.

Journal article  |  2022  |  Genome Med

BACKGROUND: Ganciclovir (GCV) is widely used in solid organ and haematopoietic stem cell transplant patients for prophylaxis and t..

HBO1 is required for the maintenance of leukaemia stem cells

Laura MacPherson, Juliana Anokye, Miriam M Yeung, Enid YN Lam, Yih-Chih Chan, Chen-Fang Weng, Paul Yeh, Kathy Knezevic, Miriam S Butler, Annabelle Hoegl, Kah-Lok Chan, Marian L Burr, Linden J Gearing, Tracy Willson, Joy Liu, Jarny Choi, Yuqing Yang, Rebecca A Bilardi, Hendrik Falk, Nguyen Nghi, et al.

Journal article  |  2020  |  NATURE

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in..

Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice

Natasha S Anstee, Rebecca A Bilardi, Ashley P Ng, Zhen Xu, Mikara Robati, Cassandra J Vandenberg, Suzanne Cory

Journal article  |  2019  |  CELL DEATH AND DIFFERENTIATION

Many acute myeloid leukaemias (AMLs) express high levels of BCL-2 and MCL-1, especially after therapy. To test the impact of these..

MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells

Bilal N Sheikh, Yuqing Yang, Jaring Schreuder, Susan K Nilsson, Rebecca Bilardi, Sebastian Carotta, Helen M McRae, Donald Metcalf, Anne K Voss, Tim Thomas

Journal article  |  2016  |  BLOOD

Hematopoietic stem cells (HSCs) are conventionally thought to be at the apex of a hierarchy that produces all mature cells of the ..

Impact of loss of BH3-only proteins on the development and treatment of MLL-fusion gene-driven AML in mice

Rebecca A Bilardi, Natasha S Anstee, Stefan P Glaser, Mikara Robati, Cassandra J Vandenberg, Suzanne Cory

Journal article  |  2016  |  CELL DEATH & DISEASE

Inhibition of the apoptosis pathway controlled by opposing members of the Bcl-2 protein family plays a central role in cancer deve..

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

Gabriela Brumatti, Marika Salmanidis, Chung H Kok, Rebecca A Bilardi, Jarrod J Sandow, Natasha Silke, Kylie Mason, Jolanda Visser, Anissa M Jabbour, Stefan P Glaser, Toru Okamoto, Philippe Bouillet, Richard J D'Andrea, Paul G Ekert

Journal article  |  2013  |  ONCOTARGET

Deregulated expression of Hox genes such as HoxA9 is associated with development of myeloproliferative disorders and leukemia and ..

Processing of anthracycline-DNA adducts via DNA replication and interstrand crosslink repair pathways.

RA Bilardi, K-I Kimura, DR Phillips, SM Cutts

Journal article  |  2012  |  Biochem Pharmacol

Anthracycline chemotherapeutics are well characterised as poisons of topoisomerase II, however many anthracyclines, including doxo..

M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe

Benny J Evison, Mile Pastuovic, Rebecca A Bilardi, Robert A Forrest, Paul P Pumuye, Brad E Sleebs, Keith G Watson, Don R Phillips, Suzanne M Cutts

Journal article  |  2011  |  BIOCHEMICAL PHARMACOLOGY

Pixantrone is a promising anti-cancer aza-anthracenedione that has prompted the development of new anthracenediones incorporating ..

New Anthracenedione Derivatives with Improved Biological Activity by Virtue of Stable Drug-DNA Adduct Formation

Oula C Mansour, Benny J Evison, Brad E Sleebs, Keith G Watson, Abraham Nudelman, Ada Rephaeli, Damian P Buck, J Grant Collins, Rebecca A Bilardi, Don R Phillips, Suzanne M Cutts

Journal article  |  2010  |  JOURNAL OF MEDICINAL CHEMISTRY

Mitoxantrone is an anticancer agent that acts as a topoisomerase II poison, however, it can also be activated by formaldehyde to f..

Drug-DNA adducts formed by formaldehyde activation of anthracyclines and related anti-cancer agents

DR Phillips, L Swift, K Coldwell, D Spencer, R Bilardi, B Evison, O Mansour, A Nudelman, A Rephaeli, TH Koch, SM Cutts

Book Chapter  |  2010