Karl-Johan Leuchowius

Colorectal Cancer Cell Line Proteomes Are Representative of Primary Tumors and Predict Drug Sensitivity

Jing Wang, Dmitri Mouradov, Xiaojing Wang, Robert N Jorissen, Matthew C Chambers, Lisa J Zimmerman, Suhas Vasaikar, Christopher G Love, Shan Li, Kym Lowes, Karl-Johan Leuchowius, Helene Jousset, Janet Weinstock, Christopher Yau, John Mariadason, Zhiao Shi, Yuguan Ban, Xi Chen, Robert JC Coffey, Robbert JC Slebos, et al.

Journal article  |  2017  |  GASTROENTEROLOGY

BACKGROUND AND AIMS: Proteomics holds promise for individualizing cancer treatment. We analyzed to what extent the proteomic lands..

Protein Diagnostics by Proximity Ligation: Combining Multiple Recognition and DNA Amplification for Improved Protein Analyses

G Cane, KJ Leuchowius, O Söderberg, M Kamali-Moghaddam, M Jarvius, I Helbing, K Pardali, B Koos, T Ebai, U Landegren

Book Chapter  |  2017

Proximity ligation assay (PLA) is a unique method in which single-stranded oligonucleotides are conjugated to affinity binders of ..

Chapter 12 Protein Diagnostics by Proximity Ligation Combining Multiple Recognition and DNA Amplification for Improved Protein Analyses

G Cane, K-J Leuchowius, O Söderberg, M Kamali-Moghaddam, M Jarvius, I Helbing, K Pardali, B Koos, T Ebai, U Landegren

Book Chapter  |  2017

Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson

Journal article  |  2015  |  Cell Communication and Signaling

INTRODUCTION: The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastat..

A Perspective on 10-Years HTS Experience at the Walter and Eliza Hall Institute of Medical Research - Eighteen Million Assays and Counting

Kurt Lackovic, Guillaume Lessene, Hendrik Falk, Karl-Johan Leuchowius, Jonathan Baell, Ian Street

Journal article  |  2014  |  COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

The Walter and Eliza Hall Institute of Medical Research (WEHI) is Australia's longest serving medical research institute. WEHI's H..

Parallel visualization of multiple protein complexes in individual cells in tumor tissue.

Karl-Johan Leuchowius, Carl-Magnus Clausson, Karin Grannas, Yücel Erbilgin, Johan Botling, Agata Zieba, Ulf Landegren, Ola Söderberg

Journal article  |  2013  |  Mol Cell Proteomics

Cellular functions are regulated and executed by complex protein interaction networks. Accordingly, it is essential to understand ..

In situ proximity ligation assay for microscopy and flow cytometry.

Karl-Johan Leuchowius, Irene Weibrecht, Ola Söderberg

Journal article  |  2011  |  Curr Protoc Cytom

The ability to study proteins and protein interactions inside cells and tissues is important for elucidating how cells function in..

In situ proximity ligation assay for microscopy and flow cytometry

KJ Leuchowius, I Weibrecht, O Söderberg

Journal article  |  2011  |  Current Protocols in Cytometry

The ability to study proteins and protein interactions inside cells and tissues is important for elucidating how cells function in..

Proximity ligation assays: a recent addition to the proteomics toolbox.

Irene Weibrecht, Karl-Johan Leuchowius, Carl-Magnus Clausson, Tim Conze, Malin Jarvius, W Mathias Howell, Masood Kamali-Moghaddam, Ola Söderberg

Journal article  |  2010  |  Expert Rev Proteomics

An essential skill for every researcher is to learn how to select and apply the most appropriate methods for the questions they ar..

Chapter 20 Protein Diagnostics by Proximity Ligation Combining Multiple Recognition and DNA Amplification for Improved Protein Analyses

Karl-Johan Leuchowius, Ola Söderberg, Masood Kamali-Moghaddam, Malin Jarvius, Irene Weibrecht, Katerina Pardali, Ulf Landegren

Book Chapter  |  2010