Matthew Call

T cell and B cell antigen receptors share a conserved core transmembrane structure

Samyuktha Ramesh, Soohyung Park, Wonpil Im, Melissa J Call, Matthew E Call

Journal article  |  2022  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The B cell and T cell antigen receptors (BCR and TCR) share a common architecture in which variable dimeric antigen-binding module..

De novo-designed transmembrane domains tune engineered receptor functions

Assaf Elazar, Nicholas J Chandler, Ashleigh S Davey, Jonathan Y Weinstein, Julie Nguyen, Raphael Trenker, Ryan S Cross, Misty R Jenkins, Melissa J Call, Matthew E Call, Sarel J Fleishman

Journal article  |  2022  |  ELIFE

De novo-designed receptor transmembrane domains (TMDs) present opportunities for precise control of cellular receptor functions. W..

Human and viral membrane-associated E3 ubiquitin ligases MARCH1 and MIR2 recognize different features of CD86 to downregulate surface expression

Raphael Trenker, Xinyu Wu, Julie Nguyen, Stephen Wilcox, Alan F Rubin, Matthew E Call, Melissa J Call

Journal article  |  2021  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Immune-stimulatory ligands, such as major histocompatibility complex molecules and the T-cell costimulatory ligand CD86, are centr..

The Influence of Chimeric Antigen Receptor Structural Domains on Clinical Outcomes and Associated Toxicities

Ashleigh S Davey, Matthew E Call, Melissa J Call

Journal article  |  2021  |  CANCERS

Chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment of B cell malignancies, improving patient survival an..

Experimentally Guided Computational Methods Yield Highly Accurate Insights into Transmembrane Interactions within the T Cell Receptor Complex

Samyuktha Ramesh, Soohyung Park, Melissa J Call, Wonpil Im, Matthew E Call

Journal article  |  2020  |  JOURNAL OF PHYSICAL CHEMISTRY B

Understanding how molecular interactions within the plasma membrane govern assembly, clustering, and conformational changes in sin..

T Cell Activation Machinery: Form and Function in Natural and Engineered Immune Receptors

Nicholas J Chandler, Melissa J Call, Matthew E Call

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The impressive success of chimeric antigen receptor (CAR)-T cell therapies in treating advanced B-cell malignancies has spurred a ..

Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning

Jessica L Bridgford, Su Min Lee, Christine MM Lee, Paola Guglielmelli, Elisa Rumi, Daniela Pietra, Stephen Wilcox, Yash Chhabra, Alan F Rubin, Mario Cazzola, Alessandro M Vannucchi, Andrew J Brooks, Matthew E Call, Melissa J Call

Journal article  |  2020  |  BLOOD

The single transmembrane domain (TMD) of the human thrombopoietin receptor (TpoR/myeloproliferative leukemia [MPL] protein), encod..

THE MECHANISM OF ONCOGENIC MUTATIONS IN THE JUXTAMEMBRANE AND TRANSMEMBRANE REGION OF IL7RA AND TPOR/MPL

Andrew Brooks, Livia Campos, Christine Lee, Yash Chhabra, Jessica Bridgford, Su Min Lee, Priscila Zenatti, Leonardo Pissinato, Gisele Rodrigues, Leonardo Artico, Thais Guimaraes, Leticia Archangelo, Leandro Martinez, Christopher Slape, Matthew Call, Melissa Call, Jose Yunes

Journal article  |  2019  |  EXPERIMENTAL HEMATOLOGY

Protein-Eye View of the in Meso Crystallization Mechanism

Leonie van't Ha, Liliana de Campo, Nhiem Tran, Anna Sokolova, Raphael Trenker, Matthew E Call, Melissa J Call, Christopher J Garvey, Anna E Leung, Tamim A Darwish, Anwen Krause-Heuer, Robert Knott, Thomas G Meikle, Calum J Drummond, Raffaele Mezzenga, Charlotte E Conn

Journal article  |  2019  |  LANGMUIR

For evolving biological and biomedical applications of hybrid protein?lipid materials, understanding the behavior of the protein w..

A serine in the first transmembrane domain of the human E3 ubiquitin ligase MARCH9 is critical for down-regulation of its protein substrates

Cyrus Tan, Eamon FX Byrne, Casey Ah-Cann, Melissa J Call, Matthew E Call

Journal article  |  2019  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The membrane-associated RING-CH (MARCH) family of membrane-bound E3 ubiquitin ligases regulates the levels of cell-surface membran..