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Dr

Melissa Call

Honorary
Medical Biology (W.E.H.I.)
Membrane proteins
Lymphocytes
NMR
Crystallography
science & technology
humans
animals
life sciences & biomedicine
models, molecular
Melissa Call's Profile Picture
Dr

Melissa Call

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Structural Immunology
Melissa Call's Profile Picture
Dr

Melissa Call

 

My research group has a long-standing interest in how molecular encounters outside the cell are translated into intracellular biochemical signals that direct immune responses.

The now-classic example of peptide:MHC complexes binding to the T cell antigen receptor (TCR) to activate T cells has been a major focus in previous work.

While the structural determinants of MHC/TCR binding, and the construction of the TCR complex are becoming better understood, the mechanism by which receptor engagement outside the cell is sensed by signaling molecules inside the cell is still an open question.

The new challenge is to understand the forces and motions linking the receptor-ligand encounter to the initiation of an intracellular biochemical signal through receptors for antigens, chemokines and other molecular cues.

I have a particular focus on how the structure and dynamics of membrane-embedded receptor domains contribute to the function of immune-signaling complexes. These portions of proteins are not mere anchors for soluble domains, but in fact provide a unique platform for protein function. They also represent the only direct physical link between ligand-binding and signaling domains across the cellular membrane.

My lab combines biochemical and biophysical methods (both X-ray crystallography and solution NMR) with expertise in cellular and molecular immunology to study the mechanics of transmembrane signaling in the immune system.

We aim to understand both how ligand binding is mechanically communicated across the lipid bilayer and how the unique physical and chemical characteristics of the membrane environment contribute to and regulate these functions.

www.wehi.edu.au/people/melissa-call

Scholarly Works

Displaying the 32 most recent scholarly works by Melissa Call.

Honours, Awards and Fellowships

2012


1

Award

Credentials

Positions

Positions


Honorary

Medical Biology (W.E.H.I.)

Education

Education


PhD in Molecular Medicine

University of Auckland

MSc in Medical Science

University of Auckland

BSc in Biological Sciences

University of Auckland

Links

Links