Jacqueline Gulbis

An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration.

Agalya Periasamy, Naomi Mitchell, Olga Zaytseva, Arjun S Chahal, Jiamin Zhao, Peter M Colman, Leonie M Quinn, Jacqueline M Gulbis

Journal article  |  2022  |  Sci Rep

Intronic polymorphic TOMM40 variants increasing TOMM40 mRNA expression are strongly correlated to late onset Alzheimer's Disease. ..

The suppressor of copper sensitivity protein C from Caulobacter crescentus is a trimeric disulfide isomerase that binds copper(I) with subpicomolar affinity

Guillaume A Petit, Yaoqin Hong, Karrera Y Djoko, Andrew E Whitten, Emily J Furlong, Airlie J McCoy, Jacqueline M Gulbis, Makrina Totsika, Jennifer L Martin, Maria A Halili

Journal article  |  2022  |  ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY

The introduction of disulfide bonds into periplasmic proteins is a critical process in many Gram-negative bacteria. The formation ..

Ion currents through Kir potassium channels are gated by anionic lipids

Ruitao Jin, Sitong He, Katrina A Black, Oliver B Clarke, Di Wu, Jani R Bolla, Paul Johnson, Agalya Periasamy, Ahmad Wardak, Peter Czabotar, Peter M Colman, Carol Robinson, Derek Laver, Brian J Smith, Jacqueline M Gulbis

Journal article  |  2022  |  NATURE COMMUNICATIONS

Ion currents through potassium channels are gated. Constriction of the ion conduction pathway at the inner helix bundle, the textb..

Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum

Silvia Haase, Melanie Condron, David Miller, Dounia Cherkaoui, Sarah Jordan, Jacqueline M Gulbis, Jake Baum

Journal article  |  2021  |  MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Recent studies highlight the emerging role of lipids as important messengers in malaria parasite biology. In an attempt to identif..

BAK core dimers bind lipids and can be bridged by them

Angus D Cowan, Nicholas A Smith, Jarrod J Sandow, Eugene A Kapp, Yepy H Rustam, James M Murphy, Jason M Brouwer, Jonathan P Bernardini, Michael J Roy, Ahmad Z Wardak, Iris K Tan, Andrew I Webb, Jacqueline M Gulbis, Brian J Smith, Gavin E Reid, Grant Dewson, Peter M Colman, Peter E Czabotar

Journal article  |  2020  |  NATURE STRUCTURAL & MOLECULAR BIOLOGY

BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of t..

A constricted opening in Kir channels does not impede potassium conduction

Katrina A Black, Sitong He, Ruitao Jin, David M Miller, Jani R Bolla, Oliver B Clarke, Paul Johnson, Monique Windley, Christopher J Burns, Adam P Hill, Derek Laver, Carol Robinson, Brian J Smith, Jacqueline M Gulbis

Journal article  |  2020  |  NATURE COMMUNICATIONS

The canonical mechanistic model explaining potassium channel gating is of a conformational change that alternately dilates and con..

Changing perspectives on how the permeation pathway through potassium channels is regulated

Katrina A Black, Ruitao Jin, Sitong He, Jacqueline M Gulbis

Journal article  |  2019  |  JOURNAL OF PHYSIOLOGY-LONDON

The primary means by which ion permeation through potassium channels is controlled, and the key to selective intervention in a ran..

Editorial overview: Membranes

Jacqueline M Gulbis, Gabriel Waksman

Journal article  |  2016  |  CURRENT OPINION IN STRUCTURAL BIOLOGY

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

S Iyer, F Bell, D Westphal, K Anwari, J Gulbis, BJ Smith, G Dewson, RM Kluck

Journal article  |  2015  |  CELL DEATH AND DIFFERENTIATION

Bak and Bax mediate apoptotic cell death by oligomerizing and forming a pore in the mitochondrial outer membrane. Both proteins an..

Engineering protocells: prospects for self-assembly and nanoscale production-lines.

David M Miller, Jacqueline M Gulbis

Journal article  |  2015  |  Life (Basel)

The increasing ease of producing nucleic acids and proteins to specification offers potential for design and fabrication of artifi..