Jacqueline Gulbis

Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum

Silvia Haase, Melanie Condron, David Miller, Dounia Cherkaoui, Sarah Jordan, Jacqueline M Gulbis, Jake Baum

Journal article  |  2021  |  MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Recent studies highlight the emerging role of lipids as important messengers in malaria parasite biology. In an attempt to identif..

BAK core dimers bind lipids and can be bridged by them

Angus D Cowan, Nicholas A Smith, Jarrod J Sandow, Eugene A Kapp, Yepy H Rustam, James M Murphy, Jason M Brouwer, Jonathan P Bernardini, Michael J Roy, Ahmad Z Wardak, Iris K Tan, Andrew I Webb, Jacqueline M Gulbis, Brian J Smith, Gavin E Reid, Grant Dewson, Peter M Colman, Peter E Czabotar

Journal article  |  2020  |  NATURE STRUCTURAL & MOLECULAR BIOLOGY

BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of t..

A constricted opening in Kir channels does not impede potassium conduction

Katrina A Black, Sitong He, Ruitao Jin, David M Miller, Jani R Bolla, Oliver B Clarke, Paul Johnson, Monique Windley, Christopher J Burns, Adam P Hill, Derek Laver, Carol Robinson, Brian J Smith, Jacqueline M Gulbis

Journal article  |  2020  |  NATURE COMMUNICATIONS

The canonical mechanistic model explaining potassium channel gating is of a conformational change that alternately dilates and con..

Changing perspectives on how the permeation pathway through potassium channels is regulated

Katrina A Black, Ruitao Jin, Sitong He, Jacqueline M Gulbis

Journal article  |  2019  |  JOURNAL OF PHYSIOLOGY-LONDON

The primary means by which ion permeation through potassium channels is controlled, and the key to selective intervention in a ran..

Editorial overview: Membranes

Jacqueline M Gulbis, Gabriel Waksman

Journal article  |  2016  |  CURRENT OPINION IN STRUCTURAL BIOLOGY

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains

S Iyer, F Bell, D Westphal, K Anwari, J Gulbis, BJ Smith, G Dewson, RM Kluck

Journal article  |  2015  |  CELL DEATH AND DIFFERENTIATION

Bak and Bax mediate apoptotic cell death by oligomerizing and forming a pore in the mitochondrial outer membrane. Both proteins an..

Engineering protocells: prospects for self-assembly and nanoscale production-lines.

David M Miller, Jacqueline M Gulbis

Journal article  |  2015  |  Life (Basel)

The increasing ease of producing nucleic acids and proteins to specification offers potential for design and fabrication of artifi..

Structure and function of LGR5: An enigmatic G-protein coupled receptor marking stem cells

Kaavya Krishna Kumar, Antony W Burgess, Jacqueline M Gulbis

Journal article  |  2014  |  PROTEIN SCIENCE

G-protein coupled receptors (GPCRs) are an important class of membrane protein that transmit extracellular signals invoked by sens..

Potassium

David M Miller, Jacqueline M Gulbis

Journal article  |  2014  |  BINDING, TRANSPORT AND STORAGE OF METAL IONS IN BIOLOGICAL CELLS

Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function

Pedro Eitz Ferrer, Paul Frederick, Jacqueline M Gulbis, Grant Dewson, Ruth M Kluck

Journal article  |  2012  |  PLOS ONE

BACKGROUND: One of two proapoptotic Bcl-2 proteins, Bak or Bax, is required to permeabilize the mitochondrial outer membrane durin..