Sandy Shultz

Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?

Tamara L Baker, Mujun Sun, Bridgette D Semple, Shiraz Tyebji, Christopher J Tonkin, Richelle Mychasiuk, Sandy R Shultz

Journal article  |  2020  |  Journal of Neuroinflammation

Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality worldwide; however, treatment development is ..

Experimental traumatic brain injury does not lead to lung infection

Mujun Sun, Rhys D Brady, Brooke Wanrooy, Richelle Mychasiuk, Glenn R Yamakawa, Pablo M Casillas-Espinosa, Connie HY Wong, Sandy R Shultz, Stuart J McDonald

Journal article  |  2020  |  Journal of Neuroimmunology

Traumatic brain injury (TBI) patients often experience post-traumatic infections, especially in the lung. Pulmonary infection is a..

Examining the Effects of Anabolic-Androgenic Steroids on Repetitive Mild Traumatic Brain Injury (RmTBI) Outcomes in Adolescent Rats

Jason Tabor, David K Wright, Jennaya Christensen, Akram Zamani, Reid Collins, Sandy R Shultz, Richelle Mychasiuk

Journal article  |  2020  |  Brain Sciences

Background: Repetitive mild traumatic brain injury (RmTBI) is increasingly common in adolescents. Anabolic–androgenic steroid (AAS..

Repetitive Mild Traumatic Brain Injury Alters Glymphatic Clearance Rates in Limbic Structures of Adolescent Female Rats.

Jennaya Christensen, David K Wright, Glenn R Yamakawa, Sandy R Shultz, Richelle Mychasiuk

Journal article  |  2020  |  Scientific Reports

The glymphatic system is the macroscopic waste clearance system for the central nervous system. Glymphatic dysfunction has been li..

The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

William T O'Brien, Louise Pham, Georgia F Symons, Mastura Monif, Sandy R Shultz, Stuart J McDonald

Journal article  |  2020  |  Journal of Neuroinflammation

There is a great clinical need to identify the underlying mechanisms, as well as related biomarkers, and treatment targets, for tr..

A novel rat model of heterotopic ossification after polytrauma with traumatic brain injury

Rhys D Brady, Michael Z Zhao, Ker R Wong, Pablo M Casilla-Espinosa, Glenn R Yamakawa, Ryan C Wortman, Mujun Sun, Brian L Grills, Richelle Mychasiuk, Terence J O'Brien, Denes Agoston, Peter VS Lee, Stuart J McDonald, Dale L Robinson, Sandy R Shultz

Journal article  |  2020  |  Bone

Neurological heterotopic ossification (NHO) is characterized by abnormal bone growth in soft tissue and joints in response to inju..

The Neurological Consequences of Engaging in Australian Collision Sports

Georgia F Symons, Meaghan Clough, Joanne Fielding, William T O'Brien, Claire E Shepherd, David K Wright, Sandy R Shultz

Journal article  |  2020  |  Journal of Neurotrauma

Collision sports are an integral part of Australian culture. The most common collision sports in Australia are Australian rules fo..

Beyond the Brain: Peripheral Interactions after Traumatic Brain Injury

Stuart J McDonald, Jessica M Sharkey, Mujun Sun, Lola M Kaukas, Sandy R Shultz, Renee J Turner, Anna Leonard, Rhys D Brady, Frances Corrigan

Journal article  |  2020  |  Journal of Neurotrauma

Traumatic brain injury (TBI) is a leading cause of death and disability, and there are currently no pharmacological treatments kno..

The need to incorporate aged animals into the preclinical modeling of neurological conditions

Mujun Sun, Stuart J McDonald, Rhys D Brady, Lyndsey Collins-Praino, Glenn R Yamakawa, Mastura Monif, Terence J O'Brien, Geoffrey C Cloud, Christopher G Sobey, Richelle Mychasiuk, David J Loane, Sandy R Shultz

Journal article  |  2020  |  Neuroscience & Biobehavioral Reviews

Neurological conditions such as traumatic brain injury, stroke, Parkinson's disease, epilepsy, multiple sclerosis, and Alzheimer's..

Chronic traumatic encephalopathy neuropathology might not be inexorably progressive or unique to repetitive neurotrauma

Grant L Iverson, Andrew J Gardner, Sandy R Shultz, Gary S Solomon, Paul McCrory, Ross Zafonte, George Perry, Lili-Naz Hazrati, C Dirk Keene, Rudolph J Castellani

Journal article  |  2019  |  Brain

Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy

Pablo M Casillas-Espinosa, Sandy R Shultz, Emma L Braine, Nigel C Jones, Terrance P Snutch, Kim L Powell, Terence J O'Brien

Journal article  |  2019  |  Progress in Neurobiology

We evaluated whether pharmacologically targeting T-type Ca2+ channels with Z944, a potent and selective antagonist, has disease-mo..

Bone Health in Rats With Temporal Lobe Epilepsy in the Absence of Anti-Epileptic Drugs

Rhys D Brady, Ker Rui Wong, Dale L Robinson, Richelle Mychasiuk, Stuart J McDonald, Ryan A D'Cunha, Glenn R Yamakawa, Mujun Sun, John D Wark, Peter Vee Sin Lee, Terence J O'Brien, Pablo M Casillas-Espinosa, Sandy R Shultz

Journal article  |  2019  |  Frontiers in Pharmacology

Rationale: Epilepsy patients often exhibit reduced bone mineral density and are at an increased risk of bone fracture. Whether the..

Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat

David K Wright, Rhys D Brady, Alaa Kamnaksh, Jack Trezise, Mujun Sun, Stuart J McDonald, Richelle Mychasiuk, Scott C Kolbe, Meng Law, Leigh A Johnston, Terence J O'Brien, Denes V Agoston, Sandy R Shultz

Journal article  |  2019  |  Scientific Reports

A single mild traumatic brain injury (mTBI) typically causes only transient symptoms, but repeated mTBI (RmTBI) is associated with..

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis

Cesar Santana-Gomez, Pedro Andrade, Matthew R Hudson, Tomi Paananen, Robert Ciszek, Gregory Smith, Idrish Ali, Brian K Rundle, Xavier Ekolle Ndode-Ekane, Pablo M Casillas-Espinosa, Riikka Immonen, Noora Puhakka, Nigel Jones, Rhys D Brady, Piero Perucca, Sandy R Shultz, Asia Pitkanen, Terence J O'Brien, Richard Staba

Journal article  |  2019  |  Epilepsy Research

Studies of chronic epilepsy show pathological high frequency oscillations (HFOs) are associated with brain areas capable of genera..

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

Kyria M Webster, Sandy R Shultz, Ezgi Ozturk, Larissa K Dill, Mujun Sun, Pablo Casillas-Espinosa, Nigel C Jones, Peter J Crack, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  Experimental Neurology

High mobility group box protein-1 (HMGB1) has been implicated as a key mediator of neuroinflammation and neurodegeneration in a ra..

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

Pablo M Casillas-Espinosa, Pedro Andrade, Cesar Santana-Gomez, Tomi Paananen, Gregory Smith, Idrish Ali, Robert Ciszek, Xavier Ekolle Ndode-Ekane, Rhys D Brady, Jussi Tohka, Matthew R Hudson, Piero Perucca, Emma L Braine, Riikka Immonen, Noora Puhakka, Sandy R Shultz, Nigel C Jones, Richard J Staba, Asia Pitkanen, Terence J O'Brien

Journal article  |  2019  |  Epilepsy Research

RATIONALE: The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Centre without walls is an NIH funded mult..

The genetic ablation of tau improves long-term, but not short-term, functional outcomes after experimental traumatic brain injury in mice

Xin Lin Tan, Ping Zheng, David K Wright, Mujun Sun, Rhys D Brady, Shijie Liu, Stuart J McDonald, Richelle Mychasiuk, Sitare Cenap, Nigel C Jones, Terence J O'Brien, Sandy R Shultz

Journal article  |  2019  |  Brain Injury

Inhibitory neuronal changes following a mixed diffuse-focal model of traumatic brain injury

Simone F Carron, Mujun Sun, Sandy R Shultz, Ramesh Rajan

Journal article  |  2019  |  Journal of Comparative Neurology

Aged rats have an altered immune response and worse outcomes after traumatic brain injury

Mujun Sun, Rhys D Brady, Pablo M Casillas-Espinosa, David K Wright, Bridgette D Semple, Hyun Ah Kim, Richelle Mychasiuk, Christopher G Sobey, Terence J O'Brien, Antony Vinh, Stuart J McDonald, Sandy R Shultz

Journal article  |  2019  |  Brain, Behavior, and Immunity

Infections after a traumatic brain injury: The complex interplay between the immune and neurological systems

Rishabh Sharma, Sandy R Shultz, Marcus J Robinson, Antonio Belli, Margaret L Hibbs, Terence J O'Brien, Bridgette D Semple

Journal article  |  2019  |  Brain, Behavior, and Immunity

Inflammation in Traumatic Brain Injury: Roles for Toxic A1 Astrocytes and Microglial-Astrocytic Crosstalk

David PQ Clark, Victoria M Perreau, Sandy R Shultz, Rhys D Brady, Enie Lei, Shilpi Dixit, Juliet M Taylor, Philip M Beart, Wah Chin Boon

Journal article  |  2019  |  Neurochemical Research

The Clinical Relevance of Behavior Testing in Animal Models of Traumatic Brain Injury

Sandy R Shultz, Stuart J McDonald, Frances Corrigan, Bridgette D Semple, Sabrina Salberg, Akram Zamani, Nigel C Jones, Richelle Mychasiuk

Journal article  |  2019  |  Journal of Neurotrauma

Neuroendocrine Whiplash: Slamming the Breaks on Anabolic-Androgenic Steroids Following Repetitive Mild Traumatic Brain Injury in Rats May Worsen Outcomes

Jason Tabor, Reid Collins, Chantel T Debert, Sandy R Shultz, Richelle Mychasiuk

Journal article  |  2019  |  Frontiers in Neurology

Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice

Kyria M Webster, Mujun Sun, Peter J Crack, Terence J O'Brien, Sandy R Shultz, Bridgette D Semple

Journal article  |  2019  |  Journal of Comparative Neurology

Mild Closed-Head Injury in Conscious Rats Causes Transient Neurobehavioral and Glial Disturbances: A Novel Experimental Model of Concussion

Louise Pham, Sandy R Shultz, Hyun Ah Kim, Rhys D Brady, Ryan C Wortman, Shannyn G Genders, Matthew W Hale, Ross D O'Shea, Elvan Djouma, Maarten van den Buuse, Jarrod E Church, Brian R Christie, Grant R Drummond, Christopher G Sobey, Stuart J McDonald

Journal article  |  2019  |  Journal of Neurotrauma

Modelling traumatic brain injury and posttraumatic epilepsy in rodents

Rhys D Brady, Pablo M Casillas-Espinosa, Denes V Agoston, Edward H Bertram, Alaa Kamnaksh, Bridgette D Semple, Sandy R Shultz

Journal article  |  2019  |  Neurobiology of Disease

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Xavier Ekolle Ndode-Ekane, Cesar Santana-Gomez, Pablo M Casillas-Espinosa, Idrish Ali, Rhys D Brady, Gregory Smith, Pedro Andrade, Riikka Immonen, Noora Puhakka, Matthew R Hudson, Emma L Braine, Sandy R Shultz, Richard J Staba, Terence J O'Brien, Asla Pitkanen

Journal article  |  2019  |  Epilepsy Research

Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

Bridgette D Semple, Akram Zamani, Genevieve Rayner, Sandy R Shultz, Nigel C Jones

Journal article  |  2019  |  Neurobiology of Disease

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Paul M Vespa, Vikesh Shrestha, Nicholas Abend, Denes Agoston, Alicia Au, Michael J Bell, Thomas P Bleck, Manuel Buitrago Blanco, Jan Claassen, Ramon Diaz-Arrastia, Dominique Duncan, Ben Ellingson, Brandon Foreman, Emily J Gilmore, Lawrence Hirsch, Martin Hunn, Alaa Kamnaksh, David McArthur, Andrew Morokoff, Terrence O'Brien, et al.

Journal article  |  2019  |  Neurobiology of Disease

Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study

Meral A Tubiv, Evan Lutkenhof, Manuel Buitrago Blanco, David McArthur, Pablo Villablanca, Benjamin Ellingson, Ramon Diaz-Arrastia, Paul Van Ness, Courtney Real, Vikesh Shrestha, Jerome Engel, Paul M Vespa, Denes Agoston, Alicia Au, Michael J Bell, Tom Bleck, Craig Branch, Manuel Buitrago Blanco, Ross Bullock, Brian T Burrows, et al.

Journal article  |  2019  |  Neurobiology of Disease

Targeting neurodegeneration to prevent post-traumatic epilepsy

Idrish Ali, Juliana C Silva, Shijie Liu, Sandy R Shultz, Patrick Kwan, Nigel C Jones, Terence J O'Brien

Journal article  |  2019  |  Neurobiology of Disease

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Riikka Immonen, Gregory Smith, Rhys D Brady, David Wright, Leigh Johnston, Neil G Harris, Eppu Manninen, Raimo Salo, Craig Branch, Dominique Duncan, Ryan Cabeen, Xavier Ekolle Ndode-Ekane, Cesar Santana Gomez, Pablo M Casillas-Espinosa, Idrish Ali, Sandy R Shultz, Pedro Andrade, Noora Puhakka, Richard J Staba, Terence J O'Brien, et al.

Journal article  |  2019  |  Epilepsy Research

Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Robert Ciszek, Xavier Ekolle Ndode-Ekane, Cesar Santana Gomez, Pablo M Casillas-Espinosa, Idrish Ali, Gregory Smith, Noora Puhakka, Niina Lapinlampi, Pedro Andrade, Alaa Kamnaksh, Riikka Immonen, Tomi Paananen, Matthew R Hudson, Rhys D Brady, Sandy R Shultz, Terence J O'Brien, Richard J Staba, Jussi Tohka, Asla Pitkanen

Journal article  |  2019  |  Epilepsy Research

Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis

Alaa Kamnaksh, Noora Puhakka, Idrish Ali, Gregory Smith, Roxanne Aniceto, Jesse McCullough, Shalini Das Gupta, Xavier Ekolle Ndode-Ekane, Rhys Brady, Pablo Casillas-Espinosa, Matt Hudson, Cesar Santana-Gomez, Riikka Immonen, Pedro Andrade de Abreu, Nigel Jones, Sandy Shultz, Richard J Staba, Terence J O'Brien, Denes Agoston, Asia Pitkanen

Journal article  |  2019  |  Epilepsy Research

Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury

Xin Lin Tan, Mujun Sun, Rhys D Brady, Shijie Liu, Roxana Llanos, Steve Cheung, David K Wright, Pablo M Casillas-Espinosa, Maithili Sashindranath, Terence J O'Brien, Stuart J McDonald, Bradley J Turner, Sandy R Shultz

Journal article  |  2019  |  Journal of Neurotrauma

Clinically Relevant Outcome Measures for Experimental Traumatic Brain Injury (TBI) Studies

DV Agoston, J McCullough, R Aniceto, A Kamnaksh, DK Wright, SR Shultz

Book Chapter  |  2019  |  Neuromethods

A Concomitant Muscle Injury Does Not Worsen Traumatic Brain Injury Outcomes in Mice

Mujun Sun, Rhys D Brady, Chris van der Poel, Danielle Apted, Bridgette D Semple, Jarrod E Church, Terence J O'Brien, Stuart J McDonald, Sandy R Shultz

Journal article  |  2018  |  Frontiers in Neurology

Pre-Clinical Testing of Therapies for Traumatic Brain Injury

Douglas S DeWitt, Bridget E Hawkins, C Edward Dixon, Patrick M Kochanek, William Armstead, Cameron R Bass, Helen M Bramlett, Andras Buki, W Dalton Dietrich, Adam R Ferguson, Edward D Hall, Ronald L Hayes, Sidney R Hinds, Michelle C LaPlaca, Joseph B Long, David F Meaney, Stefania Mondello, Linda J Noble-Haeusslein, Samuel M Poloyac, Donald S Prough, et al.

Journal article  |  2018  |  Journal of Neurotrauma

Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury

Ryan C Wortman, Alicia Meconi, Katie J Neale, Rhys D Brady, Stuart J McDonald, Brian R Christie, David K Wright, Sandy R Shultz

Journal article  |  2018  |  Annals of Clinical and Translational Neurology

Elimination of vesicular zinc alters the behavioural and neuroanatomical effects of social defeat stress in mice

Brendan B McAllister, David K Wright, Ryan C Wortman, Sandy R Shultz, Richard H Dyck

Journal article  |  2018  |  Neurobiology of Stress

Concussion incidence in amateur Australian Rules Footballers

Daniel M Costello, Joel Ernest, Andrew H Kaye, Terence J O'Brien, Sandy R Shultz

Journal article  |  2018  |  Journal of Clinical Neuroscience

Sport related concussion - Potential for biomarkers to improve acute management

Daniel M Costello, Andrew H Kaye, Terence J O'Brien, Sandy R Shultz

Journal article  |  2018  |  Journal of Clinical Neuroscience

Elimination of Vesicular Zinc Alters the Behavioural and Neuroanatomical Effects of Social Defeat Stress in Mice

Brendan McAllister, David Wright, Ryan Wortman, Sandy Shultz, Richard Dyck

Journal article  |  2018

ABSTRACT Chronic stress can have deleterious effects on mental health, increasing the risk of developing depression or anxiety. Bu..

Mild Traumatic Brain Injury in Adolescent Mice Alters Skull Bone Properties to Influence a Subsequent Brain Impact at Adulthood: A Pilot Study

Thomas J McColl, Rhys D Brady, Sandy R Shultz, Lauren Lovick, Kyria M Webster, Mujun Sun, Stuart J McDonald, Terence J O'Brien, Bridgette D Semple

Journal article  |  2018  |  Frontiers in Neurology

Repeated mild traumatic brain injury can cause acute neurologic impairment without overt structural damage in juvenile rats

Alicia Meconi, Ryan C Wortman, David K Wright, Katie J Neale, Melissa Clarkson, Sandy R Shultz, Brian R Christie

Journal article  |  2018  |  PLOS ONE

Neurological heterotopic ossification: Current understanding and future directions

Rhys D Brady, Sandy R Shultz, Stuart J McDonald, Terence J O'Brien

Journal article  |  2018  |  Bone

The influence of immunological stressors on traumatic brain injury

Mujun Sun, Stuart J McDonald, Rhys D Brady, Terence J O'Brien, Sandy R Shultz

Journal article  |  2018  |  Brain, Behavior, and Immunity

Oculomotor Cognitive Control Abnormalities in Australian Rules Football Players with a History of Concussion

Meaghan Clough, Steven Mutimer, David K Wright, Adrian Tsang, Daniel M Costello, Andrew J Gardner, Peter Stanwell, Richelle Mychasiuk, Mujun Sun, Rhys D Brady, Stuart J McDonald, Kyria M Webster, Maddison R Johnstone, Bridgette D Semple, Denes V Agoston, Owen B White, Richard Frayne, Joanne Fielding, Terence J O'Brien, Sandy R Shultz

Journal article  |  2018  |  Journal of Neurotrauma

Telomere length and advanced diffusion MRI as biomarkers for repetitive mild traumatic brain injury in adolescent rats

David K Wright, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz

Journal article  |  2018  |  NeuroImage: Clinical

Gambogic amide, a selective TrkA agonist, does not improve outcomes from traumatic brain injury in mice

Maddison R Johnstone, Mujun Sun, Caroline J Taylor, Rhys D Brady, Brian L Grills, Jarrod E Church, Sandy R Shultz, Stuart J McDonald

Journal article  |  2018  |  Brain Injury

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Mujun Sun, Rhys D Brady, David K Wright, Hyun Ah Kim, Shenpeng R Zhang, Christopher G Sobey, Maddison R Johnstone, Terence J O'Brien, Bridgette D Semple, Stuart J McDonald, Sandy R Shultz

Journal article  |  2017  |  Brain, Behavior, and Immunity

Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice

Shijie Liu, Yu Shen, Sandy R Shultz, Nguyen Anne, Christopher Hovens, Paul A Adlard, Ashley I Bush, Jianxiong Chan, Patrick Kwan, Terence J O'Brien, Nigel C Jones

Journal article  |  2017  |  EPILEPSIA

Sex matters: repetitive mild traumatic brain injury in adolescent rats

David K Wright, Terence J O'Brien, Sandy R Shultz, Richelle Mychasiuk

Journal article  |  2017  |  Annals of Clinical and Translational Neurology

Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease

David K Wright, Shijie Liu, Chris van der Poel, Stuart J McDonald, Rhys D Brady, Lily Taylor, Li Yang, Andrew J Gardner, Roger Ordidge, Terence J O'Brien, Leigh A Johnston, Sandy R Shultz

Journal article  |  2017  |  Cerebral Cortex

Differences in white matter structure between seizure prone (FAST) and seizure resistant (SLOW) rat strains

Pragati Sharma, David K Wright, Leigh A Johnston, Kim L Powell, Mary E Wlodek, Sandy R Shultz, Terence J O'Brien, Krista L Gilby

Journal article  |  2017  |  Neurobiology of Disease

Changes in Apparent Fiber Density and Track-Weighted Imaging Metrics in White Matter following Experimental Traumatic Brain Injury

David K Wright, Leigh A Johnston, Jeff Kershaw, Roger Ordidge, Terence J O'Brien, Sandy R Shultz

Journal article  |  2017  |  Journal of Neurotrauma

The potential for animal models to provide insight into mild traumatic brain injury: Translational challenges and strategies

Sandy R Shultz, Stuart J McDonald, Cole Vonder Haar, Alicia Meconi, Robert Vink, Paul van Donkelaar, Chand Taneja, Grant L Iverson, Brian R Christie

Journal article  |  2017  |  Neuroscience & Biobehavioral Reviews

MR Spectroscopy Findings in Retired Professional Rugby League Players

Andrew J Gardner, Grant L Iverson, Magdalena Wojtowicz, Christopher R Levi, Frances Kay-Lambkin, Peter W Schofield, Ross Zafonte, Sandy R Shultz, Alexander P Lin, Peter Stanwell

Journal article  |  2017  |  International Journal of Sports Medicine

Sex-dependent changes in neuronal morphology and psychosocial behaviors after pediatric brain injury

Bridgette D Semple, Shilpi Dixit, Sandy R Shultz, Wah Chin Boon, Terence J O'Brien

Journal article  |  2017  |  Behavioural Brain Research

Inflammation in epileptogenesis after traumatic brain injury

Kyria M Webster, Mujun Sun, Peter Crack, Terence J O'Brien, Sandy R Shultz, Bridgette D Semple

Journal article  |  2017  |  Journal of Neuroinflammation

Animal Models of Acquired Epilepsy and Tauopathies

Ping Zheng, Sandy Shultz, Chris Hovens, Terence J O'Brien

Book Chapter  |  2017

Neuroanatomical differences in FAST and SLOW rat strains with differential vulnerability to kindling and behavioral comorbidities

Pragati Sharma, Stefanie Dedeurwaerdere, Michael AD Vandenberg, Ke Fang, Leigh A Johnston, Sandy R Shultz, Terence J O'Brien, Krista L Gilby

Journal article  |  2016  |  Epilepsy & Behavior

Sodium selenate treatment mitigates reduction of bone volume following traumatic brain injury in rats

RD Brady, BL Grills, T Romano, JD Wark, TJ O'Brien, SR Shultz, SJ McDonald

Journal article  |  2016  |  Journal of Musculoskeletal Neuronal Interactions

Experimental Traumatic Brain Injury Induces Bone Loss in Rats

Rhys D Brady, Sandy R Shultz, Mujun Sun, Tania Romano, Chris van der Poel, David K Wright, John D Wark, Terence J O'Brien, Brian L Grills, Stuart J McDonald

Journal article  |  2016  |  Journal of Neurotrauma

Closed head experimental traumatic brain injury increases size and bone volume of callus in mice with concomitant tibial fracture

Rhys D Brady, Brian L Grills, Jarrod E Church, Nicole C Walsh, Aaron C McDonald, Denes V Agoston, Mujun Sun, Terence J O'Brien, Sandy R Shultz, Stuart J McDonald

Journal article  |  2016  |  Scientific Reports

Sodium selenate, a protein phosphatase 2A activator, mitigates hyperphosphorylated tau and improves repeated mild traumatic brain injury outcomes

Xin L Tan, David K Wright, Shijie Liu, Christopher Hovens, Terence J O'Brien, Sandy R Shultz

Journal article  |  2016  |  Neuropharmacology

Deletion of the type-1 interferon receptor in APP(SWE)/PS1(Delta E9) mice preserves cognitive function and alters glial phenotype

Myles R Minter, Zachery Moore, Moses Zhang, Kate M Brody, Nigel C Jones, Sandy R Shultz, Juliet M Taylor, Peter J Crack

Journal article  |  2016  |  ACTA NEUROPATHOLOGICA COMMUNICATIONS

BEHAVIORAL, BLOOD, AND ADVANCED MAGNETIC RESONANCE IMAGING BIOMARKERS OF EXPERIMENTAL CONCUSSION

Sandy Shultz, David Wright, Alaa Kamnaksh, Denes Agoston, Terence O'Brien

Conference Proceedings  |  2016  |  JOURNAL OF NEUROTRAUMA

Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau

Shi-jie Liu, Ping Zheng, David K Wright, Gabi Dezsi, Emma Braine, Nguyen Thanh, Niall M Corcoran, Leigh A Johnston, Christopher M Hovens, Jamie N Mayo, Matthew Hudson, Sandy R Shultz, Nigel C Jones, Terence J O'Brien

Journal article  |  2016  |  Brain

Behavioral, blood, and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury

David K Wright, Jack Trezise, Alaa Kamnaksh, Ramsey Bekdash, Leigh A Johnston, Roger Ordidge, Bridgette D Semple, Andrew J Gardner, Peter Stanwell, Terence J O'Brien, Denes V Agoston, Sandy R Shultz

Journal article  |  2016  |  SCIENTIFIC REPORTS

Social dysfunction after pediatric traumatic brain injury: A translational perspective

Nicholas P Ryan, Cathy Catroppa, Celia Godfrey, Linda J Noble-Haeusslein, Sandy R Shultz, Terence J O'Brien, Vicki Anderson, Bridgette D Semple

Journal article  |  2016  |  Neuroscience & Biobehavioral Reviews

The effect of concomitant peripheral injury on traumatic brain injury pathobiology and outcome

Stuart J McDonald, Mujun Sun, Denes V Agoston, Sandy R Shultz

Journal article  |  2016  |  Journal of Neuroinflammation

Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury

Kyria M Webster, David K Wright, Mujun Sun, Bridgette D Semple, Ezgi Ozturk, Donald G Stein, Terence J O'Brien, Sandy R Shultz

Journal article  |  2015  |  JOURNAL OF NEUROINFLAMMATION

CD11d integrin blockade reduces the systemic inflammatory response syndrome after traumatic brain injury in rats.

Lynne C Weaver, Feng Bao, Gregory A Dekaban, Todd Hryciw, Sandy R Shultz, Donald P Cain, Arthur Brown

Journal article  |  2015  |  Experimental Neurology

Traumatic CNS injury triggers a systemic inflammatory response syndrome (SIRS), in which circulating inflammatory cells invade bod..

Experimental Traumatic Brain Injury Results in Long-Term Recovery of Functional Responsiveness in Sensory Cortex but Persisting Structural Changes and Sensorimotor, Cognitive, and Emotional Deficits

Victoria PA Johnstone, David K Wright, Kendrew Wong, Terence J O'Brien, Ramesh Rajan, Sandy R Shultz

Journal article  |  2015  |  Journal of Neurotrauma

A preliminary video analysis of concussion in the National Rugby League

Andrew J Gardner, Grant L Iverson, Tanya N Quinn, Michael Makdissi, Christopher R Levi, Sandy R Shultz, David K Wright, Peter Stanwell

Journal article  |  2015  |  Brain Injury

Tibial fracture exacerbates traumatic brain injury outcomes and neuroinflammation in a novel mouse model of multitrauma

Sandy R Shultz, Mujun Sun, David K Wright, Rhys D Brady, Shijie Liu, Sinead Beynon, Shannon F Schmidt, Andrew H Kaye, John A Hamilton, Terence J O'Brien, Brian L Grills, Stuart J McDonald

Journal article  |  2015  |  Journal of Cerebral Blood Flow & Metabolism

Deletion of IFNAR1 in APPSWE/PS1 Delta E9 mice results in increased cognitive function and changed microglial phenotype

P Crack, M Minter, Z Moore, M Zhang, N Jones, S Shultz, J Taylor

Conference Proceedings  |  2015  |  JOURNAL OF NEUROCHEMISTRY

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

Sandy R Shultz, David K Wright, Ping Zheng, Ryan Stuchbery, Shi-Jie Liu, Maithili Sashindranath, Robert L Medcalf, Leigh A Johnston, Christopher M Hovens, Nigel C Jones, Terence J O'Brien

Journal article  |  2015  |  Brain

Intracerebroventricular injection of propionic acid, an enteric metabolite implicated in autism, induces social abnormalities that do not differ between seizure-prone (FAST) and seizure-resistant (SLOW) rats

Sandy R Shultz, Noor AB Aziz, Li Yang, Mujun Sun, Derrick F MacFabe, Terence J O'Brien

Journal article  |  2015  |  Behavioural Brain Research

The Acute Phase of Mild Traumatic Brain Injury Is Characterized by a Distance-Dependent Neuronal Hypoactivity

Victoria PA Johnstone, Sandy R Shultz, Edwin B Yan, Terence J O'Brien, Ramesh Rajan

Journal article  |  2014  |  Journal of Neurotrauma

Workshop on Neurobiology of Epilepsy appraisal: New systemic imaging technologies to study the brain in experimental models of epilepsy

Stefanie Dedeurwaerdere, Sandy R Shultz, Paolo Federico, Jerome Engel

Journal article  |  2014  |  Epilepsia

Hyperphosphorylated Tau is Implicated in Acquired Epilepsy and Neuropsychiatric Comorbidities

Ping Zheng, Sandy R Shultz, Chris M Hovens, Dennis Velakoulis, Nigel C Jones, Terence J O'Brien

Journal article  |  2014  |  MOLECULAR NEUROBIOLOGY

Granulocyte-Macrophage Colony-Stimulating Factor Is Neuroprotective in Experimental Traumatic Brain Injury

Sandy R Shultz, Xin L Tan, David K Wright, Shijie J Liu, Bridgette D Semple, Leigh Johnston, Nigel C Jones, Andrew D Cook, John A Hamilton, Terence J O'Brien

Journal article  |  2014  |  Journal of Neurotrauma

Neuroimaging the Epileptogenic Process

Sandy R Shultz, Terence J O'Brien, Maria Stefanidou, Ruben I Kuzniecky

Journal article  |  2014  |  Neurotherapeutics

Can structural or functional changes following traumatic brain injury in the rat predict epileptic outcome?

Sandy R Shultz, Lisa Cardamone, Ying R Liu, R Edward Hogan, Luigi Maccotta, David K Wright, Ping Zheng, Amelia Koe, Marie-Claude Gregoire, John P Williams, Rodney J Hicks, Nigel C Jones, Damian E Myers, Terence J O'Brien, Viviane Bouilleret

Journal article  |  2013  |  Epilepsia

Treatment with an anti-CD11d integrin antibody reduces neuroinflammation and improves outcome in a rat model of repeated concussion

Sandy R Shultz, Feng Bao, Lynne C Weaver, Donald P Cain, Arthur Brown

Journal article  |  2013  |  Journal of Neuroinflammation

A CD11d Monoclonal Antibody Treatment Reduces Tissue Injury and Improves Neurological Outcome after Fluid Percussion Brain Injury in Rats

Feng Bao, Sandy R Shultz, Jeff D Hepburn, Vanessa Omana, Lynne C Weaver, Donald P Cain, Arthur Brown

Journal article  |  2012  |  Journal of Neurotrauma

Sub-concussive brain injury in the Long-Evans rat induces acute neuroinflammation in the absence of behavioral impairments

Sandy R Shultz, Derrick F MacFabe, Kelly A Foley, Roy Taylor, Donald P Cain

Journal article  |  2012  |  Behavioural Brain Research

Repeated Mild Lateral Fluid Percussion Brain Injury in the Rat Causes Cumulative Long-Term Behavioral Impairments, Neuroinflammation, and Cortical Loss in an Animal Model of Repeated Concussion

Sandy R Shultz, Feng Bao, Vanessa Omana, Charlotte Chiu, Arthur Brown, Donald Peter Cain

Journal article  |  2012  |  Journal of Neurotrauma

A single mild fluid percussion injury induces short-term behavioral and neuropathological changes in the Long-Evans rat: Support for an animal model of concussion

Sandy R Shultz, Derrick F MacFabe, Kelly A Foley, Roy Taylor, Donald P Cain

Journal article  |  2011  |  Behavioural Brain Research

Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: Further development of a rodent model of autism

Sandy R Shultz, Derrick F MacFabe, Samantha Martin, Jordana Jackson, Roy Taylor, Francis Boon, Klaus-Peter Ossenkopp, Donald P Cain

Journal article  |  2009  |  Behavioural Brain Research

Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: Implications for an animal model of autism

Sandy R Shultz, Deffick E MacFabe, Klaus-Peter Ossenkopp, Shannon Scratch, Jennifer Whelan, Roy Taylor, Donald P Cain

Journal article  |  2008  |  Neuropharmacology

Sex differences in object location memory and spatial navigation in Long-Evans rats

DM Saucier, SR Shultz, AJ Keller, CM Cook, G Binsted

Journal article  |  2008  |  Animal Cognition

Enriched environment and the effect of age on ischemic brain damage

Deborah M Saucier, Jerome Y Yager, Edward A Armstrong, Avril Keller, Sandy Shultz

Journal article  |  2007  |  Brain Research