Kristy Swiderski

Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes.

Wenlan Li, Jennifer Trieu, Ronnie Blazev, Benjamin L Parker, Kate T Murphy, Kristy Swiderski, Gordon S Lynch

Journal article  |  2023  |  Am J Physiol Cell Physiol

Cancer cachexia is common in many cancers and the loss of skeletal muscle mass compromises the response to therapies and quality o..

Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia

Wenlan Li, Kristy Swiderski, Kate T Murphy, Gordon S Lynch

Journal article  |  2022  |  ANTIOXIDANTS

Cancer cachexia is the progressive muscle wasting and weakness experienced by many cancer patients. It can compromise the response..

Regenerative Rehabilitation for Duchenne Muscular Dystrophy

Kristy Swiderski, Justin P Hardee, Gordon S Lynch

Book Chapter  |  2022

Mechanisms of chemotherapy‐induced muscle wasting in mice with cancer cachexia

Kate T Murphy, Kristy Swiderski, James G Ryall, Jonathan R Davey, Hongwei Qian, Séverine Lamon, Victoria C Foletta, Jennifer Trieu, Annabel Chee, Suzannah J Read, Timur Naim, Paul Gregorevic, Gordon S Lynch

Journal article  |  2022  |  JCSM Rapid Communications

Investigating the Potential for Sulforaphane to Attenuate Gastrointestinal Dysfunction in mdx Dystrophic Mice

Kristy Swiderski, Suzannah J Read, Audrey S Chan, Jin D Chung, Jennifer Trieu, Timur Naim, Rene Koopman, Gordon S Lynch

Journal article  |  2021  |  NUTRIENTS

Gastrointestinal (GI) dysfunction is an important, yet understudied condition associated with Duchenne muscular dystrophy (DMD), w..

Murine models of Duchenne muscular dystrophy: is there a best model?

Kristy Swiderski, Gordon S Lynch

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Phosphorylation of ERK and dystrophin S3059 protects against inflammation-associated C2C12 myotube atrophy

Kristy Swiderski, Christopher J Brock, Jennifer Trieu, Annabel Chee, Savant S Thakur, Dale M Baum, Paul Gregorevic, Kate T Murphy, Gordon S Lynch

Journal article  |  2021  |  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The dystrophin-glycoprotein complex (DGC) is a multiprotein structure required to maintain muscle fiber membrane integrity, transm..

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

Justin P Hardee, Karen JB Martins, Paula M Miotto, James G Ryall, Stefan M Gehrig, Boris Reljic, Timur Naim, Jin D Chung, Jen Trieu, Kristy Swiderski, Ashleigh M Philp, Andrew Philp, Matthew J Watt, David A Stroud, Rene Koopman, Gregory R Steinberg, Gordon S Lynch

Journal article  |  2021  |  MOLECULAR METABOLISM

OBJECTIVES: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscul..

HSP70 drives myoblast fusion during C2C12 myogenic differentiation

Savant S Thakur, Kristy Swiderski, Victoria L Chhen, Janine L James, Nicki J Cranna, AM Taufiqual Islam, James G Ryall, Gordon S Lynch

Journal article  |  2020  |  BIOLOGY OPEN

In response to injury, skeletal muscle stem cells (MuSCs) undergo myogenesis where they become activated, proliferate rapidly, dif..

Colonic dilation and altered ex vivo gastrointestinal motility in the neuroligin-3 knockout mouse

Anita JL Leembruggen, Gayathri K Balasuriya, Jinghong Zhang, Shana Schokman, Kristy Swiderski, Joel C Bornstein, Jess Nithianantharajah, Elisa L Hill-Yardin

Journal article  |  2020  |  AUTISM RESEARCH

Gastrointestinal (GI) dysfunction is commonly reported by people diagnosed with autism spectrum disorder (ASD; autism) but the cau..