A/Prof Tu'Uhevaha Lino

A/Prof Tu’uhevaha Kaitu’u-Lino is a NHMRC RD Wright (CDF2) Fellow in the Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne. A/Prof Kaitu’u-Lino leads the Diagnostics Discovery and Reverse Translation team under the wider Translational Obstetrics Group, a team of clinicians and scientists who are focused on developing concepts in the laboratory, and taking these to the clinic.

She currently has two major research focuses; 1) Identifying new diagnostics to clinically identify preeclampsia and fetal growth restriction (to reduce the incidence of stillbirth) 2) Understanding the pathogenesis of these diseases to assist in identifying new therapeutic targets.

A/Prof Kaitu’u-Lino has published 90 peer-reviewed publications to date (May 2020); most are published in leading specialist journals for her field and in prestigious interdisciplinary journals.

A/Prof Kaitu’u-Lino is currently CI on three NHMRC Project Grants, one NHMRC Fellowship and one NHMRC Synergy grant. Since being awarded her PhD in 2008 (and with 32 months of career interruption for child rearing since), she has amassed >$10M in funding (including University and Philanthropic funding)

A/Prof Kaitu’u-Lino has received many awards for presentations given at national and international conferences and also for community engagement, including being awarded Young Tall Poppy of the Year in 2012.
A/Prof Kaitu’u-Lino is currently a Council Member for the Society for Reproductive Biology and has previously served as a Board Member for the Australian Society for Medical Research. She also regularly acts as an ad hoc reviewer for International journals within the field of reproductive biology, including Human Reproduction, Endocrinology and Molecular Human Reproduction.

Find out more about Tu'Uhevaha Lino's experience

Tu'Uhevaha Lino's highlights

FEATURED Journal article

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction

Tu'Uhevaha Lino's selected work

Developing New Diagnostics To Prevent Stillbirth

Research Grant

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic f..

Journal article

Developing New Diagnostics To Prevent Stillbirth

Research Grant

Circulating mRNAs are differentially expressed in pregnancies with severe placental insuff..

Journal article

Validation Of A Blood Test To Predict Macrosomia

Research Grant

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal gr..

Journal article

Projects

Displaying the 33 most recent projects by Tu'Uhevaha Lino.

Validation Of Lead Marker, Splntl, In New Cohorts And Investigatlon Of 11 Additional Identified Proteins

2019 - 2020

Active

Identifying Blood Biomarkers To Predict Women At Risk Of Stillbirth

2019 - 2022

Active

New Diagnostics To Predict Preeclampsia And Fetal Growth Restriction

2019 - 2022

Active

Metabolomics To Identify Pregnancies At Risk Of Fetal Growth Restriction Or Preeclampsia

2019 - 2019

Completed

Is Elevated Endothelin-1 A Reliable Marker Of Preeclampsia And Fetal Growth Restriction

2019 - 2020

Active

Using Biomarkers And Ultrasound In Late Pregnancy To Minimise Preventable Stillbirth: The Bumps Study

Small babies contribute disproportionately to stillbirth, yet existing methods mostly fail to detect the fetus that is not growing well. We ..

2019 - 2022

Active

Identifying New Biomarkers To Predict Preeclampsia And Fetal Growth Restriction

2018 - 2020

Completed

Validating Mrna Biomarkers To Predict Fetal Growth Restriction

2018 - 2019

Completed

Developing A Biomarker To Prevent Stillbirth

2018 - 2019

Completed

Microrna Biomarkers For Preeclampsia At 28 Weeks Gestation

2018 - 2019

Completed

Identifying Biomakers For Prediction Of Preeclampsia At 28 Weeks Gestation

2017 - 2017

Completed

Treating Preterm Preeclampsia With Sulfasalazine: An Early Phase Clinical Trial

2017 - 2018

Completed

From Pathogenesis To Therapeutics: Targeting Two Signalling Pathways As A Therapeutic Strategy To Treat Preeclampsia

Preeclampsia is a serious complication of pregnancy that claims the lives of thousands of mothers and babies each year. There is no efficaci..

2017 - 2020

Active

Development Of Vinorelbine As A Tablet Based Therapy To Cure Ectopic Pregnancies

Ectopic pregnancies occur if the pregnancy implants in the Fallopian tube. They can be deadly and most are treated surgically. We will exami..

2017 - 2020

Active

Preeclampsia Therapeutics Screening Of Gsk Small Molecules

2016 - 2017

Completed

Identifying Protein Biomarkers To Improve The Prediction Of Stillbirth Grant Application

2016 - 2016

Completed

Combination Of Treaputics To Treat Preeclampsia Grant Application

2016 - 2016

Completed

Vinorelbine: A New Potential Therapeutic For Ectopic Pregnancy

2016 - 2017

Completed

Systematic Screening Approach To Identify New Therapeutics For Preeclampsia

Preeclampsia is a pregnancy complication where factors are released from the placenta into the mum's bloodstream, causing widespread blood v..

2016 - 2019

Completed

Sulfasalazine - A Novel Treatment Option For Preclampsia

2015 - 2015

Completed

Purchase Of The Floid Cell Imaging Station

2014 - 2014

Completed

Targeting The Toxins Of Preeclampsia

Preeclampsia is a severe disease of pregnancy - the placenta releases toxins in to mum's bloodstream that circulate her body and damage her ..

2014 - 2018

Completed

Treating Severe Early Onset Preeclampsia With Pravastatin: An Early Phase Clinical Trial

2013 - 2014

Completed

Soluble Endoglin In The Pathogenesis Of Preeclampsia: Investigation Of Mechanisms And The Development Of Therapeutics

Preeclampsia is a severe disease of pregnancy. As the pathogenesis is poorly understood, the only treatment is for clinicians to deliver bab..

2013 - 2015

Completed

Understanding How Sflt-1, A Toxin Of Preeclampsia Is Released

2013 - 2014

Completed

Blocking Soluble Endoglin Release As A Therapeutic Strategy For Severe Preeclampsia.

2012 - 2012

Completed

Blocking Soluble Endoglin Release As A Therapeutic For Severe Preeclampsia.

2012 - 2012

Completed

Australian Based Biomedical Fellowship

The endometrium (lining of the uterus) undergoes breakdown and re-growth each month as part of the menstrual cycle. This restorative process..

2011 - 2012

Completed

Mmp-14 Blockade As A Potential Cure Of Pre-Eclampsia

2011 - 2011

Completed

New Diagnostics Markers To Identify Pregnancy Complications

33

Projects

Project Types

Research Grant

Research Contracts

Internal Research Grant

Scholarly Works

Displaying the 128 most recent scholarly works by Tu'Uhevaha Lino.

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction

Sally Beard, Natasha Pritchard, Natalie Binder, Karen Schindler, Natasha De Alwis, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Natalie J Hannan

Journal article | 2020 | Placenta

INTRODUCTION: Oxidative damage and biochemical ageing are implicated in placental dysfunction and potentially fetal death. Cellula..

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic factors from the placenta: Implications for the treatment of preeclampsia

Fiona C Brownfoot, Roxanne Hastie, Natalie J Hannan, Ping Cannon, Tuong Nguyen, Laura Tuohey, Cathy Cluver, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2020 | Placenta

INTRODUCTION: The antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are elevated in p..

Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth

Natalie J Hannan, Owen Stock, Rebecca Spencer, Clare Whitehead, Anna L David, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Lavinia Gordon, Sally Beard, Kantaraja Chindera, Smita Karegodar, Richard Hiscock, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Stephen Tong

Journal article | 2020 | BMC Medicine

BACKGROUND: Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricte..

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Nguyen Tuong-Vi, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong

Journal article | 2020 | Nature Communications

Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental ins..

Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction

Natasha de Alwis, Sally Beard, Yeukai T Mangwiro, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Stephen Tong, Natalie J Hannan

Journal article | 2020 | Pregnancy Hypertension

OBJECTIVES: There is avid interest in pravastatin as a therapeutic intervention for pre-eclampsia, however little is known on stat..

Circulating Delta-like homolog 1 (DLK1) at 36 weeks is correlated with birthweight and is of placental origin

Teresa M MacDonald, Susan P Walker, Richard Hiscock, Ping Cannon, Alesia Harper, Elizabeth Murray, Lisa Hui, Kirsten Dane, Anna Middleton, Valerie Kyritsis, Natasha de Alwis, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2020 | Placenta

Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia

Cameron Yung, Teresa M MacDonald, Susan P Walker, Ping Cannon, Alesia Harper, Natasha Pritchard, Natalie J Hannan, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2019 | Placenta

INTRODUCTION: Death associated protein kinase-1 (DAPK-1) is highly expressed in the placenta relative to all other human tissues. ..

Sulfasalazine decreases soluble fms-like tyrosine kinase-1 secretion potentially via inhibition of upstream placental epidermal growth factor receptor signalling

Roxanne Hastie, Fiona C Brownfoot, Ping Cannon, Nguyen Vi, Laura Tuohey, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | Placenta

OBJECTIVES: Preeclampsia is a hypertensive disorder of pregnancy with no available medical treatment. We recently reported sulfasa..

Screening circulating proteins to identify biomarkers of fetal macrosomia.

Tess Cruickshank, Tu'uhevaha J Kaitu'u-Lino, Ping Cannon, Alesia Harper, Tuong-Vi Nguyen, Kirsten M Dane, Anna L Middleton, Valerie P Kyritsis, Roxanne Hastie, Stephen Tong, Susan P Walker, Teresa M MacDonald

Journal article | 2019 | BMC Research Notes

OBJECTIVE: Fetal macrosomia is a major risk factor for shoulder dystocia, which can lead to birth asphyxia, maternal and neonatal ..

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | Placenta

Pregnancy complications such as fetal growth restriction and preeclampsia are diseases with limited biomarkers for prediction, and..

Blood-based biomarkers in the maternal circulation associated with fetal growth restriction

Stephen Tong, Tu'uhevaha Joy Kaitu'u-Lino, Susan Philippa Walker, Teresa Mary MacDonald

Journal article | 2019 | Prenatal Diagnosis

Fetal growth restriction (FGR) is associated with threefold to fourfold increased risk of stillbirth. Identifying FGR, through its..

Therapeutic interventions: The importance of including diseased and healthy samples in preclinical studies

Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | EBioMedicine

A double blind, randomised, placebo-controlled trial to evaluate the efficacy of metformin to treat preterm pre-eclampsia (PI2 Trial): study protocol

Catherine Cluver, Susan P Walker, Ben W Mol, David Hall, Richard Hiscock, Fiona C Brownfoot, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2019 | BMJ Open

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women A Swedish Population Register-Based Cohort Study

Roxanne Hastie, Lina Bergman, Catherin A Cluver, Anna Wikman, Natalie J Hannan, Susan P Walker, Anna-Karin Wikstrom, Stephen Tong, Susanne Hesselman

Journal article | 2019 | Hypertension

Circulating adrenomedullin mRNA is decreased in women destined to develop term preeclampsia

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natasha Pritchard, Natalie J Hannan, Roxanne Hastie, Natasha De Alwis, Ping Cannon, Vi Nguyen Tuong, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Journal article | 2019 | Pregnancy Hypertension

Epidermal Growth Factor and Mitochondrial Respiration-Two Pathways That Regulate Placental Growth Factor Secretion from Placental Cells.

Carole-Anne Whigham, Roxanne Hastie, Natalie Hannan, Ping Canon, Vi Nguyen Tuong, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction

Fiona C Brownfoot, Natalie J Hannan, Ping Cannon, Nguyen Vi, Roxanne Hastie, Laura J Parry, Sevvandi Senadheera, Laura Tuohey, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | EBioMedicine

Comparing the Ability of Pravastatin, Simvastatin and Rosuvastatin to Quench Markers of Endothelial Dysfunction in Pregnancy.

Natasha de Alwis, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Fiona Brownfoot, Stephen Tong, Natalie Hannan

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

New Generation Antiplatelet Agents Mitigate Pathophysiological Aspects of Preeclampsia in Both Human and Mouse Models of Preeclampsia, Representing Exciting Novel Candidate Therapeutics.

Natalie Hannan, Sally Beard, Natalie Binder, Natasha De Alwis, Natasha Pritchard, Tu'uhevaha Kaitu'u-Lino, Stephen Tong

Conference Proceedings | 2019 | REPRODUCTIVE SCIENCES

Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Natasha Pritchard, Natalie J Hannan, Ping Cannon, Vi Nguyen Tuong, Roxanne Hastie, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2019 | Scientific Reports

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia

Clare L Whitehead, Tu'uhevaha J Kaitu'u-Lino, Natalie K Binder, Sally Beard, Natasha De Alwis, Fiona Brownfoot, Stephen Tong, Natalie J Hannan

Journal article | 2018 | Pregnancy Hypertension

Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome

Roxanne Hastie, Louie Ye, Natalie J Hannan, Fiona C Brownfoot, Ping Cannon, Vi Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2018 | Pregnancy Hypertension

AURORA KINASE EXPRESSION IS NOT ALTERED IN GROWTH RESTRICTED OR PREECLAMPTIC PLACENTAS, AND IS NOT CHANGED WITH PLACENTAL AGING

Natasha Pritchard, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Stephen Tong, Natalie Hannan

Conference Proceedings | 2018 | PLACENTA

TWO PARALLEL PATHWAYS REGULATING SFLT-1 SECRETION FROM PLACENTA

Roxanne Hastie, Fiona C Brownfoot, Natalie J Hannan, Ping Cannon, Nguyen Tuong-Vi, Natasha Pritchard, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Conference Proceedings | 2018 | PLACENTA

NOVEL STRATEGIES TO TREAT PREECLAMPSIA: FROM NEW DRUGS TO NEW DELIVERY

Natalie Hannan, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Stephen Tong

Conference Proceedings | 2018 | PLACENTA

Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks' gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study

Teresa M MacDonald, Tran Chuong, Tu'uhevaha J Kaitu'u-Lino, Shaun P Brennecke, Richard J Hiscock, Lisa Hui, Kirsten M Dane, Anna L Middleton, Ping Cannon, Susan P Walker, Stephen Tong

Journal article | 2018 | BMC PREGNANCY AND CHILDBIRTH

ELABELA/APELA Levels Are Not Decreased in the Maternal Circulation or Placenta among Women with Preeclampsia

Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Sungsam Gong, Justyna Dopierala, Gordon CS Smith, D Stephen Charnock-Jones, Stephen Tong

Journal article | 2018 | The American Journal of Pathology

Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Ping Cannon, Nguyen Vi, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2018 | Pregnancy Hypertension

Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia

Natalie J Hannan, Natalie K Binder, Sally Beard, Nguyen Tuong-Vi, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2018 | PLOS ONE

Circulating mRNA Coding Adrenomedullin is Decreased in Women Destined to Develop Pre-Eclampsia and May Be of Placental and/or Endothelial Origin.

Carole-Anne Whigham, Teresa MacDonald, Sue Walker, Natalie Hannan, Ping Canon, Vi Nguyen Tuong, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

sFlt-1 Transcription and Secretion is Regulated through the Mitochondrial Electron Transport Chain - A New Mechanism to Target for Treating Preeclampsia.

Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Natalie J Hannan, Roxanne Hastie, Ping Cannon, Nguyen Tuong-Vi, Stephen Tong

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

Combination Sulfasalazine and Metformin Are Additive in Reducing Placental Anti-Angiogenic Factor Secretion and Up-Regulating Angiogenic Factors.

Fiona C Brownfoot, Stephen Tong, Ping Cannon, Nguyen Vi, Natalie Hannan, Roxanne Hastie, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

Altered Placental Expression of Candidate Blood Markers of Severe Fetal Growth Restriction is Driven by Hypoxia.

Natasha De Alwis, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Susan Walker, Stephen Tong, Natalie J Hannan

Conference Proceedings | 2018 | REPRODUCTIVE SCIENCES

Vinorelbine Potently Induces Placental Cell Death, Does Not Harm Fertility and is a Potential Treatment for Ectopic Pregnancy

Roxanne Hastie, Elgene Lim, Pavel Sluka, Lisa Campbell, Andrew W Horne, Lenore Ellett, Natalie J Hannan, Fiona Brownfoot, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2018 | EBioMedicine

Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia

Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Sally Beard, Ping Cannon, Roxanne Hastie, Tuong V Nguyen, Natalie K Binder, Stephen Tong, Natalie J Hannan

Journal article | 2018 | PLOS ONE

Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta

Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Roxanne Hastie, Ashwini Chand, Ping Cannon, Minh Deo, Laura Tuohey, Clare Whitehead, Natalie J Hannan, Stephen Tong

Journal article | 2017 | Hypertension

sFlt-1 and soluble endoglin concentrations in serum vs plasma in preterm preeclampsia: Are they interchangeable for biomarker studies?

Fiona Brownfoot, Tu'uhevaha Kaitu'u-Lino, Sally Beard, Stephen Tong, Natalie Hannan

Journal article | 2017 | Pregnancy Hypertension

CIRCULATING ENDOTHELIAL TRANSCRIPTION FACTOR GATA2 IS DECREASED IN PREECLAMPSIA AND MAY CONTRIBUTE TO MATERNAL ENDOTHELIAL DYSFUNCTION

Carole-Anne Whigham, Teresa MacDonald, Sue Walker, Lisa Hui, Natalie Hannan, Ping Cannon, Tuong Vi Nguyen, Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2017 | Placenta

Epidermal Growth Factor Rescues Endothelial Dysfunction in Primary Human Tissues In Vitro

Roxanne Hastie, Stephen Tong, Natalie J Hannan, Fiona Brownfoot, Ping Cannon, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2017 | Reproductive Sciences

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment

Natalie J Hannan, Fiona C Brownfoot, Ping Cannon, Minh Deo, Sally Beard, Tuong V Nguyen, Kirsten R Palmer, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2017 | Scientific Reports

Variable effect of maternal oral glucose load on circulating cell-free placental mRNAs

Teresa Mary MacDonald, Tu'uhevaha Joy Kaitu'u-Lino, Susan Philippa Walker, Kirsten Margaret Dane, Elizabeth Beatrice Lockie, Stephen Tong, Clare Louise Whitehead, Lisa Hui

Journal article | 2017 | The Journal of Maternal-Fetal & Neonatal Medicine

Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia

Kirsten R Palmer, Tu'uhevaha J Kaitu'u-Lino, Ping Cannon, Laura Tuohey, Manarangi S De Silva, Manuel Varas-Godoy, Stephanie Acuna, Jose Galaz, Stephen Tong, Sebastian E Illanes

Journal article | 2017 | The Journal of Maternal-Fetal & Neonatal Medicine

Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction

Natalie J Hannan, Sally Beard, Natalie K Binder, Kenji Onda, Tu'uhevaha J Kaitu'u-Lino, Qi Chen, Laura Tuohey, Manarangi De Silva, Stephen Tong

Journal article | 2017 | Placenta

Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction

Kenji Onda, Stephen Tong, Sally Beard, Natalie Binder, Masanaga Muto, Sevvandi N Senadheera, Laura Parry, Mark Dilworth, Lewis Renshall, Fiona Brownfoot, Roxanne Hastie, Laura Tuohey, Kirsten Palmer, Toshihiko Hirano, Masahito Ikawa, Tu'uhevaha Kaitu'u-Lino, Natalie J Hannan

Journal article | 2017 | Hypertension

Targeted Nanoparticle Delivery of Short Interfering RNAs to Treat Preeclampsia.

Natalie J Hannan, Scott Pattison, Sally Beard, Natalie K Binder, Jennifer MacDiarmid, Himanshu Brahmbhatt, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Conference Proceedings | 2017 | REPRODUCTIVE SCIENCES

Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis

KR Palmer, S Tong, TJ Kaitu'u-Lino

Journal article | 2017 | MOLECULAR HUMAN REPRODUCTION

Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta

Louie Ye, Amy Gratton, Natalie J Hannan, Ping Cannon, Minh Deo, Kirsten R Palmer, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot

Journal article | 2016 | PLACENTA

Steroid sulfatase is increased in the placentas and whole blood of women with early-onset preeclampsia

Amy M Gratton, Louie Ye, Fiona C Brownfoot, Natalie J Hannan, Clare Whitehead, Ping Cannon, Minh Deo, Peter J Fuller, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2016 | Placenta

ATF3 is a negative regulator of inflammation in human fetal membranes

Ratana Lim, Gillian Barker, Stella Liong, Caitlyn Nguyen-Ngo, Stephen Tong, Tu'uhevaha Kaitu'u-Lino, Martha Lappas

Journal article | 2016 | PLACENTA

Placental Growth Factor Is Secreted by the Human Endometrium and Has Potential Important Functions during Embryo Development and Implantation

Natalie K Binder, Jemma Evans, Lois A Salamonsen, David K Gardner, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article | 2016 | PLOS ONE

NEW GENERATION ANTIPLATELET THERAPIES TO PREVENT PREECLAMPSIA

Natalie Hannnan, Tu'uhevaha Kaitu'u-Lino, Sally Beard, Natalie Binder, Stephen Tong

Conference Proceedings | 2016 | Placenta

MITOCHONDRIAL BIOGENESIS MOLECULES AMPK, SIRT1 AND PGC1 alpha AND THEIR RELATIONSHIP TO sFLT1 RELEASE IN PREECLAMPSIA

Tu'uhevaha Kaitu'u-Lino, Fiona Brownfoot, Roxanne Hastie, Natalie Hannan, Ping Cannon, Minh Deo, Stephen Tong

Conference Proceedings | 2016 | Placenta

A comparison of sample collection methods for quantifying cell-free fetal neurodevelopment transcripts in amniotic fluid.

Lisa Hui, Stephen Tong, Tu'Uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article | 2016 | BMC Research Notes

BACKGROUND: Cell-free RNA (cfRNA) transcripts known to be expressed by the fetal brain are detectable by quantitative reverse tran..

Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Roxanne Hastie, Ping Cannon, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2016 | BMC PREGNANCY AND CHILDBIRTH

Identifying late-onset fetal growth restriction by measuring circulating placental RNA in the maternal blood at 28 weeks' gestation

Clare L Whitehead, Helen McNamara, Susan P Walker, Maria Alexiadis, Peter J Fuller, Daniel K Vickers, Natalie J Hannan, Roxanne Hastie, Laura Tuohey, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2016 | American Journal of Obstetrics and Gynecology

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta

Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Natalie J Hannan, Fiona Brownfoot, Manarangi De Silva, Ping Cannon, Laura Tuohey, Stephen Tong

Journal article | 2016 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Metformin: A Novel Candidate Therapeutic for Preeclampsia.

Fiona C Brownfoot, Tu'uhevaha Kaitu'u-Lino, Natalie Hannan, Roxanne Hastie, Ping Cannon, Laura Tuohey, Laura Parry, Sevvandi Senadheera, Stephen Tong

Conference Proceedings | 2016 | REPRODUCTIVE SCIENCES

Epidermal Growth Factor Receptor Positively Regulates Sflt1 Secretion.

Roxanne Hastie, Stephen Tong, Natalie Hannan, Fiona Brownfoot, Kenji Onda, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2016 | REPRODUCTIVE SCIENCES

New Generation, Orally Available Antiplatelet Agents as Novel Therapeutic Candidates for Preeclampsia.

Natalie J Hannan, Sally Beard, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Conference Proceedings | 2016 | REPRODUCTIVE SCIENCES

Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production

Kirsten R Palmer, Stephen Tong, Laura Tuohey, Ping Cannon, Louie Ye, Natalie J Hannan, Fiona C Brownfoot, Sebastian E Illanes, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2016 | Biology of Reproduction

Reduced Placental ATF3 Increases sFlt1 Export via the Cargo Proteins Rab11a and Arf1.

Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Fiona C Brownfoot, Natalie J Hannan, Ping Cannon, Laura Tuohey, Stephen Tong

Conference Proceedings | 2016 | REPRODUCTIVE SCIENCES

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction

Fiona C Brownfoot, Roxanne Hastie, Natalie J Hannan, Ping Cannon, Laura Tuohey, Laura J Parry, Sevvandi Senadheera, Sebastian E Illanes, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article | 2016 | American Journal of Obstetrics and Gynecology

Prediction of late onset fetal growth restriction using circulating placental RNA in the maternal blood

Clare Whitehead, Tu'uhevaha Kaitu'u-Lino, Susan Walker, Maria Alexiadis, Laura Tuohey, Helen McNamara, Daniel Vickers, Stephen TOng

Conference Proceedings | 2016 | American Journal of Obstetrics and Gynecology

Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity

Kirsten R Palmer, Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Natalie J Hannan, Louie Ye, Natalie Binder, Ping Cannon, Laura Tuohey, Terrance G Johns, Alexis Shub, Stephen Tong

Journal article | 2015 | HYPERTENSION

Human HtrA4 Expression Is Restricted to the Placenta, Is Significantly Up-Regulated in Early-Onset Preeclampsia, and High Levels of HtrA4 Cause Endothelial Dysfunction (vol 100, pg E936, 2015)

H Singh, M Zhao, Q Chen, Y Wang, Y Li, TJ Kaitu'u-Lino, S Tong, G Nie

Journal article | 2015 | The Journal of Clinical Endocrinology & Metabolism

Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion

Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Kenji Onda, Sally Beard, Roxanne Hastie, Natalie K Binder, Cathy Cluver, Laura Tuohey, Clare Whitehead, Fiona Brownfoot, Manarangi De Silva, Natalie J Hannan

Journal article | 2015 | HYPERTENSION

Expression of Myostatin in Intrauterine Growth Restriction and Preeclampsia Complicated Pregnancies and Alterations to Cytokine Production by First-Trimester Placental Explants Following Myostatin Treatment

Hassendrini N Peiris, Harry Georgiou, Martha Lappas, Tu'uhevaha Kaitu'u-Lino, Carlos Salomon, Kanchan Vaswani, Gregory E Rice, Murray D Mitchell

Journal article | 2015 | Reproductive Sciences

Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan, Manarangi De Silva, Natalie Binder, Laura Tuohey, Ping Cannon, Stephen Tong

Journal article | 2015 | Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Roxanne Hastie, Ping Cannon, Laura Tuohey, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2015 | Molecular and Cellular Endocrinology

EGF DECREASES SFLT1 SECRETION AND ENDOTHELIAL DYSFUNCTION: A POTENTIAL THERAPEUTIC FOR PREECIAMPSIA

Roxanne Hastie, Stephen Tong, Ping Cannon, Fiona Brownfoot, Natalie Hannan, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings | 2015 | Placenta

Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe Preeclampsia

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Natalie K Binder, Susan P Walker, Ping Cannon, Roxanne Hastie, Kenji Onda, Tu'uhevaha J Kaitu'u-Lino

Journal article | 2015 | HYPERTENSION

ACTIVATING TRANSCRIPTION FACTOR 3-A KEY MOLECULE IN THE PATHOGENESIS OF PREECLAMPSIA

Tu'uhevaha Kaitu'u-Lino, Fiona Brownfoot, Natalie Hannan, Roxanne Hastie, Ping Cannon, Laura Tuohey, Stephen Tong

Conference Proceedings | 2015 | Placenta

PROTON PUMP INHIBITORS QUENCH THE PATHOPHYSIOLOGICAL CHARACTERISTICS OF PREECLAMPSIA IN BOTH HUMAN AND MOUSE MODELS AND REPRESENT AN EXCITING NOVEL CANDIDATE THERAPEUTIC

Kenji Onda, Stephen Tong, Natalie Binder, Sally Beard, Tu'uhevaha Kaitu'u-Lino, Masanaga Muto, Masahito Ikawa, Mark Dilworth, Lewis Renshal, Sevvandi Senadheera, Laura Parry, Roxanne Hastie, Fiona Brownfoot, Laura Tuohey, Kirsten Palmer, Natalie Hannan

Conference Proceedings | 2015 | Placenta

Transcription factors E2F1 and E2F3 are expressed in placenta but do not regulate MMP14

TJ Kaitu'u-Lino, R Hastie, P Cannon, H Nguyen, S Lee, NJ Hannan, S Tong

Journal article | 2015 | Placenta

Human HtrA4 Expression Is Restricted to the Placenta, Is Significantly Up-Regulated in Early-Onset Preeclampsia, and High Levels of HtrA4 Cause Endothelial Dysfunction

Harmeet Singh, Min Zhao, Qi Chen, Yao Wang, Ying Li, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Guiying Nie

Journal article | 2015 | The Journal of Clinical Endocrinology & Metabolism

Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation

Owen Stock, Lavinia Gordon, Jada Kapoor, Susan P Walker, Clare Whitehead, Tu'uhevaha J Kaitu'u-Lino, Gabrielle Pell, Natalie J Hannan, Stephen Tong

Journal article | 2015 | REPRODUCTIVE SCIENCES

Paternal obesity in a rodent model affects placental gene expression in a sex-specific manner

Natalie K Binder, Sally A Beard, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Natalie J Hannan, David K Gardner

Journal article | 2015 | REPRODUCTION

Sofalcone Upregulates the Nuclear Factor (Erythroid-Derived 2)-Like 2/Heme Oxygenase-1 Pathway, Reduces Soluble fms-Like Tyrosine Kinase-1, and Quenches Endothelial Dysfunction Potential Therapeutic for Preeclampsia

Kenji Onda, Stephen Tong, Anzu Nakahara, Mei Kondo, Hideaki Monchusho, Toshihiko Hirano, Tu'uhevaha Kaitu'u-Lino, Sally Beard, Natalie Binder, Laura Tuohey, Fiona Brownfoot, Natalie J Hannan

Journal article | 2015 | HYPERTENSION

Pravastatin Quenches Preeclampsia in Humans: A Potential Therapeutic

Fiona Brownfoot, Stephen Tong, Natalie Hannan, Natalie Binder, Roxanne Hastie, Tu'uhevaha Kaitu'u-Lino