Tu'Uhevaha Lino

MicroRNAs 363 and 149 are differentially expressed in the maternal circulation preceding a diagnosis of preeclampsia.

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Richard Hiscock, Natalie J Hannan, Natasha Pritchard, Ping Cannon, Tuong Vi Nguyen, Manisha Miranda, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2020  |  Scientific Reports

Preeclampsia is a pregnancy complication associated with angiogenic dysbalance, maternal endothelial dysfunction and end-organ inj..

Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia.

Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Fiona Brownfoot, Catherine Cluver, Natalie Hannan

Journal article  |  2020  |  American Journal of Obstetrics and Gynecology

There has been increasing research momentum to identify new therapeutic agents for the prevention or treatment of preeclampsia, dr..

Novel approaches to combat preeclampsia: from new drugs to innovative delivery.

Natasha de Alwis, Natalie K Binder, Sally Beard, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Fiona Brownfoot, Natalie J Hannan

Journal article  |  2020  |  Placenta

Preeclampsia is a complex disease affecting 2-8% of pregnancies worldwide. It poses significant risk of maternal and perinatal mor..

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia.

Natalie K Binder, Fiona C Brownfoot, Sally Beard, Ping Cannon, Tuong V Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article  |  2020  |  Pregnancy Hypertension

Development and repurposing of therapies that show promise in the prevention or treatment of preeclampsia would be a major advance..

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic factors from the placenta: Implications for the treatment of preeclampsia

Fiona C Brownfoot, Roxanne Hastie, Natalie J Hannan, Ping Cannon, Tuong Nguyen, Laura Tuohey, Cathy Cluver, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2020  |  Placenta

INTRODUCTION: The antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are elevated in p..

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction

Sally Beard, Natasha Pritchard, Natalie Binder, Karen Schindler, Natasha De Alwis, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Natalie J Hannan

Journal article  |  2020  |  Placenta

INTRODUCTION: Oxidative damage and biochemical ageing are implicated in placental dysfunction and potentially fetal death. Cellula..

Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth

Natalie J Hannan, Owen Stock, Rebecca Spencer, Clare Whitehead, Anna L David, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Lavinia Gordon, Sally Beard, Kantaraja Chindera, Smita Karegodar, Richard Hiscock, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Stephen Tong

Journal article  |  2020  |  BMC Medicine

BACKGROUND: Fetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricte..

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Nguyen Tuong-Vi, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong

Journal article  |  2020  |  Nature Communications

Placental insufficiency can cause fetal growth restriction and stillbirth. There are no reliable screening tests for placental ins..

Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction

Natasha de Alwis, Sally Beard, Yeukai T Mangwiro, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Stephen Tong, Natalie J Hannan

Journal article  |  2020  |  Pregnancy Hypertension

OBJECTIVES: There is avid interest in pravastatin as a therapeutic intervention for pre-eclampsia, however little is known on stat..

GDF15 is Increased in Preeclampsia and May be Regulated via Transcription Factors EGR1 and SP1.

Tess Cruickshank, Teresa M MacDonald, Susan P Walker, Natalie J Hannan, Damanpreet Singh, Ping Cannon, Alesia Harper, Murray Elizabeth, Tuong-Vi Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Conference Proceedings  |  2020  |  REPRODUCTIVE SCIENCES