Tu'uhevaha Kaitu'u-Lino

Analysis of mitochondrial regulatory transcripts in publicly available datasets with validation in placentae from pre-term, post-term and fetal growth restriction pregnancies

Lucy A Bartho, Jessica L O'Callaghan, Joshua J Fisher, James SM Cuffe, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan, Vicki L Clifton, Anthony V Perkins

Journal article  |  2021  |  PLACENTA

INTRODUCTION: The human placenta has a defined lifespan and placental aging is a key feature as pregnancy progresses. Placental ag..

Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria

Damanpreet Garcha, Susan P Walker, Teresa M MacDonald, Jon Hyett, Jessica Jellins, Jenny Myers, Sebastian E Illanes, Jhy K Nien, Manuel Schepeler, Emerson Keenan, Carole-Anne Whigham, Ping Cannon, Elizabeth Murray, Tuong-Vi Nguyen, Manju Kandel, Joshua Masci, Ciara Murphy, Tess Cruickshank, Natasha Pritchard, Natalie J Hannan, et al.

Journal article  |  2021  |  SCIENTIFIC REPORTS

Fetal growth restriction is a leading cause of stillbirth that often remains undetected during pregnancy. Identifying novel biomar..

Placental growth factor is negatively regulated by epidermal growth factor receptor (EGFR) signaling.

Carole-Anne Whigham, Roxanne Hastie, Natalie J Hannan, Fiona Brownfoot, Natasha Pritchard, Ping Cannon, Tuong Vi Nguyen, Manju Kandel, Joshua Masci, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2021  |  Placenta

INTRODUCTION: Preeclampsia is associated with reduced pro-angiogenic Placental Growth Factor (PlGF) and increased levels of anti-a..

LOX-1 expression is reduced in placenta from pregnancies complicated by preeclampsia and in hypoxic cytotrophoblast

Natasha de Alwis, Sally Beard, Natalie K Binder, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Owen Stock, Katie M Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Stephen Tong, Natalie J Hannan

Journal article  |  2021  |  PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH

OBJECTIVES: The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is upregulated in the maternal vasculature in pree..

Pre-Clinical Investigation of Cardioprotective Beta-Blockers as a Therapeutic Strategy for Preeclampsia

Natalie K Binder, Teresa M MacDonald, Sally A Beard, Natasha de Alwis, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article  |  2021  |  JOURNAL OF CLINICAL MEDICINE

Despite significant maternal and fetal morbidity, a treatment for preeclampsia currently remains an unmet need in clinical care. A..

Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Susan P Walker, Teresa M MacDonald, Ping Cannon, Tuong-Vi Nguyen, Suresh Anand Sadananthan, Mya-Thway Tint, Yi Ying Ong, Loy See Ling, Peter D Gluckman, Yap-Seng Chong, Keith M Godfrey, Shiao-Yng Chan, Kok Hian Tan, Yung Seng Lee, Navin Michael, Johan G Eriksson, Mary E Wlodek

Journal article  |  2021  |  PLACENTA

Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low materna..

DAAM2 is elevated in the circulation and placenta in pregnancies complicated by fetal growth restriction and is regulated by hypoxia

Natasha de Alwis, Sally Beard, Natalie K Binder, Natasha Pritchard, Tu'uhevaha J Kaitu'u-Lino, Susan P Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M Said, Sean Seeho, Stefan C Kane, Lisa Hui, Stephen Tong, Natalie J Hannan

Journal article  |  2021  |  SCIENTIFIC REPORTS

Previously, we identified increased maternal circulating DAAM2 mRNA in pregnancies complicated by preterm fetal growth restriction..

Nanoparticles in pregnancy: the next frontier in reproductive therapeutics

Natasha Pritchard, Tu'uhevaha Kaitu'u-Lino, Lynda Harris, Stephen Tong, Natalie Hannan

Journal article  |  2021  |  HUMAN REPRODUCTION UPDATE

BACKGROUND: Nanotechnology involves the engineering of structures on a molecular level. Nanomedicine and nano-delivery systems hav..

Circulating Tissue Factor Pathway Inhibitor (TFPI) is increased preceding preeclampsia diagnosis and in established preeclampsia

Teresa M MacDonald, Stephen Tong, Jenny Myers, Ping Cannon, Nguyen Tuong-Vi, Emerson Keenan, Elizabeth Murray, Alesia Harper, Natasha Pritchard, Natalie J Hannan, Kirsten M Dane, Anna L Middleton, Valerie P Kyritsis, Susan P Walker, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2021  |  PLACENTA

INTRODUCTION: Tissue Factor Pathway Inhibitor (TFPI) is a part of the extrinsic coagulation pathway, and highly expressed in the p..

Measuring circulating miRNAs in early pregnancy could identify fetuses' destined to undergrow and be at increased risk of stillbirth.

Stephen Tong, Tu'uhevaha Kaitu'u-Lino

Journal article  |  2021  |  EBioMedicine