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High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by down..
Functionally distinct roles for different miR-155 expression levels through contrasting ef..
'Did He Who Made the Lamb Make Thee?' New Developments in Treating the `Fearful Symmetry' ..
Displaying the 39 most recent scholarly works by Gabriela Brumatti.
Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death
Jarrod J Sandow, Giuseppe Infusini, Aliaksei Z Holik, Gabriela Brumatti, Tessa V Averink, Paul G Ekert, Andrew I Webb
Journal article | 2017 | PROTEOMICS - Clinical Applications
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death
Isabel Jaco, Alessandro Annibaldi, Najoua Lalaoui, Rebecca Wilson, Tencho Tenev, Lucie Laurien, Chun Kim, Kunzah Jamal, Sidonie Wicky John, Gianmaria Liccardi, Diep Chau, James M Murphy, Gabriela Brumatti, Rebecca Feltham, Manolis Pasparakis, John Silke, Pascal Meier
Journal article | 2017 | Molecular Cell
High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression
Nicole L Wittwer, Gabriela Brumatti, Ceilidh Marchant, Jarrod J Sandow, Melanie K Pudney, Mara Dottore, Richard J D'Andrea, Angel F Lopez, Paul G Ekert, Hayley S Ramshaw
Journal article | 2017 | Blood Advances
DR5 and caspase-8 are dispensable in ER stress-induced apoptosis
Jason A Glab, Marcel Doerflinger, Christina Nedeva, Irvin Jose, George W Mbogo, James C Paton, Adrienne W Paton, Andrew J Kueh, Marco J Herold, David CS Huang, David Segal, Gabriella Brumatti, Hamsa Puthalakath
Journal article | 2017 | Cell Death & Differentiation
Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia
N Narayan, L Morenos, B Phipson, SN Willis, G Brumatti, S Eggers, N Lalaoui, LM Brown, HJ Kosasih, RC Bartolo, L Zhou, D Catchpoole, R Saffery, A Oshlack, GJ Goodall, PG Ekert
Journal article | 2017 | Leukemia
Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (vol 29, pg 145, 2016)
Najoua Lalaoui, Kay Hanggi, Gabriela Brumatti, Diep Chau, Nhu-Y N Nguyen, Lazaros Vasilikos, Lisanne M Spilgies, Denise A Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M Salmon, Geoffrey M Matthews, Elisha de Valle, Donia M Moujalled, Manoj B Menon, Sukhdeep Kaur Spaii, Stefan P Glaser, Jennifer Richmond, Richard B Lock, Stephen M Condon, et al.
Journal article | 2016 | Cancer Cell
The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia
Gabriela Brumatti, Chunyan Ma, Najoua Lalaoui, Nhu-Y Nguyen, Mario Navarro, Maria C Tanzer, Jennifer Richmond, Margherita Ghisi, Jessica M Salmon, Natasha Silke, Giovanna Pomilio, Stefan P Glaser, Elisha de Valle, Raffi Gugasyan, Mark A Gurthridge, Stephen M Condon, Ricky W Johnstone, Richard Lock, Guy Salvesen, Andrew Wei, et al.
Journal article | 2016 | Science Translational Medicine
Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics
Najoua Lalaoui, Kay Haenggi, Gabriela Brumatti, Diep Chau, Nhu-Y N Nguyen, Lazaros Vasilikos, Lisanne M Spilgies, Denise A Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M Salmon, Geoffrey M Matthews, Elisha de Valle, Donia M Moujalled, Manoj B Menon, Sukhdeep Kaur Spall, Stefan P Glaser, Jennifer Richmond, Richard B Lock, Stephen M Condon, et al.
Journal article | 2016 | Cancer Cell
Interleukin-3-mediated regulation of beta-catenin in myeloid transformation and acute myeloid leukemia
Teresa Sadras, Michelle Perugini, Chung H Kok, Diana G Iarossi, Susan L Heatley, Gabriela Brumatti, Michael S Samuel, Luen B To, Ian D Lewis, Angel F Lopez, Paul G Ekert, Hayley S Ramshaw, Richard J D'Andrea
Journal article | 2014 | Journal of Leukocyte Biology
HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia
Gabriela Brumatti, Marika Salmanidis, Chung H Kok, Rebecca A Bilardi, Jarrod J Sandow, Natasha Silke, Kylie Mason, Jolanda Visser, Anissa M Jabbour, Stefan P Glaser, Toru Okamoto, Philippe Bouillet, Richard J D'Andrea, Paul G Ekert
Journal article | 2013 | Oncotarget
Hoxb8 regulates expression of microRNAs to control cell death and differentiation
M Salmanidis, G Brumatti, N Narayan, BD Green, JA van den Bergen, JJ Sandow, AG Bert, N Silke, R Sladic, H Puthalakath, L Rohrbeck, T Okamoto, P Bouillet, MJ Herold, GJ Goodall, AM Jabbour, PG Ekert
Journal article | 2013 | Cell Death & Differentiation
Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
Alexander U Luethi, Sean P Cullen, Edel A McNeela, Patrick J Duriez, Inna S Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C Taylor, Kristof Kersse, Peter Vandenabeele, Ed C Lavelle, Seamus J Martin
Journal article | 2009 | Immunity
Conversion of CD95 (Fas) Type II into Type I signaling by sub-lethal doses of cycloheximide.
G Brumatti, M Yon, FA Castro, AEB Bueno-da-Silva, JF Jacysyn, T Brunner, GP Amarante-Mendes
Journal article | 2008 | Experimental Cell Research
CD95 (Fas/Apo-1)-mediated apoptosis was shown to occur through two distinct pathways. One involves a direct activation of caspase-..
Involvement of DNA replication in ultraviolet-induced apoptosis of mammalian cells.
Luis Francisco Zirnberger Batista, Vanessa Chiganças, Gabriela Brumatti, Gustavo Pessini Amarante-Mendes, Carlos Frederico Martins Menck
Journal article | 2006 | Apoptosis
Exposure of cells to ultraviolet (UV) light damages the genome and the persistence of DNA lesions triggers apoptosis in mammalian ..
The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics.
Colin Adrain, Patrick J Duriez, Gabriela Brumatti, Petrina Delivani, Seamus J Martin
Journal article | 2006 | Journal of Biological Chemistry
Granzyme B, a serine protease derived from cytotoxic T lymphocyte (CTL) and Natural Killer (NK) cell granules, plays an important ..
Butyrate increases apoptosis induced by different antineoplastic drugs in monocytic leukemia cells.
MG Ramos, FLA Rabelo, G Brumatti, AE Bueno-da-Silva, GP Amarante-Mendes, JI Alvarez-Leite
Journal article | 2004 | Chemotherapy
BACKGROUND: Apoptosis is an essential form of cell death, the failure of which can lead to cancer development. Cancer including le..
Effect of cell confluence on ultraviolet light apoptotic responses in DNA repair deficient cells.
Helotonio Carvalho, Renata Maria Augusto da Costa, Vanessa Chiganças, Ricardo Weinlich, Gabriela Brumatti, Gustavo P Amarante-Mendes, Alain Sarasin, Carlos Frederico Martins Menck
Conference Proceedings | 2003 | Mutation Research/Reviews in Mutation Research
One of the major critical factors for cancer proneness is the cell response to DNA damage. In this work, we used human DNA repair ..
Myriadenolide, a labdane diterpene isolated from Alomia myriadenia (asteraceae) induces depolarization of mitochondrial membranes and apoptosis associated with activation of caspases-8, -9, and -3 in Jurkat and THP-1 cells.
Elaine Maria Souza-Fagundes, Gabriela Brumatti, Olindo Assis Martins-Filho, Rodrigo Corrêa-Oliveira, Carlos Leomar Zani, Gustavo Pessini Amarante-Mendes
Journal article | 2003 | Experimental Cell Research
Myriadenolide is a diterpene that we have recently isolated from the extract of Alomia myriadenia (Asteraceae). Here we show for t..
Bcr-Abl-mediated resistance to apoptosis is independent of constant tyrosine-kinase activity.
AEB Bueno-da-Silva, G Brumatti, FO Russo, DR Green, GP Amarante-Mendes
Journal article | 2003 | Cell Death & Differentiation
Bcr-Abl is one of the most potent antiapoptotic molecules and is the tyrosine-kinase implicated in Philadelphia (Ph) chromosome-po..
Comparison of the anti-apoptotic effects of Bcr-Abl, Bcl-2 and Bcl-x(L) following diverse apoptogenic stimuli.
Gabriela Brumatti, Ricardo Weinlich, Cristina F Chehab, Monica Yon, Gustavo P Amarante-Mendes
Journal article | 2003 | FEBS Letters
Ectopic expression of Bcr-Abl, Bcl-2 or Bcl-x(L) in HL-60 cells conferred resistance to apoptosis against a variety of death-induc..
Apoptosis induced by butyrate is independent of Jak/STAT signaling in a fibrosarcoma cell line.
Flávia LA Rabelo, Mariana G Ramos, Gabriela Brumatti, Gustavo P Amarante-Mendes, Catherine Ropert, Cláudio A Bonjardim, Jacqueline I Alvarez-Leite
Journal article | 2003 | Biochemical and Biophysical Research Communications
The aim of this study was to evaluate the participation of the Jak-1 and STAT-1 proteins in sodium butyrate-induced apoptosis in 2..
Low amounts of the DNA repair XPA protein are sufficient to recover UV-resistance.
Alysson R Muotri, Maria CN Marchetto, Miriam F Suzuki, Kayo Okazaki, Claudimara FP Lotfi, Gabriela Brumatti, Gustavo P Amarante-Mendes, Carlos FM Menck
Journal article | 2002 | Carcinogenesis
DNA integrity is threatened by the damaging effects of physical and chemical agents that can affect its function. Nucleotide excis..
Medical Biology (W.E.H.I.)