Gabriela Brumatti

Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death

Jarrod J Sandow, Giuseppe Infusini, Aliaksei Z Holik, Gabriela Brumatti, Tessa V Averink, Paul G Ekert, Andrew I Webb

Journal article  |  2017  |  PROTEOMICS - Clinical Applications

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

Isabel Jaco, Alessandro Annibaldi, Najoua Lalaoui, Rebecca Wilson, Tencho Tenev, Lucie Laurien, Chun Kim, Kunzah Jamal, Sidonie Wicky John, Gianmaria Liccardi, Diep Chau, James M Murphy, Gabriela Brumatti, Rebecca Feltham, Manolis Pasparakis, John Silke, Pascal Meier

Journal article  |  2017  |  Molecular Cell

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression

Nicole L Wittwer, Gabriela Brumatti, Ceilidh Marchant, Jarrod J Sandow, Melanie K Pudney, Mara Dottore, Richard J D'Andrea, Angel F Lopez, Paul G Ekert, Hayley S Ramshaw

Journal article  |  2017  |  Blood Advances

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis

Jason A Glab, Marcel Doerflinger, Christina Nedeva, Irvin Jose, George W Mbogo, James C Paton, Adrienne W Paton, Andrew J Kueh, Marco J Herold, David CS Huang, David Segal, Gabriella Brumatti, Hamsa Puthalakath

Journal article  |  2017  |  Cell Death & Differentiation

Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia

N Narayan, L Morenos, B Phipson, SN Willis, G Brumatti, S Eggers, N Lalaoui, LM Brown, HJ Kosasih, RC Bartolo, L Zhou, D Catchpoole, R Saffery, A Oshlack, GJ Goodall, PG Ekert

Journal article  |  2017  |  Leukemia

'Did He Who Made the Lamb Make Thee?' New Developments in Treating the `Fearful Symmetry' of Acute Myeloid Leukemia

Gabriela Brumatti, Najoua Lalaoui, Andrew H Wei, John Silke

Journal article  |  2017  |  Trends in Molecular Medicine

Relevance of necroptosis in cancer

Najoua Lalaoui, Gabriela Brumatti

Journal article  |  2017  |  Immunology and Cell Biology

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (vol 29, pg 145, 2016)

Najoua Lalaoui, Kay Hanggi, Gabriela Brumatti, Diep Chau, Nhu-Y N Nguyen, Lazaros Vasilikos, Lisanne M Spilgies, Denise A Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M Salmon, Geoffrey M Matthews, Elisha de Valle, Donia M Moujalled, Manoj B Menon, Sukhdeep Kaur Spaii, Stefan P Glaser, Jennifer Richmond, Richard B Lock, Stephen M Condon, et al.

Journal article  |  2016  |  Cancer Cell

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Gabriela Brumatti, Chunyan Ma, Najoua Lalaoui, Nhu-Y Nguyen, Mario Navarro, Maria C Tanzer, Jennifer Richmond, Margherita Ghisi, Jessica M Salmon, Natasha Silke, Giovanna Pomilio, Stefan P Glaser, Elisha de Valle, Raffi Gugasyan, Mark A Gurthridge, Stephen M Condon, Ricky W Johnstone, Richard Lock, Guy Salvesen, Andrew Wei, et al.

Journal article  |  2016  |  Science Translational Medicine

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Najoua Lalaoui, Kay Haenggi, Gabriela Brumatti, Diep Chau, Nhu-Y N Nguyen, Lazaros Vasilikos, Lisanne M Spilgies, Denise A Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M Salmon, Geoffrey M Matthews, Elisha de Valle, Donia M Moujalled, Manoj B Menon, Sukhdeep Kaur Spall, Stefan P Glaser, Jennifer Richmond, Richard B Lock, Stephen M Condon, et al.

Journal article  |  2016  |  Cancer Cell

Lentiviral Vectors to Analyze Cell Death Regulators.

Ueli Nachbur, Gabriela Brumatti

Journal article  |  2016  |  Methods in molecular biology (Clifton, N.J.)

Ectopic expression of proteins involved in cell death pathways is an important tool to analyze their role during apoptosis or othe..

Interleukin-3-mediated regulation of beta-catenin in myeloid transformation and acute myeloid leukemia

Teresa Sadras, Michelle Perugini, Chung H Kok, Diana G Iarossi, Susan L Heatley, Gabriela Brumatti, Michael S Samuel, Luen B To, Ian D Lewis, Angel F Lopez, Paul G Ekert, Hayley S Ramshaw, Richard J D'Andrea

Journal article  |  2014  |  Journal of Leukocyte Biology

Seeking a MCL-1 inhibitor

G Brumatti, PG Ekert

Journal article  |  2013  |  Cell Death & Differentiation

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

Gabriela Brumatti, Marika Salmanidis, Chung H Kok, Rebecca A Bilardi, Jarrod J Sandow, Natasha Silke, Kylie Mason, Jolanda Visser, Anissa M Jabbour, Stefan P Glaser, Toru Okamoto, Philippe Bouillet, Richard J D'Andrea, Paul G Ekert

Journal article  |  2013  |  Oncotarget

Hoxb8 regulates expression of microRNAs to control cell death and differentiation

M Salmanidis, G Brumatti, N Narayan, BD Green, JA van den Bergen, JJ Sandow, AG Bert, N Silke, R Sladic, H Puthalakath, L Rohrbeck, T Okamoto, P Bouillet, MJ Herold, GJ Goodall, AM Jabbour, PG Ekert

Journal article  |  2013  |  Cell Death & Differentiation

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

BD Green, AM Jabbour, JJ Sandow, CD Riffkin, D Masouras, CP Daunt, M Salmanidis, G Brumatti, BA Hemmings, MA Guthridge, RB Pearson, PG Ekert

Journal article  |  2013  |  Cell Death & Differentiation

Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA

Nicholas C Wong, Jane Ng, Nathan E Hall, Sebastian Lunke, Marika Salmanidis, Gabriela Brumatti, Paul G Ekert, Jeffrey M Craig, Richard Saffery

Journal article  |  2013  |  Genomics

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival

Mohamed Elgendy, Clare Sheridan, Gabriela Brumatti, Seamus J Martin

Journal article  |  2011  |  Molecular Cell

An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs

C Sheridan, G Brumatti, M Elgendy, M Brunet, SJ Martin

Journal article  |  2010  |  Oncogene

Crossing paths: interactions between the cell death machinery and growth factor survival signals

Gabriela Brumatti, Marika Salmanidis, Paul G Ekert

Journal article  |  2010  |  Cellular and Molecular Life Sciences

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

Alexander U Luethi, Sean P Cullen, Edel A McNeela, Patrick J Duriez, Inna S Afonina, Clare Sheridan, Gabriela Brumatti, Rebecca C Taylor, Kristof Kersse, Peter Vandenabeele, Ed C Lavelle, Seamus J Martin

Journal article  |  2009  |  Immunity

Bicaudal Is a Conserved Substrate for Drosophila and Mammalian Caspases and Is Essential for Cell Survival

Emma M Creagh, Gabriela Brumatti, Clare Sheridan, Patrick J Duriez, Rebecca C Taylor, Sean P Cullen, Colin Adrain, Seamus J Martin

Journal article  |  2009  |  PLoS ONE

Oncogenic B-Raf(V600E) inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim

Clare Sheridan, Gabriela Brumatti, Seamus J Martin

Journal article  |  2008  |  Journal of Biological Chemistry

Expression and purification of recombinant annexin V for the detection of membrane alterations on apoptotic cells

Gabriela Brumatti, Clare Sheridan, Seamus J Martin

Journal article  |  2008  |  Methods

Conversion of CD95 (Fas) Type II into Type I signaling by sub-lethal doses of cycloheximide.

G Brumatti, M Yon, FA Castro, AEB Bueno-da-Silva, JF Jacysyn, T Brunner, GP Amarante-Mendes

Journal article  |  2008  |  Experimental Cell Research

CD95 (Fas/Apo-1)-mediated apoptosis was shown to occur through two distinct pathways. One involves a direct activation of caspase-..

Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease

Rebecca C Taylor, Gabriela Brumatti, Shu Ito, Michael O Hengartner, W Brent Derry, Seamus J Martin

Journal article  |  2007  |  Journal of Biological Chemistry

Involvement of DNA replication in ultraviolet-induced apoptosis of mammalian cells.

Luis Francisco Zirnberger Batista, Vanessa Chiganças, Gabriela Brumatti, Gustavo Pessini Amarante-Mendes, Carlos Frederico Martins Menck

Journal article  |  2006  |  Apoptosis

Exposure of cells to ultraviolet (UV) light damages the genome and the persistence of DNA lesions triggers apoptosis in mammalian ..

Apoptosomes: protease activation platforms to die from

Colin Adrain, Gabriela Brumatti, Seamus J Martin

Journal article  |  2006  |  Trends in Biochemical Sciences

The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics.

Colin Adrain, Patrick J Duriez, Gabriela Brumatti, Petrina Delivani, Seamus J Martin

Journal article  |  2006  |  Journal of Biological Chemistry

Granzyme B, a serine protease derived from cytotoxic T lymphocyte (CTL) and Natural Killer (NK) cell granules, plays an important ..

TRAIL and thymocyte apoptosis: not so deadly?

N Corazza, G Brumatti, S Jakob, A Villunger, T Brunner

Journal article  |  2004  |  Cell Death & Differentiation

TRAIL and immunity: more than a license to kill tumor cells.

N Corazza, G Brumatti, C Schaer, I Cima, C Wasem, T Brunner

Journal article  |  2004  |  Cell Death & Differentiation

Butyrate increases apoptosis induced by different antineoplastic drugs in monocytic leukemia cells.

MG Ramos, FLA Rabelo, G Brumatti, AE Bueno-da-Silva, GP Amarante-Mendes, JI Alvarez-Leite

Journal article  |  2004  |  Chemotherapy

BACKGROUND: Apoptosis is an essential form of cell death, the failure of which can lead to cancer development. Cancer including le..

Effect of cell confluence on ultraviolet light apoptotic responses in DNA repair deficient cells.

Helotonio Carvalho, Renata Maria Augusto da Costa, Vanessa Chiganças, Ricardo Weinlich, Gabriela Brumatti, Gustavo P Amarante-Mendes, Alain Sarasin, Carlos Frederico Martins Menck

Conference Proceedings  |  2003  |  Mutation Research/Reviews in Mutation Research

One of the major critical factors for cancer proneness is the cell response to DNA damage. In this work, we used human DNA repair ..

Myriadenolide, a labdane diterpene isolated from Alomia myriadenia (asteraceae) induces depolarization of mitochondrial membranes and apoptosis associated with activation of caspases-8, -9, and -3 in Jurkat and THP-1 cells.

Elaine Maria Souza-Fagundes, Gabriela Brumatti, Olindo Assis Martins-Filho, Rodrigo Corrêa-Oliveira, Carlos Leomar Zani, Gustavo Pessini Amarante-Mendes

Journal article  |  2003  |  Experimental Cell Research

Myriadenolide is a diterpene that we have recently isolated from the extract of Alomia myriadenia (Asteraceae). Here we show for t..

Bcr-Abl-mediated resistance to apoptosis is independent of constant tyrosine-kinase activity.

AEB Bueno-da-Silva, G Brumatti, FO Russo, DR Green, GP Amarante-Mendes

Journal article  |  2003  |  Cell Death & Differentiation

Bcr-Abl is one of the most potent antiapoptotic molecules and is the tyrosine-kinase implicated in Philadelphia (Ph) chromosome-po..

Comparison of the anti-apoptotic effects of Bcr-Abl, Bcl-2 and Bcl-x(L) following diverse apoptogenic stimuli.

Gabriela Brumatti, Ricardo Weinlich, Cristina F Chehab, Monica Yon, Gustavo P Amarante-Mendes

Journal article  |  2003  |  FEBS Letters

Ectopic expression of Bcr-Abl, Bcl-2 or Bcl-x(L) in HL-60 cells conferred resistance to apoptosis against a variety of death-induc..

Apoptosis induced by butyrate is independent of Jak/STAT signaling in a fibrosarcoma cell line.

Flávia LA Rabelo, Mariana G Ramos, Gabriela Brumatti, Gustavo P Amarante-Mendes, Catherine Ropert, Cláudio A Bonjardim, Jacqueline I Alvarez-Leite

Journal article  |  2003  |  Biochemical and Biophysical Research Communications

The aim of this study was to evaluate the participation of the Jak-1 and STAT-1 proteins in sodium butyrate-induced apoptosis in 2..

A rapid and sensitive method for the screening of DNA intercalating antibiotics

RLA Furlan, LM Garrido, G Brumatti, GP Amarante-Mendes, RA Martins, MCR Facciotti, G Padilla

Journal article  |  2002  |  Biotechnology Letters

Low amounts of the DNA repair XPA protein are sufficient to recover UV-resistance.

Alysson R Muotri, Maria CN Marchetto, Miriam F Suzuki, Kayo Okazaki, Claudimara FP Lotfi, Gabriela Brumatti, Gustavo P Amarante-Mendes, Carlos FM Menck

Journal article  |  2002  |  Carcinogenesis

DNA integrity is threatened by the damaging effects of physical and chemical agents that can affect its function. Nucleotide excis..