Charley Mackenzie-Kludas

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection

Richard J Mills, Sean J Humphrey, Patrick RJ Fortuna, Mary Lor, Simon R Foster, Gregory A Quaife-Ryan, Rebecca L Johnston, Troy Dumenil, Cameron Bishop, Rajeev Rudraraju, Daniel J Rawle, Thuy Le, Wei Zhao, Leo Lee, Charley Mackenzie-Kludas, Neda R Mehdiabadi, Christopher Halliday, Dean Gilham, Li Fu, Stephen J Nicholls, et al.

Journal article  |  2021  |  CELL

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined but could be ..

Passaging of an influenza A(H1N1)pdm09 virus in a difluoro sialic acid inhibitor selects for a novel, but unfit I106M neuraminidase mutant

Jennifer L McKimm-Breschkin, Susan Barrett, Charley McKenzie-Kludas, Julie McAuley, Victor A Streltsov, Stephen G Withers

Journal article  |  2019  |  ANTIVIRAL RESEARCH

An influenza A(H1N1)pdm09 and an influenza B virus were passaged in 3-fluoro(eq)-4-guanidino difluoro sialic acid (3Feq4Gu DFSA), ..

Topical application of human-derived Ig isotypes for the control of acute respiratory infection evaluated in a human CD89-expressing mouse model

Sandra Koernig, Ian K Campbell, Charley Mackenzie-Kludas, Alexander Schaub, Marius Loetscher, Wy Ching Ng, Roland Zehnder, Pawel Pelczar, Ildem Sanli, Monther Alhamdoosh, Milica Ng, Lorena E Brown, Fabian Kasermann, Cedric Vonarburg, Adrian W Zuercher

Journal article  |  2019  |  MUCOSAL IMMUNOLOGY

Recurrent and persistent airway infections remain prevalent in patients with primary immunodeficiency (PID), despite restoration o..

Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection

Julie McAuley, Yi-Mo Deng, Brad Gilbertson, Charley Mackenzie-Kludas, Ian Barr, Lorena Brown

Journal article  |  2017  |  VIROLOGY JOURNAL

Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-l..

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis

Ian K Campbell, David Leong, Kirsten M Edwards, Veronika Rayzman, Milica Ng, Gabrielle L Goldberg, Nicholas J Wilson, Karen Scalzo-Inguanti, Charley Mackenzie-Kludas, Kate E Lawlor, Ian P Wicks, Lorena E Brown, Adriana Baz Morelli, Con Panousis, Michael J Wilson, Andrew D Nash, Brent S McKenzie, Arna E Andrews

Journal article  |  2016  |  JOURNAL OF IMMUNOLOGY

G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation an..

Induction of memory cytotoxic T cells to influenza A virus and subsequent viral clearance is not modulated by PB1-F2-dependent inflammasome activation

Patricia Hoi Yee Lee, Nicola Bird, Charley MacKenzie-Kludas, Ashley Mansell, Katherine Kedzierska, Lorena Brown, Julie McAuley

Journal article  |  2016  |  IMMUNOLOGY AND CELL BIOLOGY

Expression of the viral virulence protein PB1-F2 during infection has been linked to NLRP3 inflammasome complex activation in macr..

Removal of myeloid cytokines from the cellular environment enhances T-cell development in vitro

Monique FMA Smeets, Charley Mackenzie-Kludas, Mahmood Mohtashami, Hui-Hua Zhang, Juan Carlos Zuniga-Pfluecker, David J Izon

Journal article  |  2013  |  INTERNATIONAL IMMUNOLOGY

The majority of T-cell development occurs in the thymus. Thymic epithelial cells are specialized cells that express NOTCH ligands ..

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

Julie L McAuley, Michelle D Tate, Charley J MacKenzie-Kludas, Anita Pinar, Weiguang Zeng, Andrea Stutz, Eicke Latz, Lorena E Brown, Ashley Mansell

Journal article  |  2013  |  PLOS PATHOGENS

The ability for a host to recognize infection is critical for virus clearance and often begins with induction of inflammation. The..

Activin inhibits telomerase activity in cancer.

Indzi Katik, Charley Mackenzie-Kludas, Craig Nicholls, Fang-Xu Jiang, Shufeng Zhou, He Li, Jun-Ping Liu

Journal article  |  2009  |  Biochem Biophys Res Commun

Activin is a pleiotropic cytokine with broad tissue distributions. Recent studies demonstrate that activin-A inhibits cancer cell ..