Makhala Khammy

The beta(2)-adrenoceptor agonist bronchodilators terbutaline and orciprenaline are also weak alpha(1)-adrenoceptor antagonists

Makhala M Khammy, Cindy Kha Han Truong, Christine E Wright, James A Angus

Journal article  |  2020  |  EUROPEAN JOURNAL OF PHARMACOLOGY

Recently, the β2-adrenoceptor agonist terbutaline was shown to have α1-adrenolytic activity in mouse isolated pulmonary arteries i..

Estimation of the vascular resistance amplifier in the renal vascular bed in conscious hypertensive rabbits: comparison with the total peripheral vasculature

Makhala M Khammy, James A Angus, Christine E Wright

Journal article  |  2020  |  HELIYON

OBJECTIVES: The vascular amplifier in hypertension is a result of structural changes in resistance arteries. We estimated the vasc..

[Ca2 ] changes in sympathetic varicosities and Schwann cells in rat mesenteric arteries-Relation to noradrenaline release and contraction

Thomas Hansen, Olga S Tarasova, Makhala M Khammy, Avelino Ferreira, James A Kennard, Jorgen Andresen, Christian Staehr, Keith L Brain, Holger Nilsson, Christian Aalkjaer

Journal article  |  2019  |  ACTA PHYSIOLOGICA

AIM: This study aimed to assess intracellular Ca2+ dynamics in nerve cells and Schwann cells in isolated rat resistance arteries a..

Microtubule Regulation of Kv7 Channels Orchestrates cAMP-Mediated Vasorelaxations in Rat Arterial Smooth Muscle

Johanna Lindman, Makhala M Khammy, Pia R Lundegaard, Christian Aalkjaer, Thomas A Jepps

Journal article  |  2018  |  HYPERTENSION

Microtubules can regulate GPCR (G protein-coupled receptor) signaling in various cell types. In vascular smooth muscle, activation..

4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances K(v)7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries

Makhala Khammy, Sukhan Kim, Bo H Bentzen, Soojung Lee, Inyeong Choi, Christian Aalkjaer, Thomas A Jepps

Journal article  |  2018  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: Kv 7.4 and Kv 7.5 channels are regulators of vascular tone. 4-Aminopyridine (4-AP) is considered a broad i..

PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries

Makhala Michell Khammy, Thomas Dalsgaard, Peter Hjorringgaard Larsen, Claus Tornby Christoffersen, Dorte Clausen, Lars Kyhn Rasmussen, Lasse Folkersen, Morten Grunnet, Jan Kehler, Christian Aalkjr, Jacob Nielsen

Journal article  |  2017  |  BRITISH JOURNAL OF PHARMACOLOGY

BACKGROUND AND PURPOSE: PDE1, a subfamily of cyclic nucleotide PDEs consisting of three isoforms, PDE1A, PDE1B and PDE1C, has been..

GLP-1 inhibits VEGFA-mediated signaling in isolated human endothelial cells and VEGFA-induced dilation of rat mesenteric arteries

Cecilie Egholm, Makhala Michell Khammy, Thomas Dalsgaard, Aleksandra Mazur, Katerina Tritsaris, Anker J Hansen, Christian Aalkjaer, Steen Dissing

Journal article  |  2016  |  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

We investigated the acute effects of glucagon-like peptide-1 (GLP-1), GLP-1(1-36), and GLP-1(7-36) on vascular endothelial growth ..

Vascular reactivity of rabbit isolated renal and femoral resistance arteries in renal wrap hypertension

Makhala M Khammy, James A Angus, Christine E Wright

Journal article  |  2016  |  EUROPEAN JOURNAL OF PHARMACOLOGY

In rabbits with cellophane renal wrap hypertension, hindquarter and total vascular resistance changes to pressor and depressor age..

274 DIFFERENCES IN VASCULAR RESPONSIVENESS IN THE RAT KIDNEY

Makhala Khammy, James Angus, Christine Wright

Journal article  |  2012  |  Journal of Hypertension

Abstract P132: Diabetes-Induced Cardiac Dysfunction Is Rescued by Endothelial Cationic Amino Acid Transporter 1 Overexpression in Mice

Rebecca H Ritchie, Makhala M Khammy, Marissa A Bowden, Jennifer Irvine, Karen Andrews, Karina Huynh, Helen Kiriazis, David Kaye, Kylie Venardos

Journal article  |  2011  |  Circulation Research

Nitric oxide (NO) bioavailability is markedly impaired in diabetes, contributing to endothelial and myocardial dysfunction. Our ai..