Andreas Hofmann

Combined use of feature engineering and machine-learning to predict essential genes in Drosophila melanogaster

Tulio L Campos, Pasi K Korhonen, Andreas Hofmann, Robin B Gasser, Neil D Young

Journal article  |  2020  |  NAR GENOMICS AND BIOINFORMATICS

Characterizing genes that are critical for the survival of an organism (i.e. essential) is important to gain a deep understanding ..

Natural Compounds from the Marine Brown Alga Caulocystis cephalornithos with Potent In Vitro-Activity against the Parasitic Nematode Haemonchus contortus

Aya C Taki, Robert Brkljaca, Tao Wang, Anson Koehler, Guangxu Ma, Jill Danne, Sarah Ellis, Andreas Hofmann, Bill CH Chang, Abdul Jabbar, Sylvia Urban, Robin B Gasser

Journal article  |  2020  |  PATHOGENS

Eight secondary metabolites (1 to 8) were isolated from a marine sponge, a marine alga and three terrestrial plants collected in A..

Global Prevalence Estimates of Toxascaris leonina Infection in Dogs and Cats

Ali Rostami, Seyed Mohammad Riahi, Vahid Fallah Omrani, Tao Wang, Andreas Hofmann, Aliyar Mirzapour, Masoud Foroutan, Yadolah Fakhri, Calum NL Macpherson, Robin B Gasser

Journal article  |  2020  |  PATHOGENS

Toxascaris leonina is an ascaridoid nematode of dogs and cats; this parasite affects the health of these animals. This study estim..

Synthetic Kavalactone Analogues with Increased Potency and Selective Anthelmintic Activity against Larvae of Haemonchus contortus In Vitro

HMP Dilrukshi Herath, Aya C Taki, Nguyen Nghi, Jose Garcia-Bustos, Andreas Hofmann, Tao Wang, Guangxu Ma, Bill CH Chang, Abdul Jabbar, Brad E Sleebs, Robin B Gasser

Journal article  |  2020  |  MOLECULES

Kava extract, an aqueous rhizome emulsion of the plant Piper methysticum, has been used for centuries by Pacific Islanders as a ce..

Synthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus

Banfeng Ruan, Yuezhou Zhang, Solomon Tadesse, Sarah Preston, Aya C Taki, Abdul Jabbar, Andreas Hofmann, Yaqing Jiao, Jose Garcia-Bustos, Jitendra Harjani, Thuy Giang Le, Swapna Varghese, Silvia Teguh, Yiyue Xie, Jephthah Odiba, Min Hu, Robin B Gasser, Jonathan Baell

Journal article  |  2020  |  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Parasitic roundworms (nematodes) are significant pathogens of humans and animals and cause substantive socioeconomic losses due to..

The developmental phosphoproteome of Haemonchus contortus

Tao Wang, Guangxu Ma, Ching-Seng Ang, Pasi K Korhonen, Andreas J Stroehlein, Neil D Young, Andreas Hofmann, Bill CH Chang, Nicholas A Williamson, Robin B Gasser

Journal article  |  2020  |  JOURNAL OF PROTEOMICS

Protein phosphorylation plays essential roles in many cellular processes. Despite recent progress in the genomics, transcriptomics..

Elucidating the molecular and developmental biology of parasitic nematodes: Moving to a multiomics paradigm

Guangxu Ma, Tao Wang, Pasi K Korhonen, Andreas Hofmann, Paul W Sternberg, Neil D Young, Robin B Gasser

Book Chapter  |  2020  |  Advances in Parasitology

In the past two decades, significant progress has been made in the sequencing, assembly, annotation and analyses of genomes and tr..

Global prevalence of Toxocara infection in dogs

Ali Rostami, Seyed Mohammad Riahi, Andreas Hofmann, Guangxu Ma, Tao Wang, Hamed Behniafar, Ali Taghipour, Yadolah Fakhri, Adel Spotin, Bill CH Chang, Calum NL Macpherson, Peter J Hotez, Robin B Gasser

Book Chapter  |  2020  |  Advances in Parasitology

Dogs serve as the most important definitive hosts for Toxocara canis—a causative agent of human toxocariasis and one of the most w..

A perspective on the discovery of selected compounds with anthelmintic activity against the barber's pole worm-Where to from here?

Yaqing Jiao, Sarah Preston, Andreas Hofmann, Aya Taki, Jonathan Baell, Bill CH Chang, Abdul Jabbar, Robin B Gasser

Book Chapter  |  2020  |  Advances in Parasitology

Parasitic roundworms (nematodes) cause substantial morbidity and mortality in animals worldwide. Anthelmintic treatment is central..

Global and regional seroprevalence estimates for human toxocariasis: A call for action

Guangxu Ma, Ali Rostami, Tao Wang, Andreas Hofmann, Peter J Hotez, Robin B Gasser

Book Chapter  |  2020  |  Advances in Parasitology

Human toxocariasis is a parasitic disease transmitted usually from dogs and/or cats that are infected with Toxocara species, and c..