Michael Chopin

Transcriptional Networks Driving Dendritic Cell Differentiation and Function

Stephen L Nutt, Michael Chopin

Journal article  |  2020  |  Immunity

Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of pathogens to stimulate a robust and appro..

Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity

Yifan Zhan, Isabella Kong, Michael Chopin, Christophe Macri, Jian-Guo Zhang, Jiaying Xie, Stephen L Nutt, Meredith O'Keeffe, Edwin D Hawkins, Eric F Morand, Andrew M Lew

Journal article  |  2020  |  Immunology & Cell Biology

The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent stra..

EZH2 function in immune cell development.

Stephen L Nutt, Christine Keenan, Michaël Chopin, Rhys S Allan

Journal article  |  2020  |  Biological Chemistry

The polycomb repressive complex 2 (PRC2) consists of three core components EZH2, SUZ12 and EED. EZH2 catalyzes the methylation of ..

CCR2 enhances CD25 expression by FoxP3( ) regulatory T cells and regulates their abundance independently of chemotaxis and CCR2( ) myeloid cells

Yifan Zhan, Nancy Wang, Ajithkumar Vasanthakumar, Yuxia Zhang, Michael Chopin, Stephen L Nutt, Axel Kallies, Andrew M Lew

Journal article  |  2020  |  Cellular & Molecular Immunology

A wide array of chemokine receptors, including CCR2, are known to control Treg migration. Here, we report that CCR2 regulates Treg..

The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game

Yifan Zhan, Andrew M Lew, Michael Chopin

Journal article  |  2019  |  Frontiers in Immunology

Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system

Ludovica Bruno, Vijendra Ramlall, Romain A Studer, Stephan Sauer, David Bradley, Gopuraja Dharmalingam, Thomas Carroll, Mohamed Ghoneim, Michael Chopin, Stephen L Nutt, Sarah Elderkin, David S Rueda, Amanda G Fisher, Trevor Siggers, Pedro Beltrao, Matthias Merkenschlager

Journal article  |  2019  |  Nature Immunology

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

Mark D McKenzie, Margherita Ghisi, Ethan P Oxley, Steven Ngo, Luisa Cimmino, Cecile Esnault, Ruijie Liu, Jessica M Salmon, Charles C Bell, Nouraiz Ahmed, Michael Erlichster, Matthew T Witkowski, Grace J Liu, Michael Chopin, Aleksandar Dakic, Emilia Simankowicz, Giovanna Pomilio, Tina Vu, Pavle Krsmanovic, Shian Su, et al.

Journal article  |  2019  |  Cell Stem Cell

TCF-1 limits the formation of Tc17 cells via repression of the MAF-ROR gamma t axis

Lisa A Mielke, Yang Liao, Ella Bridie Clemens, Matthew A Firth, Brigette Duckworth, Qiutong Huang, Francisca F Almeida, Michael Chopin, Hui-Fern Koay, Carolyn A Bell, Soroor Hediyeh-Zadeh, Simone L Park, Dinesh Raghu, Jarny Choi, Tracy L Putoczki, Philip D Hodgkin, Ashley E Franks, Laura K Mackay, Dale Godfrey, Melissa J Davis, et al.

Journal article  |  2019  |  Journal of Experimental Medicine

Langerhans cells drive TNF induced chronic proliferative dermatitis in SHARPIN deficient mice

H Anderton, M Chopin, C Dawson, N Lalaoui, J Silke

Conference Proceedings  |  2019  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

Michael Chopin, Aaron T Lun, Yifan Zhan, Jaring Schreuder, Hannah Coughlan, Angela D'Amico, Lisa A Mielke, Francisca F Almeida, Andrew J Kueh, Ross A Dickins, Gabrielle T Belz, Shalin H Naik, Andrew M Lew, Phillipe Bouillet, Marco J Herold, Gordon K Smyth, Lynn M Corcoran, Stephen L Nutt

Journal article  |  2019  |  Immunity

Natural-Killer-like B Cells Display the Phenotypic and Functional Characteristics of Conventional B Cells

Yann M Kerdiles, Francisca F Almeida, Thornton Thompson, Michael Chopin, Margaux Vienne, Pierre Bruhns, Nicholas D Huntington, David H Raulet, Stephen L Nutt, Gabrielle T Belz, Eric Vivier

Journal article  |  2017  |  Immunity

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

Nima Etemadi, Michael Chopin, Holly Anderton, Maria C Tanzer, James A Rickard, Waruni Abeysekera, Cathrine Hall, Sukhdeep K Spall, Bing Wang, Yuquan Xiong, Timothy Hla, Stuart M Pitson, Claudine S Bonder, Wendy Wei-Lynn Wong, Matthias Ernst, Gordon K Smyth, David L Vaux, Stephen L Nutt, Ueli Nachbur, John Silke

Journal article  |  2017  |  eLife

Changes in the sympathetic innervation of the gut in rotenone treated mice as possible early biomarker for Parkinson's disease

Mike Arnhold, Yanina Dening, Michael Chopin, Esteban Arevalo, Mathias Schwarz, Heinz Reichmann, Gabriele Gille, Richard HW Funk, Francisco Pan-Montojo

Journal article  |  2016  |  Clinical Autonomic Research

RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity

Michael Chopin, Simon P Preston, Aaron TL Lun, Julie Tellier, Gordon K Smyth, Marc Pellegrini, Gabrielle T Belz, Lynn M Corcoran, Jane E Visvader, Li Wu, Stephen L Nutt

Journal article  |  2016  |  Cell Reports

TRAF2 regulates TNF and NF-kappa B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

Nima Etemadi, Michael Chopin, Holly Anderton, Maria C Tanzer, James A Rickard, Waruni Abeysekera, Cathrine Hall, Sukhdeep K Spall, Bing Wang, Yuquan Xiong, Timothy Hla, Stuart M Pitson, Claudine S Bonder, Wendy Wei-Lynn Wong, Matthias Ernst, Gordon K Smyth, David L Vaux, Stephen L Nutt, Ueli Nachbur, John Silke

Journal article  |  2015  |  eLife

Establishing and maintaining the Langerhans cell network

Michael Chopin, Stephen L Nutt

Journal article  |  2015  |  Seminars in Cell & Developmental Biology

The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation

Sebastian Carotta, Simon N Willis, Jhagvaral Hasbold, Michael Inouye, Swee Heng Milon Pang, Dianne Emslie, Amanda Light, Michael Chopin, Wei Shi, Hongsheng Wang, Herbert C Morse, David M Tarlinton, Lynn M Corcoran, Philip D Hodgkin, Stephen L Nutt

Journal article  |  2014  |  Journal of Experimental Medicine

Nfil3 is required for the development of all innate lymphoid cell subsets

Cyril Seillet, Lucille C Rankin, Joanna R Groom, Lisa A Mielke, Julie Tellier, Michael Chopin, Nicholas D Huntington, Gabrielle T Belz, Sebastian Carotta

Journal article  |  2014  |  Journal of Experimental Medicine

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells

Priyanka Sathe, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Cyril Seillet, Michael Chopin, Cassandra J Vandenberg, Lucille C Rankin, Lisa A Mielke, Ingela Vikstrom, Tatiana B Kolesnik, Sandra E Nicholson, Eric Vivier, Mark J Smyth, Stephen L Nutt, Stefan P Glaser, Andreas Strasser, Gabrielle T Belz, Sebastian Carotta, Nicholas D Huntington

Journal article  |  2014  |  Nature Communications

The Closely Related CD103( ) Dendritic Cells (DCs) and Lymphoid-Resident CD8( ) DCs Differ in Their Inflammatory Functions

Zhijun Jiao, Sammy Bedoui, Jamie L Brady, Anne Walter, Michael Chopin, Emma M Carrington, Robyn M Sutherland, Stephen L Nutt, Yuxia Zhang, Hyun-Ja Ko, Li Wu, Andrew M Lew, Yifan Zhan

Journal article  |  2014  |  PLoS One

Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks

Michael Chopin, Cyril Seillet, Stephane Chevrier, Li Wu, Hongsheng Wang, Herbert C Morse, Gabrielle T Belz, Stephen L Nutt

Journal article  |  2013  |  Journal of Experimental Medicine

Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells

Yuxia Zhang, Jovana Maksimovic, Gaetano Naselli, Junyan Qian, Michael Chopin, Marnie E Blewitt, Alicia Oshlack, Leonard C Harrison

Journal article  |  2013  |  Blood

The transcription factor T-bet is essential for the development of NKp46( ) innate lymphocytes via the Notch pathway (vol 14, pg 389, 2013)

Lucille Rankin, Joanna R Groom, Michael Chopin, Marco J Herold, Jennifer A Walker, Lisa A Mielke, Andrew NJ McKenzie, Sebastian Carotta, Stephen L Nutt, Gabrielle T Belz

Journal article  |  2013  |  Nature Immunology

The transcription factor T-bet is essential for the development of NKp46( ) innate lymphocytes via the Notch pathway

Lucille C Rankin, Joanna R Groom, Michael Chopin, Marco J Herold, Jennifer A Walker, Lisa A Mielke, Andrew NJ McKenzie, Sebastian Carotta, Stephen L Nutt, Gabrielle T Belz

Journal article  |  2013  |  Nature Immunology

Regulation of bone mass and osteoclast function depend on the F-actin modulator SWAP-70

Annette I Garbe, Anne Roscher, Christiane Schueler, Anne-Helen Lutter, Martin Gloesmann, Ricardo Bernhardt, Michael Chopin, Ute Hempel, Lorenz C Hofbauer, Stefan Rammelt, Monika Egerbacher, Reinhold G Erben, Rolf Jessberger

Journal article  |  2012  |  Journal of Bone and Mineral Research

Transcriptional regulation of dendritic cell diversity

Michael Chopin, Rhys S Allan, Gabrielle T Belz

Journal article  |  2012  |  Frontiers in Immunology

Fine tuning of IRF-4 expression by SWAP-70 controls the initiation of plasma cell development

Michael Chopin, Carlos Andres Chacon-Martinez, Rolf Jessberger

Journal article  |  2011  |  European Journal of Immunology

Sphingosine 1-Phosphate-Induced Motility and Endocytosis of Dendritic Cells Is Regulated by SWAP-70 through RhoA

Carlos Ocana-Morgner, Peter Reichardt, Michael Chopin, Sarah Braungart, Christine Wahren, Matthias Gunzer, Rolf Jessberger

Journal article  |  2011  |  The Journal of Immunology

SWAP-70 controls formation of the splenic marginal zone through regulating T1B-cell differentiation

Michael Chopin, Laurence Quemeneur, Tatsiana Ripich, Rolf Jessberger

Journal article  |  2010  |  European Journal of Immunology

T1 and T2 transitional B cells are precursors for marginal zone B cells (MZB), which surround splenic follicles. MZB are essential..

SWAP-70 deficiency causes high-affinity plasma cell generation despite impaired germinal center formation

Laurence Quemeneur, Veronique Angeli, Michael Chopin, Rolf Jessberger

Journal article  |  2008  |  Blood

Germinal centers (GCs) are lymphoid tissue structures central to the generation of long-lived, high-affinity, antibody-forming B c..

Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCB4: a potential mechanism for the metastasis suppressor activity of kisspeptins

JM Navenot, ZX Wang, N Chopin, N Fujii, SC Peiper

Journal article  |  2005  |  Cancer Research

The product of the KiSS-1 gene is absent or expressed at low level in metastatic melanoma and breast cancer compared with their no..