Michael Chopin

CIS controls the functional polarization of GM-CSF-derived macrophages

Shengbo Zhang, Jai Rautela, Naiara G Bediaga, Tatiana B Kolesnik, Yue You, Junli Nie, Laura F Dagley, Justin Bedo, Hanqing Wang, Li Sun, Robyn Sutherland, Elliot Surgenor, Nadia Iannarella, Rhys Allan, Fernando Souza-Fonseca-Guimaraes, Yi Xie, Qike Wang, Yuxia Zhang, Yuekang Xu, Stephen L Nutt, et al.

Journal article  |  2022  |  CELLULAR & MOLECULAR IMMUNOLOGY

The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the capacity to differentiate monocytes into macr..

Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis.

Ashleigh R Poh, Megan O'Brien, David Chisanga, Hong He, David Baloyan, Jasmin Traichel, Christine Dijkstra, Michaël Chopin, Stephen Nutt, Lachlan Whitehead, Louis Boon, Ashleigh Parkin, Clifford Lowell, Marina Pajic, Wei Shi, Mehrdad Nikfarjam, Matthias Ernst

Journal article  |  2022  |  Cell Rep

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a low 5-year survival rate and is associated with poor respo..

Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy

Ashleigh R Poh, Christopher G Love, David Chisanga, James H Steer, David Baloyan, Michael Chopin, Stephen Nutt, Jai Rautela, Nicholas D Huntington, Nima Etemadi, Megan O'Brien, Ryan O'Keefe, Lesley G Ellies, Christophe Macri, Justine D Mintern, Lachlan Whitehead, Gangadhara Gangadhara, Louis Boon, Ashwini L Chand, Clifford A Lowell, et al.

Journal article  |  2022  |  SCIENCE ADVANCES

Although immunotherapy has revolutionized cancer treatment, many immunogenic tumors remain refractory to treatment. This can be la..

Langerhans cells are an essential cellular intermediary in chronic dermatitis

Holly Anderton, Michael Chopin, Caleb A Dawson, Stephen L Nutt, Lachlan Whitehead, Natasha Silke, Najoua Lalaloui, John Silke

Journal article  |  2022  |  CELL REPORTS

SHARPIN regulates signaling from the tumor necrosis factor (TNF) superfamily and pattern-recognition receptors. An inactivating Sh..

ZC3H12C expression in dendritic cells is necessary to prevent lymphadenopathy of skin-draining lymph nodes

Elise Clayer, Daniel Frank, Holly Anderton, Shengbo Zhang, Andrew Kueh, Valentin Heim, Stephen L Nutt, Michael Chopin, Philippe Bouillet

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

The role of RNA-binding proteins of the CCCH-containing family in regulating proinflammatory cytokine production and inflammation ..

ILC2-derived IL-13 promotes skin cDC2 diversity

Stephen L Nutt, Michael Chopin

Journal article  |  2021  |  IMMUNOLOGY AND CELL BIOLOGY

In a new study, researchers have identified a new population of type 2 conventional dendritic cells in the skin that depend on IL-..

Type 1 conventional dendritic cells: ontogeny, function, and emerging roles in cancer immunotherapy

Shengbo Zhang, Michael Chopin, Stephen L Nutt

Journal article  |  2021  |  TRENDS IN IMMUNOLOGY

Dendritic cells (DCs) are key immune sentinels that orchestrate protective immune responses against pathogens or cancers. DCs have..

Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis

Yifan Zhan, Yuxia Zhang, Shengbo Zhang, Hannah Coughlan, Pedro L Baldoni, Nicolas Jacquelot, Wang HJ Cao, Simon Preston, Cynthia Louis, Jai Rautela, Marc Pellegrini, Ian P Wicks, Warren S Alexander, Leonard C Harrison, Andrew M Lew, Gordon K Smyth, Stephen L Nutt, Michael Chopin

Journal article  |  2021  |  SCIENCE IMMUNOLOGY

Dendritic cells (DCs) and macrophages are at the forefront of immune responses, modifying their transcriptional programs in respon..

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Nicolas Jacquelot, Cyril Seillet, Minyu Wang, Angela Pizzolla, Yang Liao, Soroor Hediyeh-zadeh, Sharon Grisaru-Tal, Cynthia Louis, Qiutong Huang, Jaring Schreuder, Fernando Souza-Fonseca-Guimaraes, Carolyn A de Graaf, Kevin Thia, Sean Macdonald, Mary Camilleri, Kylie Luong, Shengbo Zhang, Michael Chopin, Tristan Molden-Hauer, Stephen L Nutt, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigen..

EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis

Camilla M Reehorst, Rebecca Nightingale, Ian Y Luk, Laura Jenkins, Frank Koentgen, David S Williams, Charbel Darido, Fiona Tan, Holly Anderton, Michael Chopin, Kael Schoffer, Moritz F Eissmann, Michael Buchert, Dmitri Mouradov, Oliver M Sieber, Matthias Ernst, Amardeep S Dhillon, John M Mariadason

Journal article  |  2021  |  DEVELOPMENT

Ets homologous factor (EHF) is a member of the epithelial-specific Ets (ESE) family of transcription factors. To investigate its r..