Michael Chopin

EZH2 function in immune cell development

Stephen L Nutt, Christine Keenan, Michael Chopin, Rhys S Allan

Journal article  |  2020  |  Biological Chemistry

The polycomb repressive complex 2 (PRC2) consists of three core components EZH2, SUZ12 and EED. EZH2 catalyzes the methylation of ..

Transcriptional Networks Driving Dendritic Cell Differentiation and Function

Stephen L Nutt, Michael Chopin

Journal article  |  2020  |  Immunity

Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of pathogens to stimulate a robust and appro..

Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity

Yifan Zhan, Isabella Kong, Michael Chopin, Christophe Macri, Jian-Guo Zhang, Jiaying Xie, Stephen L Nutt, Meredith O'Keeffe, Edwin D Hawkins, Eric F Morand, Andrew M Lew

Journal article  |  2020  |  Immunology & Cell Biology

The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent stra..

CCR2 enhances CD25 expression by FoxP3( ) regulatory T cells and regulates their abundance independently of chemotaxis and CCR2( ) myeloid cells

Yifan Zhan, Nancy Wang, Ajithkumar Vasanthakumar, Yuxia Zhang, Michael Chopin, Stephen L Nutt, Axel Kallies, Andrew M Lew

Journal article  |  2020  |  Cellular & Molecular Immunology

A wide array of chemokine receptors, including CCR2, are known to control Treg migration. Here, we report that CCR2 regulates Treg..

The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game

Yifan Zhan, Andrew M Lew, Michael Chopin

Journal article  |  2019  |  Frontiers in Immunology

Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system

Ludovica Bruno, Vijendra Ramlall, Romain A Studer, Stephan Sauer, David Bradley, Gopuraja Dharmalingam, Thomas Carroll, Mohamed Ghoneim, Michael Chopin, Stephen L Nutt, Sarah Elderkin, David S Rueda, Amanda G Fisher, Trevor Siggers, Pedro Beltrao, Matthias Merkenschlager

Journal article  |  2019  |  Nature Immunology

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

Mark D McKenzie, Margherita Ghisi, Ethan P Oxley, Steven Ngo, Luisa Cimmino, Cecile Esnault, Ruijie Liu, Jessica M Salmon, Charles C Bell, Nouraiz Ahmed, Michael Erlichster, Matthew T Witkowski, Grace J Liu, Michael Chopin, Aleksandar Dakic, Emilia Simankowicz, Giovanna Pomilio, Tina Vu, Pavle Krsmanovic, Shian Su, et al.

Journal article  |  2019  |  Cell Stem Cell

TCF-1 limits the formation of Tc17 cells via repression of the MAF-ROR gamma t axis

Lisa A Mielke, Yang Liao, Ella Bridie Clemens, Matthew A Firth, Brigette Duckworth, Qiutong Huang, Francisca F Almeida, Michael Chopin, Hui-Fern Koay, Carolyn A Bell, Soroor Hediyeh-Zadeh, Simone L Park, Dinesh Raghu, Jarny Choi, Tracy L Putoczki, Philip D Hodgkin, Ashley E Franks, Laura K Mackay, Dale Godfrey, Melissa J Davis, et al.

Journal article  |  2019  |  Journal of Experimental Medicine

Langerhans cells drive TNF induced chronic proliferative dermatitis in SHARPIN deficient mice

H Anderton, M Chopin, C Dawson, N Lalaoui, J Silke

Conference Proceedings  |  2019  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT

Michael Chopin, Aaron T Lun, Yifan Zhan, Jaring Schreuder, Hannah Coughlan, Angela D'Amico, Lisa A Mielke, Francisca F Almeida, Andrew J Kueh, Ross A Dickins, Gabrielle T Belz, Shalin H Naik, Andrew M Lew, Phillipe Bouillet, Marco J Herold, Gordon K Smyth, Lynn M Corcoran, Stephen L Nutt

Journal article  |  2019  |  Immunity