Michael Chopin

EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis.

Camilla M Reehorst, Rebecca Nightingale, Ian Y Luk, Laura Jenkins, Frank Koentgen, David S Williams, Charbel Darido, Fiona Tan, Holly Anderton, Michael Chopin, Kael Schoffer, Moritz F Eissmann, Michael Buchert, Dmitri Mouradov, Oliver M Sieber, Matthias Ernst, Amardeep S Dhillon, John M Mariadason

Journal article  |  2021  |  Development

Ets homologous factor (EHF) is a member of the epithelial-specific Ets (ESE) family of transcription factors. To investigate its r..

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Nicolas Jacquelot, Cyril Seillet, Minyu Wang, Angela Pizzolla, Yang Liao, Soroor Hediyeh-zadeh, Sharon Grisaru-Tal, Cynthia Louis, Qiutong Huang, Jaring Schreuder, Fernando Souza-Fonseca-Guimaraes, Carolyn A de Graaf, Kevin Thia, Sean Macdonald, Mary Camilleri, Kylie Luong, Shengbo Zhang, Michael Chopin, Tristan Molden-Hauer, Stephen L Nutt, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigen..

Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT

Shengbo Zhang, Hannah D Coughlan, Mitra Ashayeripanah, Simona Seizova, Andrew J Kueh, Daniel Brown, Wang Cao, Nicolas Jacquelot, Angela D'Amico, Andrew M Lew, Yifan Zhan, Christopher J Tonkin, Jose A Villadangos, Gordon K Smyth, Michael Chopin, Stephen L Nutt

Journal article  |  2021  |  SCIENCE IMMUNOLOGY

The functional diversification of dendritic cells (DCs) is a key step in establishing protective immune responses. Despite the imp..

EZH2 function in immune cell development

Stephen L Nutt, Christine Keenan, Michael Chopin, Rhys S Allan

Journal article  |  2020  |  BIOLOGICAL CHEMISTRY

The polycomb repressive complex 2 (PRC2) consists of three core components EZH2, SUZ12 and EED. EZH2 catalyzes the methylation of ..

Transcriptional Networks Driving Dendritic Cell Differentiation and Function

Stephen L Nutt, Michael Chopin

Journal article  |  2020  |  IMMUNITY

Dendritic cells (DCs) are the sentinels of the immune system, sensing a diverse array of pathogens to stimulate a robust and appro..

Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity

Yifan Zhan, Isabella Kong, Michael Chopin, Christophe Macri, Jian-Guo Zhang, Jiaying Xie, Stephen L Nutt, Meredith O'Keeffe, Edwin D Hawkins, Eric F Morand, Andrew M Lew

Journal article  |  2020  |  IMMUNOLOGY AND CELL BIOLOGY

The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent stra..

CCR2 enhances CD25 expression by FoxP3( ) regulatory T cells and regulates their abundance independently of chemotaxis and CCR2( ) myeloid cells

Yifan Zhan, Nancy Wang, Ajithkumar Vasanthakumar, Yuxia Zhang, Michael Chopin, Stephen L Nutt, Axel Kallies, Andrew M Lew

Journal article  |  2020  |  CELLULAR & MOLECULAR IMMUNOLOGY

A wide array of chemokine receptors, including CCR2, are known to control Treg migration. Here, we report that CCR2 regulates Treg..

The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game

Yifan Zhan, Andrew M Lew, Michael Chopin

Journal article  |  2019  |  FRONTIERS IN IMMUNOLOGY

Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a myelopoietic growth factor that has pleiotropic effects not only in..

Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system

Ludovica Bruno, Vijendra Ramlall, Romain A Studer, Stephan Sauer, David Bradley, Gopuraja Dharmalingam, Thomas Carroll, Mohamed Ghoneim, Michael Chopin, Stephen L Nutt, Sarah Elderkin, David S Rueda, Amanda G Fisher, Trevor Siggers, Pedro Beltrao, Matthias Merkenschlager

Journal article  |  2019  |  NATURE IMMUNOLOGY

In multicellular organisms, duplicated genes can diverge through tissue-specific gene expression patterns, as exemplified by highl..

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia

Mark D McKenzie, Margherita Ghisi, Ethan P Oxley, Steven Ngo, Luisa Cimmino, Cecile Esnault, Ruijie Liu, Jessica M Salmon, Charles C Bell, Nouraiz Ahmed, Michael Erlichster, Matthew T Witkowski, Grace J Liu, Michael Chopin, Aleksandar Dakic, Emilia Simankowicz, Giovanna Pomilio, Tina Vu, Pavle Krsmanovic, Shian Su, et al.

Journal article  |  2019  |  CELL STEM CELL

Tumors are composed of phenotypically heterogeneous cancer cells that often resemble various differentiation states of their linea..