Carleen Cullinane

Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer

Shunfei Yan, Piyush Madhamshettiwar, Kaylene Simpson, Sarah Ellis, Jian Kang, Carleen Cullinane, Karen Sheppard, Katherine Hannan, Ross Hannan, Elaine Sanij, Richard Pearson, Keefe Chan

Journal article  |  2019

Abstract Limited effective therapeutic options are available for patients with recurrent high-grade serous carcinoma (HGSC), the m..

Reprogrammed mRNA translation drives metabolic response to therapeutic targeting of ribosome biogenesis

EP Kusnadi, AS Trigos, C Cullinane, DL Goode, O Larsson, JR Devlin, KT Chan, DP De Souza, MJ McConville, GA McArthur, G Thomas, E Sanij, G Poortinga, RD Hannan, KM Hannan, J Kang, RB Pearson

Journal article  |  2019  |  bioRxiv

Abstract Elevated ribosome biogenesis in oncogene-driven cancers is commonly targeted by DNA-damaging cytotoxic drugs. Our first-i..

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Marian L Burr, Christina E Sparbier, Kah Lok Chan, Yih-Chih Chan, Ariena Kersbergen, Enid YN Lam, Elizabeth Azidis-Yates, Dane Vassiliadis, Charles C Bell, Omer Gilan, Susan Jackson, Lavinia Tan, Stephen Q Wong, Sebastian Hollizeck, Ewa M Michalak, Hannah Siddle, Michael T McCabe, Rab K Prinjha, Glen R Guerra, Benjamin J Solomon, et al.

Journal article  |  2019  |  Cancer Cell

A Bivalent Inhibitor of Prostate Specific Membrane Antigen Radiolabeled with Copper-64 with High Tumor Uptake and Retention

Nicholas A Zia, Carleen Cullinane, Jessica K Van Zuylekom, Kelly Waldeck, Lachlan E McInnes, Gojko Buncic, Mohammad B Haskali, Peter D Roselt, Rodney J Hicks, Paul S Donnelly

Journal article  |  2019  |  Angewandte Chemie International Edition

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Huiqin Chen, Alison Slater, Kerry Ardley, Laura Kirby, Keefe T Chan, Natalie Brajanovski, Lorey K Smith, Aparna D Rao, Emily J Lelliott, Margarete Kleinschmidt, Ismael A Vergara, Anthony T Papenfuss, Peter Lau, Prerana Ghosh, Sue Haupt, et al.

Journal article  |  2019  |  Proceedings of the National Academy of Sciences

Development of a new bifunctional PSMA ligand as a theranostic for prostate cancer

Nicholas Zia, Carleen Cullinane, Jessica Van Zuylekom, Mohammad Haskali, Peter Roselt, Ellen van Dam, Matthew Harris, Rodney Hicks, Paul Donnelly

Conference Proceedings  |  2019  |  JOURNAL OF NUCLEAR MEDICINE

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

Elaine Sanij, Katherine Hannan, Shunfei Yan, Jiachen Xuan, Jessica Ahern, Keefe Chan, Jinbae Son, Olga Kondrashova, Elizabeth Lieschke, Matthew Wakefield, Anna Trigos, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Kum Kum Khanna, Linda Mileshkin, Grant McArthur, et al.

Journal article  |  2019

Abstract High-grade serous ovarian cancer (HGSOC) accounts for the majority of ovarian cancer and has a dismal prognosis. PARP inh..

Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups

Brett M Paterson, Carleen Cullinane, Peter J Crouch, Anthony R White, Kevin J Barnham, Peter D Roselt, Wayne Noonan, David Binns, Rodney J Hicks, Paul S Donnelly

Journal article  |  2019  |  Inorganic Chemistry

Potential Diagnostic Imaging of Alzheimer's Disease with Copper-64 Complexes That Bind to Amyloid-beta Plaques

Lachlan E McInnes, Asif Noor, Kai Kysenius, Carleen Cullinane, Peter Roselt, Catriona A McLean, Francis CK Chiu, Andrew K Powell, Peter J Crouch, Jonathan M White, Paul S Donnelly

Journal article  |  2019  |  Inorganic Chemistry

A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy

Emily J Lelliott, Carleen Cullinane, Claire A Martin, Rachael Walker, Kelly M Ramsbottom, Fernando Souza-Fonseca-Guimaraes, Shatha Abuhammad, Jessica Michie, Laura Kirby, Richard J Young, Alison Slater, Peter Lau, Katrina Meeth, Jane Oliaro, Nicole Haynes, Grant A McArthur, Karen E Sheppard

Journal article  |  2019  |  Scientific Reports

Novel Combination Therapy Targeting rDNA Transcription and Histone Deacetylation Provides Effective Treatment for Multiple Myeloma, and Synergises in Bortezomib-Resistant MM

Kylee H Maclachlan, Andrew Cuddihy, Nadine Hein, Carleen Cullinane, Simon J Harrison, Ross Hannan, Gretchen Poortinga

Conference Proceedings  |  2018  |  Blood

Immunomodulatory activities of pixatimod: emerging nonclinical and clinical data, and its potential utility in combination with PD-1 inhibitors

Edward Hammond, Nicole M Haynes, Carleen Cullinane, Todd Brennan, Darryn Bampton, Paul Handley, Tomislav Karoli, Fleur Lanksheer, Liwen Lin, Yiping Yang, Keith Dredge

Journal article  |  2018  |  Journal for ImmunoTherapy of Cancer

Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin

Charbel Darido, Smitha R Georgy, Carleen Cullinane, Darren D Partridge, Rachael Walker, Seema Srivastava, Suraya Roslan, Marina R Carpinelli, Sebastian Dworkin, Richard B Pearson, Stephen M Jane

Journal article  |  2018  |  Cell Death & Differentiation

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth

Helen B Pearson, Jason Li, Valerie S Meniel, Christina M Fennell, Paul Waring, Karen G Montgomery, Richard J Rebello, Arthi A Macpherson, Sarah Koushyar, Luc Furic, Carleen Cullinane, Richard W Clarkson, Matthew J Smalley, Kaylene J Simpson, Toby J Phesse, Peter R Shepherd, Patrick O Humbert, Owen J Sansom, Wayne A Phillips

Journal article  |  2018  |  Cancer Discovery

Palbociclib synergizes with BRAF and MEK inhibitors in treatment naive melanoma but not after the development of BRAF inhibitor resistance

Claire A Martin, Carleen Cullinane, Laura Kirby, Shatha Abuhammad, Emily J Lelliott, Kelly Waldeck, Richard J Young, Natalie Brajanovski, Donald P Cameron, Rachael Walker, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Richard B Pearson, Rodney J Hicks, Grant A McArthur, Karen E Sheppard

Journal article  |  2018  |  International Journal of Cancer

Comparing the therapeutic efficacy of Cu-67-SARTATE and (17)7Lu-DOTA-octreotate in a neuroendocrine tumor model

Carleen Cullinane, Charmaine Jeffery, Rachael Walker, Peter Roselt, David Binns, Ellen van Dam, Matthew Harris, Paul Donnelly, Rodney Hicks

Conference Proceedings  |  2018  |  JOURNAL OF NUCLEAR MEDICINE

Synthesis and antiproliferative activity of a series of new platinum and palladium diphosphane complexes

Carleen Cullinane, Glen B Deacon, Penny R Drago, Anja P Erven, Peter C Junk, Jenny Luu, Gerd Meyer, Simon Schmitz, Ingo Ott, Julia Schur, Lorraine K Webster, Axel Klein

Journal article  |  2018  |  Dalton Transactions

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R Devlin, Amee J George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J Harrison, James D Rozario, et al.

Journal article  |  2017  |  Blood

The utility of genomics and functional imaging to predict irinotecan pharmacokinetics and pharmacodynannics: The PREDICT IR study.

Michael Michael, Winston Liauw, Sue-Anne McLachlan, Emma Link, Anetta Matera, Mick Thompson, Michael Jefford, Rodney J Hicks, Carleen Cullinane, Ian Campbell, Philip James Beale, Christos Stelios Karapetis, Timothy Price, Matthew E Burge

Conference Proceedings  |  2017  |  Journal of Clinical Oncology

Sulfonation of Tyrosine as a Method To Improve Biodistribution of Peptide-Based Radiotracers: Novel F-18-Labeled Cyclic RGD Analogues

Mohammad B Haskali, Delphine Denoyer, Wayne Noonan, Carleen Culinane, Christine Rangger, Normand Pouliot, Roland Haubner, Peter D Roselt, Rodney J Hicks, Craig A Hutton

Journal article  |  2017  |  Molecular Pharmaceutics

Selective Targeting of Cyclin E1-Amplified High-Grade Serous Ovarian Cancer by Cyclin-Dependent Kinase 2 and AKT Inhibition

George Au-Yeung, Franziska Lang, Walid J Azar, Chris Mitchell, Kate E Jarman, Kurt Lackovic, Diar Aziz, Carleen Cullinane, Richard B Pearson, Linda Mileshkin, Danny Rischin, Alison M Karst, Ronny Drapkin, Dariush Etemadmoghadam, David DL Bowtell

Journal article  |  2017  |  Clinical Cancer Research

Inhibiting the system x((C)over-bar)/glutathione axis selectively targets cancers with mutant-p53 accumulation

David S Liu, Cuong P Duong, Sue Haupt, Karen G Montgomery, Colin M House, Walid J Azar, Helen B Pearson, Oliver M Fisher, Matthew Read, Glen R Guerra, Ygal Haupt, Carleen Cullinane, Klas G Wiman, Lars Abrahmsen, Wayne A Phillips, Nicholas J Clemons

Journal article  |  2017  |  Nature Communications

Enhancing PET Signal at Target Tissue in Vivo: Dendritic and Multimeric Tris(hydroxypyridinone) Conjugates for Molecular Imaging of alpha(v)beta(3) Integrin Expression with Gallium-68

Cinzia Imberti, Samantha YA Terry, Carleen Cullinane, Fiona Clarke, Georgina H Cornish, Nisha K Ramakrishnan, Peter Roselt, Andrew P Cope, Rodney J Hicks, Philip J Blower, Michelle T Ma

Journal article  |  2017  |  Bioconjugate Chemistry

beta-[F-18] Fluoro Azomycin Arabinoside (beta-[F-18] FAZA): Synthesis, Radiofluorination and Preliminary PET Imaging of Murine A431 Tumors

Piyush Kumar, Peter Roselt, Gerald Reischl, Carlene Cullinane, Davood Beiki, Walter Ehrlichmann, David Binns, Ebrahim Naimi, Jennifer Yang, Rodney Hicks, Hans-Juergen Machulla, Leonard I Wiebe

Journal article  |  2017  |  Current Radiopharmaceuticals

Circulating Tumor DNA Analysis and Functional Imaging Provide Complementary Approaches for Comprehensive Disease Monitoring in Metastatic Melanoma

Stephen Q Wong, Jeanette M Raleigh, Jason Callahan, Ismael A Vergara, Sarah Ftouni, Athena Hatzimihalis, Andrew J Colebatch, Jason Li, Timothy Semple, Kenneth Doig, Christopher Mintoff, Devbarna Sinha, Paul Yeh, Maria Joao Silva, Kathryn Alsop, Heather Thorne, David D Bowtell, David E Gyorki, Gisela Mir Arnau, Carleen Cullinane, et al.

Journal article  |  2017  |  JCO Precision Oncology

Strand breakage by decay of DNA-bound I-124 provides a basis for combined PET imaging and Auger endoradiotherapy

Pavel Lobachevsky, George R Clark, Patrycja D Pytel, Brenda Leung, Colin Skene, Laura Andrau, Jonathan M White, Tom Karagiannis, Carleen Cullinane, Boon Q Lee, Andrew Stuchbery, Tibor Kibedi, Rodney J Hicks, Roger F Martin

Journal article  |  2016  |  International Journal of Radiation Biology

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George, Katherine M Hannan, Gretchen Poortinga, Karen E Sheppard, Kum Kum Khanna, Ricky W Johnstone, Denis Drygin, Grant A McArthur, Richard B Pearson, Elaine Sanij, Ross D Hannan

Journal article  |  2016  |  Oncotarget

Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model

Kelly Waldeck, Carleen Cullinane, Kerry Ardley, Jake Shortt, Ben Martin, Richard W Tothill, Jason Li, Ricky W Johnstone, Grant A McArthur, Rodney J Hicks, Paul J Wood

Journal article  |  2016  |  Int J Cancer

New Tris(hydroxypyridinone) Bifunctional Chelators Containing Isothiocyanate Groups Provide a Versatile Platform for Rapid One Step Labeling and PET Imaging with Ga-68(3 )

Michelle T Ma, Carleen Cullinane, Cinzia Imberti, Julia Baguna Torres, Samantha YA Terry, Peter Roselt, Rodney J Hicks, Philip J Blower

Journal article  |  2016  |  Bioconjugate Chemistry

Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts

Matthew Read, David Liu, Cuong P Duong, Carleen Cullinane, William K Murray, Christina M Fennell, Jake Shortt, David Westerman, Paul Burton, Nicholas J Clemons, Wayne A Phillips

Journal article  |  2016  |  Annals of Surgical Oncology

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Jennifer R Devlin, Katherine M Hannan, Nadine Hein, Carleen Cullinane, Eric Kusnadi, Pui Yee Ng, Amee J George, Jake Shortt, Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Jian Kang, Denis Drygin, Sean O'Brien, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson

Journal article  |  2016  |  Cancer Discovery

A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies (vol 52, 11889, 2016)

Stacey E Rudd, Peter Roselt, Carleen Cullinane, Rodney J Hicks, Paul S Donnelly

Journal article  |  2016  |  Chemical Communications

A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies

Stacey E Rudd, Peter Roselt, Carleen Cullinane, Rodney J Hicks, Paul S Donnelly

Journal article  |  2016  |  Chemical Communications

UV-Associated Mutations Underlie the Etiology of MCV-Negative Merkel Cell Carcinomas

Stephen Q Wong, Kelly Waldeck, Ismael A Vergara, Jan Schroeder, Jason Madore, James S Wilmott, Andrew J Colebatch, Ricardo De Paoli-Iseppi, Jason Li, Richard Lupat, Timothy Semple, Gisela Mir Arnau, Andrew Fellowes, J Helen Leonard, George Hruby, Graham J Mann, John F Thompson, Carleen Cullinane, Meredith Johnston, Mark Shackleton, et al.

Journal article  |  2015  |  Cancer Res

Rapid kit-based Ga-68-labelling and PET imaging with THP-Tyr(3)-octreotate: a preliminary comparison with DOTA-Tyr(3)-octreotate

Michelle T Ma, Carleen Cullinane, Kelly Waldeck, Peter Roselt, Rodney J Hicks, Philip J Blower

Journal article  |  2015  |  EJNMMI Research

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

David SH Liu, Matthew Read, Carleen Cullinane, Walid J Azar, Christina M Fennell, Karen G Montgomery, Sue Haupt, Ygal Haupt, Klas G Wiman, Cuong P Duong, Nicholas J Clemons, Wayne A Phillips

Journal article  |  2015  |  Gut

Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes

Jessamy C Tiffen, Dilini Gunatilake, Stuart J Gallagher, Kavitha Gowrishankar, Anja Heinemann, Carleen Cullinane, Ken Dutton-Regester, Gulietta M Pupo, Dario Strbenac, Jean Y Yang, Jason Madore, Graham J Mann, Nicholas K Hayward, Grant A McArthur, Fabian V Filipp, Peter Hersey

Journal article  |  2015  |  Oncotarget

Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling

Anja Heinemann, Carleen Cullinane, Ricardo De Paoli-Iseppi, James S Wilmott, Dilini Gunatilake, Jason Madore, Dario Strbenac, Jean Y Yang, Kavitha Gowrishankar, Jessamy C Tiffen, Rab K Prinjha, Nicholas Smithers, Grant A McArthur, Peter Hersey, Stuart J Gallagher

Journal article  |  2015  |  Oncotarget

Ubiquitous expression of the Pik3ca(H1047R) mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly

Kathryn M Kinross, Karen G Montgomery, Salvatore P Mangiafico, Lauren M Hare, Margarete Kleinschmidt, Megan J Bywater, Ingrid J Poulton, Christina Vrahnas, Holger Henneicke, Jordane Malaterre, Paul M Waring, Carleen Cullinane, Natalie A Sims, Grant A McArthur, Sofianos Andrikopoulos, Wayne A Phillips

Journal article  |  2015  |  The FASEB Journal

Applying advanced imaging techniques to a murine model of orthotopic osteosarcoma

Matthew L Broadhead, Zerina Lokmic, Mei Lin Tan, Andrew Stevenson, David S Binns, Carleen Cullinane, Rodney J Hicks, Peter FM Choong, Damian E Myers

Journal article  |  2015  |  Frontiers in Surgery

Peptide receptor chemoradionuclide therapy in small cell carcinoma: from bench to bedside

Jeremy Lewin, Carleen Cullinane, Tim Akhurst, Kelly Waldeck, D Neil Watkins, Aparna Rao, Peter Eu, Linda Mileshkin, Rodney J Hicks

Journal article  |  2015  |  European Journal of Nuclear Medicine and Molecular Imaging

Bifunctional Cu-64-labelled macrobicyclic cage amine isothiocyanates for immuno-positron emission tomography

Brett M Paterson, Gojko Buncic, Lachlan E McInnes, Peter Roselt, Carleen Cullinane, David S Binns, Charmaine M Jeffery, Roger I Price, Rodney J Hicks, Paul S Donnelly

Journal article  |  2015  |  Dalton Transactions

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo

IA Elsum, LL Yates, HB Pearson, TJ Phesse, F Long, R O'Donoghue, M Ernst, C Cullinane, PO Humbert

Journal article  |  2014  |  Oncogene

Measuring apoptosis in mammals in vivo.

Andrea Newbold, Ben P Martin, Carleen Cullinane, Michael Bots

Journal article  |  2014  |  Cold Spring Harbor Protocols

Apoptosis is a mode of cell death that is essential in multicellular organisms for the removal of superfluous, damaged, or potenti..

Detection of apoptotic cells using immunohistochemistry.

Andrea Newbold, Ben P Martin, Carleen Cullinane, Michael Bots

Journal article  |  2014  |  Cold Spring Harbor Protocols

Immunohistochemistry is commonly used to show the presence of apoptotic cells in situ. In this protocol, B-cell lymphoma cells are..

Detection of apoptotic cells using propidium iodide staining.

Andrea Newbold, Ben P Martin, Carleen Cullinane, Michael Bots

Journal article  |  2014  |  Cold Spring Harbor Protocols

Flow cytometry assays are often used to detect apoptotic cells in in vitro cultures. Depending on the experimental model, these as..

The Epigenetic Regulator I-BET151 Induces BIM-Dependent Apoptosis and Cell Cycle Arrest of Human Melanoma Cells

Stuart J Gallagher, Branka Mijatov, Dilini Gunatilake, Jessamy C Tiffen, Kavitha Gowrishankar, Lei Jin, Gulietta M Pupo, Carleen Cullinane, Rab K Prinjha, Nicholas Smithers, Grant A McArthur, Helen Rizos, Peter Hersey

Journal article  |  2014  |  Journal of Investigative Dermatology

Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151

Stuart J Gallagher, Branka Mijatov, Dilini Gunatilake, Kavitha Gowrishankar, Jessamy Tiffen, Wilmott James, Lei Jin, Gulietta Pupo, Carleen Cullinane, Grant A McArthur, Peter J Tummino, Helen Rizos, Peter Hersey

Journal article  |  2014  |  Pigment Cell & Melanoma Research

Fluorodeoxyglucose-based positron emission tomography imaging to monitor drug responses in solid tumors.

Andrea Newbold, Ben P Martin, Carleen Cullinane, Michael Bots

Journal article  |  2014  |  Cold Spring Harbor Protocols

Positron emission tomography (PET) is used to monitor the uptake of the labeled glucose analogue fluorodeoxyglucose (¹⁸F-FDG) by s..

Fluorodeoxyglucose-based positron emission tomography imaging to monitor drug responses in hematological tumors.

Andrea Newbold, Ben P Martin, Carleen Cullinane, Michael Bots

Journal article  |  2014  |  Cold Spring Harbor Protocols

Positron emission tomography (PET) can be used to monitor the uptake of the labeled glucose analog fluorodeoxyglucose (¹⁸F-FDG), a..

Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines

Richard J Young, Kelly Waldeck, Claire Martin, Jung H Foo, Donald P Cameron, Laura Kirby, Hongdo Do, Catherine Mitchell, Carleen Cullinane, Wendy Liu, Stephen B Fox, Ken Dutton-Regester, Nicholas K Hayward, Nicholas Jene, Alexander Dobrovic, Richard B Pearson, James G Christensen, Sophia Randolph, Grant A McArthur, Karen E Sheppard

Journal article  |  2014  |  Pigment Cell & Melanoma Research

Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Tiffany J Parmenter, Margarete Kleinschmidt, Kathryn M Kinross, Simon T Bond, Jason Li, Mohan R Kaadige, Aparna Rao, Karen E Sheppard, Willy Hugo, Gulietta M Pupo, Richard B Pearson, Sean L Mcgee, Georgina V Long, Richard A Scolyer, Helen Rizos, Roger S Lo, Carleen Cullinane, Donald E Ayer, Antoni Ribas, Ricky W Johnstone, et al.

Journal article  |  2014  |  Cancer Discov

Co-targeting Deoxyribonucleic Acide-Dependent Protein Kinase and Poly(Adenosine Diphosphate-Ribose) Polymerase-1 Promotes Accelerated Senescence of Irradiated Cancer Cells

Arun Azad, Patricia Bukczynska, Susan Jackson, Ygal Haput, Carleen Cullinane, Grant A McArthur, Benjamin Solomon

Journal article  |  2014  |  International Journal of Radiation: Oncology - Biology - Physics

Preclinical FLT-PET and FDG-PET imaging of tumor response to the multi-targeted Aurora B kinase inhibitor, TAK-901

Carleen Cullinane, Kelly L Waldeck, David Binns, Ekaterina Bogatyreva, Daniel P Bradley, Ron de Jong, Grant A McArthur, Rodney J Hicks

Journal article  |  2014  |  Nuclear Medicine and Biology

PET imaging of tumours with a Cu-64 labeled macrobicyclic cage amine ligand tethered to Tyr(3)-octreotate

Brett M Paterson, Peter Roselt, Delphine Denoyer, Carleen Cullinane, David Binns, Wayne Noonan, Charmaine M Jeffery, Roger I Price, Jonathan M White, Rodney J Hicks, Paul S Donnelly

Journal article  |  2014  |  Dalton Transactions

Imaging of molecular target modulation in oncology: Challenges of early clinical trials

C Cullinane, B Solomon, RJ Hicks

Journal article  |  2014  |  Clinical and Translational Imaging

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

Maya Kansara, Huei San Leong, Dan Mei Lin, Sophie Popkiss, Puiyi Pang, Dale W Garsed, Carl R Walkley, Carleen Cullinane, Jason Ellul, Nicole M Haynes, Rod Hicks, Marieke L Kuijjer, Anne-Marie Cleton-Jansen, Philip W Hinds, Mark J Smyth, David M Thomas

Journal article  |  2013  |  Journal of Clinical Investigation

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

Karen E Sheppard, Carleen Cullinane, Katherine M Hannan, Meaghan Wall, Joanna Chan, Frances Barber, Jung Foo, Donald Cameron, Amelia Neilsen, Pui Ng, Jason Ellul, Margarete Kleinschmidt, Kathryn M Kinross, David D Bowtell, James G Christensen, Rodney J Hicks, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Wayne A Phillips, et al.

Journal article  |  2013  |  European Journal of Cancer

Molecular and Biologic Analysis of Histone Deacetylase Inhibitors with Diverse Specificities

Andrea Newbold, Geoffrey M Matthews, Michael Bots, Leonie A Cluse, Christopher JP Clarke, Kellie-Marie Banks, Carleen Cullinane, Jessica E Bolden, Ailsa J Christiansen, Ross A Dickins, Claudia Miccolo, Susanna Chiocca, Astrid M Kral, Nicole D Ozerova, Thomas A Miller, Joey L Methot, Victoria M Richon, J Paul Secrist, Saverio Minucci, Ricky W Johnstone

Journal article  |  2013  |  Molecular Cancer Therapeutics

Resistance to CDK2 Inhibitors Is Associated with Selection of Polyploid Cells in CCNE1-Amplified Ovarian Cancer

Dariush Etemadmoghadam, George Au-Yeung, Meaghan Wall, Chris Mitchell, Maya Kansara, Elizabeth Loehrer, Crisoula Batzios, Joshy George, Sarah Ftouni, Barbara A Weir, Scott Carter, Irma Gresshoff, Linda Mileshkin, Danny Rischin, William C Hahn, Paul M Waring, Gad Getz, Carleen Cullinane, Lynda J Campbell, David D Bowtell

Journal article  |  2013  |  Clinical Cancer Research

AKT signalling is required for ribosomal RNA synthesis and progression of E mu-Myc B-cell lymphoma in vivo

Jennifer R Devlin, Katherine M Hannan, Pui Y Ng, Megan J Bywater, Jake Shortt, Carleen Cullinane, Grant A McArthur, Ricky W Johnstone, Ross D Hannan, Richard B Pearson

Journal article  |  2013  |  The FEBS Journal

Diagnostic Imaging Agents for Alzheimer's Disease: Copper Radiopharmaceuticals that Target A beta Plaques

James L Hickey, SinChun Lim, David J Hayne, Brett M Paterson, Jonathan M White, Victor L Villemagne, Peter Roselt, David Binns, Carleen Cullinane, Charmaine M Jeffery, Roger I Price, Kevin J Barnham, Paul S Donnelly

Journal article  |  2013  |  Journal of the American Chemical Society

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Jake Shortt, Benjamin P Martin, Andrea Newbold, Katherine M Hannan, Jennifer R Devlin, Adele J Baker, Rachael Ralli, Carleen Cullinane, Clemens A Schmitt, Maurice Reimann, Michael N Hall, Meaghan Wall, Ross D Hannan, Richard B Pearson, Grant A McArthur, Ricky W Johnstone

Journal article  |  2013  |  Blood

Establishing reliable production of the PET isotope 89Zr for research use: From target fabrication to preclinical imaging

RK Scharli, RI Price, S Chan, D Cryer, CM Jeffery, AH Asad, L Morandeau, P Eu, C Cullinane, A Kasbollah, A Katsifis

Conference Proceedings  |  2012  |  AIP Conference Proceedings

Systematic differences in electrochemical reduction of the structurally characterized anti-cancer platinum(IV) complexes [Pt{((p-HC6F4)NCH2)(2)}-(pyridine)(2)Cl-2], [Pt{((p-HC6F4)NCH2)(2)}(pyridine)(2)(OH)(2)], and [Pt{((p-HC6F4)NCH2)(2)}(pyridine)(2)(OH)Cl]

Si-Xuan Guo, Dayna N Mason, Susan A Turland, Eric T Lawrenz, Lance C Kelly, Gary D Fallon, Bryan M Gatehouse, Alan M Bond, Glen B Deacon, Andrew R Battle, Trevor W Hambley, Silvina Rainone, Lorraine K Webster, Carleen Cullinane

Journal article  |  2012  |  Journal of Inorganic Biochemistry

Structural and anticancer properties of hydrogen bonded diphenyl phosphate adducts of Pt(IV) complexes: The importance of pK(a) matching

Timothy W Failes, Andrew R Battle, Catherine Chen, Carleen Cullinane, Ross Woods, Robyn Elliott, Glen B Deacon, Trevor W Hambley

Journal article  |  2012  |  Journal of Inorganic Biochemistry

LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal Doxorubicin

Prue A Cowin, Joshy George, Sian Fereday, Elizabeth Loehrer, Peter Van Loo, Carleen Cullinane, Dariush Etemadmoghadam, Sarah Ftouni, Laura Galletta, Michael S Anglesio, Joy Hendley, Leanne Bowes, Karen E Sheppard, Elizabeth L Christie, Richard B Pearson, Paul R Harnett, Viola Heinzelmann-Schwarz, Michael Friedlander, Orla McNally, Michael Quinn, et al.

Journal article  |  2012  |  Cancer Research

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck, Carleen Cullinane, Meaghan Wall, Leonie Cluse, Denis Drygin, Kenna Anderes, Nanni Huser, Chris Proffitt, Joshua Bliesath, Mustapha Haddach, Michael K Schwaebe, David M Ryckman, William G Rice, Clemens Schmitt, Scott W Lowe, Ricky W Johnstone, et al.

Journal article  |  2012  |  Cancer Cell

Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy

Christina SF Wong, Jaclyn Sceneay, Colin M House, Heloise M Halse, Mira CP Liu, Joshy George, Titaina CU Potdevin Hunnam, Belinda S Parker, Izhak Haviv, Ze'ev Ronai, Carleen Cullinane, David D Bowtell, Andreas Moeller

Journal article  |  2012  |  Cancer Research

[F-18] FLT-PET Imaging Does Not Always "Light Up" Proliferating Tumor Cells

Cathy C Zhang, Zhengming Yan, Wenlin Li, Kyle Kuszpit, Cory L Painter, Qin Zhang, Patrick B Lappin, Tim Nichols, Maruja E Lira, Timothy Affolter, Neeta R Fahey, Carleen Cullinane, Mary Spilker, Kenneth Zasadny, Peter O'Brien, Dana Buckman, Anthony Wong, James G Christensen

Journal article  |  2012  |  Clinical Cancer Research

Doxorubicin-Conjugated PEGylated Dendrimers Show Similar Tumoricidal Activity but Lower Systemic Toxicity When Compared to PEGylated Liposome and Solution Formulations in Mouse and Rat Tumor Models

Lisa M Kaminskas, Victoria M McLeod, Brian D Kelly, Carleen Cullinane, Gian Sberna, Mark Williamson, Ben J Boyd, David J Owen, Christopher JH Porter

Journal article  |  2012  |  Molecular Pharmaceutics

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

Kathryn M Kinross, Karen G Montgomery, Margarete Kleinschmidt, Paul Waring, Ivan Ivetac, Anjali Tikoo, Mirette Saad, Lauren Hare, Vincent Roh, Theo Mantamadiotis, Karen E Sheppard, Georgina L Ryland, Ian G Campbell, Kylie L Gorringe, James G Christensen, Carleen Cullinane, Rodney J Hicks, Richard B Pearson, Ricky W Johnstone, Grant A McArthur, et al.

Journal article  |  2012  |  Journal of Clinical Investigation

Docetaxel pharmacokinetics and its correlation with two in vivo probes for cytochrome P450 enzymes: the C-14-erythromycin breath test and the antipyrine clearance test

M Michael, C Cullinane, A Hatzimihalis, C O'Kane, A Milner, R Booth, S Schlicht, SJ Clarke, P Francis

Journal article  |  2012  |  Cancer Chemotherapy and Pharmacology

Inhibition of DNA-Dependent Protein Kinase Induces Accelerated Senescence in Irradiated Human Cancer Cells

Arun Azad, Susan Jackson, Carleen Cullinane, Anthony Natoli, Paul M Neilsen, David F Callen, Sauveur-Michel Maira, Wolfgang Hackl, Grant A McArthur, Benjamin Solomon

Journal article  |  2011  |  Molecular Cancer Research

Differential F-18-FDG and 3 '-Deoxy-3 '-F-18-Fluorothymidine PET Responses to Pharmacologic Inhibition of the c-MET Receptor in Preclinical Tumor Models

Carleen Cullinane, Donna S Dorow, Susan Jackson, Benjamin Solomon, Ekaterina Bogatyreva, David Binns, Richard Young, Maria E Arango, James G Christensen, Grant A McArthur, Rodney J Hicks

Journal article  |  2011  |  Journal of Nuclear Medicine

In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a Kras(G12D);Pten Deletion Mouse Model of Ovarian Cancer

Kathryn M Kinross, Daniel V Brown, Margarete Kleinschmidt, Susan Jackson, James Christensen, Carleen Cullinane, Rodney J Hicks, Ricky W Johnstone, Grant A McArthur

Journal article  |  2011  |  Molecular Cancer Therapeutics

A Dual Radiologic Contrast Agent Protocol for F-18-FDG and F-18-FLT PET/CT Imaging of Mice Bearing Abdominal Tumors

Nicolas Aide, Kathryn Kinross, Jean-Mathieu Beauregard, Oliver Neels, Titaina Potdevin, Peter Roselt, Donna Dorow, Carleen Cullinane, Rodney J Hicks

Journal article  |  2011  |  Molecular Imaging and Biology

RNAi-Mediated Knock-Down of Arylamine N-acetyltransferase-1 Expression Induces E-cadherin Up-Regulation and Cell-Cell Contact Growth Inhibition

Jacky M Tiang, Neville J Butcher, Carleen Cullinane, Patrick O Humbert, Rodney F Minchin

Journal article  |  2011  |  PLoS One

Amplicon-Dependent CCNE1 Expression Is Critical for Clonogenic Survival after Cisplatin Treatment and Is Correlated with 20q11 Gain in Ovarian Cancer

Dariush Etemadmoghadam, Joshy George, Prue A Cowin, Carleen Cullinane, Maya Kansara, Kylie L Gorringe, Gordon K Smyth, David DL Bowtell

Journal article  |  2010  |  PLoS One

Preclinical Evaluation of Nilotinib Efficacy in an Imatinib-Resistant KIT-Driven Tumor Model

Carleen Cullinane, Anthony Natoli, Yorlon Hui, Nelly Conus, Susan Jackson, Joseph Brueggen, Paul W Manley, Grant A McArthur

Journal article  |  2010  |  Molecular Cancer Therapeutics

Applications of positron emission tomography in the development of molecular targeted cancer therapeutics

B Solomon, GA McArthur, C Cullinane, JR Zalcberg, RJ Hicks

Journal article  |  2003  |  BioDrugs

Optimizing DNA Vaccines Against Nuclear Oncogenes

Sandra Carpinteri

Journal article  |  ImmunoGastroenterology