Richard Tothill

γδ T cells in Merkel cell carcinomas have a proinflammatory profile prognostic of patient survival.

Nicholas A Gherardin, Kelly Waldeck, Alex Caneborg, Luciano G Martelotto, Shiva Balachander, Magnus Zethoven, Pasquale M Petrone, Andrew Pattison, James S Wilmott, Sergio M Quiñones-Parra, Fernando Rossello, Atara Posner, Annie Wong, Alison M Weppler, Kerwin F Shannon, Angela Hong, Peter M Ferguson, Valerie Jakrot, Jeanette Raleigh, Athena Hatzimihalis, et al.

Journal article  |  2021  |  Cancer Immunology Research

Merkel cell carcinomas (MCC) are immunogenic skin cancers associated with viral infection or UV-mutagenesis. To study T-cell infil..

FAPI PET/CT: Will It End the Hegemony of F-18-FDG in Oncology?

Rodney J Hicks, Peter J Roselt, Kumarswamy G Kallur, Richard W Tothill, Linda Mileshkin

Journal article  |  2021  |  Journal of Nuclear Medicine

For over 40 years, 18F-FDG has been the dominant PET tracer in neurology, cardiology, inflammatory diseases, and, most particularl..

Towards Routine Implementation of Liquid Biopsies in Cancer Management: It Is Always Too Early, until Suddenly It Is Too Late

Maarten J IJzerman, Jasper de Boer, Arun Azad, Koen Degeling, Joel Geoghegan, Chelsee Hewitt, Frederic Hollande, Belinda Lee, Yat Ho To, Richard W Tothill, Gavin Wright, Jeanne Tie, Sarah-Jane Dawson

Journal article  |  2021  |  Diagnostics

Blood-based liquid biopsies are considered a new and promising diagnostic and monitoring tool for cancer. As liquid biopsies only ..

CUP-AI-Dx: A tool for inferring cancer tissue of origin and molecular subtype using RNA gene-expression data and artificial intelligence

Yue Zhao, Ziwei Pan, Sandeep Namburi, Andrew Pattison, Atara Posner, Shiva Balachander, Carolyn A Paisie, Honey Reddi, Jens Rueter, Anthony J Gill, Stephen Fox, Kanwal PS Raghav, William F Flynn, Richard W Tothill, Sheng Li, R Krishna Murthy Karuturi, Joshy George

Journal article  |  2020  |  EBioMedicine

BACKGROUND: Cancer of unknown primary (CUP), representing approximately 3-5% of all malignancies, is defined as metastatic cancer ..

The changing paradigm of managing Merkel cell carcinoma in Australia: An expert commentary

David L Kok, Annie Wang, Wen Xu, Margaret ST Chua, Alexander Guminski, Michael Veness, Julie Howle, Richard Tothill, Ganessan Kichendasse, Michael Poulsen, Shahneen Sandhu, Gerald Fogarty

Journal article  |  2020  |  Asia Pacific Journal of Clinical Oncology

Enhancing the anti-tumour activity of 177Lu-DOTA-octreotate radionuclide therapy in somatostatin receptor-2 expressing tumour models by targeting PARP

Carleen Cullinane, Kelly Waldeck, Laura Kirby, Buck E Rogers, Peter Eu, Richard W Tothill, Rodney J Hicks

Journal article  |  2020  |  Scientific Reports

Peptide receptor radionuclide therapy (PRRT) is an important treatment option for patients with somatostatin receptor-2 (SSTR2)-ex..

A xenograft and cell line model of SDH-deficient pheochromocytoma derived from Sdhb plus /- rats

James F Powers, Brent Cochran, James D Baleja, Hadley D Sikes, Andrew D Pattison, Xue Zhang, Inna Lomakin, Annette Shepard-Barry, Karel Pacak, Sun Jin Moon, Troy F Langford, Kassi Taylor Stein, Richard W Tothill, Yingbin Ouyang, Arthur S Tischler

Journal article  |  2020  |  Endocrine-Related Cancer

Tumors caused by loss-of-function mutations in genes encoding TCA cycle enzymes have been recently discovered and are now of great..

Clinical, FDG-PET and molecular markers of immune checkpoint inhibitor response in patients with metastatic Merkel cell carcinoma

Alison M Weppler, Andrew Pattison, Prachi Bhave, Paolo De Ieso, Jeanette Raleigh, Athena Hatzimihalis, Anthony J Gill, Shiva Balachander, Jason Callahan, Margaret Chua, George Au-Yeung, Grant A McArthur, Rodney J Hicks, Richard W Tothill, Shahneen Sandhu

Conference Proceedings  |  2020  |  Journal for ImmunoTherapy of Cancer

A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1

Jerome Le Nours, Nicholas A Gherardin, Sri H Ramarathinam, Wael Awad, Florian Wiede, Benjamin S Gully, Yogesh Khandokar, T Praveena, Jacinta M Wubben, Jarrod J Sandow, Andrew I Webb, Anouk von Borstel, Michael T Rice, Samuel J Redmond, Rebecca Seneviratna, Maria L Sandoval-Romero, Shihan Li, Michael NT Souter, Sidonia BG Eckle, Alexandra J Corbett, et al.

Journal article  |  2019  |  Science

T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..

Combination of avelumabwith peptide receptor radionuclide therapy (PRRT) or conventional fractionated radiotherapy (RT) in metastatic merkel cell carcinoma (mMCC) [GoTHAM study]

Shahneen Sandhu, Richard Tothill, Richard Scolyer, Alexander Guminski, Juergen Becker, Michael Poulsen, Victoria Atkinson, Paul Neeson, Mark Shackleton, David Pattison, Narelle Williams, Elizabeth Paton

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY