Gayle Philip

FokI-dCas9 mediates high-fidelity genome editing in pigs

Nella Fisicaro, Evelyn J Salvaris, Gayle K Philip, Matthew J Wakefield, Mark B Nottle, Wayne J Hawthorne, Peter J Cowan

Journal article  |  2019  |  XENOTRANSPLANTATION

Gene editing using clustered regularly interspaced short palindromic repeats/Cas9 has great potential for improving the compatibil..

Gene Expression and Pathways Underlying Form Deprivation Myopia in the Guinea Pig Sclera

Nethrajeith Srinivasalu, Sally A McFadden, Callan Medcalf, Lena Fuchs, Jessica Chung, Gayle Philip, Andrea Richardson, Moeen Riaz, Paul N Baird

Journal article  |  2018  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Purpose: Posterior scleral remodeling accompanies myopia. In guinea pigs developing myopia, the region around the optic nerve (per..

In mammalian foetal testes, SOX9 regulates expression of its target genes by binding to genomic regions with conserved signatures

Massilva Rahmoun, Rowena Lavery, Sabine Laurent-Chaballier, Nicolas Bellora, Gayle K Philip, Moira Rossitto, Aleisha Symon, Eric Pailhoux, Florence Cammas, Jessica Chung, Stefan Bagheri-Fam, Mark Murphy, Vivian Bardwell, David Zarkower, Brigitte Boizet-Bonhoure, Philippe Clair, Vincent R Harley, Francis Poulat

Journal article  |  2017  |  NUCLEIC ACIDS RESEARCH

In mammalian embryonic gonads, SOX9 is required for the determination of Sertoli cells that orchestrate testis morphogenesis. To i..

Variant effect prediction tools assessed using independent, functional assay-based datasets: implications for discovery and diagnostics

Khalid Mahmood, Chol-hee Jung, Gayle Philip, Peter Georgeson, Jessica Chung, Bernard J Pope, Daniel J Park

Journal article  |  2017  |  HUMAN GENOMICS

BACKGROUND: Genetic variant effect prediction algorithms are used extensively in clinical genomics and research to determine the l..

Spatially extensive microbial biogeography of the Indian Ocean provides insights into the unique community structure of a pristine coral atoll

Thomas C Jeffries, Martin Ostrowski, Rohan B Williams, Chao Xie, Rachelle M Jensen, Joseph J Grzymski, Svend Jacob Senstius, Michael Givskov, Ron Hoeke, Gayle K Philip, Russell Y Neches, Daniela I Drautz-Moses, Caroline Chenard, Ian T Paulsen, Federico M Lauro

Journal article  |  2015  |  SCIENTIFIC REPORTS

Microorganisms act both as drivers and indicators of perturbations in the marine environment. In an effort to establish baselines ..

The Common Oceanographer: Crowdsourcing the Collection of Oceanographic Data

Federico M Lauro, Svend Jacob Senstius, Jay Cullen, Russell Neches, Rachelle M Jensen, Mark V Brown, Aaron E Darling, Michael Givskov, Diane McDougald, Ron Hoeke, Martin Ostrowski, Gayle K Philip, Ian T Paulsen, Joseph J Grzymski

Journal article  |  2014  |  PLOS BIOLOGY

Did Evolution Select a Nonrandom "Alphabet" of Amino Acids?

Gayle K Philip, Stephen J Freeland

Journal article  |  2011  |  ASTROBIOLOGY

The last universal common ancestor of contemporary biology (LUCA) used a precise set of 20 amino acids as a standard alphabet with..

Microbial community structure in the North Pacific ocean

Mark V Brown, Gayle K Philip, John A Bunge, Matthew C Smith, Andrew Bissett, Federico M Lauro, Jed A Fuhrman, Stuart P Donachie

Journal article  |  2009  |  ISME JOURNAL

We report a ribosomal tag pyrosequencing study of the phylogenetic diversity of Archaea, Bacteria and Eucarya over a depth profile..

Gene evolution and drug discovery.

James O McInerney, Caroline S Finnerty, Jennifer M Commins, Gayle K Philip

Journal article  |  2006  |  Methods Mol Biol

Mutation and selection are the principle forces governing gene and protein sequence. Mutation is the major source of variation, an..

The Opisthokonta and the Ecdysozoa may not be clades: Stronger support for the grouping of plant and animal than for animal and fungi and stronger support for the Coelomata than Ecdysozoa

GK Philip, CJ Creevey, JO McInerney

Journal article  |  2005  |  MOLECULAR BIOLOGY AND EVOLUTION

In considering the best possible solutions for answering phylogenetic questions from genomic sequences, we have chosen a strategy ..