Fern Koay

γδ T cells unveil invisible tumors.

Hui-Fern Koay, Lydia Lynch

Journal article  |  2023  |  Trends Immunol

Tumors can evade conventional T cell recognition by rendering the HLA class I antigen presentation system defective. In a recent s..

RIPK3 controls MAIT cell accumulation during development but not during infection

Timothy Patton, Zhe Zhao, Xin Yi Lim, Eleanor Eddy, Huimeng Wang, Adam G Nelson, Bronte Ennis, Sidonia BG Eckle, Michael NT Souter, Troi J Pediongco, Hui-Fern Koay, Jian-Guo Zhang, Tirta M Djajawi, Cynthia Louis, Najoua Lalaoui, Nicolas Jacquelot, Andrew M Lew, Daniel G Pellicci, James McCluskey, Yifan Zhan, et al.

Journal article  |  2023  |  CELL DEATH & DISEASE

Cell death mechanisms in T lymphocytes vary according to their developmental stage, cell subset and activation status. The cell de..

Unconventional haircare

Hui-Fern Koay, Laura K Mackay

Journal article  |  2023  |  NATURE IMMUNOLOGY

Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells.

Harry Kane, Nelson M LaMarche, Áine Ní Scannail, Amanda E Garza, Hui-Fern Koay, Adiba I Azad, Britta Kunkemoeller, Brenneth Stevens, Michael B Brenner, Lydia Lynch

Journal article  |  2022  |  Elife

Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in ..

SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity

Wuji Zhang, Brendon Y Chua, Kevin J Selva, Lukasz Kedzierski, Thomas M Ashhurst, Ebene R Haycroft, Suzanne K Shoffner-Beck, Luca Hensen, David F Boyd, Fiona James, Effie Mouhtouris, Jason C Kwong, Kyra YL Chua, George Drewett, Ana Copaescu, Julie E Dobson, Louise C Rowntree, Jennifer R Habel, Lilith F Allen, Hui-Fern Koay, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying COVID-19. We examine cellular, humoral a..

Are NKT cells a useful predictor of COVID-19 severity?

Hui-Fern Koay, Nicholas A Gherardin, Thi HO Nguyen, Wuji Zhang, Jennifer R Habel, Rebecca Seneviratna, Fiona James, Natasha E Holmes, Olivia C Smibert, Claire L Gordon, Jason A Trubiano, Katherine Kedzierska, Dale I Godfrey

Journal article  |  2022  |  IMMUNITY

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Sergio Abrignani, Richard Addo, Muebeccel Akdis, Immanuel Andrae, Francesco Andreata, Francesco Annunziato, Eduardo Arranz, Petra Bacher, Sudipto Bari, Vincenzo Barnaba, Joana Barros-Martins, Dirk Baumjohann, Cristian G Beccaria, David Bernardo, Dominic A Boardman, Jessica Borger, Chotima Boettcher, et al.

Journal article  |  2021  |  EUROPEAN JOURNAL OF IMMUNOLOGY

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and..

MAIT cells regulate NK cell-mediated tumor immunity

Emma Petley, Hui-Fern Koay, Melissa A Henderson, Kevin Sek, Kirsten L Todd, Simon P Keam, Junyun Lai, Imran G House, Jasmine Li, Magnus Zethoven, Amanda XY Chen, Amanda J Oliver, Jessica Michie, Andrew J Freeman, Lauren Giuffrida, Jack D Chan, Angela Pizzolla, Jeffrey YW Mak, Timothy R McCulloch, Fernando Souza-Fonseca-Guimaraes, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT ce..

An unconventional view of COVID-19 T cell immunity

Hui-Fern Koay, Thomas S Fulford, Dale I Godfrey

Journal article  |  2020  |  JOURNAL OF EXPERIMENTAL MEDICINE

In this issue of JEM, Jouan et al. (https://doi.org/10.1084/jem.20200872) report the activation and skewed function of unconventio..

Thymic development of unconventional T cells: how NKT cells, MAIT cells and gamma delta T cells emerge

Daniel G Pellicci, Hui-Fern Koay, Stuart P Berzins

Journal article  |  2020  |  NATURE REVIEWS IMMUNOLOGY

T cell lineages are defined by specialized functions and differential expression of surface antigens, cytokines and transcription ..