Fern Koay

An unconventional view of COVID-19 T cell immunity

Hui-Fern Koay, Thomas S Fulford, Dale I Godfrey

Journal article  |  2020  |  Journal of Experimental Medicine

In this issue of JEM, Jouan et al. (https://doi.org/10.1084/jem.20200872) report the activation and skewed function of unconventio..

Thymic development of unconventional T cells: how NKT cells, MAIT cells and gamma delta T cells emerge

Daniel G Pellicci, Hui-Fern Koay, Stuart P Berzins

Journal article  |  2020  |  Nature Reviews Immunology

T cell lineages are defined by specialized functions and differential expression of surface antigens, cytokines and transcription ..

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

Hui Fern Koay, Shian Su, Daniela Amann-Zalcenstein, Stephen R Daley, Iain Comerford, Carly E Whyte, Igor E Konstantinov, Yves d'Udekem, Tracey Baldwin, Peter F Hickey, Stuart P Berzins, Jeffrey YW Mak, Axel Kallies, Zhenjun Chen, Simone Nussing, Katherine Kedzierska, Laura K Mackay, Shaun R McColl, Elissa K Deenick, David P Fairlie, et al.

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCR alpha beta Clonotypes with Potent Antimicrobial Responses

Liyen Loh, Nicholas A Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L Bird, Hui-Fern Koay, Carolien E van de Sandt, Marcela L Moreira, Martha Lappas, E Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L Flanagan, Kylie M Quinn, Jamie Rossjohn, Paul G Thomas, Sidonia BG Eckle, James McCluskey, Dale I Godfrey, et al.

Journal article  |  2020  |  The Journal of Immunology

Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to und..

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

H-F Koay, S Su, D Amann-Zalcenstein, SR Daley, I Comerford, L Miosge, CE Whyte, IE Konstantinov, Y d'Udekem, T Baldwin, PF Hickey, SP Berzins, JYW Mak, Y Sontani, CM Roots, T Sidwell, A Kallies, Z Chen, S Nussing, K Kedzierska, et al.

Journal article  |  2019  |  Science Immunology

MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These cells develop intrathymi..

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Andreas Acs, Dieter Adam, Sabine Adam-Klages, William W Agace, Nima Aghaeepour, Muebeccel Akdis, Matthieu Allez, Larissa Nogueira Almeida, Giorgia Alvisi, Graham Anderson, Immanuel Andrae, Francesco Annunziato, Achille Anselmo, Petra Bacher, Cosima T Baldari, Sudipto Bari, Vincenzo Barnaba, et al.

Journal article  |  2019  |  European Journal of Immunology

These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They pro..

The biology and functional importance of MAIT cells

Dale Godfrey, Hui-Fern Koay, James McCluskey, Nicholas A Gherardin

Journal article  |  2019  |  Nature Immunology

In recent years, a population of unconventional T cells called 'mucosal-associated invariant T cells' (MAIT cells) has captured th..

TCF-1 limits the formation of Tc17 cells via repression of the MAF-ROR gamma t axis

Lisa A Mielke, Yang Liao, Ella Bridie Clemens, Matthew A Firth, Brigette Duckworth, Qiutong Huang, Francisca F Almeida, Michael Chopin, Hui-Fern Koay, Carolyn A Bell, Soroor Hediyeh-Zadeh, Simone L Park, Dinesh Raghu, Jarny Choi, Tracy L Putoczki, Philip D Hodgkin, Ashley E Franks, Laura K Mackay, Dale Godfrey, Melissa J Davis, et al.

Journal article  |  2019  |  Journal of Experimental Medicine

Interleukin (IL)-17-producing CD8+ T (Tc17) cells have emerged as key players in host-microbiota interactions, infection, and canc..

Cysteine and hydrophobic residues in CDR3 serve as distinct T-cell self-reactivity indices

Stephen R Daley, Hui-Fern Koay, Kerry Dobbs, Marita Bosticardo, Rushika C Wirasinha, Francesca Pala, Riccardo Castagnoli, Jared H Rowe, Lisa M Ott de Bruin, Sevgi Keles, Yu Nee Lee, Raz Somech, Steven M Holland, Ottavia M Delmonte, Debbie Draper, Sandra Maxwell, Julie Niemela, Jennifer Stoddard, Sergio D Rosenzweig, Pietro Luigi Poliani, et al.

Journal article  |  2019  |  Journal of Allergy and Clinical Immunology

Diverse MR1-restricted T cells in mice and humans.

Hui-Fern Koay, Nicholas A Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P Fairlie, James McCluskey, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey

Journal article  |  2019  |  Nature Communications

Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like mol..