Nicholas Gherardin

Influenza, but not SARS-CoV-2, infection induces a rapid interferon response that wanes with age and diminished tissue-resident memory CD8( ) T cells

Thi HO Nguyen, Julie L McAuley, Youry Kim, Ming ZM Zheng, Nicholas A Gherardin, Dale Godfrey, Damian FJ Purcell, Lucy C Sullivan, Glen P Westall, Patrick C Reading, Katherine Kedzierska, Linda M Wakim

Journal article  |  2021  |  Clinical & Translational Immunology

Older individuals exhibit a diminished ability to respond to and clear respiratory pathogens and, as such, experience a higher rat..

Butyrophilin molecules govern gamma delta T cell reactivity against phosphoantigens

Marc Rigau, Simone Ostrouska, Tom Fulford, Darryl Neil Johnson, Katherine Woods, Zheng Ruan, Hamish McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Hammet, Anne M Verhagen, Gino Vairo, Eugene Maraskovsky, et al.

Conference Proceedings  |  2020  |  JOURNAL OF IMMUNOLOGY

Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCR alpha beta Clonotypes with Potent Antimicrobial Responses

Liyen Loh, Nicholas A Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L Bird, Hui-Fern Koay, Carolien E van de Sandt, Marcela L Moreira, Martha Lappas, E Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L Flanagan, Kylie M Quinn, Jamie Rossjohn, Paul G Thomas, Sidonia BG Eckle, James McCluskey, Dale I Godfrey, et al.

Journal article  |  2020  |  The Journal of Immunology

Mucosal-associated invariant T (MAIT) cells are important for immune responses against microbial infections. Although known to und..

Butyrophilin 2A1 is essential for phosphoantigen reactivity by gamma delta T cells

Marc Rigau, Simone Ostrouska, Thomas S Fulford, Darryl N Johnson, Katherine Woods, Zheng Ruan, Hamish EG McWilliam, Christopher Hudson, Candani Tutuka, Adam K Wheatley, Stephen J Kent, Jose A Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D Nash, Andrew Hammet, Anne M Verhagen, Gino Vairo, et al.

Journal article  |  2020  |  Science

Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) ..

A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1

Jerome Le Nours, Nicholas A Gherardin, Sri H Ramarathinam, Wael Awad, Florian Wiede, Benjamin S Gully, Yogesh Khandokar, T Praveena, Jacinta M Wubben, Jarrod J Sandow, Andrew I Webb, Anouk von Borstel, Michael T Rice, Samuel J Redmond, Rebecca Seneviratna, Maria L Sandoval-Romero, Shihan Li, Michael NT Souter, Sidonia BG Eckle, Alexandra J Corbett, et al.

Journal article  |  2019  |  Science

T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We ..

Characterization of Human Mucosal-associated Invariant T (MAIT) Cells.

Michael NT Souter, Liyen Loh, Shihan Li, Bronwyn S Meehan, Nicholas A Gherardin, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, Katherine Kedzierska, Daniel G Pellicci, Zhenjun Chen, Lars Kjer-Nielsen, Alexandra J Corbett, James McCluskey, Sidonia BG Eckle

Journal article  |  2019  |  Current Protocols in Immunology

Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells restricted by the major histocompatibility comp..

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Andrea Cossarizza, Hyun-Dong Chang, Andreas Radbruch, Andreas Acs, Dieter Adam, Sabine Adam-Klages, William W Agace, Nima Aghaeepour, Muebeccel Akdis, Matthieu Allez, Larissa Nogueira Almeida, Giorgia Alvisi, Graham Anderson, Immanuel Andrae, Francesco Annunziato, Achille Anselmo, Petra Bacher, Cosima T Baldari, Sudipto Bari, Vincenzo Barnaba, et al.

Journal article  |  2019  |  European Journal of Immunology

These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They pro..

The biology and functional importance of MAIT cells

Dale Godfrey, Hui-Fern Koay, James McCluskey, Nicholas A Gherardin

Journal article  |  2019  |  Nature Immunology

Diverse MR1-restricted T cells in mice and humans.

Hui-Fern Koay, Nicholas A Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P Fairlie, James McCluskey, Daniel G Pellicci, Adam P Uldrich, Dale I Godfrey

Journal article  |  2019  |  Nature Communications

Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like mol..

The Diverse Family of MR1-Restricted T Cells

Nicholas A Gherardin, James McCluskey, Jamie Rossjohn, Dale I Godfrey

Journal article  |  2018  |  The Journal of Immunology