Nicholas Gherardin

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2 (vol 13, 889372, 2022)

Bruce D Wines, Liriye Kurtovic, Halina M Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L Mordant, Wen Shi Lee, Nicholas A Gherardin, Sheila K Patel, Gemma E Hartley, Phillip Pymm, James P Cooney, James G Beeson, Dale I Godfrey, Louise M Burrell, Menno C van Zelm, Adam K Wheatley, Amy WW Chung, et al.

Journal article  |  2023  |  FRONTIERS IN IMMUNOLOGY

[This corrects the article .].

CD1 and MR1: An update after a long-awaited reunion.

Nicholas A Gherardin, Francois Legoux, Michela Consonni, Christophe Paget

Conference Proceedings  |  2022  |  Immunity

CD1 molecules and the MHC-related protein 1 (MR1) present lipid and small molecule antigens, respectively, for T cell surveillance..

Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

Phillip Pymm, Samuel J Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P Cooney, Kathryn C Davidson, Ebene R Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L Grimley, Damian FJ Purcell, Stephen J Kent, Adam K Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W Chung, Kanta Subbarao, et al.

Journal article  |  2022  |  ISCIENCE

The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monocl..

CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells

Michael NT Souter, Wael Awad, Shihan Li, Troi Pediongco, Bronwyn S Meehan, Lucy J Meehan, Zehua Tian, Zhe Zhao, Huimeng Wang, Adam Nelson, Jérôme Le Nours, Yogesh Khandokar, T Praveena, Jacinta Wubben, Jie Lin, Lucy C Sullivan, George Lovrecz, Jeffrey YW Mak, Ligong Liu, Lyudmila Kostenko, et al.

Journal article  |  2022  |  Journal of Experimental Medicine

Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of riboflavin-based antigens presented by t..

Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2

Bruce D Wines, Liriye Kurtovic, Halina M Trist, Sandra Esparon, Ester Lopez, Klasina Chappin, Li-Jin Chan, Francesca L Mordant, Wen Shi Lee, Nicholas A Gherardin, Sheila K Patel, Gemma E Hartley, Phillip Pymm, James P Cooney, James G Beeson, Dale Godfrey, Louise M Burrell, Menno C van Zelm, Adam K Wheatley, Amy W Chung, et al.

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain ..

Differential antigen requirements by diverse MR1-restricted T cells (vol 100, pg 112, 2022)

Rebecca Seneviratna, Samuel J Redmond, Hamish EG McWilliam, Rangsima Reantragoon, Jose A Villadangos, James McCluskey, Dale Godfrey, Nicholas A Gherardin

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

Correction to: Immunol Cell Biol 2022; 100: 112–126; https://doi.org/10.1111/imcb.12519 The authors omitted a grant from the Natio..

Are NKT cells a useful predictor of COVID-19 severity?

Hui-Fern Koay, Nicholas A Gherardin, Thi HO Nguyen, Wuji Zhang, Jennifer R Habel, Rebecca Seneviratna, Fiona James, Natasha E Holmes, Olivia C Smibert, Claire L Gordon, Jason A Trubiano, Katherine Kedzierska, Dale I Godfrey

Journal article  |  2022  |  IMMUNITY

Intracellular radar: Understanding γδ T cell immune surveillance and implications for clinical strategies in oncology.

Anne BC Cherry, Nicholas A Gherardin, Hafiz I Sikder

Journal article  |  2022  |  Front Oncol

T cells play a key role in anticancer immunity, with responses mediated through a diversity of αβ or γδ T cell receptors. Although..

Differential antigenic requirements by diverse MR1-restricted T cells

Rebecca Seneviratna, Samuel J Redmond, Hamish EG McWilliam, Rangsima Reantragoon, Jose A Villadangos, James McCluskey, Dale Godfrey, Nicholas A Gherardin

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

MHC-related protein 1 (MR1) presents microbial riboflavin metabolites to mucosal-associated invariant T (MAIT) cells for surveilla..

Heterologous SARS-CoV-2 IgA neutralising antibody responses in convalescent plasma

Samantha K Davis, Kevin John Selva, Ester Lopez, Ebene R Haycroft, Wen Shi Lee, Adam K Wheatley, Jennifer A Juno, Amy Adair, Phillip Pymm, Samuel J Redmond, Nicholas A Gherardin, Dale Godfrey, Wai-Hong Tham, Stephen J Kent, Amy W Chung

Journal article  |  2022  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

OBJECTIVES: Following infection with SARS-CoV-2, virus-specific antibodies are generated, which can both neutralise virions and cl..