Ashley Ng

Iron homeostasis governs erythroid phenotype in Polycythemia Vera.

Cavan Bennett, Victoria E Jackson, Anne Pettikiriarachchi, Thomas Hayman, Ute Schaeper, Gemma L Moir-Meyer, Katherine Louise Fielding, Ricardo Ataide, Danielle Clucas, Andrew James Baldi, Alexandra L Garnham, Connie Sn Li-Wai-Suen, Stephen John Loughran, E Joanna Baxter, Anthony R Green, Warren S Alexander, Melanie Bahlo, Kate Burbury, Ashley P Ng, Sant-Rayn Pasricha

Journal article  |  2023  |  Blood

Polycythemia Vera (PV) is a myeloproliferative neoplasm driven by activating mutations in JAK2 that result in unrestrained erythro..

Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL

Teresa Sadras, Fatimah BB Jalud, Hansen JJ Kosasih, Christopher RR Horne, Lauren MM Brown, Sam El-Kamand, Charles EE de Bock, Lachlan McAloney, Ashley PP Ng, Nadia MM Davidson, Louise EA Ludlow, Alicia Oshlack, Mark JJ Cowley, Seong LL Khaw, James MM Murphy, Paul GG Ekert

Journal article  |  2023  |  LEUKEMIA

MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis

Hai Vu Nguyen, Cassandra J Vandenberg, Mikara R Robati, Ashley P Ng, Suzanne Cory

Journal article  |  2023  |  CELL DEATH AND DIFFERENTIATION

The importance of c-MYC in regulating lymphopoiesis and promoting lymphomagenesis is well-established. Far less appreciated is the..

Real-world utility of early measurable residual disease assessments by multi-parametric flow cytometry in adult patients with B-lymphoblastic leukemia receiving Hyper-CVAD induction chemotherapy

Rithin Nedumannil, David Ritchie, Ashish Bajel, Ashley P Ng, Simon J Harrison, David Westerman

Journal article  |  2022  |  EUROPEAN JOURNAL OF HAEMATOLOGY

Multi-parametric flow cytometry (MFC) has a well-established role in measurable residual disease (MRD) monitoring in patients with..

Generation of a CRISPR activationmouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance (vol 13, 4739, 2022)

Yexuan Deng, Sarah T Diepstraten, Margaret A Potts, Goknur Giner, Stephanie Trezise, Ashley P Ng, Gerry Healey, Serena R Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S Alexander, Jane E Visvader, Stephen L Nutt, Andreas Strasser, Benjamin Haley, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

In this article the affiliation details for Amy Heidersbach were incorrectly given as ‘School of Dentistry and Medical Sciences, C..

Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance

Yexuan Deng, Sarah T Diepstraten, Margaret A Potts, Goeknur Giner, Stephanie Trezise, Ashley P Ng, Gerry Healey, Serena R Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S Alexander, Jane E Visvader, Stephen L Nutt, Andreas Strasser, Benjamin Haley, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

CRISPR technologies have advanced cancer modelling in mice, but CRISPR activation (CRISPRa) methods have not been exploited in thi..

[F-18]FDG-PET-CT compared with CT for persistent or recurrent neutropenic fever in high-risk patients (PIPPIN): a multicentre, open-label, phase 3, randomised, controlled trial

Abby Douglas, Karin Thursky, Timothy Spelman, Jeff Szer, Ashish Bajel, Simon Harrison, Shio Yen Tio, Olivia Bupha-Intr, Michelle Tew, Leon Worth, Benjamin Teh, Lynette Chee, Ashley Ng, Dennis Carney, Amit Khot, Gabrielle Haeusler, Michelle Yong, Jason Trubiano, Sharon Chen, Rodney Hicks, et al.

Journal article  |  2022  |  LANCET HAEMATOLOGY

BACKGROUND: Management of neutropenic fever in high-risk haematology patients is challenging; there are often few localising clini..

What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy?

Kerstin Brinkmann, Ashley P Ng, Carolyn A de Graaf, Andreas Strasser

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

In many human cancers the control of apoptosis is dysregulated, for instance as a result of the overexpression of pro-survival BCL..

P361: EARLY MEASURABLE RESIDUAL DISEASE ANALYSIS IS ONLY PREDICTIVE OF SURVIVAL OUTCOMES AFTER TWO CYCLES OF TREATMENT IN ADULTS WITH B-LYMPHOBLASTIC LEUKEMIA RECEIVING HYPER-CVAD INDUCTION.

R Nedumannil, D Ritchie, A Bajel, AP Ng, SJ Harrison, D Westerman

Journal article  |  2022  |  HemaSphere

Diagnostic Utility of Multimodal Genomic Profiling for Molecular Classification and MRD Assessment in Adult B-Cell Acute Lymphoblastic Leukemia

Georgina L Ryland, Ashish Bajel, Michael Dickinson, Paul G Ekert, Oliver Hofmann, Maartenl Jzerman, Ashley P Ng, Alicia Oshlack, Breon Schmidt, Ing S Tiong, Martin Vu, David Alan Westerman, Sean Grimmond, Piers Blombery

Conference Proceedings  |  2021  |  BLOOD

Abstract Genomic markers define molecular subtypes and measurable residual disease (MRD) targets in B-cell acute ly..