Ashley Ng

miR17~92 restrains pro-apoptotic BIM to ensure survival of haematopoietic stem and progenitor cells

Kerstin Brinkmann, Ashley P Ng, Carolyn A de Graaf, Ladina Di Rago, Craig D Hyland, Eugenio Morelli, Jai Rautela, Nicholas D Huntington, Andreas Strasser, Warren S Alexander, Marco J Herold

Journal article  |  2020  |  Cell Death & Differentiation

The miR17~92 cluster plays important roles in haematopoiesis. However, it is not clear at what stage of differentiation and throug..

Development and survival of MYC-driven lymphomas require the MYC antagonist MNT to curb MYC-induced apoptosis

Vu Nguyen Hai, Cassandra J Vandenberg, Ashley P Ng, Mikara R Robati, Natasha S Anstee, Joel Rimes, Edwin D Hawkins, Suzanne Cory

Journal article  |  2020  |  Blood

Deregulated overexpression of MYC is implicated in the development and malignant progression of most (∼70%) human tumors. MYC driv..

An Erg driven transcriptional program controls B-lymphopoiesis

Ashley Ng, Hannah Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy Johanson, Michael Sze Yuan Low, Charles Bell, Omer Gilan, Yih-Chih Chan, Andrew Kueh, Thomas Boudier, Ladina DiRago, Craig Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark Dawson, Rhys Allan, Marco Herold, et al.

Journal article  |  2019

Summary/Abstract B-cell development is initiated by the stepwise differentiation of hematopoietic stem cells into lineage committe..

Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice

Natasha S Anstee, Rebecca A Bilardi, Ashley P Ng, Zhen Xu, Mikara Robati, Cassandra J Vandenberg, Suzanne Cory

Journal article  |  2019  |  Cell Death & Differentiation

RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development

Holly Anderton, Esther Bandala-Sanchez, Daniel S Simpson, James A Rickard, Ashley P Ng, Ladina Di Rago, Cathrine Hall, James E Vince, John Silke, Gianmaria Liccardi, Rebecca Feltham

Journal article  |  2019  |  Cell Death & Differentiation

I myelofibrosis! Veni VitD! Et tu, macrophage?

Ashley P Ng

Journal article  |  2019  |  Blood

Haemopedia RNA-seq: a database of gene expression during haematopoiesis in mice and humans

Jarny Choi, Tracey M Baldwin, Mae Wong, Jessica E Bolden, Kirsten A Fairfax, Erin C Lucas, Rebecca Cole, Christine Biben, Clare Morgan, Kerry A Ramsay, Ashley P Ng, Maria Kauppi, Lynn M Corcoran, Wei Shi, Nick Wilson, Michael J Wilson, Warren S Alexander, Douglas J Hilton, Carolyn A de Graaf

Journal article  |  2019  |  Nucleic Acids Research

Identification of Potent BH3-Mimetic Combinations Targeting Pro-Survival Pathways in Human B-Cell Acute Lymphoblastic Leukemia

Donia M Moujalled, Diane T Hanna, Giovanna Pomilio, Veronique Litalien, Shaun Fleming, Marie Chanrion, Ana-Leticia Maragno, Laurence Kraus-Berthier, Seong Lin Khaw, Guillaume Lessene, David Huang, Andrew W Roberts, Olivier Geneste, Paul G Ekert, Ashley P Ng, Andrew H Wei

Conference Proceedings  |  2018  |  Blood

JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias

Sang-Kyu Kim, Deborah A Knight, Lisa R Jones, Stephin Vervoort, Ashley P Ng, John F Seymour, James E Bradner, Michaela Waibel, Lev Kats, Ricky W Johnstone

Journal article  |  2018  |  Genes and Develpment

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

Jacob T Jackson, Ashley P Ng, Benjamin J Shields, Sue Haupt, Ygal Haupt, Matthew P McCormack

Journal article  |  2018  |  Blood Advances

Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling

Amanda E Au, Marion Lebois, Starling A Sim, Ping Cannon, Jason Corbin, Pradnya Gangatirkar, Craig D Hyland, Diane Moujalled, Angelika Rutgersson, Fatme Yassinson, Benjamin T Kile, Kylie D Mason, Ashley P Ng, Warren S Alexander, Emma C Josefsson

Journal article  |  2017  |  Scientific Reports

Thrombocytopenia and CD34 expression is decoupled from -granule deficiency with mutation of the first growth factor-independent 1B zinc finger

DJ Rabbolini, M-C Morel-Kopp, Q Chen, S Gabrielli, LC Dunlop, LP Chew, N Blair, TA Brighton, N Singh, AP Ng, CM Ward, WS Stevenson

Journal article  |  2017  |  Journal of Thrombosis and Haemostasis

Haematopoietic stem cells: past, present and future

Ashley P Ng, Warren S Alexander

Journal article  |  2017  |  Cell Death Discovery

Haemopedia: An Expression Atlas of Murine Hematopoietic Cells

Carolyn A De Graaf, Jarny Choi, Tracey M Baldwin, Jessica E Bolden, Kirsten A Fairfax, Aaron J Robinson, Christine Biben, Clare Morgan, Kerry Ramsay, Ashley P Ng, Maria Kauppi, Elizabeth A Kruse, Tobias J Sargeant, Nick Seidenman, Angela D'Amico, Marthe C D'Ombrain, Erin C Lucas, Sandra Koernig, Adriana Baz Morelli, Michael J Wilson, et al.

Journal article  |  2016  |  Stem Cell Reports

Professor Donald Metcalf, AC, BSc(Med) Sydney, MD Sydney, FRACP, HonDSc Sydney, HonMD Oslo, HonFRCPath London, FRCPA, FAA, FRS

Ashley P Ng, Warren S Alexander, Douglas J Hilton, Nicos A Nicola

Journal article  |  2015  |  STEM CELLS

Tribute to Donald Metcalf.

Ann Murphy, Martin J Murphy, C Glenn Begley, E Richard Stanley, Anna Rita Migliaccio, Kenneth Kaushansky, Ashley P Ng, Warren S Alexander, Douglas J Hilton, Nicos A Nicola

Journal article  |  2015  |  STEM CELLS

A collection of tributes and remembrances from esteemed colleagues, mentees, and friends on the life and work of "the father of he..

In memoriam: Donald Metcalf (1929-2014) A historical perspective of his contributions to hematology (Reprinted from Exp Hematol, vol 43, pg 425-427, 2015)

Nicos A Nicola, Warren S Alexander, Douglas J Hilton, Ashley P Ng

Journal article  |  2015  |  Experimental Hematology

In memoriam: Donald Metcalf (1929-2014)--A historical perspective of his contributions to hematology

NA Nicola, WS Alexander, DJ Hilton, AP Ng

Journal article  |  2015  |  Experimental hematology

In memoriam: Donald Metcalf (1929-2014) A historical perspective of his contributions to hematology

Nicos A Nicola, Warren S Alexander, Douglas J Hilton, Ashley P Ng

Journal article  |  2015  |  Experimental Hematology

In memoriam: Donald Metcalf (1929-2014)--A historical perspective of his contributions to hematology

NA Nicola, WS Alexander, DJ Hilton, AP Ng

Journal article  |  2015  |  Experimental hematology

Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model

Ashley P Ng, Yifang Hu, Donald Metcalf, Craig D Hyland, Helen Ierino, Belinda Phipson, Di Wu, Tracey M Baldwin, Maria Kauppi, Hiu Kiu, Ladina Di Rago, Douglas J Hilton, Gordon K Smyth, Warren S Alexander

Journal article  |  2015  |  PLoS genetics

BCL-2 is dispensable for thrombopoiesis and platelet survival

MA Debrincat, I Pleines, M Lebois, RM Lane, ML Holmes, J Corbin, CJ Vandenberg, WS Alexander, AP Ng, A Strasser, P Bouillet, M Sola-Visner, BT Kile, EC Josefsson

Journal article  |  2015  |  Cell Death & Disease

PROFESSOR DONALD METCALF 26 FEBRUARY 1929 - 15 DECEMBER 2014 OBITUARY

Douglas Hilton, Warren Alexander, Nicos Nicola, Ashley Ng

Journal article  |  2015  |  CANCER FORUM

Professor Donald Metcalf (1929-2014) Obituary

Ken Shortman, Nicos A Nicola, Ashley P Ng

Journal article  |  2015  |  Immunity

A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation (vol 193, pg 1766, 2014)

Hongsheng Wang, Ming Yan, Jiafang Sun, Shweta Jain, Ryusuke Yoshimi, Sanaz Momben Abolfath, Keiko Ozato, William G Coleman, Ashley P Ng, Donald Metcalf, Ladina DiRago, Stephen L Nutt, Herbert C Morse

Journal article  |  2014  |  The Journal of Immunology

A Reporter Mouse Reveals Lineage-Specific and Heterogeneous Expression of IRF8 during Lymphoid and Myeloid Cell Differentiation

Hongsheng Wang, Ming Yan, Jiafang Sun, Shweta Jain, Ryusuke Yoshimi, Sanaz Momben Abolfath, Keiko Ozato, William G Coleman, Ashley P Ng, Donald Metcalf, Ladina DiRago, Stephen L Nutt, Herbert C Morse

Journal article  |  2014  |  Journal of Immunology

Screening with Spirometry Is a Useful Predictor of Later Development of Noninfectious Pulmonary Syndromes in Patients Undergoing Allogeneic Stem Cell Transplantation

Philip A Thompson, Andrew Lim, Yvonne Panek-Hudson, Mark Tacey, Ramzi Hijazi, Ashley P Ng, Jeff Szer, David Ritchie, Ashish Bajel

Journal article  |  2014  |  Biology of Blood and Marrow Transplantation

GFI1B MUTATION CAUSES A NOVEL HUMAN PLATELET DEFECT WITH COMPLEX CHANGES OBSERVED IN ALPHA-GRANULES AND MITOCHONDRIA ASSOCIATED WITH ALTERED EXPRESSION OF PLATELET PROTEINS

W Stevenson, MC Morel-Kopp, Q Chen, D Rabbolini, A Ng, A Roberts, M Bahlo, C Ward

Conference Proceedings  |  2014  |  HAEMATOLOGICA

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

Ashley P Ng, Maria Kauppi, Donald Metcalf, Craig D Hyland, Emma C Josefsson, Marion Lebois, Jian-Guo Zhang, Tracey M Baldwin, Ladina Di Rago, Douglas J Hilton, Warren S Alexander

Journal article  |  2014  |  Proceedings of the National Academy of Sciences of the United States of America

GFI1B Mutation Causes a Platelet Function Defect With Reduced Alpha-Granule Content and Abnormal Aggregation Response

Christopher M Ward, Marie-Christine Morel-Kopp, Qiang Chen, Hai Po Liang, Ashley P Ng, Andrew W Roberts, Melanie Bahlo, William S Stevenson

Conference Proceedings  |  2013  |  Blood

GFI1B mutation causes a bleeding disorder with abnormal platelet function

WS Stevenson, M-C Morel-Kopp, Q Chen, HP Liang, CJ Bromhead, S Wright, R Turakulov, AP Ng, AW Roberts, M Bahlo, CM Ward

Journal article  |  2013  |  Journal of Thrombosis and Haemostasis

On the origin of clones: learning from concurrent or sequential Philadelphia negative and positive myeloproliferative neoplasms

Ashley P Ng

Journal article  |  2013  |  Leukemia and Lymphoma

Concordant mast cell and basophil production by individual hematopoietic blast colony-forming cells

Donald Metcalf, Ashley P Ng, Tracey M Baldwin, Ladina Di Rago, Sandra Mifsud

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

Hematopoietic stem cells, progenitor cells and leukemic stem cells in adult myeloproliferative neoplasms

Ashley P Ng

Journal article  |  2013  |  Leukemia and Lymphoma

Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia

Jian Zhong Tang, Catherine L Carmichael, Wei Shi, Donald Metcalf, Ashley P Ng, Craig D Hyland, Nancy A Jenkins, Neal G Copeland, Viive M Howell, Zhizhuang Joe Zhao, Gordon K Smyth, Benjamin T Kile, Warren S Alexander

Journal article  |  2013  |  Proceedings of the National Academy of Sciences of the United States of America

FISH Detection of PML-RARA Fusion in ins(15;17) Acute Promyelocytic Leukaemia Depends on Probe Size

Lynda J Campbell, Paul Oei, Ross Brookwell, Jake Shortt, Nicola Eaddy, Ashley Ng, Edward Chew, Peter Browett

Journal article  |  2013  |  BioMed Research International

Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential

Ashley P Ng, Maria Kauppi, Donald Metcalf, Ladina Di Rago, Craig D Hyland, Warren S Alexander

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin beta minor chain

Maria Kauppi, Adrienne A Hilton, Donald Metcalf, Ashley P Ng, Craig D Hyland, Janelle E Collinge, Benjamin T Kile, Douglas J Hilton, Warren S Alexander

Journal article  |  2012  |  Proceedings of the National Academy of Sciences of the United States of America

Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice

Ashley P Ng, Stephen J Loughran, Donald Metcalf, Craig D Hyland, Carolyn A de Graaf, Yifang Hu, Gordon K Smyth, Douglas J Hilton, Benjamin T Kile, Warren S Alexander

Journal article  |  2011  |  Blood

Multipotential hematopoietic blast colony-forming cells exhibit delays in self-generation and lineage commitment

Donald Metcalf, Ashley Ng, Sandra Mifsud, Ladina Di Rago

Journal article  |  2010  |  Proceedings of the National Academy of Sciences of the United States of America

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome

Ashley P Ng, Craig D Hyland, Donald Metcalf, Catherine L Carmichael, Stephen J Loughran, Ladina Di Rago, Benjamin T Kile, Warren S Alexander

Journal article  |  2010  |  Blood

Murine hematopoietic blast colony-forming cells and their progeny have distinctive membrane marker profiles

Donald Metcalf, Ashley P Ng, Stephen JL Loughran, Belinda Phipson, Gordon K Smyth, Ladina Di Rago, Sandra Mifsud

Journal article  |  2009  |  Proceedings of the National Academy of Sciences of the United States of America

Resolution of platelet function defects with imatinib therapy in a patient with chronic myeloid leukaemia in chronic phase

Ashley P Ng, Patricia Servadei, Annabel Tuckfield, Anna Friedhuber, Andrew Grigg

Journal article  |  2009  |  Blood Coagul. Fibrinolysis

Thrombotic thrombocytopenic purpura is associated with a high relapse rate after plasma exchange: a single-centre experience

N Frawley, AP Ng, K Nicholls, S Cohney, C Hogan, A Grigg

Journal article  |  2009  |  Intern. Med. J.

Epilepsy, progressive movement disorder and cognitive decline

B Robertson, AH Evans, M Walterfang, AP Ng, D Velakoulis

Journal article  |  2008  |  Journal of Clinical Neuroscience

Epilepsy, progressive movement disorder and cognitive decline

B Robertson, AH Evans, M Walterfang, AP Ng, D Velakoulis

Journal article  |  2008  |  J Clin Neurosci

Adolescent obsessive compulsive disorder heralding chorea-acanthocytosis

Mark Walterfang, Murat Yucel, Ruth Walker, Andrew Evans, Benedikt Bader, Ashley Ng, Adrian Danek, Ramon Mocellin, Dennis Velakoulis

Journal article  |  2008  |  Movement Disorders

Early therapeutic response assessment by 18 FDG-positron emission tomography during chemotherapy in patients with diffuse large B-cell lymphoma: Isolated residual positivity involving bone is not usually a predictor of subsequent treatment failure

Ashley P Ng, Andrew Wirth, John F Seymour, Michael Lee, Annette Hogg, Henry Januszewicz, Max Wolf, H Miles Prince, Michael Macmanus, Rodney J Hicks

Journal article  |  2007  |  Leukemia and Lymphoma

Thrombotic thrombocytopenic purpura: Is plasma exchange enough? A fifteen year Australian experience at the Royal Melbourne hospital.

Ashley P Ng, Natasha Frawley, Chris Hogan, Andrew Grigg, Solomon Cohney, Kathy Nicholls, Gavin Becker

Conference Proceedings  |  2006  |  BLOOD

The sensitivity of CD138 immunostaining of bone marrow trephine specimens for quantifying marrow involvement in MGUS and myeloma, including samples with a low percentage of plasma cells

Ashley P Ng, Andrew Wei, Dinesh Bhurani, Peter Chapple, Frank Feleppa, Surender Juneja

Journal article  |  2006  |  Haematologica

The sensitivity of CD138 immunostaining of bone marrow trephine specimens for quantifying marrow involvement in MGUS and myeloma, including samples with a low percentage of plasma cells

Ashley P Ng, Andrew Wei, Dinesh Bhurani, Peter Chapple, Frank Feleppa, Surender Juneja

Journal article  |  2006  |  HAEMATOLOGICA

Primary cutaneous CD4( )/CD56( ) hematodermic neoplasm (blastic NK-cell lymphoma): a report of five cases

AP Ng, S Lade, T Rutherford, C McCormack, HM Prince, DA Westerman

Journal article  |  2006  |  Haematologica

Primary cutaneous CD4( )/CD56( ) hematodermic neoplasm (blastic NK-cell lymphoma): a report of five cases

Ashley P Ng, Stephen Lade, Timothy Rutherford, Christopher McCormack, H Miles Prince, David A Westerman

Journal article  |  2006  |  HAEMATOLOGICA

Cytomegalovirus DNAemia and disease: incidence, natural history and management in settings other than allogeneic stem cell transplantation

Ashley P Ng, Leon Worth, Luke Chen, John F Seymour, H Miles Prince, Monica Slavin, Karin Thursky

Journal article  |  2005  |  HAEMATOLOGICA

Cytomegalovirus DNAemia and disease: incidence, natural history and management in settings other than allogeneic stem cell transplantation

AP Ng, L Worth, L Chen, JF Seymour, HM Prince, M Slavin, K Thursky

Journal article  |  2005  |  Haematologica

CD 138 immunostaining of bone marrow trephine specimens is the most sensitive method for quantifying marrow involvement in patients with plasma cell dyscrasias.

AP Ng, A Wei, D Bhurani, P Chappell, F Feleppa, S Juneja

Conference Proceedings  |  2005  |  BLOOD

A mid-treatment FDG-positron emission tomography (PET) scan is highly predictive of subsequent treatment failure in patients with diffuse large B-cell lymphoma (DLBCL).

AP Ng, M Lee, A Hogg, JF Seymour, H Janusewicz, M Prince, M MacManus, R Hicks, A Wirth

Conference Proceedings  |  2005  |  Blood

D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites

GR Hime, MP Dhungat, A Ng, DDL Bowtell

Journal article  |  1997  |  Oncogene

Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells

T Gainsford, TA Willson, D Metcalf, E Handman, C McFarlane, A Ng, NA Nicola, WS Alexander, DJ Hilton

Conference Proceedings  |  1996  |  Proceedings of the National Academy of Sciences