Jason Li

Moanna: Multi-Omics Autoencoder-Based Neural Network Algorithm for Predicting Breast Cancer Subtypes

Richard Lupat, Rashindrie Perera, Sherene Loi, Jason Li

Journal article  |  2023  |  IEEE ACCESS

Cancer subtyping delivers valuable insights into the study of cancer heterogeneity and fulfills an essential step toward personali..

Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

Emily Gruber, Joan So, Alexander C Lewis, Rheana Franich, Rachel Cole, Luciano G Martelotto, Amy J Rogers, Eva Vidacs, Peter Fraser, Kym Stanley, Lisa Jones, Anna Trigos, Niko Thio, Jason Li, Brandon Nicolay, Scott Daigle, Adriana E Tron, Marc L Hyer, Jake Shortt, Ricky W Johnstone, et al.

Journal article  |  2022  |  CELL REPORTS

Approximately 20% of acute myeloid leukemia (AML) patients carry mutations in IDH1 or IDH2 that result in over-production of the o..

TRACEBACK: Testing of Historical Tubo-Ovarian Cancer Patients for Hereditary Risk Genes as a Cancer Prevention Strategy in Family Members

Rachel Delahunty, Linh Nguyen, Stuart Craig, Belinda Creighton, Dinuka Ariyaratne, Dale W Garsed, Elizabeth Christie, Sian Fereday, Lesley Andrews, Alexandra Lewis, Sharne Limb, Ahwan Pandey, Joy Hendley, Nadia Traficante, Natalia Carvajal, Amanda B Spurdle, Bryony Thompson, Michael T Parsons, Victoria Beshay, Mila Volcheck, et al.

Journal article  |  2022  |  JOURNAL OF CLINICAL ONCOLOGY

PURPOSE: Tubo-ovarian cancer (TOC) is a sentinel cancer for BRCA1 and BRCA2 pathogenic variants (PVs). Identification of a PV in t..

CRAF dimerization with ARAF regulates KRAS-driven tumor growth.

Avinashnarayan Venkatanarayan, Jason Liang, Ivana Yen, Frances Shanahan, Benjamin Haley, Lilian Phu, Erik Verschueren, Trent B Hinkle, David Kan, Ehud Segal, Jason E Long, Tony Lima, Nicholas PD Liau, Jawahar Sudhamsu, Jason Li, Christiaan Klijn, Robert Piskol, Melissa R Junttila, Andrey S Shaw, Mark Merchant, et al.

Journal article  |  2022  |  Cell Rep

KRAS, which is mutated in ∼30% of all cancers, activates the RAF-MEK-ERK signaling cascade. CRAF is required for growth of KRAS mu..

CT slice alignment to whole-body reference geometry by convolutional neural network

Price Jackson, James Korte, Lachlan McIntosh, Tomas Kron, Jason Ellul, Jason Li, Nicholas Hardcastle

Journal article  |  2021  |  PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE

Volumetric medical imaging lacks a standardised coordinate geometry which links image frame-of-reference to specific anatomical re..

A Deep Learning Model to Automate Skeletal Muscle Area Measurement on Computed Tomography Images

Kaushalya C Amarasinghe, Jamie Lopes, Julian Beraldo, Nicole Kiss, Nicholas Bucknell, Sarah Everitt, Price Jackson, Cassandra Litchfield, Linda Denehy, Benjamin J Blyth, Shankar Siva, Michael MacManus, David Ball, Jason Li, Nicholas Hardcastle

Journal article  |  2021  |  FRONTIERS IN ONCOLOGY

BACKGROUND: Muscle wasting (Sarcopenia) is associated with poor outcomes in cancer patients. Early identification of sarcopenia ca..

Machine-Learning and Chemicogenomics Approach Defines and Predicts Cross-Talk of Hippo and MAPK Pathways.

Trang H Pham, Thijs J Hagenbeek, Ho-June Lee, Jason Li, Christopher M Rose, Eva Lin, Mamie Yu, Scott E Martin, Robert Piskol, Jennifer A Lacap, Deepak Sampath, Victoria C Pham, Zora Modrusan, Jennie R Lill, Christiaan Klijn, Shiva Malek, Matthew T Chang, Anwesha Dey

Journal article  |  2021  |  Cancer Discov

Hippo pathway dysregulation occurs in multiple cancers through genetic and nongenetic alterations, resulting in translocation of Y..

Serum microRNA is a biomarker for post-operative monitoring in glioma

Andrew Morokoff, Jordan Jones, Hong Nguyen, Chenkai Ma, Arian Lasocki, Frank Gaillard, Iwan Bennett, Rod Luwor, Stanley Stylli, Lucia Paradiso, Rachel Koldej, Iddo Paldor, Ramyar Molania, Terence P Speed, Andrew Webb, Guiseppe Infusini, Jason Li, Charles Malpas, Tomas Kalincik, Katharine Drummond, et al.

Journal article  |  2020  |  JOURNAL OF NEURO-ONCOLOGY

PURPOSE: A circulating biomarker has potential to provide more accurate information for glioma progression post treatment, however..

A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset ofNUTM1-rearranged tumors

Christopher R McEvoy, Holly Holliday, Niko Thio, Catherine Mitchell, David Y Choong, Bhargavi Yellapu, Hui San Leong, Huiling Xu, Stephen Lade, Judy Browning, Elena A Takano, David J Byrne, Anthony J Gill, Cuong P Duong, Jason Li, Andrew P Fellowes, Stephen B Fox, Alexander Swarbrick, Owen WJ Prall

Journal article  |  2020  |  LABORATORY INVESTIGATION

Most NUTM1-rearranged neoplasms (NRNs) have fusions between NUTM1 and BRD (bromodomain-containing) family members and are termed N..

Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours

Sally M Hunter, Genevieve V Dall, Maria A Doyle, Richard Lupat, Jason Li, Prue Allan, Simone M Rowley, David Bowtell, Ian G Campbell, Kylie L Gorringe

Journal article  |  2020  |  BMC RESEARCH NOTES

OBJECTIVE: Ovarian fibromas and adenofibromas are rare ovarian tumours. They are benign tumours composed of spindle-like stromal c..