Tomoko Hyakumura

Blood glucose modulation and safety of efferent vagus nerve stimulation in a type 2 diabetic rat model

Sophie C Payne, Glenn Ward, James B Fallon, Tomoko Hyakumura, Johannes B Prins, Sofianos Andrikopoulos, Richard J MacIsaac, Joel Villalobos

Journal article  |  2022  |  PHYSIOLOGICAL REPORTS

Vagus nerve stimulation is emerging as a promising treatment for type 2 diabetes. Here, we evaluated the ability of stimulation of..

Abdominal vagus nerve stimulation alleviates collagen-induced arthritis in rats.

Sophie C Payne, Evange Romas, Tomoko Hyakumura, Fenella Muntz, James B Fallon

Journal article  |  2022  |  Front Neurosci

Rheumatoid arthritis (RA) is a chronic, autoimmune inflammatory disease. Despite therapeutic advances, a significant proportion of..

Improving Deep Brain Stimulation Electrode Performance in vivo Through Use of Conductive Hydrogel Coatings.

Tomoko Hyakumura, Ulises Aregueta-Robles, Wenlu Duan, Joel Villalobos, Wendy K Adams, Laura Poole-Warren, James B Fallon

Journal article  |  2021  |  Front Neurosci

Active implantable neurological devices like deep brain stimulators have been used over the past few decades to treat movement dis..

Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices

Tomoko Hyakumura, Stuart McDougall, Sue Finch, Karina Needham, Mirella Dottori, Bryony A Nayagam

Journal article  |  2019  |  Stem Cells International

Stem cells have been touted as a source of potential replacement neurons for inner ear degeneration for almost two decades now; ye..

Anti-inflammatory Effects of Abdominal Vagus Nerve Stimulation on Experimental Intestinal Inflammation

Sophie C Payne, John B Furness, Owen Burns, Alicia Sedo, Tomoko Flyakumurat, Robert K Shepherd, James B Fallon

Journal article  |  2019  |  FRONTIERS IN NEUROSCIENCE

Electrical stimulation of the cervical vagus nerve is an emerging treatment for inflammatory bowel disease (IBD). However, side ef..

Vagus nerve stimulation to treat inflammatory bowel disease: a chronic, preclinical safety study in sheep

Sophie C Payne, Owen Burns, Martin Stebbing, Ross Thomas, Angel de Silva, Alicia Sedo, Frank Weissenborn, Tomoko Hyakumura, Mario Huynh, Clive N May, Richard A Williams, John B Furness, James B Fallon, Robert K Shepherd

Journal article  |  2018  |  Bioelectronics in Medicine

Aim: Electrical stimulation of the left cervical vagus nerve is a feasible therapy for inflammatory bowel disease (IBD). However, ..

Ndfip1 Is Required for the Development of Pyramidal Neuron Dendrites and Spines in the Neocortex

Vicki E Hammond, Jenny M Gunnersen, Choo-Peng Goh, Ley-Hian Low, Tomoko Hyakumura, Michelle M Tang, Joanne M Britto, Ulrich Putz, Jason A Howitt, Seong-Seng Tan

Journal article  |  2014  |  CEREBRAL CORTEX

Ubiquitin ligases of the Nedd4 family are important for axon and dendrite development, but little is known about their adaptor, Ne..

Epithelial–Mesenchymal Interactions During Lung Development and Their Potential Relevance to Lung Repair

Alexandra Firsova, Tomoko Hyakumura, Timothy J Cole, Richard Mollard

Book Chapter  |  2010