A/Prof Nicholas Opie is a biomedical engineer with experience in neural prostheses and co-head of the Vascular Bionics Laboratory. He completed his BE (Hons) and BSc undergraduate degrees at Monash University in 2007, his MBA at Melbourne Business School in 2018 and was awarded his PhD in 2012 for research developing a bionic eye.
He was employed as the Surgical Program Coordinator on Bionic Vision Australia's retinal prosthesis project, and was integral in development and preclinical validation of the technology designed to restore rudimentary vision to the profoundly blind. This device was implanted in three patients in 2012 with great success. In 2012, A/Prof Opie was awarded a $1.33M grant from US defence organization DARPA to develop a minimally invasive brain machine interface. This funding, and subsequent funding totaling more than $15.5M has enabled Dr Opie to establish and co-lead the Vascular Bionics Laboratory within the Department of Medicine at The University of Melbourne; a laboratory which has grown to support more than 35 graduate and undergraduate researchers. He is leading the research team conducting preclinical safety and efficacy trials on a device capable of recording neural information from within a blood vessel, which may enable direct brain control of wheelchairs, exoskeletons and computers to people with paralysis. Dr Opie is a Founding Director and CTO of Synchron, a company incorporated to translate endovascular bionic technology into clinical application.
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Nicholas Opie's selected work
Distinct Neural Correlates Underlie Inhibitory Mechanisms of Motor Inhibition and Motor Im..
Displaying the 22 most recent projects by Nicholas Opie.
Stentrode With Thought Controlled Digital Switch: A First In Human Early Feasibility Study Of The Stentrode In Participants With Loss Of Motor Function Due To Paralysis
The stentrode is an implanted endovascular stent recording electrode that records brain signals from the motor cortex. Through the use of co..
Internal Research Grant
Displaying the 43 most recent scholarly works by Nicholas Opie.
Distinct Neural Correlates Underlie Inhibitory Mechanisms of Motor Inhibition and Motor Imagery Restraint
PE Yoo, TJ Oxley, MA Hagan, S John, SM Ronayne, GS Rind, AM Brinded, NL Opie, BA Moffat, YT Wong
Journal article | 2020 | Frontiers in Behavioral Neuroscience
There is evidence to suggest that motor execution and motor imagery both involve planning and execution of the same motor plan, ho..
Sensor Modalities for Brain-Computer Interface Technology: A Comprehensive Literature Review
Michael L Martini, Eric Karl Oermann, Nicholas L Opie, Fedor Panov, Thomas Oxley, Kurt Yaeger
Journal article | 2020 | Neurosurgery
Brain-computer interface (BCI) technology is rapidly developing and changing the paradigm of neurorestoration by linking cortical ..
Neural Stimulation with an Endovascular Brain-Machine Interface
NL Opie, SE John, G Gerboni, GS Rind, TJH Lovell, SM Ronayne, YT Wong, CN May, DB Grayden, TJ Oxley
Conference Proceedings | 2019 | 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)
Stimulation of deep cortical structures has been demonstrated to provide symptomatic alleviation to people with depression, Parkin..
Evaluation of a minimally invasive endovascular neural interface for decoding motor activity
IA Forsyth, M Dunston, G Lombardi, GS Rind, S Ronayne, YT Wong, CN May, DB Grayden, T Oxley, N Opie, SE John
Conference Proceedings | 2019 | 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER)
Endovascular devices like the Stentrode™ provide a minimally invasive approach to brain-machine-interfaces that mitigates safety c..
In Vivo Impedance Characterization of Cortical Recording Electrodes Shows Dependence on Electrode Location and Size
Sam E John, Nicholas V Apollo, Nicholas L Opie, Gil S Rind, Stephen M Ronayne, Clive N May, Thomas J Oxley, David B Grayden
Journal article | 2019 | IEEE Transactions on Biomedical Engineering
Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent
Nicholas L Opie, Sam E John, Gil S Rind, Stephen M Ronayne, Yan T Wong, Giulia Gerboni, Peter E Yoo, Timothyj H Lovell, Theodore CM Scordas, Stefan L Wilson, Anthony Dornom, Thomas Vale, Terence J O'brien, David B Grayden, Clive N May, Thomasj Oxley
Journal article | 2018 | Nature Biomedical Engineering
Feasibility of identifying the ideal locations for motor intention decoding using unimodal and multimodal classification at 7T-fMRI
Peter E Yoo, Thomas J Oxley, Sam E John, Nicholas L Opie, Roger J Ordidge, Terence J O'Brien, Maureen A Hagan, Yan T Wong, Bradford A Moffat
Journal article | 2018 | SCIENTIFIC REPORTS
Optimized partial-coverage functional analysis pipeline (OPFAP): a semi-automated pipeline for skull stripping and co-registration of partial-coverage, ultra-high-field functional images
Peter E Yoo, Jon O Cleary, Scott C Kolbe, Roger J Ordidge, Terence J O'Brien, Nicholas L Opie, Sam E John, Thomas J Oxley, Bradford A Moffat
Journal article | 2018 | Magnetic Resonance Materials in Physics, Biology and Medicine
Cortical Brain Stimulation with Endovascular Electrodes.
G Gerboni, SE John, SM Ronayne, GS Rind, CN May, TJ Oxley, DB Grayden, NL Opie, YT Wong
Conference Proceedings | 2018 | 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Electrical stimulation of neural tissue and recording of neural activity are the bases of emerging prostheses and treatments for s..
Signal quality of simultaneously recorded endovascular, subdural and epidural signals are comparable
Sam E John, Nicholas L Opie, Yan T Wong, Gil S Rind, Stephen M Ronayne, Giulia Gerboni, Sebastien H Bauquier, Terence J O'Brien, Clive N May, David B Grayden, Thomas J Oxley
Journal article | 2018 | Scientific Reports
An ovine model of cerebral catheter venography for implantation of an endovascular neural interface
Thomas James Oxley, Nicholas Lachlan Opie, Gil Simon Rind, Kishan Liyanage, Sam Emmanuel John, Stephen Ronayne, Alan James McDonald, Anthony Dornom, Timothy John Haynes Lovell, Peter John Mitchell, Iwan Bennett, Sebastien Bauquier, Leon Norris Warne, Chris Steward, David Bruce Grayden, Patricia Desmond, Stephen M Davis, Terence John O'Brien, Clive N May
Journal article | 2018 | Journal of Neurosurgery
Near-field wireless power transfer to stent-based biomedical implants
A Aldaoud, Jean-Michel Redoute, Kumaravelu Ganesan, G Rind, S John, S Ronayne, N Opie, D Garrett, S Prawer
Journal article | 2018 | IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology
Safe wireless power transfer is an essential requirement for biomedical implants. Emerging technologies are becoming smaller, less..
7T-fMRI: Faster temporal resolution yields optimal BOLD sensitivity for functional network imaging specifically at high spatial resolution
Peter E Yoo, Sam E John, Shawna Farquharson, Jon O Cleary, Yan T Wong, Amanda Ng, Claire B Mulcahy, David B Grayden, Roger J Ordidge, Nicholas L Opie, Terence J O'Brien, Thomas J Oxley, Bradford A Moffat
Journal article | 2018 | NEUROIMAGE
The ovine motor cortex: A review of functional mapping and cytoarchitecture
Sam E John, Timothy JH Lovell, Nicholas L Opie, Stefan Wilson, Theodore C Scordas, Yan T Wong, Gil S Rind, Stephen Ronayne, Sebastien H Bauquier, Clive N May, David B Grayden, Terence J O'Brien, Thomas J Oxley
Journal article | 2017 | Neuroscience & Biobehavioral Reviews
Micro-CT and Histological Evaluation of an Neural Interface Implanted Within a Blood Vessel
Nicholas Lachlan Opie, Nicole R van der Nagel, Sam E John, Kirstan Vessey, Gil S Rind, Stephen M Ronayne, Erica L Fletcher, Clive N May, Terence J O'Brien, Thomas J Oxley
Journal article | 2017 | IEEE Transactions on Biomedical Engineering
Development and Implementation of a Corriedale Ovine Brain Atlas for Use in Atlas-Based Segmentation
Kishan Andre Liyanage, Christopher Steward, Bradford Armstrong Moffat, Nicholas Lachlan Opie, Gil Simon Rind, Sam Emmanuel John, Stephen Ronayne, Clive Newton May, Terence John O'Brien, Marjorie Eileen Milne, Thomas James Oxley
Journal article | 2016 | PLOS ONE
Development of a Magnetic Attachment Method for Bionic Eye Applications
Kate Fox, Hamish Meffin, Owen Burns, Carla J Abbott, Penelope J Allen, Nicholas L Opie, Ceara McGowan, Jonathan Yeoh, Arman Ahnood, Chi D Luu, Rosemary Cicione, Alexia L Saunders, Michelle McPhedran, Lisa Cardamone, Joel Villalobos, David J Garrett, David AX Nayagam, Nicholas V Apollo, Kumaravelu Ganesan, Mohit N Shivdasani, et al.
Journal article | 2016 | Artificial Organs
Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity
Thomas J Oxley, Nicholas L Opie, Sam E John, Gil S Rind, Stephen M Ronayne, Tracey L Wheeler, Jack W Judy, Alan J McDonald, Anthony Dornom, Timothy JH Lovell, Christopher Steward, David J Garrett, Bradford A Moffat, Elaine H Lui, Nawaf Yassi, Bruce CV Campbell, Yan T Wong, Kate E Fox, Ewan S Nurse, Iwan E Bennett, et al.
Journal article | 2016 | Nature biotechnology
Suitability of Nitinol Electrodes in Neural Prostheses such as Endovascular Neural Interfaces
Yan T Wong, Nicholas L Opie, Sam E John, Giulia Gerboni, Gil S Rind, Stephen M Ronayne, Kate E Fox, Thomas J Oxley, David B Grayden
Conference Proceedings | 2016 | 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Feasibility of a Chronic, Minimally Invasive Endovascular Neural Interface
Nicholas L Opie, Gil S Rind, Sam E John, Stephen M Ronayne, David B Grayden, Anthony N Burkitt, Clive N May, Terence J O'Brien, Thomas J Oxley
Conference Proceedings | 2016 | 2016 38TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
First-in-Human Trial of a Novel Suprachoroidal Retinal Prosthesis
Lauren N Ayton, Peter J Blamey, Robyn H Guymer, Chi D Luu, David AX Nayagam, Nicholas C Sinclair, Mohit N Shivdasani, Jonathan Yeoh, Mark F McCombe, Robert J Briggs, Nicholas L Opie, Joel Villalobos, Peter N Dimitrov, Mary Varsamidis, Matthew A Petoe, Chris D McCarthy, Janine G Walker, Nick Barnes, Anthony N Burkitt, Chris E Williams, et al.
Journal article | 2014 | PLOS ONE
Factors Affecting Perceptual Thresholds in a Suprachoroidal Retinal Prosthesis
Mohit N Shivdasani, Nicholas C Sinclair, Peter N Dimitrov, Mary Varsamidis, Lauren N Ayton, Chi D Luu, Thushara Perera, Hugh J McDermott, Peter J Blamey
Journal article | 2014 | Investigative Opthalmology & Visual Science
Development of a surgical procedure for implantation of a prototype suprachoroidal retinal prosthesis
Alexia L Saunders, Chris E Williams, Wilson Heriot, Robert Briggs, Jonthan Yeoh, David AX Nayagam, Mark McCombe, Joel Villalobos, Owen Burns, Chi D Luu, Lauren N Ayton, Michelle McPhedran, Nicholas L Opie, Ceara McGowan, Robert K Shepherd, Robyn Guymer, Penelope J Allen
Journal article | 2014 | CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Reproducibility of an instrumented measure for passive ankle dorsiflexion in conscious and anaesthetized children with cerebral palsy
Tandy Hastings-Ison, Christine Blackburn, Nicholas L Opie, H Kerr Graham, Barry Rawicki, Rory Wolfe, Pam Simpson, Richard Baker
Journal article | 2014 | Developmental Medicine & Child Neurology
A Suprachoroidal Retinal Prosthesis with a Flexible Lead is Reliable for Patient Testing
Joel Villalobos, Penelope Allen, Chi Luu, Lauren Ayton, Jonathan Yeoh, David Nayagam, Nicholas Opie, Mohit Shivdasani, Robert Shepherd, Chris Williams
Journal article | 2013 | Investigative Ophthalmology & Visual Science
Retinal Prosthesis Safety: Alterations in Microglia Morphology due to Thermal Damage and Retinal Implant Contact
Nicholas L Opie, Ursula Greferath, Kirstan A Vessey, Anthony N Burkitt, Hamish Meffin, David B Grayden, Erica L Fletcher
Journal article | 2012 | Investigative Ophthalmology and Visual Science
Displaying the 3 most recent news articles by Nicholas Opie.
Honours, Awards and Fellowships
3rd Place, Brain Computer Interface Award
1st Place, MedTech's Got Talent
NICTA Special Postgraduate Scholarship
Medicine - Royal Melbourne Hospital
Australasian Neuroscience Society (Ans)
Australasian Neuroscience Society (ANS)
Institute Of Electrical And Electronic Engineers (Ieee)
Institute of Electrical and Electronic Engineers (IEEE)
American Association For Teh Advancement Of Science (Aaas)
American Association for teh Advancement of Science (AAAS)
Master of Business Administration
Melbourne Business School
Doctorate of Electrical and Electronic Engineering
University of Melbourne
Bachelor of Electrical and Computer Systems Engineering (Hons)
Bachelor of Science