Nadia Warner

Role of anti-HBs in functional cure of HBeAg plus chronic hepatitis B patients infected with HBV genotype A

Hui Xu, Stephen Locarnini, Darren Wong, Rachel Hammond, Danni Colledge, Sally Soppe, Thao Huynh, Tim Shaw, Alexander J Thompson, Peter A Revill, P Mark Hogarth, Bruce D Wines, Renae Walsh, Nadia Warner

Journal article  |  2021  |  JOURNAL OF HEPATOLOGY

BACKGROUND & AIMS: HBsAg-specific antibody responses are difficult to detect during chronic hepatitis B infection (CHB) and are of..

Quantitative analysis of the splice variants expressed by the major hepatitis B virus genotypes

Chun Shen Lim, Vitina Sozzi, Margaret Littlejohn, Lilly KW Yuen, Nadia Warner, Brigid Betz-Stablein, Fabio Luciani, Peter A Revill, Chris M Brown

Journal article  |  2021  |  MICROBIAL GENOMICS

Hepatitis B virus (HBV) is a major human pathogen that causes liver diseases. The main HBV RNAs are unspliced transcripts that enc..

The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling

Manh Tran Bang, Dustin James Flanagan, Gregor Ebert, Nadia Warner, Tran Hoanh, Theodora Fifis, Georgios Kastrappis, Christopher Christophi, Marc Pellegrini, Joseph Torresi, Toby James Phesse, Elizabeth Vincan

Journal article  |  2020  |  CANCERS

An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms. Infection wi..

The role of hepatitis B surface antibodies in HBV infection, disease and clearance

Nadia Warner, Stephen Locarnini, Hui Xu

Journal article  |  2020  |  FUTURE VIROLOGY

The clinical sequelae associated with chronic HBV infection is generally regarded as a consequence of an inadequate and inappropri..

HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism

Amy P Chiu, Barbara R Tschida, Tung-Ting Sham, Lilian H Lo, Branden S Moriarity, Xiao-Xiao Li, Regina C Lo, David E Hinton, Dewi K Rowlands, Chi-On Chan, Daniel KW Mok, David A Largaespada, Nadia Warner, Vincent W Keng

Journal article  |  2019  |  MOLECULAR CANCER RESEARCH

Chronic hepatitis B viral (HBV) infection remains a high underlying cause for hepatocellular carcinoma (HCC) worldwide, while the ..

Levels of regulatory B cells do not predict serological responses to hepatitis B vaccine

Maria Bolther, Karen Lise Dahl Andersen, Martin Tolstrup, Kumar Visvanathan, Ian Woolley, Narelle Skinner, Rosemary Millen, Nadia Warner, Lars Ostergaard, Soren Jensen-Fangel

Journal article  |  2018  |  HUMAN VACCINES & IMMUNOTHERAPEUTICS

This study investigated the immunomodulatory influence of IL10 producing B regulatory cells, Bregs (CD19+CD24hiCD38hi) to standard..

Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro

Romina Salpini, Matteo Surdo, Nadia Warner, Maria Francesca Cortese, Danny Colledge, Sally Soppe, Maria Concetta Bellocchi, Daniele Armenia, Luca Carioti, Fabio Continenza, Domenico Di Carlo, Patrizia Saccomandi, Carmen Mirabelli, Michela Pollicita, Roberta Longo, Sara Romano, Giuseppina Cappiello, Alberto Spano, Pascale Trimoulet, Herve Fleury, et al.

Journal article  |  2017  |  ONCOTARGET

BACKGROUND: An impaired HBsAg-secretion can increase HBV oncogenic-properties. Here, we investigate genetic-determinants in HBsAg ..

Stop codons in the hepatitis B surface proteins are enriched during antiviral therapy and are associated with host cell apoptosis

Danielle Colledge, Sally Soppe, Lilly Yuen, Lucy Selleck, Renae Walsh, Stephen Locarnini, Nadia Warner

Journal article  |  2017  |  VIROLOGY

Premature stop codons in the hepatitis B virus (HBV) surface protein can be associated with nucleos(t)ide analogue resistance due ..

In Vitro Studies Show that Sequence Variability Contributes to Marked Variation in Hepatitis B Virus Replication, Protein Expression, and Function Observed across Genotypes

Vitina Sozzi, Renae Walsh, Margaret Littlejohn, Danni Colledge, Kathy Jackson, Nadia Warner, Lilly Yuen, Stephen A Locarnini, Peter A Revill

Journal article  |  2016  |  JOURNAL OF VIROLOGY

UNLABELLED: The hepatitis B virus (HBV) exists as 9 major genotypes (A to I), one minor strain (designated J) and multiple subtype..

Single-Molecule Sequencing Reveals Complex Genome Variation of Hepatitis B Virus during 15 Years of Chronic Infection following Liver Transplantation

BD Betz-Stablein, A Toepfer, M Littlejohn, L Yuen, D Colledge, V Sozzi, P Angus, A Thompson, P Revill, N Beerenwinkel, N Warner, F Luciani

Journal article  |  2016  |  JOURNAL OF VIROLOGY

UNLABELLED: Chronic hepatitis B (CHB) is prevalent worldwide. The infectious agent, hepatitis B virus (HBV), replicates via an RNA..