Nic Geard

Bow-tie architecture of gene regulatory networks in species of varying complexity

Gourab Ghosh Roy, Shan He, Nicholas Geard, Karin Verspoor

Journal article  |  2021  |  JOURNAL OF THE ROYAL SOCIETY INTERFACE

The gene regulatory network (GRN) architecture plays a key role in explaining the biological differences between species. We aim t..

Risk mapping for COVID-19 outbreaks in Australia using mobility data

Cameron Zachreson, Lewis Mitchell, Michael J Lydeamore, Nicolas Rebuli, Martin Tomko, Nicholas Geard

Journal article  |  2021  |  JOURNAL OF THE ROYAL SOCIETY INTERFACE

COVID-19 is highly transmissible and containing outbreaks requires a rapid and effective response. Because infection may be spread..

The acceptability and uptake of smartphone tracking for COVID-19 in Australia

Paul M Garrett, Joshua P White, Stephan Lewandowsky, Yoshihisa Kashima, Andrew Perfors, Daniel R Little, Nic Geard, Lewis Mitchell, Martin Tomko, Simon Dennis

Journal article  |  2021  |  PLOS ONE

In response to the COVID-19 pandemic, many Governments are instituting mobile tracking technologies to perform rapid contact traci..

Modelling the household-level impact of a maternal respiratory syncytial virus (RSV) vaccine in a high-income setting

Patricia T Campbell, Nicholas Geard, Alexandra B Hogan

Journal article  |  2020  |  BMC MEDICINE

BACKGROUND: Respiratory syncytial virus (RSV) infects almost all children by the age of 2 years, with the risk of hospitalisation ..

A model of population dynamics with complex household structure and mobility: implications for transmission and control of communicable diseases

Rebecca H Chisholm, Bradley Crammond, Yue Wu, Asha C Bowen, Patricia T Campbell, Steven YC Tong, Jodie McVernon, Nicholas Geard

Journal article  |  2020  |  PEERJ

Households are known to be high-risk locations for the transmission of communicable diseases. Numerous modelling studies have demo..

PoLoBag: Polynomial Lasso Bagging for signed gene regulatory network inference from expression data.

Gourab Ghosh Roy, Nicholas Geard, Karin Verspoor, Shan He

Journal article  |  2020  |  Bioinformatics

MOTIVATION: Inferring gene regulatory networks (GRNs) from expression data is a significant systems biology problem. A useful infe..

Proportional multistate lifetable modelling of preventive interventions: concepts, code and worked examples

Tony Blakely, Rob Moss, James Collins, Anja Mizdrak, Ankur Singh, Natalie Carvalho, Nick Wilson, Nicholas Geard, Abraham Flaxman

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Burden of Disease studies-such as the Global Burden of Disease (GBD) Study-quantify health loss in disability-adjusted life-years...

A model of population dynamics with complex household structure and mobility: implications for transmission and control of communicable diseases

Rebecca Chisholm, Bradley Crammond, Yue Wu, Asha Bowen, Patricia Campbell, Steven Tong, Jodie McVernon, Nicholas Geard

Journal article  |  2020

ABSTRACT Households are known to be high-risk locations for the transmission of communicable diseases. Numerous modelling studies ..

Epidemiological consequences of enduring strain-specific immunity requiring repeated episodes of infection

Rebecca H Chisholm, Nikki Sonenberg, Jake A Lacey, Malcolm I McDonald, Manisha Pandey, Mark R Davies, Steven YC Tong, Jodie McVernon, Nicholas Geard

Journal article  |  2020  |  PLOS COMPUTATIONAL BIOLOGY

Group A Streptococcus (GAS) skin infections are caused by a diverse array of strain types and are highly prevalent in disadvantage..

Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections.

Patricia Therese Campbell, Steven YC Tong, Nicholas Geard, Mark R Davies, Kate A Worthing, Jake A Lacey, Pierre R Smeesters, Michael R Batzloff, Joseph Kado, Adam WJ Jenney, Jodie Mcvernon, Andrew C Steer

Journal article  |  2020  |  Journal of Infectious Diseases

Group A Streptococcus is a pathogen of global importance, but despite the ubiquity of group A Streptococcus infections, the relati..