Christine Wells

Ten simple rules for navigating the computational aspect of an interdisciplinary PhD

Sabrina Islam, Christine A Wells

Journal article  |  2021  |  PLOS Computational Biology

Challenges for Computational Stem Cell Biology: A Discussion for the Field

Owen Rackham, Patrick Cahan, Nancy Mah, Samantha Morris, John F Ouyang, Anne L Plant, Yoshiaki Tanaka, Christine A Wells

Conference Proceedings  |  2021  |  Stem Cell Reports

The first meetup for Computational Stem Cell Biologists was held at the 2020 annual meeting of the International Society for Stem ..

Transcriptomic profiles of Plasmodium falciparum and Plasmodium vivax-infected individuals in Indonesia

Katalina Bobowik, Din Syafruddin, Chelzie Crenna Darusallam, Herawati Sudoyo, Christine Wells, Irene Gallego Romero

Journal article  |  2021

Malaria is one of the leading causes of illness and death globally. The vast majority of transcriptomic studies of the impact of m..

Computational Stem Cell Biology: Open Questions and Guiding Principles

Patrick Cahan, Davide Cacchiarelli, Sara-Jane Dunn, Martin Hemberg, Susana M Chuva de Sousa Lopes, Samantha A Morris, Owen Jl Rackham, Antonio del Sol, Christine A Wells

Journal article  |  2021  |  Cell Stem Cell

Computational biology is enabling an explosive growth in our understanding of stem cells and our ability to use them for disease m..

constclust: Consistent Clusters for scRNA-seq

Isaac Virshup, Jarny Choi, Kim-Anh Lê Cao, Christine Wells

Journal article  |  2020

1 Unsupervised clustering to identify distinct cell types is a crucial step in the analysis of scRNA-seq data. Current clustering ..

Pharmacological validation of targets regulating CD14 during macrophage differentiation

Gisela Jimenez-Duran, Rosario Luque-Martin, Meghana Patel, Emma Koppe, Sharon Bernard, Catriona Sharp, Natalie Buchan, Ceara Rea, Menno PJ de Winther, Nil Turan, Davina Angell, Christine A Wells, Rick Cousins, Palwinder K Mander, Seth L Masters

Journal article  |  2020  |  EBioMedicine

The signalling receptor for LPS, CD14, is a key marker of, and facilitator for, pro-inflammatory macrophage function. Pro-inflamma..

A simple, scalable approach to building a cross-platform transcriptome atlas

Paul W Angel, Nadia Rajab, Yidi Deng, Chris M Pacheco, Tyrone Chen, Kim-Anh Le Cao, Jarny Choi, Christine A Wells

Journal article  |  2020  |  PLoS Computational Biology

Gene expression atlases have transformed our understanding of the development, composition and function of human tissues. New tech..

Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal

Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L Baker, Tracy C McGarr, Christine A Wells, et al.

Journal article  |  2020  |  Nature Communications

Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast st..

A simple, scalable approach to building a cross-platform transcriptome atlas

Paul Angel, Nadia Rajab, Yidi Deng, Chris Pacheco, Tyrone Chen, Kim-Anh Lê Cao, Jarny Choi, Christine Wells

Journal article  |  2020

ABSTRACT Gene expression atlases have transformed our understanding of the development, composition and function of human tissues...

Multipotent RAG1 progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids

Ali Motazedian, Freya F Bruveris, Santhosh V Kumar, Jacqueline V Schiesser, Tyrone Chen, Elizabeth S Ng, Ann P Chidgey, Christine A Wells, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2020  |  Nature Cell Biology

Defining the ontogeny of the human adaptive immune system during embryogenesis has implications for understanding childhood diseas..