Mark Parsons

Effects of intensive blood pressure lowering on cerebral ischaemia in thrombolysed patients: insights from the ENCHANTED trial.

Chen Chen, Menglu Ouyang, Sheila Ong, Luyun Zhang, Guobin Zhang, Candice Delcourt, Grant Mair, Leibo Liu, Laurent Billot, Qiang Li, Xiaoying Chen, Mark Parsons, Joseph P Broderick, Andrew M Demchuk, Philip M Bath, Geoffrey A Donnan, Christopher Levi, John Chalmers, Richard I Lindley, Sheila O Martins, et al.

Journal article  |  2023  |  EClinicalMedicine

BACKGROUND: Intensive blood pressure lowering may adversely affect evolving cerebral ischaemia. We aimed to determine whether inte..

Tenecteplase Treatment and Thrombus Characteristics Associated With Early Reperfusion: An EXTEND-IA TNK Trials Analysis

Vignan Yogendrakumar, Leonid Churilov, Prodipta Guha, James Beharry, Peter J Mitchell, Timothy J Kleinig, Nawaf Yassi, Vincent Thijs, Teddy Y Wu, Helen Brown, Helen M Dewey, Tissa Wijeratne, Bernard Yan, Gagan Sharma, Patricia M Desmond, Mark W Parsons, Geoffrey A Donnan, Stephen M Davis, Bruce CV Campbell

Journal article  |  2023  |  STROKE

BACKGROUND: Intracranial occlusion site, contrast permeability, and clot burden are thrombus characteristics that influence altepl..

Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial.

Yongjun Wang, Shuya Li, Yuesong Pan, Hao Li, Mark W Parsons, Bruce CV Campbell, Lee H Schwamm, Marc Fisher, Fengyuan Che, Hongguo Dai, Deyang Li, Runhui Li, Junhai Wang, Yilong Wang, Xingquan Zhao, Zixiao Li, Huaguang Zheng, Yunyun Xiong, Xia Meng, undefined TRACE-2 Investigators

Journal article  |  2023  |  Lancet

BACKGROUND: There is increasing interest in replacing alteplase with tenecteplase as the preferred thrombolytic treatment for pati..

Basilar artery occlusion management: Specialist perspectives from an international survey

Christopher Edwards, Brian Drumm, James E Siegler, Wouter J Schonewille, Piers Klein, Xiaochuan Huo, Yimin Chen, Mohamad Abdalkader, Muhammad M Qureshi, Daniel Strbian, Xinfeng Liu, Wei Hu, Xunming Ji, Chuanhui Li, Urs Fischer, Simon Nagel, Volker Puetz, Patrik Michel, Fana Alemseged, Simona Sacco, et al.

Journal article  |  2023  |  JOURNAL OF NEUROIMAGING

BACKGROUND AND PURPOSE: Two early basilar artery occlusion (BAO) randomized controlled trials did not establish the superiority of..

Association of Perfusion Lesion Variables With Functional Outcome in Patients With Mild Stroke and Large Vessel Occlusion Managed Medically.

Peng Wang, Wenhuo Chen, Chushuang Chen, Andrew Bivard, Geng Yu, Mark W Parsons, Longting Lin, undefined INSPIRE

Journal article  |  2023  |  Neurology

BACKGROUND AND OBJECTIVES: The best management of patients with mild stroke and large vessel occlusion (LVO) remains unclear. This..

Tenecteplase versus alteplase for stroke thrombolysis evaluation (TASTE): A multicentre, prospective, randomized, open-label, blinded-endpoint, controlled phase III non-inferiority trial protocol

Andrew Bivard, Carlos Garcia-Esperon, Leonid Churilov, Neil Spratt, Michelle Russell, Bruce C Campbell, Philip Choi, Timothy Kleinig, Henry Ma, Hugh Markus, Carlos Molina, Chung Hsu, Chon-Haw Tsai, Atte Meretoja, Daniel Strbian, Kenneth Butcher, Teddy Wu, Stephen Davis, Geoffrey Donnan, Christopher Levi, et al.

Journal article  |  2023  |  INTERNATIONAL JOURNAL OF STROKE

RATIONALE: Alteplase is the only approved thrombolytic agent for acute stroke. An alternative plasminogen activator, tenecteplase,..

Association of Endovascular Thrombectomy vs Medical Management With Functional and Safety Outcomes in Patients Treated Beyond 24 Hours of Last Known Well: The SELECT Late Study.

Amrou Sarraj, Timothy J Kleinig, Ameer E Hassan, Pere Cardona Portela, Santiago Ortega-Gutierrez, Michael G Abraham, Nathan W Manning, James E Siegler, Nitin Goyal, Laith Maali, Spiros Blackburn, Teddy Y Wu, Jordi Blasco, Arturu Renú, Navdeep S Sangha, Juan F Arenillas, Margy E McCullough-Hicks, Adam Wallace, Daniel Gibson, Deep K Pujara, et al.

Journal article  |  2023  |  JAMA Neurol

IMPORTANCE: The role of endovascular thrombectomy is uncertain for patients presenting beyond 24 hours of the time they were last ..

Abstract 92: Tenecteplase Treatment And Thrombus Characteristics Associated With Early Reperfusion - An EXTEND-IA TNK Trials Analysis

Vignan Yogendrakumar, Leonid Churilov, Prodipta Guha, James Beharry, Peter J Mitchell, Timothy J Kleinig, Nawaf Yassi, Vincent Thijs, Teddy Y Wu, Helen Brown, Helen M Dewey, Tissa H Wijeratne, Bernard Yan, Gagan Sharma, Patricia Desmond, Mark W Parsons, Geoffrey A Donnan, Stephen Davis, Bruce Campbell

Journal article  |  2023  |  Stroke

Background: Intracranial occlusion site, contrast permeability, and clot burden are thrombus characteristics that infl..

Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up.

Thanh N Nguyen, Muhammad M Qureshi, Piers Klein, Hiroshi Yamagami, Robert Mikulik, Anna Czlonkowska, Mohamad Abdalkader, Petra Sedova, Anvitha Sathya, Hannah C Lo, Ossama Yassin Mansour, Husitha Reddy Vanguru, Emilie Lesaine, Georgios Tsivgoulis, Aaron I Loochtan, Jelle Demeestere, Ken Uchino, Violiza Inoa, Nitin Goyal, Andreas Charidimou, et al.

Journal article  |  2023  |  Neurology

BACKGROUND AND OBJECTIVES: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported ..

Mediation of Successful Reperfusion Effect through Infarct Growth and Cerebral Edema: A Pooled, Patient-Level Analysis of EXTEND-IA Trials and SELECT Prospective Cohort

Amrou Sarraj, Deep K Pujara, Leonid Churilov, Clark W Sitton, Felix Ng, Ameer E Hassan, Michael G Abraham, Spiros L Blackburn, Gagan Sharma, Nawaf Yassi, Timothy Kleinig, Darshan Shah, Teddy Y Wu, Wondwossen G Tekle, Ronald F Budzik, William J Hicks, Nirav Vora, Randall C Edgell, Diogo Haussen, Santiago Ortega-Gutierrez, et al.

Journal article  |  2023  |  ANNALS OF NEUROLOGY

OBJECTIVE: Reperfusion therapy is highly beneficial for ischemic stroke. Reduction in both infarct growth and edema are plausible ..