Andrew Pask

Oestrogen regulates SOX9 bioavailability by rapidly activating ERK1/2 and stabilising microtubules in a human testis-derived cell line

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

Journal article  |  2021  |  Experimental Cell Research

Nuclear SOX9 is essential for Sertoli cell differentiation and the development of a testis. Exposure of Sertoli cells to exogenous..

Evolution and expansion of the RUNX2 QA repeat corresponds with the emergence of vertebrate complexity.

Axel H Newton, Andrew J Pask

Journal article  |  2020  |  Communications Biology

Runt-related transcription factor 2 (RUNX2) is critical for the development of the vertebrate bony skeleton. Unlike other RUNX fam..

Exogenous Oestrogen Impacts Cell Fate Decision in the Developing Gonads: A Potential Cause of Declining Human Reproductive Health

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

Journal article  |  2020  |  International Journal of Molecular Sciences

The increasing incidence of testicular dysgenesis syndrome-related conditions and overall decline in human fertility has been link..

Estrogen suppresses SOX9 and activates markers of female development in a human testis-derived cell line

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

Journal article  |  2020  |  BMC Molecular and Cell Biology

Background The increasing incidence of reproductive disorders in humans has been attributed to in utero exposure to estrogenic end..

Long-term maternal exposure to atrazine in the drinking water reduces penis length in the tammar wallaby Macropus eugenii

Laura E Cook, Yu Chen, Marilyn B Renfree, Andrew J Pask

Journal article  |  2020  |  Reproduction Fertility and Development

Marsupials are experiencing devastating population declines across Australia. Exposure to environmental endocrine disruptors, thro..

Reproduction in a polluted world: implications for wildlife

Lucinda C Aulsebrook, Michael G Bertram, Jake M Martin, Anne E Aulsebrook, Tomas Brodin, Jonathan P Evans, Matthew D Hall, Moira K O'Bryan, Andrew J Pask, Charles R Tyler, Bob BM Wong

Journal article  |  2020  |  Reproduction

Environmental pollution is an increasing problem for wildlife globally. Animals are confronted with many different forms of pollut..

Atrazine induces penis abnormalities including hypospadias in mice

Luke C Govers, Alesia P Harper, Bethany J Finger, Deidre M Mattiske, Andrew J Pask, Mark P Green

Journal article  |  2020  |  Journal of Developmental Origins of Health and Disease

Use of the herbicide atrazine (ATR) is banned in the European Union; yet, it is still widely used in the USA and Australia. ATR is..

Transcriptomic Analysis of MAP3K1 and MAP3K4 in the Developing Marsupial Gonad

Monika Paranjpe, Hongshi Yu, Stephen Frankenberg, Andrew J Pask, Geoff Shaw, Marilyn B Renfree

Journal article  |  2020  |  Sexual Development

CHD9 upregulates RUNX2 and has a potential role in skeletal evolution

Axel H Newton, Andrew J Pask

Journal article  |  2020  |  BMC Molecular and Cell Biology

BACKGROUND: Changes in gene regulation are widely recognized as an important driver of adaptive phenotypic evolution. However, the..

A novel long non-coding RNA, Leat1, causes reduced anogenital distance and fertility in female mice

Deidre Mattiske, Richard R Behringer, Paul A Overbeek, Andrew J Pask

Journal article  |  2020  |  Differentiation

Defective anorectal and urogenital malformations are some of the most severe congenital anomalies encountered in children. Only a ..