Matthew Dixon

Nanobodies against Pfs230 block Plasmodium falciparum transmission

Melanie H Dietrich, Mikha Gabriela, Kitsanapong Reaksudsan, Matthew WA Dixon, Li-Jin Chan, Amy Adair, Stephanie Trickey, Matthew TO 'Neill, Li Lynn Tan, Sash Lopaticki, Julie Healer, Sravya Keremane, Alan F Cowman, Wai-Hong Tham

Journal article  |  2022  |  BIOCHEMICAL JOURNAL

Transmission blocking interventions can stop malaria parasite transmission from mosquito to human by inhibiting parasite infection..

Repurposing the mitotic machinery to drive cellular elongation and chromatin reorganisation in Plasmodium falciparum gametocytes

Jiahong Li, Gerald J Shami, Ellie Cho, Boyin Liu, Eric Hanssen, Matthew WA Dixon, Leann Tilley

Journal article  |  2022  |  NATURE COMMUNICATIONS

The sexual stage gametocytes of the malaria parasite, Plasmodium falciparum, adopt a falciform (crescent) shape driven by the asse..

Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer's clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1

Olivia MSW Carmo, Gerald Shami, Dezerae W Cox, Boyin Liu, Adam W Blanch, Snigdha Tiash, Leann W Tilley, Matthew WA Dixon

Journal article  |  2022  |  PLOS PATHOGENS

Presentation of the variant antigen, Plasmodium falciparum erythrocyte membrane protein 1 (EMP1), at knob-like protrusions on the ..

Cell biological analysis reveals an essential role for Pfcerli2 in erythrocyte invasion by malaria parasites

Benjamin Liffner, Juan Miguel Balbin, Gerald J Shami, Ghizal Siddiqui, Jan Strauss, Sonja Frolich, Gary K Heinemann, Ella May Edwards, Arne Alder, Jan Stephan Wichers, Darren J Creek, Leann Tilley, Matthew WA Dixon, Tim-Wolf Gilberger, Danny W Wilson

Journal article  |  2022  |  COMMUNICATIONS BIOLOGY

Merozoite invasion of host red blood cells (RBCs) is essential for survival of the human malaria parasite Plasmodium falciparum. P..

Multimodal imaging reveals membrane skeleton reorganisation during reticulocyte maturation and differences in dimple and rim regions of mature erythrocytes

Adam J Blanch, Juan Nunez-Iglesias, Arman Namvar, Sebastien Menant, Oliver Looker, Vijay Rajagopal, Wai-Hong Tham, Leann Tilley, Matthew WA Dixon

Journal article  |  2022  |  JOURNAL OF STRUCTURAL BIOLOGY-X

The red blood cell (RBC) is remarkable in its ability to deform as it passages through the vasculature. Its deformability derives ..

Safety, infectivity and immunogenicity of a Chick for genetically attenuated blood-stage malaria updates vaccine

Rebecca Webster, Silvana Sekuloski, Anand Odedra, Stephen Woolley, Helen Jennings, Fiona Amante, Katharine R Trenholme, Julie Healer, Alan F Cowman, Emily M Eriksson, Priyanka Sathe, Jocelyn Penington, Adam J Blanch, Matthew WA Dixon, Leann Tilley, Michael F Duffy, Alister Craig, Janet Storm, Jo-Anne Chan, Krystal Evans, et al.

Journal article  |  2021  |  BMC MEDICINE

BACKGROUND: There is a clear need for novel approaches to malaria vaccine development. We aimed to develop a genetically attenuate..

Plasmodium falciparum goes bananas for sex

Matthew WA Dixon, Leann Tilley

Journal article  |  2021  |  MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The sexual blood stages of the human malaria parasite Plasmodium falciparum undergo a remarkable transformation from a roughly sph..

Surface Area-to-Volume Ratio, not Cellular Viscoelasticity is the Major Determinant of Red Blood Cell Traversal through Small Channels

Arman Namvar, Adam Blanch, Matthew Dixon, Olivia Carmo, Boyin Liu, Snigdha Tiash, Oliver Looker, Dean Andrew, Li-Jin Chan, Wai-Hong Tham, Peter VS Lee, Vijay Rajagopat, Leann Tilley

Journal article  |  2021  |  BIOPHYSICAL JOURNAL

Surface area-to-volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels

Arman Namvar, Adam J Blanch, Matthew W Dixon, Olivia MS Carmo, Boyin Liu, Snigdha Tiash, Oliver Looker, Dean Andrew, Li-Jin Chan, Wai-Hong Tham, Peter VS Lee, Vijay Rajagopal, Leann Tilley

Journal article  |  2020  |  CELLULAR MICROBIOLOGY

The remarkable deformability of red blood cells (RBCs) depends on the viscoelasticity of the plasma membrane and cell contents and..

PfCERLI1 is a conserved rhoptry associated protein essential for Plasmodium falciparum merozoite invasion of erythrocytes

Benjamin Liffner, Sonja Frolich, Gary K Heinemann, Boyin Liu, Stuart A Ralph, Matthew WA Dixon, Tim-Wolf Gilberger, Danny W Wilson

Journal article  |  2020  |  NATURE COMMUNICATIONS

The disease-causing blood-stage of the Plasmodium falciparum lifecycle begins with invasion of human erythrocytes by merozoites. M..